Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Fu J et al. | Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. | 2012 | J. Food Sci. | pmid:22747885 |
Wajid NA and Halpern BP | Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. | 2012 | Chem. Senses | pmid:22459162 |
Ménard N et al. | Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. | 2012 | Pharm. Res. | pmid:22451248 |
Harvey KA et al. | Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. | 2012 | Lipids | pmid:22684911 |
Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
Ruparel S et al. | Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. | 2012 | Pain | pmid:22633978 |
Jarret RL and Levy IJ | Oil and fatty acid contents in seed of Citrullus lanatus Schrad. | 2012 | J. Agric. Food Chem. | pmid:22540530 |
Shimomura K et al. | Identification of the plant origin of propolis from Jeju Island, Korea, by observation of honeybee behavior and phytochemical analysis. | 2012 | Biosci. Biotechnol. Biochem. | pmid:23132582 |
Dramane G et al. | STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. | 2012 | J. Clin. Invest. | pmid:22546859 |
Macaluso F et al. | Effect of conjugated linoleic acid on testosterone levels in vitro and in vivo after an acute bout of resistance exercise. | 2012 | J Strength Cond Res | pmid:22614148 |
Naqvi AZ et al. | Dietary fatty acids and peripheral artery disease in adults. | 2012 | Atherosclerosis | pmid:22552117 |
Banti CN et al. | Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. | 2012 | Metallomics | pmid:22552402 |
Joshi S et al. | Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | 2012 | Org. Biomol. Chem. | pmid:22986997 |
Dubé E et al. | Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. | 2012 | Biol. Reprod. | pmid:22553224 |
Perdriau S et al. | Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. | 2012 | ChemSusChem | pmid:23060315 |
O'Donnell-Megaro AM et al. | Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. | 2012 | J. Dairy Sci. | pmid:23063161 |
Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
Kurotani K et al. | High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | 2012 | Nutr Res | pmid:23084639 |
Sun X et al. | Lipid peroxidation and DNA adduct formation in lymphocytes of premenopausal women: Role of estrogen metabolites and fatty acid intake. | 2012 | Int. J. Cancer | pmid:22322480 |
Zhu X et al. | Release property and antioxidant effectiveness of tocopherol-incorporated LDPE/PP blend films. | 2012 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:22257167 |
Tanaka R et al. | Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities. | 2012 | Adv. Exp. Med. Biol. | pmid:22259110 |
Raatz SK et al. | Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. | 2012 | Nutr Res | pmid:22260857 |
Gu L et al. | Chemical and cellular antioxidant activity of two novel peptides designed based on glutathione structure. | 2012 | Food Chem. Toxicol. | pmid:22940538 |
Sandoval-Montemayor NE et al. | Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. | 2012 | Molecules | pmid:22992784 |
de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
Koch C et al. | Linoleic acid positioning in psi factor producing oxygenase A, a fusion protein with an atypical cytochrome P450 activity. | 2012 | FEBS J. | pmid:21920024 |
Mormile R et al. | Linoleic acid and colorectal cancer cell growth suppression: is the deregulation of mitochondrial survivin the key factor? | 2012 | Int J Colorectal Dis | pmid:22231621 |
Luévano-MartÃnez LA et al. | A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. | 2012 | Biochem. J. | pmid:22236206 |
Jorge AT et al. | Schinus terebinthifolius Raddi extract and linoleic acid from Passiflora edulis synergistically decrease melanin synthesis in B16 cells and reconstituted epidermis. | 2012 | Int J Cosmet Sci | pmid:22738140 |
Manzoor M et al. | Variation in minerals, phenolics and antioxidant activity of peel and pulp of different varieties of peach (Prunus persica L.) fruit from Pakistan. | 2012 | Molecules | pmid:22728349 |
Tao XM et al. | Enhanced anticancer activity of gemcitabine coupling with conjugated linoleic acid against human breast cancer in vitro and in vivo. | 2012 | Eur J Pharm Biopharm | pmid:22728546 |
Zhou YJ et al. | Linoleic acid activates GPR40/FFA1 and phospholipase C to increase [Ca2+]i release and insulin secretion in islet beta-cells. | 2012 | Chin. Med. Sci. J. | pmid:22734209 |
Dundar A et al. | Antioxidant properties, chemical composition and nutritional value of Terfezia boudieri (Chatin) from Turkey. | 2012 | Food Sci Technol Int | pmid:22773542 |
Ogawa N et al. | Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. | 2012 | Metab. Clin. Exp. | pmid:22445513 |
Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Zened A et al. | In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. | 2012 | Animal | pmid:22436225 |
Liu X et al. | Method for screening of bacterial strains biosynthesizing specific conjugated linoleic acid isomers. | 2012 | J. Agric. Food Chem. | pmid:22946615 |
Eserian JK et al. | Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. | 2012 | Nutr Neurosci | pmid:22390908 |
Fei J et al. | ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. | 2012 | Atherosclerosis | pmid:22464285 |
Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
Jarvis MF | Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. | 2012 | Pain | pmid:22681878 |
Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
He M et al. | Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression. | 2012 | J. Dairy Sci. | pmid:22365227 |
Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
Li KL et al. | Characterization of cumulus expansion-inhibiting factor (CEIF) in goat follicles. | 2012 | Biol. Reprod. | pmid:22402961 |
Dall'Asta C et al. | Role of maize hybrids and their chemical composition in Fusarium infection and fumonisin production. | 2012 | J. Agric. Food Chem. | pmid:22409349 |
Mulligan CM et al. | Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. | 2012 | Cardiovasc. Res. | pmid:22411972 |
Gull J et al. | Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. | 2012 | Molecules | pmid:22418924 |
Lasa A et al. | The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. | 2011 Sep-Oct | Nutr Hosp | pmid:22072344 |
Okui T et al. | Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21723718 |
Mujtaba SF et al. | Production of ROS by photosensitized anthracene under sunlight and UV-R at ambient environmental intensities. | 2011 Sep-Oct | Photochem. Photobiol. | pmid:21668866 |
Ramandi NF et al. | Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. | 2011 Nov-Dec | J. Food Sci. | pmid:22416687 |
Olszewska MA | Variation in the phenolic content and in vitro antioxidant activity of Sorbus aucuparia leaf extracts during vegetation. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125960 |
Olszewska MA | In vitro antioxidant activity and total phenolic content of the inflorescences, leaves and fruits of Sorbus torminalis (L.) Crantz. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125961 |
Kezutyte T et al. | Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125963 |
China R et al. | In vitro antioxidant activity of different cultivars of banana flower (Musa paradicicus L.) extracts available in India. | 2011 Nov-Dec | J. Food Sci. | pmid:22416691 |
Permiakova MD and Trufanov VA | [Effect of soybean lipoxygenae on baking properties of wheat flour]. | 2011 May-Jun | Prikl. Biokhim. Mikrobiol. | pmid:21790037 |
Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
Lam YY et al. | Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21570480 |
de Luis DA et al. | Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. | 2011 Jul-Aug | Nutr Hosp | pmid:22470031 |
Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
Shin D et al. | Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. | 2011 | Poult. Sci. | pmid:21597077 |
Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
Wang L et al. | Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. | 2011 | J. Endocrinol. | pmid:21565851 |
Liu SJ et al. | Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. | 2011 | J. Dairy Sci. | pmid:21605768 |
P Wrobel T et al. | Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. | 2011 | Analyst | pmid:22007352 |
Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
Nishioka N et al. | Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1. | 2011 | Br. J. Cancer | pmid:22015554 |
Alimi H et al. | Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:22004960 |
Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
Espinosa-Neira R et al. | Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. | 2011 | Int. J. Biochem. Cell Biol. | pmid:21945809 |
Sousa A et al. | Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. | 2011 | Molecules | pmid:22031066 |
KonÄić MZ et al. | Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. | 2011 | Molecules | pmid:21788931 |
Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
Okuyama H et al. | New Cholesterol Guidelines for Longevity (2010). | 2011 | World Rev Nutr Diet | pmid:21865826 |
Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
Khan AA et al. | Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study. | 2011 | Eur J Med Chem | pmid:21868138 |
Ozcan B et al. | Antimicrobial and antioxidant activities of the various extracts of Verbascum pinetorum Boiss. O. Kuntze (Scrophulariaceae). | 2011 | Eur Rev Med Pharmacol Sci | pmid:21845800 |
Arciniega JC et al. | Effects of free fatty acids on meibomian lipid films. | 2011 | Exp. Eye Res. | pmid:21718696 |
Yang Y et al. | Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. | 2011 | Free Radic. Res. | pmid:21128731 |
Hubert DJ et al. | In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. | 2011 | Inflammopharmacology | pmid:21088994 |
Jin G et al. | Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. | 2011 | Meat Sci. | pmid:21093161 |
Du YZ et al. | Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. | 2011 | Int. J. Biol. Macromol. | pmid:21093477 |
Tuei VC et al. | Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. | 2011 | Life Sci. | pmid:21396379 |
Mihaljević B et al. | Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. | 2011 | Org. Biomol. Chem. | pmid:21442126 |
Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
Conforti F et al. | Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). | 2011 | Chem. Biodivers. | pmid:21404435 |
Serratosa MP et al. | Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. | 2011 | J. Agric. Food Chem. | pmid:21319807 |
Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
Konkel A and Schunck WH | Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. | 2011 | Biochim. Biophys. Acta | pmid:20869469 |
Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
Perona JS et al. | Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. | 2011 | Metab. Clin. Exp. | pmid:20934731 |
Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
Pan Z et al. | Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21295151 |
Tsubura A et al. | Anticancer effects of garlic and garlic-derived compounds for breast cancer control. | 2011 | Anticancer Agents Med Chem | pmid:21269259 |
Chohany LE et al. | Cationic substrates of soybean lipoxygenase-1. | 2011 | Bioorg. Chem. | pmid:21257189 |
Das R et al. | Synthesis of linoleic acid capped copper nanoparticles and their fluorescence study. | 2011 | J Fluoresc | pmid:21221748 |
White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |