Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
Louheranta AM et al. | Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. | 1996 | Am. J. Clin. Nutr. | pmid:8615351 |
van Egmond AW et al. | Effect of linoleic acid intake on growth of infants with cystic fibrosis. | 1996 | Am. J. Clin. Nutr. | pmid:8615359 |
Martinelli N et al. | FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. | 2008 | Am. J. Clin. Nutr. | pmid:18842780 |
Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Villalpando S et al. | [13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes. | 2001 | Am. J. Clin. Nutr. | pmid:11729835 |
Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
Reeves VB et al. | Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. | 1984 | Am. J. Clin. Nutr. | pmid:6507356 |
Kinsella JE et al. | Metabolism of trans fatty acids with emphasis on the effects of trans, trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. | 1981 | Am. J. Clin. Nutr. | pmid:6794350 |
Voorrips LE et al. | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. | 2002 | Am. J. Clin. Nutr. | pmid:12324303 |
James MJ et al. | Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8379505 |
Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. | 2005 | Am. J. Clin. Nutr. | pmid:16155261 |
Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
Freese R et al. | High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. | 2002 | Am. J. Clin. Nutr. | pmid:12399265 |
Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
Feunekes GI et al. | Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. | 1993 | Am. J. Clin. Nutr. | pmid:8379504 |
Rose DP | Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. | 1997 | Am. J. Clin. Nutr. | pmid:9394709 |
Ip C | Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. | 1997 | Am. J. Clin. Nutr. | pmid:9394710 |
Willett WC | Specific fatty acids and risks of breast and prostate cancer: dietary intake. | 1997 | Am. J. Clin. Nutr. | pmid:9394715 |
Djoussé L et al. | Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. | 2001 | Am. J. Clin. Nutr. | pmid:11684529 |
Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |
Venäläinen TM et al. | Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. | 2016 | Am. J. Clin. Nutr. | pmid:27581473 |
Oosthuizen W et al. | Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study. | 2006 | Am. J. Clin. Nutr. | pmid:16685065 |
Shultz TD and Leklem JE | Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. | 1983 | Am. J. Clin. Nutr. | pmid:6849273 |
Wu MJ et al. | Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). | 2004 | Am. J. Chin. Med. | pmid:15633804 |
Cho EJ et al. | The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. | 2003 | Am. J. Chin. Med. | pmid:14992543 |
Magsino CH et al. | Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. | 2000 | Am. J. Cardiol. | pmid:10946040 |
Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
Kim JB et al. | Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. | 2013 | Am. J. Cardiol. | pmid:24050409 |
Block RC et al. | Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? | 2008 | Am. Heart J. | pmid:19033007 |
Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
McDaniel HG et al. | Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. | 1981 | Am. Heart J. | pmid:6787909 |
Poole E and McQueen CE | Conjugated linoleic acid. | 2006 | Am J Health Syst Pharm | pmid:17057041 |
Kelly GS | Conjugated linoleic acid: a review. | 2001 | Altern Med Rev | pmid:11578253 |
Uden S et al. | Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. | 1992 | Aliment. Pharmacol. Ther. | pmid:1600043 |
Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
Tsukamoto S et al. | Effects of bezafibrate on ethanol oxidation in rats. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8986210 |
Cunnane SC | Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032013 |
Szebeni J et al. | Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. | 1986 | Alcohol. Clin. Exp. Res. | pmid:3101533 |
Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
Pamplona R et al. | Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. | 1999 | Aging (Milano) | pmid:10337442 |
Kramer HJ et al. | The role of renal prostaglandins in the regulation of renal sodium excretion. | 1987 | Agents Actions Suppl. | pmid:3481214 |
Henricks PA et al. | Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. | 1990 | Agents Actions Suppl. | pmid:2080762 |
Loesberg C et al. | Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. | 1988 | Agents Actions | pmid:2833083 |
Iversen L et al. | Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. | 1991 | Agents Actions | pmid:1659156 |
Loesberg C et al. | Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. | 1987 | Agents Actions | pmid:2895570 |
Ringertz B et al. | High dietary linoleic acid content modulates neutrophil function in rats. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960199 |
Eling TE et al. | Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7537437 |
Buchanan MR et al. | Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526487 |
Eling TE and Glasgow WC | Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825423 |
Gyllenhammar H et al. | Dietary essential fatty acid deficiency in rats is accompanied by impairments in neutrophil function and leukotriene B4 generation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823572 |
Hoffmann P and Förster W | Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system). | 1981 | Adv. Lipid Res. | pmid:6798829 |
Kinsella JE | Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. | 1991 | Adv. Food Nutr. Res. | pmid:1681826 |
Sauerwald TU et al. | Polyunsaturated fatty acid supply with human milk. Physiological aspects and in vivo studies of metabolism. | 2000 | Adv. Exp. Med. Biol. | pmid:11065079 |
Del Prado M et al. | Contribution of dietary and newly formed arachidonic acid to milk secretion in women on low fat diets. | 2000 | Adv. Exp. Med. Biol. | pmid:11065105 |
Lance A et al. | 13C-linoleic acid oxidation and transfer into milk in lactating women with contrasting body mass index. | 2000 | Adv. Exp. Med. Biol. | pmid:11065106 |
Kelavkar U et al. | 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. | 2002 | Adv. Exp. Med. Biol. | pmid:12664577 |
Egashira Y et al. | Dietary linoleic acid suppresses gene expression of rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum. | 2003 | Adv. Exp. Med. Biol. | pmid:15206789 |
Sharma HM et al. | Effect of MAK-4 and MAK-5 on endothelial cell and soyabean lipoxygenase-induced LDL oxidation. | 1994 | Adv. Exp. Med. Biol. | pmid:7771286 |
Brash AR et al. | Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. | 1999 | Adv. Exp. Med. Biol. | pmid:10667314 |
Buchanan MR | Linoleic acid metabolites in health and disease. | 1999 | Adv. Exp. Med. Biol. | pmid:10667369 |
Greene JF and Hammock BD | Toxicity of linoleic acid metabolites. | 1999 | Adv. Exp. Med. Biol. | pmid:10667370 |
Jira W and Spiteller G | Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. | 1999 | Adv. Exp. Med. Biol. | pmid:10667371 |
Gibson RA et al. | Long chain omega 3 polyunsaturates in formula-fed term infants. | 1992 | Adv. Exp. Med. Biol. | pmid:1353286 |
Tanaka R et al. | Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities. | 2012 | Adv. Exp. Med. Biol. | pmid:22259110 |
Camacho M et al. | IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547616 |
Louw L et al. | Impairment in the fatty acid composition of keloids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547645 |
Louw L et al. | Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. | 1997 | Adv. Exp. Med. Biol. | pmid:9547646 |
Louw L et al. | The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. | 1997 | Adv. Exp. Med. Biol. | pmid:9547647 |
Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
Hörnsten L et al. | Bisallylic hydroxylation of linoleic and arachidonic acids by adult and fetal human liver microsomes and a comparison with human recombinant cytochromes P450. | 1997 | Adv. Exp. Med. Biol. | pmid:9561118 |
Riambau V et al. | Effect of linoleic acid supplements on vessel wall hyperplasia in rabbits. | 1997 | Adv. Exp. Med. Biol. | pmid:9561150 |
Brister SJ and Buchanan MR | Effects of linoleic acid and/or marine fish oil supplements on vessel wall thromboresistance in patients undergoing cardiac surgery. | 1997 | Adv. Exp. Med. Biol. | pmid:9561151 |
Giménez-Arnau A et al. | Effects of linoleic acid supplements on atopic dermatitis. | 1997 | Adv. Exp. Med. Biol. | pmid:9561153 |
Horrobin DF and Ziboh VA | The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. | 1997 | Adv. Exp. Med. Biol. | pmid:9561154 |
Agostoni C et al. | Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation. | 2001 | Adv. Exp. Med. Biol. | pmid:11787678 |
Demmelmair H et al. | Investigation of long-chain polyunsaturated fatty acid metabolism in lactating women by means of stable isotope techniques. | 2001 | Adv. Exp. Med. Biol. | pmid:11787680 |
Fidler N et al. | Fat content and fatty acid composition of fresh, pasteurized, or sterilized human milk. | 2001 | Adv. Exp. Med. Biol. | pmid:11787720 |
Blask DE et al. | New insights into melatonin regulation of cancer growth. | 1999 | Adv. Exp. Med. Biol. | pmid:10810531 |
Eling TE et al. | Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. | 1997 | Adv. Exp. Med. Biol. | pmid:9321970 |
Asakawa T et al. | Ca2+-activated, fatty acid-dependent guanylate cyclase in synaptic plasma membranes and its requirement for Ca2+ and Mg-GTP in the activation. | 1984 | Adv. Exp. Med. Biol. | pmid:6149673 |
Louw L et al. | Keloids: peripheral and central differences in cell morphology and fatty acid compositions of lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9322000 |
GIBSON DM and ALLMANN DW | ADAPTIVE CHANGES IN FATTY ACID BIOSYNTHESIS. | 1963 | Adv. Enzyme Regul. | pmid:14190353 |
Cook ME | Nutritional effects on vaccination. | 1999 | Adv Vet Med | pmid:9890009 |
Birnbaum L | Addition of conjugated linoleic acid to a herbal anticellulite pill. | 2001 Sep-Oct | Adv Ther | pmid:11783459 |
Guyenet SJ and Carlson SE | Increase in adipose tissue linoleic acid of US adults in the last half century. | 2015 | Adv Nutr | pmid:26567191 |
Whelan J and Fritsche K | Linoleic acid. | 2013 | Adv Nutr | pmid:23674797 |
Ermidou-Pollet S et al. | Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition. | 2005 | Acta. Biol. Hung. | pmid:16196200 |
Arawwawala M et al. | In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. | 2011 | Acta. Biol. Hung. | pmid:21840826 |