Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Thorax (1)
- Am. J. Physiol., Cell Physiol. (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| CHRISTAKIS GJ et al. | EFFECT OF A SERUM CHOLESTEROL-LOWERING DIET ON COMPOSITION OF DEPOT FAT IN MAN. | 1965 | Am. J. Clin. Nutr. | pmid:14253897 |
| ZUKEL MC | FAT-CONTROLLED DIETS. | 1965 | Am. J. Clin. Nutr. | pmid:14253901 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. | 2000 | Am. J. Clin. Nutr. | pmid:10966889 |
| CAMPBELL AM et al. | SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. | 1965 | Am. J. Clin. Nutr. | pmid:14332349 |
| Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
| Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
| Louheranta AM et al. | Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. | 1996 | Am. J. Clin. Nutr. | pmid:8615351 |
| van Egmond AW et al. | Effect of linoleic acid intake on growth of infants with cystic fibrosis. | 1996 | Am. J. Clin. Nutr. | pmid:8615359 |
| Martinelli N et al. | FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. | 2008 | Am. J. Clin. Nutr. | pmid:18842780 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| SCOTT RF et al. | FATTY ACIDS OF SERUM AND ADIPOSE TISSUE IN SIX GROUPS EATING NATURAL DIETS CONTAINING 7 TO 40 PER CENT FAT. | 1964 | Am. J. Clin. Nutr. | pmid:14157830 |
| DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
| Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
| Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| Villalpando S et al. | [13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes. | 2001 | Am. J. Clin. Nutr. | pmid:11729835 |
| Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
| Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
| Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
| Hrboticky N et al. | Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. | 1991 | Am. J. Clin. Nutr. | pmid:1989416 |
| Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
| Del Prado M et al. | Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. | 2001 | Am. J. Clin. Nutr. | pmid:11470727 |
| CENTURY B et al. | INTERRELATIONSHIPS OF DIETARY LIPIDS UPON FATTY ACID COMPOSITION OF BRAIN MITOCHONDRIA, ERYTHROCYTES AND HEART TISSUE IN CHICKS. | 1963 | Am. J. Clin. Nutr. | pmid:14101397 |
| Carnielli VP et al. | Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8694014 |
| Rioux FM and Innis SM | Arachidonic acid concentrations in plasma and liver phospholipid and cholesterol esters of piglets raised on formulas with different linoleic and linolenic acid contents. | 1992 | Am. J. Clin. Nutr. | pmid:1609747 |
| Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
| Herbel BK et al. | Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9459383 |
| Reeves VB et al. | Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. | 1984 | Am. J. Clin. Nutr. | pmid:6507356 |
| Green P et al. | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. | 1990 | Am. J. Clin. Nutr. | pmid:2239789 |
| Kinsella JE et al. | Metabolism of trans fatty acids with emphasis on the effects of trans, trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. | 1981 | Am. J. Clin. Nutr. | pmid:6794350 |
| Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
| Voorrips LE et al. | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. | 2002 | Am. J. Clin. Nutr. | pmid:12324303 |
| Blair IA et al. | Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. | 1993 | Am. J. Clin. Nutr. | pmid:8424383 |
| SINGLETON WS | CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. | 1965 | Am. J. Clin. Nutr. | pmid:14262113 |
| Jiang J et al. | Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. | 1999 | Am. J. Clin. Nutr. | pmid:10393134 |
| James MJ et al. | Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8379505 |
| Reaven P et al. | Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. | 1991 | Am. J. Clin. Nutr. | pmid:1897476 |
| Iacono JM and Dougherty RM | Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. | 1991 | Am. J. Clin. Nutr. | pmid:1900384 |
| Jones PJ et al. | Whole body oxidation of dietary fatty acids: implications for energy utilization. | 1985 | Am. J. Clin. Nutr. | pmid:3933323 |
| Murphy J et al. | Fat malabsorption in cystic fibrosis patients. | 1999 | Am. J. Clin. Nutr. | pmid:10539762 |
| Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. | 2005 | Am. J. Clin. Nutr. | pmid:16155261 |
| Warensjö E et al. | Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. | 2006 | Am. J. Clin. Nutr. | pmid:16895896 |
| Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
| Freese R et al. | High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. | 2002 | Am. J. Clin. Nutr. | pmid:12399265 |
| Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
| Asciutti-Moura LS et al. | Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. | 1988 | Am. J. Clin. Nutr. | pmid:3421207 |
| Terpstra AH | Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. | 2004 | Am. J. Clin. Nutr. | pmid:14985207 |
| Feunekes GI et al. | Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. | 1993 | Am. J. Clin. Nutr. | pmid:8379504 |
| Rose DP | Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. | 1997 | Am. J. Clin. Nutr. | pmid:9394709 |
| Ip C | Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. | 1997 | Am. J. Clin. Nutr. | pmid:9394710 |
| Willett WC | Specific fatty acids and risks of breast and prostate cancer: dietary intake. | 1997 | Am. J. Clin. Nutr. | pmid:9394715 |
| Djoussé L et al. | Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. | 2001 | Am. J. Clin. Nutr. | pmid:11684529 |
| Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |
| Abbey M et al. | Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8438773 |
| Venäläinen TM et al. | Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. | 2016 | Am. J. Clin. Nutr. | pmid:27581473 |
| McMurchie EJ et al. | Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. | 1984 | Am. J. Clin. Nutr. | pmid:6720626 |
| Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
| Oosthuizen W et al. | Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study. | 2006 | Am. J. Clin. Nutr. | pmid:16685065 |
| Shultz TD and Leklem JE | Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. | 1983 | Am. J. Clin. Nutr. | pmid:6849273 |
| Freeman VL et al. | Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? | 2001 | Am. J. Clin. Nutr. | pmid:11273858 |
| Merchant AT et al. | Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. | 2005 | Am. J. Clin. Nutr. | pmid:16155282 |
| Larbi A et al. | Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans. | 2005 | Am. J. Clin. Nutr. | pmid:16280424 |
| Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
| Chan JK et al. | Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. | 1991 | Am. J. Clin. Nutr. | pmid:1673589 |
| Mahendran Y et al. | Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. | 2014 | Am. J. Clin. Nutr. | pmid:24153340 |
| Yary T et al. | Serum n-6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2016 | Am. J. Clin. Nutr. | pmid:27009754 |
| Martinez GA et al. | Nutrient intakes of American infants and children fed cow's milk or infant formula. | 1985 | Am. J. Dis. Child. | pmid:4036886 |
| BAUGHAN MA et al. | TIME, TEMPERATURE EXPOSURE TO AIR OF MILK PREPARATIONS. EFFECT ON FATTY ACIDS. | 1963 | Am. J. Dis. Child. | pmid:14063701 |
| van Staveren WA et al. | Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. | 1986 | Am. J. Epidemiol. | pmid:3946391 |
| Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
| Seidell JC et al. | Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. | 1991 | Am. J. Epidemiol. | pmid:1951263 |
| Jacobsen BK et al. | Re: "Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men". | 1993 | Am. J. Epidemiol. | pmid:8333420 |
| Brosnan MJ and Carkner RD | Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. | 2008 | Am. J. Hypertens. | pmid:18437120 |
| Zhang HY et al. | A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat. | 1999 | Am. J. Hypertens. | pmid:10090346 |
| Taylor EN et al. | Fatty acid intake and incident nephrolithiasis. | 2005 | Am. J. Kidney Dis. | pmid:15685503 |
| Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
| Weiss LA et al. | The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. | 2012 | Am. J. Med. Genet. A | pmid:22315197 |
| SCHWARTZ S et al. | LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. | 1965 | Am. J. Med. Sci. | pmid:14254823 |
| Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
| Kääpä P et al. | Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. | 1986 | Am. J. Obstet. Gynecol. | pmid:3089014 |
| MacKenzie LW et al. | Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. | 1988 | Am. J. Obstet. Gynecol. | pmid:3144917 |
| Vaughan JE and Walsh SW | Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. | 2005 | Am. J. Obstet. Gynecol. | pmid:16150282 |
| Liu H et al. | Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. | 2015 | Am. J. Pathol. | pmid:25447051 |
| McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
| Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
| Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
| Murray MJ et al. | Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. | 1993 | Am. J. Physiol. | pmid:8279548 |
| GOLD M and SPITZER JJ | METABOLISM OF FREE FATTY ACIDS BY MYOCARDIUM AND KIDNEY. | 1964 | Am. J. Physiol. | pmid:14111431 |
| SPITZER JJ and GOLD M | FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE. | 1964 | Am. J. Physiol. | pmid:14111432 |
| Spalinger JH et al. | Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. | 1998 | Am. J. Physiol. | pmid:9756493 |
| Nilsson A et al. | Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. | 1987 | Am. J. Physiol. | pmid:3109253 |
| Liu F et al. | Permeability properties of monolayers of the human trophoblast cell line BeWo. | 1997 | Am. J. Physiol. | pmid:9374645 |
| Guidot DM et al. | Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. | 1997 | Am. J. Physiol. | pmid:9374722 |
| Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Meyer C et al. | Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. | 1997 | Am. J. Physiol. | pmid:9316458 |
| Soliven B et al. | Arachidonic acid and its metabolites increase Cai in cultured rat oligodendrocytes. | 1993 | Am. J. Physiol. | pmid:8384786 |
| Ookhtens M and Baker N | Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. | 1983 | Am. J. Physiol. | pmid:6295191 |