Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Infertility, Male D007248 11 associated lipids
Varicocele D014646 4 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Wieland E et al. Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8327462
Yehuda S and Carasso RL Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7901853
Baker PR et al. Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15273286
Whittle EJ et al. Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18796606
Asaoka Y et al. Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8099446
Saeki K et al. Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15067141
Chu S et al. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624373
Wright JR et al. Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3045812
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Stocker R et al. Antioxidant activity of albumin-bound bilirubin. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3475708
Hill EG et al. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6951178
Lange LG Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6955782
Keler T et al. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1594582
REISER R Conjugated linoleic acid in rat tissue lipids after ingestion as free acid and as triglyceride. 1950 Proc. Soc. Exp. Biol. Med. pmid:14781143
STEIN O and STEIN Y FATTY ACID METABOLISM BY IN VIVO LABELED ADIPOSE TISSUE IN ESSENTIAL FATTY ACID DEFICIENT RATS. 1965 Proc. Soc. Exp. Biol. Med. pmid:14264515
SWELL L et al. ESTERIFICATION OF CHOLESTEROL BY CANINE ADRENAL CELL FRACTIONS. 1965 Proc. Soc. Exp. Biol. Med. pmid:14297887
Watkins BA et al. Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. 1996 Proc. Soc. Exp. Biol. Med. pmid:8650253
KRITCHEVSKY D and TEPPER SA AUTOXIDATION OF METHYL LINOLEATE: EFFECT OF SEX HORMONES AND OF NICOTINIC ACID AND RELATED COMPOUNDS. 1964 Proc. Soc. Exp. Biol. Med. pmid:14155843
WALKER BL and KUMMEROW FA ERYTHROCYTE FATTY ACID COMPOSITION AND APPARENT PERMEABILITY TO NON-ELECTROLYTES. 1964 Proc. Soc. Exp. Biol. Med. pmid:14166569
TUREEN LL et al. EFFECT OF HIGH LINOLEIC ACID AND ANTIOXIDANT DEFICIENT DIET ON BLOOD SERUM PROTEINS IN CHICKS. 1964 Proc. Soc. Exp. Biol. Med. pmid:14121629
DESAI ID et al. PEROXIDATION AND LYSOSOMES IN NUTRITIONAL MUSCULAR DYSTROPHY OF CHICKS. 1964 Proc. Soc. Exp. Biol. Med. pmid:14121639
HOPKINS DT et al. A RESPIRATORY DISEASE SYNDROME IN CHICKENS FED ESSENTIAL FATTY ACID DEFICIENT DIETS. 1963 Proc. Soc. Exp. Biol. Med. pmid:14076921
SWELL L et al. Influence of a family diet pattern high in linoleic acid on serum cholesterol level: one year study. 1962 Proc. Soc. Exp. Biol. Med. pmid:13979681
HOLMAN RT Metabolism of isomers of linoleic and linolenic acids. 1951 Proc. Soc. Exp. Biol. Med. pmid:14816402
GORDON S and MEAD JF CONVERSION OF LINOLEIC-1-C14 ACID TO ARACHIDONIC ACID IN THE GERBIL. 1964 Proc. Soc. Exp. Biol. Med. pmid:14194646
Izumi Y et al. Effects of dietary linoleic acid on blood pressure and renal function in subtotally nephrectomized rats. 1986 Proc. Soc. Exp. Biol. Med. pmid:3532127
Johnston DV and Marshall LA Dietary fat, prostaglandins and the immune response. 1984 Prog Food Nutr Sci pmid:6091179
Champe SP et al. Sexual sporulation. 1994 Prog Ind Microbiol pmid:7765136
Jones R et al. Monitoring changes in the blood of patients with multiple sclerosis. 1983 Prog. Brain Res. pmid:6665128
Rey HG et al. Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. 1988 Prog. Clin. Biol. Res. pmid:2906133
Vergroesen AJ Effects of dietary lipid composition on serum lipoproteins. 1985 Prog. Clin. Biol. Res. pmid:3903769
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Cunnane SC Problems with essential fatty acids: time for a new paradigm? 2003 Prog. Lipid Res. pmid:14559071
Cunnane SC Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. 1982 Prog. Lipid Res. pmid:7051042
Dwyer LA and Blomquist GJ Biosynthesis of linoleic acid in the American cockroach. 1981 Prog. Lipid Res. pmid:7342085
Launay M et al. Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. 1981 Prog. Lipid Res. pmid:7342098
Houtsmuller AJ et al. Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. 1981 Prog. Lipid Res. pmid:7342100
Cunnane SC Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. 1981 Prog. Lipid Res. pmid:7342114
Lynn WS et al. Linoleic acid: a specific cytotaxin for macrophages. 1981 Prog. Lipid Res. pmid:7342119
Kitada S et al. Characterization of a lipid mobilizing factor from tumors. 1981 Prog. Lipid Res. pmid:7342133
Houtsmuller UM and van der Beek A Effects of topical application of fatty acids. 1981 Prog. Lipid Res. pmid:6804961
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Holman RT Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids. 1986 Prog. Lipid Res. pmid:3423089
Burr GO The essential fatty acids fifty years ago. 1981 Prog. Lipid Res. pmid:7043474
Spector AA et al. Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. 1981 Prog. Lipid Res. pmid:7043481
Agradi E et al. Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. 1981 Prog. Lipid Res. pmid:7043483
Mercuri O and De Tomás ME Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. 1981 Prog. Lipid Res. pmid:6804968
Murphy MG Increasing membrane polyunsaturated fatty-acid content augments cyclic AMP formation and prostaglandin production in NIE-115 neuroblastoma. 1984 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:6099586
Sakuma S et al. Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. 1993 Prostaglandins pmid:8210445
Lewis MG et al. Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. 1981 Prostaglandins pmid:6799988
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Needleman SW et al. Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. 1982 Prostaglandins pmid:6819602
Hashimoto A et al. Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. 1988 Prostaglandins pmid:2459732
Beneytout JL et al. Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. 1986 Prostaglandins pmid:3086939
Engels F et al. Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. 1996 Prostaglandins pmid:8880897
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Bronstein JC and Bull AW The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. 1993 Prostaglandins pmid:8278616
Andersen BR et al. The effects of arachidonic and other fatty acids on canine neutrophil metabolism. 1981 Prostaglandins pmid:6795686
Hamazaki T et al. Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. 1989 Prostaglandins pmid:2503856
Singer P et al. Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. 1984 Prostaglandins pmid:6328578
Singer P et al. Defective desaturation and elongation of n-6 and n-3 fatty acids in hypertensive patients. 1984 Prostaglandins Leukot Med pmid:6387718
Kher V et al. Protective effect of polyunsaturated fatty acid supplementation in apoferritin induced murine glomerulonephritis. 1986 Prostaglandins Leukot Med pmid:3014561
Huang YS et al. Effect of dietary depletion and repletion of linoleic acid on renal fatty acid composition and urinary prostaglandin excretion. 1984 Prostaglandins Leukot Med pmid:6593743
Strong AM et al. Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar. 1984 Prostaglandins Leukot Med pmid:6588390
Ito Y et al. A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass. 1987 Prostaglandins Leukot Med pmid:3477824
Hoffmann P et al. Augmented acute hypotensive effect of dihydralazine and clonidine after linoleic acid rich diet in normotensive conscious rats. 1982 Prostaglandins Leukot Med pmid:6955801
Sullivan LM and Mathias MM Eicosanoid production in rat blood as affected by fasting and dietary fat. 1982 Prostaglandins Leukot Med pmid:6956928
Abeywardena MY et al. Effects of variable linoleate intake on aortic PGI2-like activity and fatty acid composition: difference between rat and marmoset (Callithrix jacchus). 1986 Prostaglandins Leukot Med pmid:3103139
Hoffmann P et al. Circadian rhythm of eicosanoid formation as affected by dietary linoleate. 1986 Prostaglandins Leukot Med pmid:3547416
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Stachowska E et al. Exchange of unsaturated fatty acids between adipose tissue and atherosclerotic plaque studied with artificial neural networks. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643180
Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Hsi LC et al. Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418015
Okita M et al. Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418023
Abeywardena MY et al. Dietary n-3 and n-6 polyunsaturated oils and airway contractility. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418024
Whelan J The health implications of changing linoleic acid intakes. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990554
Gueck T et al. Effects of essential fatty acids on mediators of mast cells in culture. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711248
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Angela Liou Y and Innis SM Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19356914
Wenger FA et al. Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913224
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
Pickens CA et al. Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25559239
Tribole E What happened to do no harm? The issue of dietary omega-6 fatty acids. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147337
Hendrich S et al. Phenobarbital increases rat hepatic prostaglandin F2 alpha, glutathione S-transferase activity and oxidative stress. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:2011611
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Tonogai Y and Tai HH Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2111553
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Okui T et al. Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21723718
van der Schouw YT et al. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815240
Mayer M Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815242
Krumhardt B and Dupont J The relationship between thromboxane and cytosolic calcium modifiers in rat platelets. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1652770
Perkins DM and Duncan JR The effect of gamma-linolenic acid and zinc supplementation on the growth of normal and tumour cells in vitro. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1881941
Porras-Reyes BH et al. Essential fatty acids are not required for wound healing. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1603819
Turpeinen AM et al. A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844997