Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Protein-Energy Malnutrition D011502 9 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Coronary Restenosis D023903 10 associated lipids
Myocardial Stunning D017682 10 associated lipids
Wounds, Penetrating D014950 10 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
Infertility, Male D007248 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Migraine Disorders D008881 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Retinoblastoma D012175 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Keloid D007627 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Haas TA et al. Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. 1990 Biochim. Biophys. Acta pmid:2155665
Roe CR et al. 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. 1990 J. Clin. Invest. pmid:2332510
Miyashita K et al. Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. 1990 Biochim. Biophys. Acta pmid:2386795
Schlame M and Rüstow B Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. 1990 Biochem. J. pmid:2268287
Jin SJ and Tserng KY Metabolic origins of urinary unsaturated dicarboxylic acids. 1990 Biochemistry pmid:2271537
Hamberg M and Hamberg G Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). 1990 Arch. Biochem. Biophys. pmid:2275553
Ohtani H et al. Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. 1990 J. Lipid Res. pmid:2280182
Lefkowith J et al. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. 1990 J. Exp. Med. pmid:2307932
Buckman DK et al. Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. 1990 J. Nutr. pmid:2313378
MacIver DH et al. The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure. 1990 J Hum Hypertens pmid:2283638
Jakobsson A et al. Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. 1990 Biochim. Biophys. Acta pmid:2223867
Buset M et al. Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. 1990 Cancer Lett. pmid:2322935
Katzenellenbogen BS and Norman MJ Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. 1990 Endocrinology pmid:2404751
Jensen MD et al. Measurement of non-steady-state free fatty acid turnover. 1990 Am. J. Physiol. pmid:2405695
Medini L et al. Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. 1990 Biochem. Pharmacol. pmid:2105092
Kinsella JE and Lokesh B Dietary lipids, eicosanoids, and the immune system. 1990 Crit. Care Med. pmid:2105185
Kawada H et al. Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2363935
Lernhardt W Fatty acid requirement of B lymphocytes activated in vitro. 1990 Biochem. Biophys. Res. Commun. pmid:2302243
Galaris D et al. Ferrylmyoglobin-catalyzed linoleic acid peroxidation. 1990 Arch. Biochem. Biophys. pmid:2383021
Okuyama H [Does food affect brain functions?]. 1990 Tanpakushitsu Kakusan Koso pmid:1970438
elAttar TM et al. Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:1971442
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Watanabe S et al. Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. 1990 Lipids pmid:1972260
Singer P et al. Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. 1990 J Hum Hypertens pmid:1972963
Lipids and multiple sclerosis. 1990 Lancet pmid:1973215
Moch D et al. The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octadecadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat. 1990 Biomed. Biochim. Acta pmid:2169722
Léger CL et al. Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. 1990 Biochemistry pmid:2169876
Fletcher MP and Ziboh VA Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. 1990 Inflammation pmid:2174410
Kulkarni AP et al. Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. 1990 Biochem. Biophys. Res. Commun. pmid:2105721
Umeda F et al. Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. 1990 Diabetes Res. Clin. Pract. pmid:2106424
Lasekan JB et al. Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. 1990 Nutr Cancer pmid:2106675
Tonogai Y and Tai HH Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2111553
Moore SA et al. Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. 1990 J. Neurochem. pmid:2115069
Chatterjee S and Ghosh N Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. 1990 Indian J. Biochem. Biophys. pmid:2129343
Kawashima Y et al. Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. 1990 J. Biol. Chem. pmid:2160962
Bedotti R et al. Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. 1990 Biochim. Biophys. Acta pmid:2163687
Koba K and Sugano M Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. 1990 J. Nutr. Sci. Vitaminol. pmid:2130152
Akamatsu H et al. Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. 1990 J. Invest. Dermatol. pmid:2143521
Yashiro K et al. [Changes in the free fatty acid composition of rat salivary glands induced by chronic administration of isoproterenol]. 1990 Gifu Shika Gakkai Zasshi pmid:2133668
Weaver BJ et al. Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. 1990 Am. J. Clin. Nutr. pmid:2181858
Renner HW Anticlastogenic dietary factors assessed in mammalian assays. 1990 Basic Life Sci. pmid:2183774
Farnworth ER and Kramer JK Fat supplementation to the gestation diet of older sows and its effect on maternal and fetal fat metabolism. 1990 Reprod. Nutr. Dev. pmid:1981311
Marra CA and de Alaniz MJ Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. 1990 Biochem. Int. pmid:1981670
Byczkowski JZ and Kulkarni AP Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. 1990 Bull Environ Contam Toxicol pmid:2176112
Masini E et al. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. 1990 Biochem. Pharmacol. pmid:1690007
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Stocker R et al. Antioxidant activities of bile pigments: biliverdin and bilirubin. 1990 Meth. Enzymol. pmid:2233302
Glasgow WC and Eling TE Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. 1990 Mol. Pharmacol. pmid:2233691
Hernández-Caselles T et al. Stability of liposomes on long term storage. 1990 J. Pharm. Pharmacol. pmid:1979618
Vaughan PF and Ball SG The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. 1990 Biochem. Pharmacol. pmid:1968340
Molina MT et al. Caecal and colonic uptake of both linoleic acid and cholesterol in rats following intestinal resection. 1990 Lipids pmid:2079865
Corner EJ et al. Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil. 1990 Lipids pmid:2079866
Henricks PA et al. Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. 1990 Agents Actions Suppl. pmid:2080762
Zakhariv OIa et al. [Metabolism of linoleic acid given with the feed in the calf liver]. 1990 Jan-Feb Ukr. Biokhim. Zh. pmid:2336726
Laugier C et al. Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. 1991 Biochem. Biophys. Res. Commun. pmid:1645959
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Hubbard NE and Erickson KL Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. 1991 Cancer Lett. pmid:1998946
Kim RS and Zaborniak CL The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946549
Martin JC et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. 1991 Am. J. Clin. Nutr. pmid:1951153
Seidell JC et al. Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. 1991 Am. J. Epidemiol. pmid:1951263
Andrianarison RH et al. Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. 1991 Biochem. Biophys. Res. Commun. pmid:1953704
Kanazawa K Hepatic dysfunction caused by dietary products of lipid peroxidation. 1991 Int J Tissue React pmid:1955295
Takamura H et al. Inhibition by lipoxygenase-3 of n-hexanal generation in soybeans. 1991 FEBS Lett. pmid:1959624
Boor PJ et al. Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome. 1991 J. Am. Coll. Cardiol. pmid:1960335
Kühn H et al. Formation of ketodienoic fatty acids by the pure pea lipoxygenase-1. 1991 Eicosanoids pmid:1905562
Beyers EC and Emken EA Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. 1991 Biochim. Biophys. Acta pmid:2029547
Gerwick WH et al. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. 1991 Arch. Biochem. Biophys. pmid:1929410
Ip C et al. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. 1991 Cancer Res. pmid:1933874
Butovich IA et al. The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. 1991 Eur. J. Biochem. pmid:2065670
Schreiner GF Dietary treatment of immunologically mediated renal disease. 1991 Kidney Int. Suppl. pmid:2046271
Nagao M et al. Effect of extracellular fatty acids on lipid metabolism in cultured rabbit articular chondrocytes. 1991 J. Orthop. Res. pmid:1901357
Liu B et al. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. 1991 Cell Regul. pmid:1801923
Christon R et al. Effects of a low dietary linoleic acid level on intestinal morphology and enterocyte brush border membrane lipid composition. 1991 Reprod. Nutr. Dev. pmid:1777061
Nihro Y et al. 3-O-alkylascorbic acids as free radical quenchers. II. Inhibitory effects on some lipid peroxidation models. 1991 Chem. Pharm. Bull. pmid:1777926
Sarkar G Beneficial ghee? 1991 Nature pmid:1876181
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. 1991 Poult. Sci. pmid:1784570
Pourplanche C et al. Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. 1991 Anal. Biochem. pmid:1789419
Pal S and Davis PJ Effects of different types of polyunsaturated fatty acids on cholesterol esterification in human fibroblasts. 1991 Biochem. Int. pmid:1789795
Jyothirmayi N and Ramadoss CS Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. 1991 Biochim. Biophys. Acta pmid:1903659
Uchida Y et al. Enhancement of keratin synthesis induced by lipokeratinogenoside, N-(O-linoleoyl)-omega-hydroxy fatty acyl sphingosyl glucose, in association with alteration of the intracellular Ca(2+)-content and protein kinase in cultured keratinocytes (FRSK). 1991 J. Biochem. pmid:1715342
Iwahashi H et al. Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. 1991 Arch. Biochem. Biophys. pmid:1846731
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Bellomonte G et al. Quantitative determination of linoleic acid in infant formulas. 1991 Int J Vitam Nutr Res pmid:1856052
Kinsella JE Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. 1991 Adv. Food Nutr. Res. pmid:1681826
Ledwozyw A et al. [Surfactant lipids of bovine lungs]. 1991 Pol Arch Weter pmid:1842618
Semplicini A et al. Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. 1991 J Hypertens Suppl pmid:1818979
Rose DP et al. Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. 1991 J. Natl. Cancer Inst. pmid:1920496
Burri BJ et al. Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. 1991 Am. J. Clin. Nutr. pmid:1858699
Bell JG et al. High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. 1991 J. Nutr. pmid:1861166
DaTorre SD and Creer MH Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes. 1991 J. Lipid Res. pmid:1940640
Byczkowski JZ et al. Proline hydroxylation by soybean lipoxygenase. 1991 Biochem. Int. pmid:1815499
Hiramatsu N et al. Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate. 1991 J. Nutr. Sci. Vitaminol. pmid:1880633
Laganiere S and Fernandes G Study on the lipid composition of aging Fischer-344 rat lymphoid cells: effect of long-term calorie restriction. 1991 Lipids pmid:1881243
Perkins DM and Duncan JR The effect of gamma-linolenic acid and zinc supplementation on the growth of normal and tumour cells in vitro. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1881941
Iwado H et al. Mutagenicity and antimutagenicity of air-borne particulates. 1991 Mutat. Res. pmid:1986270
Hollander D and Tarnawski A Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection? 1991 J. Clin. Gastroenterol. pmid:1940200
Huynh S et al. Metabolic utilization of linoleate and alpha-linolenate in cultured Sertoli cells. 1991 Comp. Biochem. Physiol., B pmid:1684926
Baer AN et al. Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales. 1991 J. Lipid Res. pmid:1906083
Nemecz G et al. Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. 1991 Arch. Biochem. Biophys. pmid:1897956
Owen S et al. Evidence of free-radical activity in asthma. 1991 N. Engl. J. Med. pmid:1857396