Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fotouhi N and Jenkins TC | Ruminal biohydrogenation of linoleoyl methionine and calcium linoleate in sheep. | 1992 | J. Anim. Sci. | pmid:1459921 |
Moshitzky P et al. | Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum. | 2003 | Insect Biochem. Mol. Biol. | pmid:14599501 |
Lapenna D et al. | Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation. | 2003 | Free Radic. Biol. Med. | pmid:14607519 |
Alzoghaibi MA et al. | Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn's disease. | 2003 | Clin Nutr | pmid:14613754 |
Henderson WR and Chi EY | Cytotoxic activity of 13-hydroxyoctadecadienoic acid against Toxoplasma gondii. | 1992 | Parasitology | pmid:1461675 |
Williams LL et al. | Quantitative association between altered plasma esterified omega-6 fatty acid proportions and psychological stress. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1461929 |
Wang Y et al. | Effects of fatty acids and iontophoresis on the delivery of midodrine hydrochloride and the structure of human skin. | 2003 | Pharm. Res. | pmid:14620516 |
High KP et al. | Advanced age, but not anergy, is associated with altered serum polyunsaturated fatty acid levels. | 2003 | J Nutr Health Aging | pmid:14625615 |
Loor JJ et al. | Effects of dietary cis 9, trans 11-18:2, trans 10, cis 12-18:2, or vaccenic acid (trans 11-18:1) during lactation on body composition, tissue fatty acid profiles, and litter growth in mice. | 2003 | Br. J. Nutr. | pmid:14641963 |
Sneddon AA et al. | Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. | 2003 | Atherosclerosis | pmid:14642406 |
Stachowska E et al. | Exchange of unsaturated fatty acids between adipose tissue and atherosclerotic plaque studied with artificial neural networks. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643180 |
Salvati S et al. | Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. | 2004 | Neurochem. Int. | pmid:14643750 |
Alzoghaibi MA et al. | Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14656710 |
Randich A et al. | Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14660477 |
Hu Y et al. | Evaluation of antioxidant potential of aloe vera (Aloe barbadensis miller) extracts. | 2003 | J. Agric. Food Chem. | pmid:14664546 |
Mitoulas LR et al. | Infant intake of fatty acids from human milk over the first year of lactation. | 2003 | Br. J. Nutr. | pmid:14667191 |
Iwahashi H | Identification of the several new radicals formed in the reaction mixture of oxidized linoleic acid with ferrous ions using HPLC-ESR and HPLC-ESR-MS. | 2003 | Free Radic. Res. | pmid:14670001 |
Plantinga EA et al. | Relationship between the amount of linoleic acid in the diet and that in the adipose tissue of adult cats living freely in households. | 2003 | Vet. Res. Commun. | pmid:14672449 |
de La Puerta Vázquez R et al. | Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. | 2004 | Metab. Clin. Exp. | pmid:14681843 |
Viswanathan S et al. | Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. | 2003 | J Am Coll Nutr | pmid:14684755 |
He HP and Corke H | Oil and squalene in amaranthus grain and leaf. | 2003 | J. Agric. Food Chem. | pmid:14690373 |
Hatanaka A | [So-called "green odor" as plant origin--chemistry and biochemistry]. | 2003 | Seikagaku | pmid:14699842 |
Mizukuchi A et al. | Effect of dietary fat level and sesamin on the polyunsaturated fatty acid metabolism in rats. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:14703306 |
Dahly EM et al. | Intestinal adaptation occurs independently of parenteral long-chain triacylglycerol and with no change in intestinal eicosanoids after mid-small bowel resection in rats. | 2004 | J. Nutr. | pmid:14704302 |
Morise A et al. | Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain. | 2004 | J. Nutr. Biochem. | pmid:14711461 |
Aro A | Fatty acid composition of serum lipids: is this marker of fat intake still relevant for identifying metabolic and cardiovascular disorders? | 2003 | Nutr Metab Cardiovasc Dis | pmid:14717056 |
Goodfriend TL et al. | Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. | 2004 | Hypertension | pmid:14718355 |
Cahoon EB and Kinney AJ | Dimorphecolic acid is synthesized by the coordinate activities of two divergent Delta12-oleic acid desaturases. | 2004 | J. Biol. Chem. | pmid:14718523 |
Sari P et al. | Isotropic medium chain mono-diglyceride/oil/water formulations for solubilization of lipophilic and hydrophilic drugs. | 2004 | Int J Pharm | pmid:14726143 |
Zöllner N and Tatò F | Fatty acid composition of the diet: impact on serum lipids and atherosclerosis. | 1992 | Clin Investig | pmid:1472837 |
Esteban AB et al. | Growth temperature control of the linoleic acid content in safflower (Carthamus tinctorius) seed oil. | 2004 | J. Agric. Food Chem. | pmid:14733517 |
Ando H et al. | Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function. | 2004 | J. Biol. Chem. | pmid:14739285 |
Mutsvangwa T et al. | Short communication: Effects of a monensin premix on milk fatty acid content during subacute ruminal acidosis in dairy cows. | 2003 | J. Dairy Sci. | pmid:14740842 |
Montoudis A et al. | Influence of a maternal cholesterol-enriched diet on [1-14C]-linoleic acid and L-[4, 5-3H]-leucine entry in plasma of rabbit offspring. | 2004 | Life Sci. | pmid:14741733 |
Yamabe S et al. | Maturation of fermented rice-koji miso can be monitored by an increase in fatty acid ethyl ester. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745195 |
Szuchman A et al. | Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: studies in various oxidative systems. | 2003 | Free Radic. Res. | pmid:14753752 |
Blask DE et al. | Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential role of phytomelatonin. | 2004 | Carcinogenesis | pmid:14754876 |
Jokela H et al. | Fatty acid and cholesterol composition of the uterine artery intima in relation to menopausal status, age, and serum cholesterol. | 2004 | Maturitas | pmid:14757270 |
Pérez-Gálvez A and MÃnguez-Mosquera MI | Degradation, under non-oxygen-mediated autooxidation, of carotenoid profile present in paprika oleoresins with lipid substrates of different fatty acid composition. | 2004 | J. Agric. Food Chem. | pmid:14759160 |
Tomaino RM et al. | The effect of Lactococcus lactis starter cultures on the oxidative stability of liquid whey. | 2004 | J. Dairy Sci. | pmid:14762072 |
Egerton-Warburton LM and Ghisalberti EL | Isolation and structural identification of a germination inhibitor in fire-recruiters from the California chaparral. | 2001 | J. Chem. Ecol. | pmid:14768821 |
GarcÃa de Lorenzo A and Culebras JM | [Linoleic acid and the immune system. Controversies about lipid emulsions]. | 1992 Nov-Dec | Nutr Hosp | pmid:1477148 |
REISER R | Conjugated linoleic acid in rat tissue lipids after ingestion as free acid and as triglyceride. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:14781143 |
HOLMAN RT | Metabolism of isomers of linoleic and linolenic acids. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816402 |
Crevel RW and Saul JA | Linoleic acid and the immune response. | 1992 | Eur J Clin Nutr | pmid:1483413 |
MEDES G et al. | Dienoic acid contents of rats with linoleic acid and pyridoxine deficiencies. | 1951 | Arch. Biochem. Biophys. | pmid:14847665 |
Wang PF and Zheng RL | Inhibitions of the autoxidation of linoleic acid by flavonoids in micelles. | 1992 | Chem. Phys. Lipids | pmid:1486658 |
Bazinet RP et al. | Intramuscular injection of antigens and adjuvant preferentially decreases 18:2n-6 and 18:3n-3 in pig neck muscle. | 2003 | Lipids | pmid:14870924 |
Kishimoto N et al. | Two distinct pathways for the formation of hydroxy FA from linoleic acid by lactic acid bacteria. | 2003 | Lipids | pmid:14870930 |
Cristea M et al. | Linoleate diol synthase of the rice blast fungus Magnaporthe grisea. | 2003 | Lipids | pmid:14870931 |
Huang YS et al. | Effect of dietary linoleic acid content on the distribution of triacylglycerol molecular species in rat adipose tissue. | 1992 | Lipids | pmid:1487970 |
ROTH OA | [Improved wound healing through linoleic and linolenic acid]. | 1951 | Med Welt | pmid:14882090 |
Chen HW et al. | Gender and dietary fat affect alpha-tocopherol status in F344/N rats. | 1992 | Lipids | pmid:1491600 |
STANGL E | [The so-called Vitamin F & its clinical importance]. | 1951 | Int Z Vitaminforsch Beih | pmid:14937871 |
MARTINET M | [Embryonic hemorrhages caused by deficiency in linoleic acid]. | 1952 | Ann Med Interne (Paris) | pmid:14952971 |
Naber FB et al. | [Effect of short-term use of omega-3-type polyunsaturated fatty acids in subjects with hypertriglyceridemia]. | 1992 | Ned Tijdschr Geneeskd | pmid:1495569 |
Wang Y et al. | LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1. | 2004 | J. Lipid Res. | pmid:14967823 |
Hu Q et al. | Antioxidant activity of extracts of black sesame seed (Sesamum indicum L.) by supercritical carbon dioxide extraction. | 2004 | J. Agric. Food Chem. | pmid:14969554 |
Agostoni C | The difficult balance between dietary polyunsaturated fatty acids. | 2003 | Acta Paediatr. | pmid:14971782 |
Thiombiano-Coulibaly N et al. | Seasonal and environmental effects on breast milk fatty acids in Burkina Faso and the need to improve the omega 3 PUFA content. | 2003 | Acta Paediatr. | pmid:14971787 |
Liu J et al. | Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). | 2004 | Phytomedicine | pmid:14974442 |
Tadera K et al. | Synthesis and antioxidative activity of 6-hydroxypyridoxine. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:14974735 |
Umeda-Sawada R et al. | Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:14974737 |
Kudoh K et al. | Antioxidative activity and protective effect against ethanol-induced gastric mucosal damage of a potato protein hydrolysate. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:14974739 |
Kang K et al. | Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14975733 |
Lalman JA et al. | Kinetics of glucose fermentation by a mixed culture in the presence of linoleic, oleic, and stearic acid. | 2003 | Environ Technol | pmid:14977143 |
Kawai Y et al. | 2'-deoxycytidine in free nucleosides and double-stranded DNA as the major target of lipid peroxidation products. | 2004 | Free Radic. Biol. Med. | pmid:14980698 |
Terpstra AH | Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. | 2004 | Am. J. Clin. Nutr. | pmid:14985207 |
Cho EJ et al. | The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. | 2003 | Am. J. Chin. Med. | pmid:14992543 |
Saraswathi V et al. | Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling. | 2004 | J. Lipid Res. | pmid:14993245 |
Tepe B et al. | In vitro antimicrobial and antioxidant activities of the essential oils and various extracts of Thymus eigii M. Zohary et P.H. Davis. | 2004 | J. Agric. Food Chem. | pmid:14995110 |
el-Saadani MA | A scorpion venom peptide fraction induced prostaglandin biosynthesis in guinea pig kidneys: incorporation of 14C-linoleic acid. | 2004 | J. Biochem. | pmid:14999016 |
Walters D et al. | Antifungal activities of four fatty acids against plant pathogenic fungi. | 2004 | Mycopathologia | pmid:15008350 |
Attar-Bashi NM et al. | Alpha-linolenic acid and the risk of prostate cancer. What is the evidence? | 2004 | J. Urol. | pmid:15017185 |
Colla LM et al. | Fatty acids profile of Spirulina platensis grown under different temperatures and nitrogen concentrations. | 2004 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:15018053 |
Smith DE and Salerno JW | Selective growth inhibition of a human malignant melanoma cell line by sesame oil in vitro. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1502251 |
Weigert C et al. | Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. | 2004 | J. Biol. Chem. | pmid:15028733 |
Vahvaselkä M et al. | Enrichment of conjugated linoleic acid in oats (Avena sativa L.) by microbial isomerization. | 2004 | J. Agric. Food Chem. | pmid:15030240 |
Merendino N et al. | Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. | 2003 | Ann. N. Y. Acad. Sci. | pmid:15033753 |
Rayner BS et al. | Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution. | 2004 | Biochem. J. | pmid:15035657 |
Scislowski V et al. | Linoleate supplementation in steers modifies lipid composition of plasma lipoproteins but does not alter their fluidity. | 2004 | Br. J. Nutr. | pmid:15035684 |
de Wergifosse B et al. | Coelenterazine: a two-stage antioxidant in lipid micelles. | 2004 | Free Radic. Biol. Med. | pmid:15036347 |
Colazo MG et al. | Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed. | 2004 | Theriogenology | pmid:15036999 |
Sauer LA and Dauchy RT | Uptake of plasma lipids by tissue-isolated hepatomas 7288CTC and 7777 in vivo. | 1992 | Br. J. Cancer | pmid:1503901 |
Thorisson S et al. | Some oxidation products of ethoxyquin including those found in autoxidising systems. | 1992 Jan-Feb | Chem. Phys. Lipids | pmid:1505065 |
Reiterer G et al. | Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. | 2004 | J. Nutr. | pmid:15051824 |
Akahoshi A et al. | Dietary protein modulates the effect of CLA on lipid metabolism in rats. | 2004 | Lipids | pmid:15055231 |
Cherian G and Goeger MP | Hepatic lipid characteristics and histopathology of laying hens fed CLA or n-3 fatty acids. | 2004 | Lipids | pmid:15055232 |
Shigeta Y et al. | Skin whitening effect of linoleic acid is enhanced by liposomal formulations. | 2004 | Biol. Pharm. Bull. | pmid:15056874 |
Furusawa H and Koyama N | Effect of fatty acids on the membrane potential of an alkaliphilic bacillus. | 2004 | Curr. Microbiol. | pmid:15057464 |
Cox JE et al. | Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions. | 2004 | Physiol. Behav. | pmid:15059681 |
Saeki K et al. | Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15067141 |
Nielsen GS et al. | Formation of volatile compounds in model experiments with crude leek (Allium ampeloprasum Var. Lancelot) enzyme extract and linoleic acid or linolenic acid. | 2004 | J. Agric. Food Chem. | pmid:15080639 |
Pannier AK et al. | Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin. | 2004 | Int J Pharm | pmid:15081152 |
Mikkola JP et al. | Utilisation of on-line acoustic irradiation as a means to counter-effect catalyst deactivation in heterogeneous catalysis. | 2004 | Ultrason Sonochem | pmid:15081987 |
Speake BK et al. | Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. | 2004 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:15085383 |
Cardoso CR et al. | Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. | 2004 Mar-Apr | Wound Repair Regen | pmid:15086775 |
Tokudome S et al. | n-6 Polyunsaturated fatty acids and breast cancer. | 2003 | Nutr Cancer | pmid:15087274 |
Adlof RO | Separation of conjugated linoleic acid methyl esters by silver-ion high performance liquid chromatography in semi-preparative mode. | 2004 | J Chromatogr A | pmid:15088760 |
Zhao X et al. | Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. | 2004 | J. Am. Soc. Nephrol. | pmid:15100364 |