Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Dermatitis, Seborrheic D012628 10 associated lipids
Retinoblastoma D012175 12 associated lipids
Retinal Degeneration D012162 9 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Refsum Disease D012035 19 associated lipids
Refractive Errors D012030 1 associated lipids
Pulmonary Edema D011654 23 associated lipids
Psoriasis D011565 47 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Proteinuria D011507 30 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Dermatitis, Toxicodendron D011040 3 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Pellagra D010383 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Moran JH et al. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. 2000 Toxicol. Appl. Pharmacol. pmid:11042099
Ha J et al. Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. 2002 Toxicol. Appl. Pharmacol. pmid:12127265
Moran JH et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. 1997 Toxicol. Appl. Pharmacol. pmid:9299596
Moran JH et al. Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. 2001 Toxicol. Appl. Pharmacol. pmid:11714247
Yu WK and Wells PG Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. 1995 Toxicol. Appl. Pharmacol. pmid:7878664
Wey HE et al. Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation. 1993 Toxicol. Appl. Pharmacol. pmid:8511784
Moran JH et al. Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. 2001 Toxicol. Appl. Pharmacol. pmid:11298501
Slim R et al. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. 2001 Toxicol. Appl. Pharmacol. pmid:11243918
Matsusue K et al. A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. 1997 Toxicol. Lett. pmid:9175845
Shchepinov MS et al. Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. 2011 Toxicol. Lett. pmid:21906664