Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Dermatitis, Seborrheic D012628 10 associated lipids
Retinoblastoma D012175 12 associated lipids
Retinal Degeneration D012162 9 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Refsum Disease D012035 19 associated lipids
Refractive Errors D012030 1 associated lipids
Pulmonary Edema D011654 23 associated lipids
Psoriasis D011565 47 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Proteinuria D011507 30 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Dermatitis, Toxicodendron D011040 3 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Pellagra D010383 1 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Lasa A et al. Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. 2011 Nutrition pmid:20619605
Tan B et al. Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. 2011 J. Nutr. Biochem. pmid:20619625
Shirakawa J et al. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. 2011 J. Biol. Chem. pmid:21613229
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Monfregola L et al. Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. 2011 Biomacromolecules pmid:21553919
Márquez-Castillo A and Vidal-Quintanar RL Improvements in the shelf life of commercial corn dry masa flour (CMF) by reducing lipid oxidation. 2011 J. Food Sci. pmid:21535741
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Wang L et al. Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. 2011 J. Endocrinol. pmid:21565851
Nigam S et al. On mechanism of quorum sensing in Candida albicans by 3(R)-hydroxy-tetradecaenoic acid. 2011 Curr. Microbiol. pmid:20509029
de Lima-Salgado TM et al. Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. 2011 Cell Biochem. Biophys. pmid:20809180
Retamal MA et al. Biphasic effect of linoleic acid on connexin 46 hemichannels. 2011 Pflugers Arch. pmid:21360038
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Popescu FD et al. Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21328065
Lee MJ et al. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. 2011 Mol. Cells pmid:21331775
Gelhaus SL et al. Cellular lipid extraction for targeted stable isotope dilution liquid chromatography-mass spectrometry analysis. 2011 J Vis Exp pmid:22127066
Andreu I et al. Probing lipid peroxidation by using linoleic acid and benzophenone. 2011 Chemistry pmid:21793062
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
Royan M et al. Effects of conjugated linoleic acid, fish oil and soybean oil on PPARs (α & γ) mRNA expression in broiler chickens and their relation to body fat deposits. 2011 Int J Mol Sci pmid:22272093
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Salleh WM et al. Chemical compositions, antioxidant and antimicrobial activities of essential oils of Piper caninum Blume. 2011 Int J Mol Sci pmid:22174627
Shofian NM et al. Effect of freeze-drying on the antioxidant compounds and antioxidant activity of selected tropical fruits. 2011 Int J Mol Sci pmid:21845104
Lebold KM et al. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 2011 J. Nutr. pmid:22013196
Nishioka N et al. Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1. 2011 Br. J. Cancer pmid:22015554
Alimi H et al. Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. 2011 Environ. Toxicol. Pharmacol. pmid:22004960
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Espinosa-Neira R et al. Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. 2011 Int. J. Biochem. Cell Biol. pmid:21945809
Sousa A et al. Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. 2011 Molecules pmid:22031066
Li J et al. [Extraction and comparison of volatile oil components from water caltrop and kernel by supercritical carbon dioxide extraction]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22032133
Zened A et al. Starch and oil in the donor cow diet and starch in substrate differently affect the in vitro ruminal biohydrogenation of linoleic and linolenic acids. 2011 J. Dairy Sci. pmid:22032386
Yahya A et al. Effect of J-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T. 2011 J Magn Reson Imaging pmid:21953706
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Khadake R et al. Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. 2011 J. Sci. Food Agric. pmid:21769878
Cai W et al. 3,4,4'-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent. 2011 Free Radic. Res. pmid:21974738
Banta JP et al. Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. 2011 J. Anim. Sci. pmid:21788431
Gibson R and Makrides M α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22019216
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Ramsden CE et al. All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. 2011 World Rev Nutr Diet pmid:21865817
Okuyama H et al. New Cholesterol Guidelines for Longevity (2010). 2011 World Rev Nutr Diet pmid:21865826
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Khan AA et al. Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study. 2011 Eur J Med Chem pmid:21868138
Ozcan B et al. Antimicrobial and antioxidant activities of the various extracts of Verbascum pinetorum Boiss. O. Kuntze (Scrophulariaceae). 2011 Eur Rev Med Pharmacol Sci pmid:21845800
Simon E et al. Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression. 2011 Exp. Eye Res. pmid:21821023
Arawwawala M et al. In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. 2011 Acta. Biol. Hung. pmid:21840826
Martinchik AN [Nutritional value of sesame seeds]. 2011 Vopr Pitan pmid:21842753
Danish HH et al. Hydrogen tunneling steps in cyclooxygenase-2 catalysis. 2011 J. Am. Chem. Soc. pmid:21902213
Bowden JA et al. Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. 2011 Lipids pmid:21904795
Shchepinov MS et al. Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. 2011 Toxicol. Lett. pmid:21906664
Hanada H et al. Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs. 2011 Cell Biol. Int. pmid:20812919
Zhou XR et al. Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions. 2011 J. Biol. Chem. pmid:22041902
Arciniega JC et al. Effects of free fatty acids on meibomian lipid films. 2011 Exp. Eye Res. pmid:21718696
Lam WM et al. In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. 2011 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:21053263
Yang Y et al. Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. 2011 Free Radic. Res. pmid:21128731
Hubert DJ et al. In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. 2011 Inflammopharmacology pmid:21088994
Jin G et al. Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. 2011 Meat Sci. pmid:21093161
Du YZ et al. Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. 2011 Int. J. Biol. Macromol. pmid:21093477
Huang YS et al. Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. 2011 Mol. Cell. Biochem. pmid:21688154
Gorissen L et al. Linoleate isomerase activity occurs in lactic acid bacteria strains and is affected by pH and temperature. 2011 J. Appl. Microbiol. pmid:21699633
Chen Q et al. Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. 2011 Biochem. Biophys. Res. Commun. pmid:21679695
Pink RC et al. Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism. 2011 Nutr Cancer pmid:21667399
Morganti P et al. Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial. 2011 Int J Cosmet Sci pmid:21668835
Yuan Y et al. [Study on fat-soluble components in different parts of miao ethnomedicine Pileostegia viburnoides by the herbal blitzkrieg extractor]. 2011 Zhong Yao Cai pmid:22500427
You Q et al. Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. 2011 Bioprocess Biosyst Eng pmid:21340675
Rybicka M et al. Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. 2011 J. Agric. Food Chem. pmid:21391598
Rakib MA et al. Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. 2011 J. Agric. Food Chem. pmid:21391601
Tuei VC et al. Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. 2011 Life Sci. pmid:21396379
Mihaljević B et al. Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. 2011 Org. Biomol. Chem. pmid:21442126
Blum JL et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. 2011 Toxicol In Vitro pmid:21443943
Conforti F et al. Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). 2011 Chem. Biodivers. pmid:21404435
Serratosa MP et al. Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. 2011 J. Agric. Food Chem. pmid:21319807
Parra-Cabrera S et al. Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. 2011 Matern Child Nutr pmid:21410881
Litinas KE et al. Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers. 2011 J Enzyme Inhib Med Chem pmid:21381887
Min Y et al. Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity. 2011 Eur J Clin Nutr pmid:21386858
Zoia L et al. Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping. 2011 Bioorg. Med. Chem. pmid:21474321
Martins SV et al. Dietary conjugated linoleic acid isomers change the unsaturation degree of hepatic fatty acids in neutral lipids but not in polar lipids. 2011 Nutr Res pmid:21481719
Negrini R and Mezzenga R pH-responsive lyotropic liquid crystals for controlled drug delivery. 2011 Langmuir pmid:21452814
Zouboulis CC et al. Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. 2011 Br. J. Dermatol. pmid:21457203
Ferreira TC et al. Cell density-dependent linoleic acid toxicity to Saccharomyces cerevisiae. 2011 FEMS Yeast Res. pmid:21457450
Sala-Vila A et al. Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia. 2011 Clin Nutr pmid:21458117
Li M et al. Isolation of a novel C18-Δ9 polyunsaturated fatty acid specific elongase gene from DHA-producing Isochrysis galbana H29 and its use for the reconstitution of the alternative Δ8 pathway in Saccharomyces cerevisiae. 2011 Biotechnol. Lett. pmid:21538137
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Tang H et al. [Analysis of fatty acids in leaves of Loropetalum chinense and L. chinense var. rubrum by GC-MS]. 2011 Zhong Yao Cai pmid:22372144
Wong WT et al. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. 2011 Nutr Metab Cardiovasc Dis pmid:20005687
Alloatti A and Uttaro AD Highly specific methyl-end fatty-acid desaturases of trypanosomatids. 2011 Mol. Biochem. Parasitol. pmid:20974196
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Liou AP et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. 2011 Gastroenterology pmid:20955703
Perona JS et al. Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. 2011 Metab. Clin. Exp. pmid:20934731
Mariutto M et al. The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. 2011 BMC Plant Biol. pmid:21294872
Pan Z et al. Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21295151
Tsubura A et al. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. 2011 Anticancer Agents Med Chem pmid:21269259
Chohany LE et al. Cationic substrates of soybean lipoxygenase-1. 2011 Bioorg. Chem. pmid:21257189
Das R et al. Synthesis of linoleic acid capped copper nanoparticles and their fluorescence study. 2011 J Fluoresc pmid:21221748
Senadheera SD et al. Effects of dietary α-linolenic acid (18:3n-3)/linoleic acid (18:2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii). 2011 J. Agric. Food Chem. pmid:21222433
Liu WM et al. Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes. 2011 Mol. Cell. Biochem. pmid:21274596
Siddique BM et al. Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. 2011 J. Food Sci. pmid:22417332
Lin X et al. Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs. 2011 J. Nutr. Biochem. pmid:21216581
Chen HH and Chiu TH Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. 2011 J. Food Sci. pmid:22417350
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381
Rosberg-Cody E et al. Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. 2011 Microbiology (Reading, Engl.) pmid:21178166