Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Haataja M et al. | Prostaglandin precursors in rheumatoid arthritis. | 1982 Jan-Feb | J. Rheumatol. | pmid:7086783 |
Eisen EJ et al. | Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity. | 1982 | Lipids | pmid:7087689 |
O'Connell M et al. | The interaction of free fatty acids in radioimmunoassays for reverse triiodothyronine. | 1982 | J. Clin. Endocrinol. Metab. | pmid:7096540 |
Barbeau A | Friedreich's disease 1982: etiologic hypotheses a personal analysis. | 1982 | Can J Neurol Sci | pmid:7104891 |
Yoo TJ et al. | Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells. | 1982 | Cancer Res. | pmid:7105033 |
Letts V et al. | Synthesis and utilization of fatty acids by wild-type and fatty acid auxotrophs of Caulobacter crescentus. | 1982 | J. Bacteriol. | pmid:7107555 |
Kelly R | Drug treatment in multiple sclerosis. | 1982 | Physiotherapy | pmid:7111474 |
Smith FB et al. | Increased saturated phospholipid in cultured cells grown with linoleic acid. | 1982 | In Vitro | pmid:7118125 |
Stantcheva IG et al. | Metabolic fate of fatty acids in type II cells isolated from adult rat lung. | 1982 | Lung | pmid:7121064 |
Rosing U et al. | Relative fatty acid composition of serum lecithin in the second half of the normal pregnancy. | 1982 | Gynecol. Obstet. Invest. | pmid:7129232 |
Mogenson GJ and Box BM | Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. | 1982 | Ann. Nutr. Metab. | pmid:7137945 |
Adam O et al. | Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. | 1982 | Ann. Nutr. Metab. | pmid:7137955 |
Moore CE and Dhopeshwarkar GA | Trans fatty acids: transport and positional specificity in rat placental lecithin. | 1982 | Biol. Neonate | pmid:7138987 |
Miura S et al. | Lymphatic role in the pathogenesis of fat malabsorption in liver cirrhosis in rats. | 1982 | Dig. Dis. Sci. | pmid:7140488 |
Cuebas D and Schulz H | Evidence for a modified pathway of linoleate degradation. Metabolism of 2,4-decadienoyl coenzyme A. | 1982 | J. Biol. Chem. | pmid:7142199 |
Iritani N and Ikeda Y | Activation of catalase and other enzymes by corn oil intake. | 1982 | J. Nutr. | pmid:7143106 |
Hølmer G et al. | Influence of partially hydrogenated vegetable and marine oils on lipid metabolism in rat liver and heart. | 1982 | Lipids | pmid:7144446 |
Hoffmann P et al. | Alterations in renal and aortic prostaglandin E and F formation correlate with blood pressure dietary linoleate deficiency. | 1982 | Arch Int Pharmacodyn Ther | pmid:7181575 |
Alberghina M et al. | Axonal transport of phospholipids in rabbit optic pathway. | 1981 | Neurochem. Res. | pmid:7279114 |
Liffmann SM and Lynch RD | Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. | 1981 | Biochim. Biophys. Acta | pmid:7295748 |
Macdonald MC et al. | Dietary linoleic acid and salt-induced hypertension. | 1981 | Can. J. Physiol. Pharmacol. | pmid:7296385 |
Lindström M et al. | Aqueous lipid phases of relevance to intestinal fat digestion and absorption. | 1981 | Lipids | pmid:7300594 |
Cunnane SC and Wahle KW | Zinc deficiency increases the rate of delta 6 desaturation of linoleic acid in rat mammary tissue. | 1981 | Lipids | pmid:7300596 |
Alling C et al. | Decreased linoleic acid in serum lecithin after ethanol abuse. | 1980 | Subst Alcohol Actions Misuse | pmid:7302797 |
Murphy DJ and Stumpf PK | Polyunsaturation systems from higher plants. | 1981 | Meth. Enzymol. | pmid:7311864 |
Cherif A | [Linoleic acid synthesis in oleaginous seeds]. | 1981 Sep-Dec | Arch Inst Pasteur Tunis | pmid:7316620 |
Naidoo J | Effect of pH on inhibition of plasmid-carrying cultures of Staphylococcus aureus by lipids. | 1981 | J. Gen. Microbiol. | pmid:7320698 |
Rice DA et al. | Reproduction of nutritional degenerative myopathy in the post ruminant calf. | 1981 | Vet. Rec. | pmid:7324363 |
Fernandes J et al. | The effect of a virtually cholesterol-free, high-linoleic-acid vegetarian diet on serum lipoproteins of children with familial hypercholesterolemia (type II-A). | 1981 | Acta Paediatr Scand | pmid:7324917 |
Twaddle ML et al. | Kinetics of appearance of lipoprotein particles in perisinusoidal cisternae of smooth endoplasmic reticulum of isolated rat livers perfused with free fatty acid. | 1981 | Eur. J. Cell Biol. | pmid:7327182 |
Otsuka H et al. | [Studies on anti-inflammatory agents. IV. Anti-inflammatory constituents from roots of Panax ginseng C.A. Meyer (author's transl)]. | 1981 | Yakugaku Zasshi | pmid:7338798 |
Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
Cunnane SC | Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. | 1981 | Prog. Lipid Res. | pmid:7342114 |
Lynn WS et al. | Linoleic acid: a specific cytotaxin for macrophages. | 1981 | Prog. Lipid Res. | pmid:7342119 |
Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
Cho Y and Ziboh VA | Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. | 1995 | J. Nutr. | pmid:7472653 |
Al MD et al. | Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy. | 1995 | J. Nutr. | pmid:7472662 |
Matsui K and Kajiwara T | Cucumber cotyledon lipoxygenase oxygenizes trilinolein at the lipid/water interface. | 1995 | Lipids | pmid:7475989 |
Cunnane SC et al. | Synthesis of linoleate and alpha-linolenate by chain elongation in the rat. | 1995 | Lipids | pmid:7475996 |
Christen MO et al. | Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. | 1995 | Meth. Enzymol. | pmid:7476369 |
Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
Ramchurren N and Karmali R | Effects of gamma-linolenic and dihomo-gamma-linolenic acids on 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors in rats. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480079 |
Kerner J et al. | Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. | 1995 | Am. J. Physiol. | pmid:7485605 |
Iwase H et al. | pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488065 |
Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
Johanning GL and Lin TY | Unsaturated fatty acid effects on human breast cancer cell adhesion. | 1995 | Nutr Cancer | pmid:7491298 |
Groscolas R et al. | Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. | 1995 | Nutr Cancer | pmid:7491300 |
Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
Bondy SC and Marwah S | Stimulation of synaptosomal free radical production by fatty acids: relation to esterification and to degree of unsaturation. | 1995 | FEBS Lett. | pmid:7498480 |
Campbell FM and Dutta-Roy AK | Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. | 1995 | FEBS Lett. | pmid:7498505 |
Teboul L et al. | Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. | 1995 | J. Biol. Chem. | pmid:7499310 |
Yamamoto A et al. | Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. | 1994 | J. Pharm. Pharmacol. | pmid:7515417 |
McKenzie KE et al. | Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7535935 |
Eling TE et al. | Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7537437 |
Shintani T et al. | Recognition system for dietary fatty acids in the rat small intestine. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7549092 |
Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
Yurawecz MP et al. | Furan fatty acids determined as oxidation products of conjugated octadecadienoic acid. | 1995 | Lipids | pmid:7564913 |
Nakayama T et al. | Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575511 |
Glickman MH and Klinman JP | Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. | 1995 | Biochemistry | pmid:7578005 |
Gieseg SP et al. | 7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant. | 1995 | Free Radic. Res. | pmid:7581810 |
Laryea MD et al. | Fatty acid composition of the milk of well-nourished Sudanese women. | 1995 | Int J Food Sci Nutr | pmid:7584158 |
Jiang WG et al. | Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). | 1995 | Cancer Res. | pmid:7585549 |
Greco AV et al. | Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. | 1995 | Clin. Chim. Acta | pmid:7586583 |
Berardesca E et al. | Acute irritant dermatitis: effect of short-term topical corticoid treatment. | 1995 | Curr. Probl. Dermatol. | pmid:7587340 |
Rodier M et al. | Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in NIDDM with secondary failure to oral antidiabetic agents. | 1995 | Diabetes Res. Clin. Pract. | pmid:7587908 |
Engman L et al. | Organotellurium compounds as efficient retarders of lipid peroxidation in methanol. | 1995 | Free Radic. Biol. Med. | pmid:7590393 |
Tappia PS et al. | Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. | 1995 | Mol. Cell. Biochem. | pmid:7596352 |
Blée E and Schuber F | Stereocontrolled hydrolysis of the linoleic acid monoepoxide regioisomers catalyzed by soybean epoxide hydrolase. | 1995 | Eur. J. Biochem. | pmid:7601104 |
van de Sandt JJ et al. | Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. | 1995 | Fundam Appl Toxicol | pmid:7601324 |
Kurushima H et al. | Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. | 1995 | Atherosclerosis | pmid:7605390 |
Jenkins TC | Butylsoyamide protects soybean oil from ruminal biohydrogenation: effects of butylsoyamide on plasma fatty acids and nutrient digestion in sheep. | 1995 | J. Anim. Sci. | pmid:7608016 |
Pyles LA et al. | Plasma antioxidant depletion after cardiopulmonary bypass in operations for congenital heart disease. | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609540 |
Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
Norman HA et al. | Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. | 1995 | FEBS Lett. | pmid:7615067 |
Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
Kitano M et al. | Lack of promoting effects of alpha-linolenic, linoleic or palmitic acid on urinary bladder carcinogenesis in rats. | 1995 | Jpn. J. Cancer Res. | pmid:7622416 |
Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
Rudel LL et al. | Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. | 1995 | Am. J. Clin. Nutr. | pmid:7625361 |
Gillet B and Doan BT | Phase-sensitive two-dimensional experiment on living animals. | 1995 | J Magn Reson B | pmid:7627434 |
van der Heijdt LM et al. | Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. | 1995 | Eur. J. Biochem. | pmid:7628469 |
Chen CC and Chen CS | Brugia pahangi: effects of melanization on the uptake of nutrients by microfilariae in vitro. | 1995 | Exp. Parasitol. | pmid:7628569 |
Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
Guo L et al. | Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. | 1995 | Free Radic. Biol. Med. | pmid:7628726 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
Appel MJ and Woutersen RA | Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. | 1995 | Cancer Lett. | pmid:7634246 |
Rao GN et al. | Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. | 1995 | J. Clin. Invest. | pmid:7635978 |
Laneuville O et al. | Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. | 1995 | J. Biol. Chem. | pmid:7642610 |
Noguchi M et al. | Effects of indomethacin with or without linoleic acid on human breast cancer cells in vitro. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644559 |
Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Schønberg S and Krokan HE | The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. | 1995 Jul-Aug | Anticancer Res. | pmid:7654003 |
Raederstorff D et al. | Polyunsaturated fatty acid metabolism of human skin fibroblasts during cellular aging. | 1995 | Int J Vitam Nutr Res | pmid:7657482 |
Khan MF et al. | Hematopoietic toxicity of linoleic acid anilide: importance of aniline. | 1995 | Fundam Appl Toxicol | pmid:7665006 |
Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |
Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |