Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Leukemia, Experimental D007942 42 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Psoriasis D011565 47 associated lipids
Starvation D013217 47 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nerve Degeneration D009410 53 associated lipids
Parkinson Disease D010300 53 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Colitis D003092 69 associated lipids
Melanoma D008545 69 associated lipids
Coronary Disease D003327 70 associated lipids
Leukemia D007938 74 associated lipids
Stomach Ulcer D013276 75 associated lipids
Alzheimer Disease D000544 76 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Uygun DA et al. A novel support for antibody purification: fatty acid attached chitosan beads. 2009 Colloids Surf B Biointerfaces pmid:19196498
Carlotti ME et al. Role of particle coating in controlling skin damage photoinduced by titania nanoparticles. 2009 Free Radic. Res. pmid:19199115
Rodríguez-Cruz M et al. Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. 2009 Nutrition pmid:18849148
Bannenberg G et al. Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. 2009 Lipids pmid:18949503
Pandey NR et al. An induction in hepatic HDL secretion associated with reduced ATPase expression. 2009 Am. J. Pathol. pmid:19717637
Radunz AE et al. Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. 2009 J. Anim. Sci. pmid:19717771
Staiger H et al. Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. 2009 Diabetes pmid:19074989
Shah KB et al. The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling. 2009 Hypertension pmid:19597033
Hernández ML et al. Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. 2009 J. Agric. Food Chem. pmid:19601663
Yasuda M et al. Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. 2009 Carcinogenesis pmid:19414503
Celia C et al. Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent. 2009 Colloids Surf B Biointerfaces pmid:19376689
Evans LM et al. Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice. 2009 Clin. Exp. Metastasis pmid:19267249
Detsi A et al. Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. 2009 Bioorg. Med. Chem. pmid:19853459
Luo J et al. Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. 2009 J Enzyme Inhib Med Chem pmid:19912062
Ozen T Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. 2009 Mar-Apr Acta Pol Pharm pmid:19719054
Zeng Z et al. Identification of lactic acid bacterial strains with high conjugated linoleic acid-producing ability from natural sauerkraut fermentations. 2009 May-Jul J. Food Sci. pmid:19490332
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Parnas M et al. Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. 2009 May-Jun Channels (Austin) pmid:19535910
Vlahov G 13C nuclear magnetic resonance spectroscopic detection of the adulteration of extra virgin olive oils extracted from different cultivars with cold-pressed hazelnut oil. 2009 Nov-Dec J AOAC Int pmid:20166593
Yu C et al. Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. 2009 Nov-Dec Plant Physiol. Biochem. pmid:19648018
Habermann N et al. Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. 2009 Sep-Oct Biofactors pmid:19798733
Wang L et al. [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. 2010 Sheng Li Xue Bao pmid:21170499
Bartók T et al. Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₁ fumonisin isomers from a solid culture of Fusarium verticillioides. 2010 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:21108092
Herdmann A et al. Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing. 2010 J. Agric. Food Chem. pmid:20597504
Zaman MM et al. Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20656894
Frangioudakis G et al. Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. 2010 Endocrinology pmid:20660065
Beezhold BL et al. Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. 2010 Nutr J pmid:20515497
Brito GA et al. Lymphocytes transfer [(14)C]-labeled fatty acids to skeletal muscle in culture; modulation by exercise. 2010 Cell Biochem. Funct. pmid:20517891
Li TL et al. [Study on the chemical constituents of Humulus scandens]. 2010 Zhong Yao Cai pmid:20518305
Czernichow S et al. n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. 2010 Br. J. Nutr. pmid:20522273
Sorrentino F et al. Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. 2010 Appl. Microbiol. Biotechnol. pmid:20571794
Tu WC et al. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20573490
Li GY et al. [Studies on chemistry component and the biological activity of petroleum ether extraction from pre-and post-processed of Cornus officinalis]. 2010 Zhong Yao Cai pmid:20575409
Wei M et al. [Kinetics of bioconversion of linoleic acid to conjugated linoleic acid by permeabilized Lactobacillus acidophilus cells]. 2010 Sheng Wu Gong Cheng Xue Bao pmid:20575439
Caroprese M et al. Flaxseed supplementation improves fatty acid profile of cow milk. 2010 J. Dairy Sci. pmid:20494167
Wien M et al. Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. 2010 Lipids pmid:20496049
Castellanos P et al. Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. 2010 Reprod. Toxicol. pmid:20096347
Coyral-Castel S et al. Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells. 2010 Domest. Anim. Endocrinol. pmid:20097509
Nakamura T et al. Excessive fat restriction might promote the recurrence of colorectal tumors. 2010 Nutr Cancer pmid:20099189
Beevi SS et al. Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. 2010 Plant Foods Hum Nutr pmid:20072818
Privé F et al. Temperature and duration of heating of sunflower oil affect ruminal biohydrogenation of linoleic acid in vitro. 2010 J. Dairy Sci. pmid:20105542
Rodríguez AM et al. Time-course effects of increased fatty acid supply on the expression of genes involved in lipid/glucose metabolism in muscle cells. 2010 Cell. Physiol. Biochem. pmid:20110694
Ivanova L et al. Phomenins and fatty acids from Alternaria infectoria. 2010 Toxicon pmid:20060014
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Dimri M et al. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. 2010 Carcinogenesis pmid:19969553
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Jernerén F et al. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. 2010 Biochim. Biophys. Acta pmid:20045744
Paraszkiewicz K et al. Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. 2010 Arch. Microbiol. pmid:20047047
Esmaeili MA and Sonboli A Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. 2010 Food Chem. Toxicol. pmid:20036303
Even P et al. Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. 2010 Metab. Clin. Exp. pmid:19775712
Renaville B et al. Plasma and follicular fluid fatty acid profiles in dairy cows. 2010 Reprod. Domest. Anim. pmid:19055554
Kubala L et al. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. 2010 Free Radic. Biol. Med. pmid:20156554
Li YF et al. Properties of synthetic homoisoflavonoids to reduce oxidants and to protect linoleic acid and dna against oxidation. 2010 J. Agric. Food Chem. pmid:20199083
Jernerén F et al. Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. 2010 Arch. Biochem. Biophys. pmid:20043865
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Gholivand MB et al. Chemical composition and antioxidant activities of the essential oil and methanol extracts of Psammogeton canescens. 2010 Food Chem. Toxicol. pmid:19748545
Kim BS et al. Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. 2010 N Biotechnol pmid:19748603
Joshi SC et al. Antioxidant and antibacterial activities of the leaf essential oils of Himalayan Lauraceae species. 2010 Food Chem. Toxicol. pmid:19766161
Fekete K and Decsi T Long-chain polyunsaturated fatty acids in inborn errors of metabolism. 2010 Nutrients pmid:22254065
Alvaro A et al. Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids. 2010 J. Nutr. Biochem. pmid:19443194
Walloschke B et al. Enrichment of RAW264.7 macrophages with essential 18-carbon fatty acids affects both respiratory burst and production of immune modulating cytokines. 2010 J. Nutr. Biochem. pmid:19447017
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Gutiérrez-Correa J Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. 2010 Free Radic. Res. pmid:20815787
Serhan Z et al. Complete determination of natural site-specific enantio-isotopomeric excesses in linoleic acid using natural abundance deuterium 2D NMR in polypeptide mesophases. 2010 Chem. Commun. (Camb.) pmid:20721385
Noel JT et al. Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. 2010 PLoS ONE pmid:20824208
Macouzet M et al. Genetic and structural comparison of linoleate isomerases from selected food-grade bacteria. 2010 J. Appl. Microbiol. pmid:20825518
Collin F et al. Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals. 2010 Biochimie pmid:20685376
Calder PC The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? 2010 Br. J. Nutr. pmid:21118616
Ramsden CE et al. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. 2010 Br. J. Nutr. pmid:21118617
Lu XF et al. Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. 2010 J Zhejiang Univ Sci B pmid:21121070
Duckett SK and Gillis MH Effects of oil source and fish oil addition on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. 2010 J. Anim. Sci. pmid:20348369
Aluf Y et al. Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydroxydopamine as assessed by a novel multifunctional marker molecule. 2010 Free Radic. Res. pmid:20370558
Tume RK et al. Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. 2010 Meat Sci. pmid:20374755
Berthelot V et al. Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. 2010 Meat Sci. pmid:20374762
Della Casa G et al. Performance and fat quality of heavy pigs fed maize differing in linoleic acid content. 2010 Meat Sci. pmid:20374768
Aldai N et al. Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. 2010 Meat Sci. pmid:20374865
Christensen KB et al. Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. 2010 Phytother Res pmid:20222152
Chen T et al. Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. 2010 J Diet Suppl pmid:22435611
Xiao C et al. Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA. 2010 Eur J Med Chem pmid:20332056
Bitis L et al. Flavonoids and antioxidant activity of Rosa agrestis leaves. 2010 Nat. Prod. Res. pmid:20397108
Georgiadi A et al. Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. 2010 Circ. Res. pmid:20378851
Zulkifli RM et al. Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. 2010 J. Anim. Sci. pmid:20382866
Domínguez T et al. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. 2010 Plant Physiol. pmid:20382895
Kamkar A et al. The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil. 2010 Food Chem. Toxicol. pmid:20385193
Matsuoka T et al. Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. 2010 Br. J. Cancer pmid:20842125
Lau BY et al. Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. 2010 Appl Physiol Nutr Metab pmid:20962915
Giroix MH et al. Fatty acid pattern of pancreatic islet lipids in Goto-Kakizaki rats. 2010 Endocrine pmid:20963567
Corriher VA et al. Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets. 2010 J. Dairy Sci. pmid:20965347
Liu S and Han B Differential expression pattern of an acidic 9/13-lipoxygenase in flower opening and senescence and in leaf response to phloem feeders in the tea plant. 2010 BMC Plant Biol. pmid:20969806
Martin H Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. 2010 Mutat. Res. pmid:20973164
Brodhun F et al. PpoC from Aspergillus nidulans is a fusion protein with only one active haem. 2010 Biochem. J. pmid:19878096
Khiaosa-Ard R et al. Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. 2010 J. Dairy Res. pmid:20482940
Sahoo PK and Behera P Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. 2010 Eur J Med Chem pmid:20434240
Campoy C et al. [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. 2010 Med Clin (Barc) pmid:20434734
Goicoechea E and Guillen MD Analysis of hydroperoxides, aldehydes and epoxides by 1H nuclear magnetic resonance in sunflower oil oxidized at 70 and 100 degrees C. 2010 J. Agric. Food Chem. pmid:20438132
Zurabashvili DZ et al. [The effect of toxic components in tobacco smoke on the fatty acid profile of dental pulp]. 2010 Georgian Med News pmid:20413813
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Macouzet M et al. Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus. 2010 Appl. Microbiol. Biotechnol. pmid:20461509
McKay DL et al. Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. 2010 Nutr J pmid:20462428
Alloatti A et al. Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. 2010 PLoS ONE pmid:21151902