Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
Kitano M et al. | Lack of promoting effects of alpha-linolenic, linoleic or palmitic acid on urinary bladder carcinogenesis in rats. | 1995 | Jpn. J. Cancer Res. | pmid:7622416 |
Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
Norman HA et al. | Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. | 1995 | FEBS Lett. | pmid:7615067 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
Pyles LA et al. | Plasma antioxidant depletion after cardiopulmonary bypass in operations for congenital heart disease. | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609540 |
Jenkins TC | Butylsoyamide protects soybean oil from ruminal biohydrogenation: effects of butylsoyamide on plasma fatty acids and nutrient digestion in sheep. | 1995 | J. Anim. Sci. | pmid:7608016 |
Kurushima H et al. | Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. | 1995 | Atherosclerosis | pmid:7605390 |
van de Sandt JJ et al. | Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. | 1995 | Fundam Appl Toxicol | pmid:7601324 |
Blée E and Schuber F | Stereocontrolled hydrolysis of the linoleic acid monoepoxide regioisomers catalyzed by soybean epoxide hydrolase. | 1995 | Eur. J. Biochem. | pmid:7601104 |
Tappia PS et al. | Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. | 1995 | Mol. Cell. Biochem. | pmid:7596352 |
Engman L et al. | Organotellurium compounds as efficient retarders of lipid peroxidation in methanol. | 1995 | Free Radic. Biol. Med. | pmid:7590393 |
Rodier M et al. | Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in NIDDM with secondary failure to oral antidiabetic agents. | 1995 | Diabetes Res. Clin. Pract. | pmid:7587908 |
Berardesca E et al. | Acute irritant dermatitis: effect of short-term topical corticoid treatment. | 1995 | Curr. Probl. Dermatol. | pmid:7587340 |
Greco AV et al. | Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. | 1995 | Clin. Chim. Acta | pmid:7586583 |
Jiang WG et al. | Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). | 1995 | Cancer Res. | pmid:7585549 |
Laryea MD et al. | Fatty acid composition of the milk of well-nourished Sudanese women. | 1995 | Int J Food Sci Nutr | pmid:7584158 |
Gieseg SP et al. | 7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant. | 1995 | Free Radic. Res. | pmid:7581810 |
Glickman MH and Klinman JP | Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. | 1995 | Biochemistry | pmid:7578005 |
Nakayama T et al. | Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575511 |
Yurawecz MP et al. | Furan fatty acids determined as oxidation products of conjugated octadecadienoic acid. | 1995 | Lipids | pmid:7564913 |
Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
Shintani T et al. | Recognition system for dietary fatty acids in the rat small intestine. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7549092 |
Eling TE et al. | Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7537437 |
McKenzie KE et al. | Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7535935 |
Yamamoto A et al. | Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. | 1994 | J. Pharm. Pharmacol. | pmid:7515417 |
Teboul L et al. | Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. | 1995 | J. Biol. Chem. | pmid:7499310 |
Campbell FM and Dutta-Roy AK | Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. | 1995 | FEBS Lett. | pmid:7498505 |
Bondy SC and Marwah S | Stimulation of synaptosomal free radical production by fatty acids: relation to esterification and to degree of unsaturation. | 1995 | FEBS Lett. | pmid:7498480 |
Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
Groscolas R et al. | Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. | 1995 | Nutr Cancer | pmid:7491300 |
Johanning GL and Lin TY | Unsaturated fatty acid effects on human breast cancer cell adhesion. | 1995 | Nutr Cancer | pmid:7491298 |
Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
Iwase H et al. | pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488065 |
Kerner J et al. | Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. | 1995 | Am. J. Physiol. | pmid:7485605 |
Ramchurren N and Karmali R | Effects of gamma-linolenic and dihomo-gamma-linolenic acids on 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors in rats. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480079 |
Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
Christen MO et al. | Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. | 1995 | Meth. Enzymol. | pmid:7476369 |
Cunnane SC et al. | Synthesis of linoleate and alpha-linolenate by chain elongation in the rat. | 1995 | Lipids | pmid:7475996 |
Matsui K and Kajiwara T | Cucumber cotyledon lipoxygenase oxygenizes trilinolein at the lipid/water interface. | 1995 | Lipids | pmid:7475989 |
Al MD et al. | Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy. | 1995 | J. Nutr. | pmid:7472662 |
Cho Y and Ziboh VA | Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. | 1995 | J. Nutr. | pmid:7472653 |
Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
Lynn WS et al. | Linoleic acid: a specific cytotaxin for macrophages. | 1981 | Prog. Lipid Res. | pmid:7342119 |
Cunnane SC | Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. | 1981 | Prog. Lipid Res. | pmid:7342114 |
Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
Otsuka H et al. | [Studies on anti-inflammatory agents. IV. Anti-inflammatory constituents from roots of Panax ginseng C.A. Meyer (author's transl)]. | 1981 | Yakugaku Zasshi | pmid:7338798 |
Twaddle ML et al. | Kinetics of appearance of lipoprotein particles in perisinusoidal cisternae of smooth endoplasmic reticulum of isolated rat livers perfused with free fatty acid. | 1981 | Eur. J. Cell Biol. | pmid:7327182 |
Fernandes J et al. | The effect of a virtually cholesterol-free, high-linoleic-acid vegetarian diet on serum lipoproteins of children with familial hypercholesterolemia (type II-A). | 1981 | Acta Paediatr Scand | pmid:7324917 |
Rice DA et al. | Reproduction of nutritional degenerative myopathy in the post ruminant calf. | 1981 | Vet. Rec. | pmid:7324363 |
Naidoo J | Effect of pH on inhibition of plasmid-carrying cultures of Staphylococcus aureus by lipids. | 1981 | J. Gen. Microbiol. | pmid:7320698 |
Cherif A | [Linoleic acid synthesis in oleaginous seeds]. | 1981 Sep-Dec | Arch Inst Pasteur Tunis | pmid:7316620 |
Murphy DJ and Stumpf PK | Polyunsaturation systems from higher plants. | 1981 | Meth. Enzymol. | pmid:7311864 |
Alling C et al. | Decreased linoleic acid in serum lecithin after ethanol abuse. | 1980 | Subst Alcohol Actions Misuse | pmid:7302797 |
Cunnane SC and Wahle KW | Zinc deficiency increases the rate of delta 6 desaturation of linoleic acid in rat mammary tissue. | 1981 | Lipids | pmid:7300596 |
Lindström M et al. | Aqueous lipid phases of relevance to intestinal fat digestion and absorption. | 1981 | Lipids | pmid:7300594 |
Macdonald MC et al. | Dietary linoleic acid and salt-induced hypertension. | 1981 | Can. J. Physiol. Pharmacol. | pmid:7296385 |
Liffmann SM and Lynch RD | Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. | 1981 | Biochim. Biophys. Acta | pmid:7295748 |
Alberghina M et al. | Axonal transport of phospholipids in rabbit optic pathway. | 1981 | Neurochem. Res. | pmid:7279114 |
Hoffmann P et al. | Alterations in renal and aortic prostaglandin E and F formation correlate with blood pressure dietary linoleate deficiency. | 1982 | Arch Int Pharmacodyn Ther | pmid:7181575 |
Hølmer G et al. | Influence of partially hydrogenated vegetable and marine oils on lipid metabolism in rat liver and heart. | 1982 | Lipids | pmid:7144446 |
Iritani N and Ikeda Y | Activation of catalase and other enzymes by corn oil intake. | 1982 | J. Nutr. | pmid:7143106 |
Cuebas D and Schulz H | Evidence for a modified pathway of linoleate degradation. Metabolism of 2,4-decadienoyl coenzyme A. | 1982 | J. Biol. Chem. | pmid:7142199 |
Miura S et al. | Lymphatic role in the pathogenesis of fat malabsorption in liver cirrhosis in rats. | 1982 | Dig. Dis. Sci. | pmid:7140488 |
Moore CE and Dhopeshwarkar GA | Trans fatty acids: transport and positional specificity in rat placental lecithin. | 1982 | Biol. Neonate | pmid:7138987 |
Adam O et al. | Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. | 1982 | Ann. Nutr. Metab. | pmid:7137955 |
Mogenson GJ and Box BM | Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. | 1982 | Ann. Nutr. Metab. | pmid:7137945 |
Rosing U et al. | Relative fatty acid composition of serum lecithin in the second half of the normal pregnancy. | 1982 | Gynecol. Obstet. Invest. | pmid:7129232 |
Stantcheva IG et al. | Metabolic fate of fatty acids in type II cells isolated from adult rat lung. | 1982 | Lung | pmid:7121064 |
Smith FB et al. | Increased saturated phospholipid in cultured cells grown with linoleic acid. | 1982 | In Vitro | pmid:7118125 |
Kelly R | Drug treatment in multiple sclerosis. | 1982 | Physiotherapy | pmid:7111474 |
Letts V et al. | Synthesis and utilization of fatty acids by wild-type and fatty acid auxotrophs of Caulobacter crescentus. | 1982 | J. Bacteriol. | pmid:7107555 |
Yoo TJ et al. | Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells. | 1982 | Cancer Res. | pmid:7105033 |
Barbeau A | Friedreich's disease 1982: etiologic hypotheses a personal analysis. | 1982 | Can J Neurol Sci | pmid:7104891 |
O'Connell M et al. | The interaction of free fatty acids in radioimmunoassays for reverse triiodothyronine. | 1982 | J. Clin. Endocrinol. Metab. | pmid:7096540 |
Eisen EJ et al. | Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity. | 1982 | Lipids | pmid:7087689 |
Haataja M et al. | Prostaglandin precursors in rheumatoid arthritis. | 1982 Jan-Feb | J. Rheumatol. | pmid:7086783 |
Anderson RL | Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. | 1982 | Am. J. Clin. Nutr. | pmid:7081132 |
Hansen HS | Essential fatty acid-supplemented diet decreases renal excretion of immunoreactive arginine-vasopressin in essential fatty acid-deficient rats. | 1982 | Lipids | pmid:7078362 |
Okano G and Shimojo T | Utilization of long-chain free fatty acids in white and red muscle of rats. | 1982 | Biochim. Biophys. Acta | pmid:7066350 |
McKerrow JH and Jeong KH | Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel. | 1982 | Exp. Parasitol. | pmid:7060706 |
Greenspan MD et al. | Studies on the in vivo synthesis of triacylglycerol in mouse liver. | 1982 | Biochim. Biophys. Acta | pmid:7055591 |
Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
Melancon SB et al. | Oral lecithin and linoleic acid in Friedreich's ataxia: II. Clinical results. | 1982 | Can J Neurol Sci | pmid:7049341 |
Melancon SB et al. | Oral lecithin and linoleic acid in Friedreich's ataxia: I. Design of the study, material and methods. | 1982 | Can J Neurol Sci | pmid:7049340 |
Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
Burr GO | The essential fatty acids fifty years ago. | 1981 | Prog. Lipid Res. | pmid:7043474 |
Darfler FJ and Insel PA | Serum-free culture of resting, PHA-stimulated, and transformed lymphoid cells, including hybridomas. | 1982 | Exp. Cell Res. | pmid:7042376 |
Goodnight SH et al. | Polyunsaturated fatty acids, hyperlipidemia, and thrombosis. | 1982 Mar-Apr | Arteriosclerosis | pmid:7039582 |
Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee. | 1982 Mar-Apr | Arteriosclerosis | pmid:7039581 | |
Colca JR and Hazelwood RL | Insulin, pancreatic polypeptide, and glucagon release from the chicken pancreas in vitro: responses to changes in medium glucose and free fatty acid content. | 1981 | Gen. Comp. Endocrinol. | pmid:7037532 |
Kuriki Y | Effects of unsaturated fatty acids on the morphogenesis of an unsaturated fatty acid auxotroph of Escherichia coli. | 1981 | J. Bacteriol. | pmid:7024246 |
Nakazawa T et al. | Radiation-induced changes of liposomes and lecithin in non-aqueous media. | 1981 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:6975251 |
Sullivan LM and Mathias MM | Eicosanoid production in rat blood as affected by fasting and dietary fat. | 1982 | Prostaglandins Leukot Med | pmid:6956928 |
Hoffmann P et al. | Augmented acute hypotensive effect of dihydralazine and clonidine after linoleic acid rich diet in normotensive conscious rats. | 1982 | Prostaglandins Leukot Med | pmid:6955801 |
Lange LG | Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6955782 |