Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lundell KH et al. | Plasma metabolites after a lipid load in infants with congenital heart disease. | 1999 | Acta Paediatr. | pmid:10447129 |
Beuerle T and Schwab W | Metabolic profile of linoleic acid in stored apples: formation of 13(R)-hydroxy-9(Z),11(E)-octadecadienoic acid. | 1999 | Lipids | pmid:10443970 |
Freese R et al. | Green tea extract decreases plasma malondialdehyde concentration but does not affect other indicators of oxidative stress, nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy females. | 1999 | Eur J Nutr | pmid:10443337 |
Jarmuszkiewicz W et al. | Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii. | 1999 | J. Biol. Chem. | pmid:10438491 |
Ahn DU et al. | Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. | 1999 | Poult. Sci. | pmid:10438141 |
Rudel LL | Atherosclerosis and conjugated linoleic acid. | 1999 | Br. J. Nutr. | pmid:10434843 |
Yamasaki M et al. | Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10427699 |
Calvo AM et al. | Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. | 1999 | Appl. Environ. Microbiol. | pmid:10427064 |
Babin F et al. | Suspicion of latent delta5-desaturase and peroxisomal beta-oxidation deficiency in elderly women over 75 years of age. | 1999 | Lipids | pmid:10419136 |
Belza K et al. | Carbon recycling from linoleate during severe dietary linoleate deficiency. | 1999 | Lipids | pmid:10419120 |
Cunnane SC et al. | Magnetic resonance imaging-based balance analysis of linoleate utilization during weight loss in obese humans. | 1999 | Lipids | pmid:10419101 |
Demmelmair H et al. | Comparison of bolus versus fractionated oral applications of [13C]-linoleic acid in humans. | 1999 | Eur. J. Clin. Invest. | pmid:10411666 |
Sammon AM | Maize meal, non-esterified linoleic acid, and endemic cancer of the esophagus--preliminary findings. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410386 |
Kim S et al. | C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. | 1999 | Mol. Cell. Biol. | pmid:10409760 |
Ding XZ et al. | Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10405349 |
Dontsov AE et al. | Retinal pigment epithelium pigment granules stimulate the photo-oxidation of unsaturated fatty acids. | 1999 | Free Radic. Biol. Med. | pmid:10401607 |
O'Donnell VB et al. | 15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase. | 1999 | J. Biol. Chem. | pmid:10400618 |
Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
Bousquet MP et al. | Enzymatic synthesis of unsaturated fatty acid glucoside esters for dermo-cosmetic applications. | 1999 | Biotechnol. Bioeng. | pmid:10397830 |
Ingkaninan K et al. | Interference of linoleic acid fraction in some receptor binding assays. | 1999 | J. Nat. Prod. | pmid:10395519 |
Hidaka T et al. | Screening of microbial products modifying the action of leptin (obese gene product) by a biosensor. | 1999 | J. Antibiot. | pmid:10395281 |
Ando H et al. | Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis. | 1999 | J. Lipid Res. | pmid:10393216 |
Su HM et al. | Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. | 1999 | J. Lipid Res. | pmid:10393215 |
Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
Jiang J et al. | Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. | 1999 | Am. J. Clin. Nutr. | pmid:10393134 |
Greenberg D et al. | Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. | 1999 | Physiol. Behav. | pmid:10386906 |
Parodi PW | Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat. | 1999 | J. Dairy Sci. | pmid:10386321 |
Akeo K et al. | Effects of fluorescent light on growth of bovine retinal pigment epithelial cells in vitro incubated with linoleic acid or linoleic acid hydroperoxide. | 1999 | Pigment Cell Res. | pmid:10385917 |
Forster C et al. | Molecular analysis of a null mutant for pea (Pisum sativum L.) seed lipoxygenase-2. | 1999 | Plant Mol. Biol. | pmid:10380807 |
Gänzle MG et al. | Resistance of Escherichia coli and Salmonella against nisin and curvacin A. | 1999 | Int. J. Food Microbiol. | pmid:10375133 |
Kavanaugh CJ et al. | Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. | 1999 | Nutr Cancer | pmid:10368807 |
Stimers JR et al. | Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. | 1999 | Biochim. Biophys. Acta | pmid:10366778 |
Dodge ML et al. | Glutathione peroxidase activity modulates fatty acid profiles of plasma and breast milk in Chinese women. | 1999 | J Trace Elem Med Biol | pmid:10365375 |
Takeuchi H et al. | Regulation of plasma and liver total cholesterol levels by dietary oleic acid in rats fed a high-cholesterol diet. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10360242 |
Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
Banni S et al. | Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. | 1999 | Carcinogenesis | pmid:10357782 |
Hilakivi-Clarke L et al. | The influence of maternal diet on breast cancer risk among female offspring. | 1999 | Nutrition | pmid:10355854 |
Fukushima M et al. | Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. | 1999 | Nutrition | pmid:10355850 |
Meuillet EJ et al. | Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. | 1999 | Biochim. Biophys. Acta | pmid:10354513 |
Araujo de Vizcarrondo C et al. | Fatty acid composition of beef, pork, and poultry fresh cuts, and some of their processed products. | 1998 | Arch Latinoam Nutr | pmid:10347702 |
Pamplona R et al. | Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. | 1999 | Aging (Milano) | pmid:10337442 |
Yen GC and Hsieh CL | Antioxidant effects of dopamine and related compounds. | 1997 | Biosci. Biotechnol. Biochem. | pmid:10336274 |
Nuñez A et al. | Cofactor recycling in a coupled enzyme oxidation-reduction reaction: conversion of omega-oxo-fatty acids into omega-hydroxy and dicarboxylic acids. | 1999 | Biotechnol. Appl. Biochem. | pmid:10334949 |
Kapich A et al. | Coupling of manganese peroxidase-mediated lipid peroxidation with destruction of nonphenolic lignin model compounds and 14C-labeled lignins. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334942 |
Wei T et al. | Antioxidant properties of EPC-K1: a study on mechanisms. | 1999 | Biophys. Chem. | pmid:10326248 |
Haggarty P et al. | Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. | 1999 | Biol. Neonate | pmid:10325438 |
Geetha T and Varalakshmi P | Anticomplement activity of triterpenes from Crataeva nurvala stem bark in adjuvant arthritis in rats. | 1999 | Gen. Pharmacol. | pmid:10323491 |
Burke PA et al. | Conditionally essential fatty acid deficiencies in end-stage liver disease. | 1999 | Nutrition | pmid:10319364 |
Iuliano L et al. | Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue. | 1999 | Free Radic. Biol. Med. | pmid:10232829 |
Szitanyi P et al. | Metabolism of 13C-labeled linoleic acid in newborn infants during the first week of life. | 1999 | Pediatr. Res. | pmid:10231862 |
Banni S et al. | An increase in vitamin A status by the feeding of conjugated linoleic acid. | 1999 | Nutr Cancer | pmid:10227044 |
Cortez-Pinto H et al. | Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. | 1999 | Gastroenterology | pmid:10220511 |
Juanéda P and Sébédio JL | Combined silver-ion and reversed-phase high-performance liquid chromatography for the separation and identification of C20 metabolites of conjugated linoleic acid isomers in rat liver lipids. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10219661 |
Minich DM et al. | Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. | 1999 | Biochim. Biophys. Acta | pmid:10216285 |
Spaide RF et al. | Characterization of peroxidized lipids in Bruch's membrane. | 1999 | Retina (Philadelphia, Pa.) | pmid:10213241 |
Bergamini S et al. | Prooxidant activity of ferrioxamine in isolated rat hepatocytes and linoleic acid micelles. | 1999 | Chem. Res. Toxicol. | pmid:10207126 |
Hennig B et al. | Antioxidant-like properties of zinc in activated endothelial cells. | 1999 | J Am Coll Nutr | pmid:10204831 |
DeLany JP et al. | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. | 1999 | Am. J. Physiol. | pmid:10198400 |
Jayawickreme SP et al. | Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. | 1999 | Am. J. Physiol. | pmid:10198357 |
Augé N et al. | Uptake of 13-hydroperoxylinoleic acid by cultured cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195919 |
Hardwick SJ et al. | Glutathione (GSH) and the toxicity of oxidised low-density lipoprotein to human monocyte-macrophages. | 1999 | Free Radic. Res. | pmid:10193569 |
Oh-hashi K et al. | Dietary alpha-linolenate suppresses endotoxin-induced platelet-activating factor production in rat kidney. | 1999 | Lipids | pmid:10188594 |
Stewart JM et al. | Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals. | 1998 | Biochem. Cell Biol. | pmid:10099779 |
Galli A et al. | High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. | 1999 | Hepatology | pmid:10094961 |
Zhang HY et al. | A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat. | 1999 | Am. J. Hypertens. | pmid:10090346 |
Blask DE et al. | New actions of melatonin on tumor metabolism and growth. | 1999 Jan-Apr | Biol Signals Recept | pmid:10085462 |
Brodie AE et al. | Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. | 1999 | J. Nutr. | pmid:10082762 |
Olsson U et al. | Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins. | 1999 | Diabetes | pmid:10078565 |
Chancharme L et al. | Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073990 |
Dhiman TR et al. | Conjugated linoleic acid content of milk and cheese from cows fed extruded oilseeds. | 1999 | J. Dairy Sci. | pmid:10068962 |
Rukkwamsuk T et al. | Hepatic fatty acid composition in periparturient dairy cows with fatty liver induced by intake of a high energy diet in the dry period. | 1999 | J. Dairy Sci. | pmid:10068949 |
Jussila M et al. | Separation of linoleic acid oxidation products by micellar electrokinetic capillary chromatography and nonaqueous capillary electrophoresis. | 1999 | Electrophoresis | pmid:10065966 |
Josyula S and Schut HA | Effects of dietary conjugated linoleic acid on DNA adduct formation of PhIP and IQ after bolus administration to female F344 rats. | 1998 | Nutr Cancer | pmid:10050263 |
Josyula S et al. | Inhibition of DNA adduct formation of PhIP in female F344 rats by dietary conjugated linoleic acid. | 1998 | Nutr Cancer | pmid:10050262 |
Avery SV et al. | Stimulation of strontium accumulation in linoleate-enriched Saccharomyces cerevisiae is a result of reduced Sr2+ efflux. | 1999 | Appl. Environ. Microbiol. | pmid:10049882 |
Aki T et al. | Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049752 |
Cunnane SC | The long history of essential fatty acids but belated knowledge about linoleate deficiency per se: a paradox. | 1999 | J. Nutr. | pmid:10024625 |
Umezawa M et al. | High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. | 1999 | J. Nutr. | pmid:10024623 |
Cogo PE et al. | Endogenous surfactant metabolism in critically ill infants measured with stable isotope labeled fatty acids. | 1999 | Pediatr. Res. | pmid:10022597 |
pmid: |