Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Disease D004194 2 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis D003872 30 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Deficiency Diseases D003677 12 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Disease D003327 70 associated lipids
Constipation D003248 8 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colitis D003092 69 associated lipids
Cholestasis D002779 23 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cattle Diseases D002418 24 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Carcinoma D002277 18 associated lipids
Cachexia D002100 21 associated lipids
Breast Neoplasms D001943 24 associated lipids
Brain Edema D001929 20 associated lipids
Body Weight D001835 333 associated lipids
Birth Weight D001724 23 associated lipids
Biliary Atresia D001656 4 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Ascites D001201 25 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Aortic Diseases D001018 11 associated lipids
Hypoxia D000860 23 associated lipids
Olfaction Disorders D000857 17 associated lipids
Anorexia D000855 8 associated lipids
Aneurysm D000783 2 associated lipids
Alzheimer Disease D000544 76 associated lipids
Alopecia D000505 14 associated lipids
Alcoholism D000437 27 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Adenocarcinoma D000230 166 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acidosis D000138 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Bartók T et al. Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₁ fumonisin isomers from a solid culture of Fusarium verticillioides. 2010 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:21108092
Livraghi S et al. Decreasing the oxidative potential of TiO(2) nanoparticles through modification of the surface with carbon: a new strategy for the production of safe UV filters. 2010 Chem. Commun. (Camb.) pmid:20938530
Tu WC et al. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20573490
Li GY et al. [Studies on chemistry component and the biological activity of petroleum ether extraction from pre-and post-processed of Cornus officinalis]. 2010 Zhong Yao Cai pmid:20575409
Wei M et al. [Kinetics of bioconversion of linoleic acid to conjugated linoleic acid by permeabilized Lactobacillus acidophilus cells]. 2010 Sheng Wu Gong Cheng Xue Bao pmid:20575439
Caroprese M et al. Flaxseed supplementation improves fatty acid profile of cow milk. 2010 J. Dairy Sci. pmid:20494167
Wien M et al. Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. 2010 Lipids pmid:20496049
Can-Karabulut DC et al. Influence of experimental provisional cements containing zeolite, bone hydroxyapatite and linoleic Acid on bond strength of composite to dentin in vitro. 2010 J Adhes Dent pmid:20157651
Biro A et al. Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. 2010 Biochemistry pmid:20166680
Maia MR et al. Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens. 2010 BMC Microbiol. pmid:20167098
Sarikurkcu C et al. Evaluation of metal concentration and antioxidant activity of three edible mushrooms from Mugla, Turkey. 2010 Food Chem. Toxicol. pmid:20167240
Dimri M et al. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. 2010 Carcinogenesis pmid:19969553
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Jernerén F et al. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. 2010 Biochim. Biophys. Acta pmid:20045744
Paraszkiewicz K et al. Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. 2010 Arch. Microbiol. pmid:20047047
Esmaeili MA and Sonboli A Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. 2010 Food Chem. Toxicol. pmid:20036303
da Silva JK et al. Essential oil composition, antioxidant capacity and antifungal activity of Piper divaricatum. 2010 Nat Prod Commun pmid:20420331
Li Y et al. Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats. 2010 Br. J. Nutr. pmid:20420751
Edwards SJ et al. Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase. 2010 J Phys Chem B pmid:20423074
Patwardhan AM et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. 2010 J. Clin. Invest. pmid:20424317
Brown DA and Passmore GM Some new insights into the molecular mechanisms of pain perception. 2010 J. Clin. Invest. pmid:20424321
Even P et al. Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. 2010 Metab. Clin. Exp. pmid:19775712
Lábaque MC et al. Effect of age and body weight of Greater Rhea (Rhea americana) females on egg number, size and composition. 2010 Br. Poult. Sci. pmid:21161792
Zidi A et al. Pleiotropic effects of the goat prolactin receptor genotype on milk fatty acid composition. 2010 Domest. Anim. Endocrinol. pmid:20399061
Walloschke B et al. Enrichment of RAW264.7 macrophages with essential 18-carbon fatty acids affects both respiratory burst and production of immune modulating cytokines. 2010 J. Nutr. Biochem. pmid:19447017
Peoples GE and McLennan PL Dietary fish oil reduces skeletal muscle oxygen consumption, provides fatigue resistance and improves contractile recovery in the rat in vivo hindlimb. 2010 Br. J. Nutr. pmid:20691135
Bolton B and Halpern BP Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids. 2010 Chem. Senses pmid:20100787
Calder PC The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? 2010 Br. J. Nutr. pmid:21118616
Ramsden CE et al. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. 2010 Br. J. Nutr. pmid:21118617
Lu XF et al. Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. 2010 J Zhejiang Univ Sci B pmid:21121070
Luo H et al. The In vitro antioxidant properties of chinese highland lichens. 2010 J. Microbiol. Biotechnol. pmid:21124057
Olszewska MA et al. Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. 2010 Molecules pmid:21127463
Gotoh N et al. Highly unsaturated fatty acid might act as an antioxidant in emulsion system oxidized by azo compound. 2010 J Oleo Sci pmid:21099140
Guo JJ and Hu CH Mechanism of chain termination in lipid peroxidation by carotenes: a theoretical study. 2010 J Phys Chem B pmid:21105679
Safarinejad MR et al. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. 2010 Clin Nutr pmid:19666200
Demir AS and Talpur FN Chemoenzymatic conversion of linoleic acid into conjugated linoleic acid. 2010 J. Agric. Food Chem. pmid:20058923
Bitis L et al. Flavonoids and antioxidant activity of Rosa agrestis leaves. 2010 Nat. Prod. Res. pmid:20397108
Georgiadi A et al. Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. 2010 Circ. Res. pmid:20378851
Zulkifli RM et al. Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. 2010 J. Anim. Sci. pmid:20382866
Domínguez T et al. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. 2010 Plant Physiol. pmid:20382895
Kamkar A et al. The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil. 2010 Food Chem. Toxicol. pmid:20385193
Sarikurkcu C et al. Essential oil composition and antioxidant activity of Thymus longicaulis C. Presl subsp. longicaulis var. longicaulis. 2010 Food Chem. Toxicol. pmid:20385197
Marei WF et al. Impact of linoleic acid on bovine oocyte maturation and embryo development. 2010 Reproduction pmid:20215338
Litvinov D et al. Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. 2010 Atherosclerosis pmid:19880116
Wan ZX et al. Lipid content and fatty acids composition of mature human milk in rural North China. 2010 Br. J. Nutr. pmid:19825220
Li Z et al. Dual response surface-optimized synthesis of L-menthyl conjugated linoleate in solvent-free system by Candida rugosa lipase. 2010 Bioresour. Technol. pmid:19833506
Corriher VA et al. Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets. 2010 J. Dairy Sci. pmid:20965347
Liu S and Han B Differential expression pattern of an acidic 9/13-lipoxygenase in flower opening and senescence and in leaf response to phloem feeders in the tea plant. 2010 BMC Plant Biol. pmid:20969806
Martin H Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. 2010 Mutat. Res. pmid:20973164
Benammar C et al. Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation. 2010 BMC Complement Altern Med pmid:20868496
Lu X et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. 2010 Lipids Health Dis pmid:20868498
Zurabashvili DZ et al. [The effect of toxic components in tobacco smoke on the fatty acid profile of dental pulp]. 2010 Georgian Med News pmid:20413813
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Macouzet M et al. Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus. 2010 Appl. Microbiol. Biotechnol. pmid:20461509
McKay DL et al. Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. 2010 Nutr J pmid:20462428
Rodrigues AS et al. Proton leak modulation in testicular mitochondria affects reactive oxygen species production and lipid peroxidation. 2010 Cell Biochem. Funct. pmid:20235330
Zabielski P et al. The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. 2010 Prostaglandins Other Lipid Mediat. pmid:20599517
Zengin G et al. In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey. 2010 Food Chem. Toxicol. pmid:20600531
Shen Q et al. Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. 2010 Anaerobe pmid:20601030
Habermann N et al. Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. 2009 Sep-Oct Biofactors pmid:19798733
Vlahov G 13C nuclear magnetic resonance spectroscopic detection of the adulteration of extra virgin olive oils extracted from different cultivars with cold-pressed hazelnut oil. 2009 Nov-Dec J AOAC Int pmid:20166593
Yu C et al. Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. 2009 Nov-Dec Plant Physiol. Biochem. pmid:19648018
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Parnas M et al. Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. 2009 May-Jun Channels (Austin) pmid:19535910
Zeng Z et al. Identification of lactic acid bacterial strains with high conjugated linoleic acid-producing ability from natural sauerkraut fermentations. 2009 May-Jul J. Food Sci. pmid:19490332
Ozen T Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. 2009 Mar-Apr Acta Pol Pharm pmid:19719054
Pacini G et al. Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19211728
Toyosaki T and Iwabuchi M New antioxidant protein in seaweed (Porphyra yezoensis Ueda). 2009 Int J Food Sci Nutr pmid:19212859
Liavonchanka A et al. On the mechanism of a polyunsaturated fatty acid double bond isomerase from Propionibacterium acnes. 2009 J. Biol. Chem. pmid:19164287
Ibrahim A et al. Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. 2009 Br. J. Nutr. pmid:19166630
Nasrollahzadeh J et al. Study of in vitro and in vivo effect of docosahexaenoic acid on rat C6 glioma. 2009 J. Exp. Ther. Oncol. pmid:20192116
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
de Meijer VE et al. Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. 2009 Pediatr. Surg. Int. pmid:18828026
Saitou K et al. Contribution of gustation to the palatability of linoleic acid. 2009 Physiol. Behav. pmid:18835400
Choi NJ et al. Characterizations of environmental factors in conjugated linoleic acid production by mixed rumen bacteria. 2009 J. Agric. Food Chem. pmid:19754193
Zhang B et al. [Studies on the chemical constituents of the root and rhizoma of Ligusticum jeholense]. 2009 Zhong Yao Cai pmid:19771843
Chow CK Dietary beta-tocopherol and serum concentrations of sex hormone-binding globulin. 2009 J. Nutr. pmid:19710160
Roche M et al. Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. 2009 Biochim. Biophys. Acta pmid:19714864
Pianaro A et al. Stingless bees: chemical differences and potential functions in Nannotrigona testaceicornis and Plebeia droryana males and workers. 2009 J. Chem. Ecol. pmid:19730955
Ramsden CE et al. Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147338
Du YZ et al. Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin. 2009 Colloids Surf B Biointerfaces pmid:19131223
Plaisance V et al. Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. 2009 Mol. Cell. Endocrinol. pmid:19133313
Lee CM et al. SPION-loaded chitosan-linoleic acid nanoparticles to target hepatocytes. 2009 Int J Pharm pmid:19138733
Zhang M et al. Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. 2009 Chem. Biol. Interact. pmid:19497410
Villa PM et al. Free fatty acid profiles in preeclampsia. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19497719
Jeng JY et al. Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. 2009 Biosci. Biotechnol. Biochem. pmid:19502730
Pinho RS et al. Potential oilseed crops from the semiarid region of northeastern Brazil. 2009 Bioresour. Technol. pmid:19577461
Guyenet SJ High-fat diets: details matter. 2009 Obesity (Silver Spring) pmid:19553921
Zhang HM et al. Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. 2009 PLoS ONE pmid:19557129
Daly TJ et al. Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells. 2009 Food Chem. Toxicol. pmid:19406198
Lux CA et al. Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. 2009 Atherosclerosis pmid:19423111
Hamel FG Preliminary report: inhibition of cellular proteasome activity by free fatty acids. 2009 Metab. Clin. Exp. pmid:19423142
Cheong SJ et al. Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. 2009 Int J Pharm pmid:19429277
Fukasawa R et al. Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids. 2009 J Oleo Sci pmid:19430189
Lata M et al. Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. 2009 Phytomedicine pmid:17574826
Artwohl M et al. Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. 2009 Atherosclerosis pmid:18597758
Watanabe A et al. In vitro free radical scavenging activity of platinum nanoparticles. 2009 Nanotechnology pmid:19834242
Hernández-Ledesma B et al. Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. 2009 Biochem. Biophys. Res. Commun. pmid:19836349
Shimomura H et al. Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. 2009 FEMS Microbiol. Lett. pmid:19843309
Chen Q et al. Generation of fad2 transgenic mice that produce omega-6 fatty acids. 2009 Sci. China, C, Life Sci. pmid:19937203