Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Murphy MG | Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma. | 1986 | J. Neurochem. | pmid:3011993 |
| Kühn H et al. | The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. | 1986 | Biochim. Biophys. Acta | pmid:3006782 |
| May V and Eipper BA | Long term culture of primary rat pituitary adrenocorticotropin/endorphin-producing cells in serum-free medium. | 1986 | Endocrinology | pmid:3004908 |
| Poisson JP | Comparative in vivo and in vitro study of the influence of experimental diabetes on rat liver linoleic acid delta 6- and delta 5-desaturation. | 1985 | Enzyme | pmid:3002783 |
| Cunnane SC et al. | Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids. | 1985 | Br. J. Nutr. | pmid:2998444 |
| Cunnane SC et al. | Essential fatty acids in the liver and adipose tissue of genetically obese mice: effect of supplemental linoleic and gamma-linolenic acids. | 1985 | Br. J. Nutr. | pmid:2998443 |
| Claeys M et al. | Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. | 1985 | Biochim. Biophys. Acta | pmid:2996610 |
| Kharasch ED and Novak RF | Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. | 1985 | J. Biol. Chem. | pmid:2993283 |
| Eren R and Duksin D | Inhibition of the formation of lipid-linked intermediates in normal and transformed cells by a purified tunicamycin homologue. | 1985 | Mol. Cell. Biochem. | pmid:2991743 |
| Salafsky B and Fusco AC | Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen. | 1985 | Exp. Parasitol. | pmid:2990990 |
| Banerjee N and Rosenthal MD | High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. | 1985 | Biochim. Biophys. Acta | pmid:2990563 |
| O'Brien PM et al. | The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? | 1985 | Br J Clin Pharmacol | pmid:2985102 |
| Pascaud M and Strouve-Vallet C | Desaturation of 14C linoleic acid by the rat fetus. | 1985 | Ann. Nutr. Metab. | pmid:2983600 |
| Stephens RJ et al. | Lipid peroxidation and retinal phototoxic degeneration. | 1988 | Basic Life Sci. | pmid:2977946 |
| Collier A et al. | Reduced free radical activity detected by decreased diene conjugates in insulin-dependent diabetic patients. | 1988 | Diabet. Med. | pmid:2975566 |
| Perisho K et al. | Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. | 1988 | J. Invest. Dermatol. | pmid:2964492 |
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Strauss JS et al. | The effect of 13-cis-retinoic acid on sebaceous glands. | 1987 | Arch Dermatol | pmid:2960273 |
| Ringertz B et al. | High dietary linoleic acid content modulates neutrophil function in rats. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960199 |
| del Nido PJ et al. | Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. | 1987 | Circulation | pmid:2959398 |
| Young MR et al. | Stimulation of hematopoiesis and bone marrow suppressor cells by the subcutaneous injection of linoleic acid. | 1987 | Cell. Immunol. | pmid:2953447 |
| pmid:29491708 | ||||
| pmid:29474768 | ||||
| Olivi O et al. | [A new and original therapy for seborrheic dermatitis]. | 1986 May-Jun | Pediatr Med Chir | pmid:2947051 |
| Stewart ME et al. | Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. | 1986 | J. Invest. Dermatol. | pmid:2946783 |
| pmid:29459509 | ||||
| Orchard S et al. | Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis. | 1986 | Arch Dermatol | pmid:2942115 |
| Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
| Narce M and Poisson JP | [In vitro study of delta-6- and delta-5-desaturation of linoleic and dihomo-gamma-linolenic acids in WKY rats on a high-sodium diet]. | 1985 | C. R. Seances Soc. Biol. Fil. | pmid:2939926 |
| pmid:29397403 | ||||
| Boberg M et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1986 | Eur. J. Clin. Invest. | pmid:2938965 |
| Geer BW et al. | The effect of dietary ethanol on the composition of lipids of Drosophila melanogaster larvae. | 1986 | Biochem. Genet. | pmid:2938574 |
| Pornputtapitak W et al. | Development of γ-Oryzanol Rich Extract from Leum Pua Glutinous Rice Bran Loaded Nanostructured Lipid Carriers for Topical Delivery. | 2018 | J Oleo Sci | pmid:29367479 |
| pmid:29359556 | ||||
| Kageyama K et al. | Synergistic inhibition of DNA synthesis in Ehrlich ascites tumour cells by a combination of unsaturated fatty acids and hyperthermia. | 1989 | J Appl Toxicol | pmid:2926093 |
| Watkins BA | Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. | 1989 | Br. J. Nutr. | pmid:2923859 |
| Hubbard NE and Erickson KL | Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases. | 1989 | Cancer Lett. | pmid:2920371 |
| Bernbäck S et al. | Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. | 1989 | Biochim. Biophys. Acta | pmid:2917153 |
| Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
| Nanji AA and French SW | Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury. | 1989 | Life Sci. | pmid:2915600 |
| Du H et al. | Extraction and the Fatty Acid Profile of Rosa acicularis Seed Oil. | 2017 | J Oleo Sci | pmid:29129896 |
| Teh SS et al. | Recovery and Utilization of Palm Oil Mill Effluent Source as Value-Added Food Products. | 2017 | J Oleo Sci | pmid:29093377 |
| pmid:29070717 | ||||
| Rey HG et al. | Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. | 1988 | Prog. Clin. Biol. Res. | pmid:2906133 |
| Shimokawa T et al. | Effect of dietary alpha-linolenate/linoleate balance on mean survival time, incidence of stroke and blood pressure of spontaneously hypertensive rats. | 1988 | Life Sci. | pmid:2905408 |
| Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
| Garg ML et al. | Differential effects of dietary linoleic and alpha-linolenic acid on lipid metabolism in rat tissues. | 1988 | Lipids | pmid:2903427 |
| Norman A et al. | Postirradiation protection of chromosomes by linoleate. | 1988 | Int. J. Radiat. Biol. | pmid:2902149 |
| Hashimoto A et al. | [Effect of dietary alpha-linolenate/linoleate balance on the formation of leukotrienes in rat polymorphonuclear leukocytes]. | 1988 | Arerugi | pmid:2901255 |
| Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
| pmid:28968903 | ||||
| pmid:28965514 | ||||
| Loesberg C et al. | Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. | 1987 | Agents Actions | pmid:2895570 |
| Zhao A et al. | Use of real-time cellular analysis and Plackett-Burman design to develop the serum-free media for PC-3 prostate cancer cells. | 2017 | PLoS ONE | pmid:28945791 |
| Atrokhov VV and Markov KhM | [Influence of rations with various linoleic acid contents on the fatty acid composition of phospholipids in blood platelets of rats]. | 1987 Sep-Oct | Vopr Pitan | pmid:2894094 |
| Laposata M et al. | Icosanoid production can be decreased without alterations in cellular arachidonate content or enzyme activities required for arachidonate release and icosanoid synthesis. | 1988 | J. Biol. Chem. | pmid:2893800 |
| Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
| Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
| Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
| pmid:28923202 | ||||
| Thoresen L and Bjerve KS | [From clinical nursing: long-term tube feeding can cause deficiency diseases]. | 1987 | Sykepleien | pmid:2891206 |
| Coté GG and Brody S | Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. | 1987 | Biochim. Biophys. Acta | pmid:2889471 |
| Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
| Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
| Vrignaud P and Robert J | Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. | 1987 | Biochim. Biophys. Acta | pmid:2886153 |
| pmid:28833935 | ||||
| Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
| pmid:28831021 | ||||
| pmid:28823016 | ||||
| Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
| Berge RK et al. | Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:2880562 |
| pmid:28803650 | ||||
| Morson LA and Clandinin MT | Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. | 1986 | J. Nutr. | pmid:2879899 |
| Siguel EN et al. | Monitoring the optimal infusion of intravenous lipids. Detection of essential fatty acid deficiency. | 1986 | Arch. Pathol. Lab. Med. | pmid:2875703 |
| pmid:28754711 | ||||
| Qian J et al. | Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades. | 2017 | Cell. Mol. Biol. Lett. | pmid:28747926 |
| Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
| Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
| Köhler VH et al. | [Results of a long-term study of arteriosclerotic circulatory disorders with polyene fatty acid therapy]. | 1986 | Z Gesamte Inn Med | pmid:2871668 |
| Rocquelin G et al. | [Influence of linoleic acid (18:2 n-6) and alpha-linolenic acid (18:3 n-3) on the composition, permeability and fluidity of cardiac phospholipids in the rat: study using membrane models (liposomes)]. | 1986 | Reprod Nutr Dev | pmid:2871601 |
| Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
| Wolfram G et al. | Pain, prostaglandins, and food lipids. Influences of dietary polyunsaturated fatty acids on eicosanoid synthesis and effects. | 1986 | Bibl Nutr Dieta | pmid:2870709 |
| Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
| Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
| Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
| pmid:28667077 | ||||
| Ohsugi M et al. | Biosynthesis of biotin-vitamers from unsaturated higher fatty acids by bacteria. | 1985 | J. Nutr. Sci. Vitaminol. | pmid:2866239 |
| pmid:28660529 | ||||
| Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
| pmid:28646265 | ||||
| Smith MT and Thompson S | Free radicals and alcoholics. | 1985 | Lancet | pmid:2864501 |
| Liu F et al. | Simultaneous silencing of GhFAD2-1 and GhFATB enhances the quality of cottonseed oil with high oleic acid. | 2017 | J. Plant Physiol. | pmid:28644971 |
| pmid:28643621 | ||||
| Fink R et al. | Increased free-radical activity in alcoholics. | 1985 | Lancet | pmid:2862465 |
| Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
| pmid:28605735 | ||||
| pmid:28604646 | ||||
| Clarke SD and Salati LM | Fatty acid-mediated disaggregation of acetyl-CoA carboxylase in isolated liver cells. | 1985 | Fed. Proc. | pmid:2859222 |
| pmid:28583888 | ||||
| pmid:28582540 |