Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Merchant AT et al. | Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. | 2005 | Am. J. Clin. Nutr. | pmid:16155282 |
Coffa G et al. | On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. | 2005 | J. Biol. Chem. | pmid:16157595 |
Bertrandt J et al. | Polyunsaturated fatty acid (PUFA) changes in serum and liver of undernourished rats given dietary vitamin B6 supplementation. | 2005 | J. Nutr. Sci. Vitaminol. | pmid:16161761 |
Addis M et al. | Milk and cheese fatty acid composition in sheep fed Mediterranean forages with reference to conjugated linoleic acid cis-9,trans-11. | 2005 | J. Dairy Sci. | pmid:16162517 |
Pariza MW | Designer foods: effects on development of cancer. | 1992 | J. Natl. Cancer Inst. Monographs | pmid:1616792 |
Zhao G et al. | Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16169525 |
Lee J et al. | Resistance of Lactobacillus plantarum KCTC 3099 from Kimchi to oxidative stress. | 2005 | J Med Food | pmid:16176138 |
Le May C et al. | Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells. | 2005 | J. Nutr. | pmid:16177188 |
Nelson-Dooley C et al. | Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes. | 2005 | Curr. Med. Chem. | pmid:16178781 |
Kadifkova Panovska T et al. | In vitro antioxidant activity of some Teucrium species (Lamiaceae). | 2005 | Acta Pharm | pmid:16179134 |
Leskinen MH et al. | Serum fatty acids in postinfarction middle-aged men. | 2005 | Scand. J. Clin. Lab. Invest. | pmid:16179281 |
Paventi G et al. | Plant uncoupling protein in mitochondria from aged-dehydrated slices of Jerusalem artichoke tubers becomes sensitive to superoxide and to hydrogen peroxide without increase in protein level. | 2006 | Biochimie | pmid:16181725 |
Dhiman TR et al. | Factors affecting conjugated linoleic acid content in milk and meat. | 2005 | Crit Rev Food Sci Nutr | pmid:16183568 |
Decsi T et al. | Polyunsaturated fatty acids in plasma lipids of diabetic children during and after diabetic ketoacidosis. | 2005 | Acta Paediatr. | pmid:16188805 |
Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
Ermidou-Pollet S et al. | Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition. | 2005 | Acta. Biol. Hung. | pmid:16196200 |
König B and Eder K | Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines. | 2006 | J. Nutr. Biochem. | pmid:16216487 |
Blask DE et al. | Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal. | 2005 | Endocrine | pmid:16217131 |
Krist S et al. | Analysis of volatile compounds and triglycerides of seed oils extracted from different poppy varieties (Papaver somniferum L.). | 2005 | J. Agric. Food Chem. | pmid:16218681 |
Gregor JI et al. | Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16226437 |
Ribeiro CV et al. | Biohydrogenation of fatty acids and digestibility of fresh alfalfa or alfalfa hay plus sucrose in continuous culture. | 2005 | J. Dairy Sci. | pmid:16230707 |
Ando H et al. | Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. | 2006 | Biochem. J. | pmid:16232122 |
Cury-Boaventura MF et al. | Comparative toxicity of oleic and linoleic acid on human lymphocytes. | 2006 | Life Sci. | pmid:16236329 |
Timke M et al. | Fatty acid analysis and spoilage potential of biofilms from two breweries. | 2005 | J. Appl. Microbiol. | pmid:16238741 |
RodrÃguez-Lee M et al. | Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16239593 |
Colombo C et al. | Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial. | 2005 Jul-Sep | Int. J. Biol. Markers | pmid:16240844 |
Herrera JA et al. | Calcium plus linoleic acid therapy for pregnancy-induced hypertension. | 2005 | Int J Gynaecol Obstet | pmid:16243339 |
Gülçin I | Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). | 2006 | Toxicology | pmid:16243424 |
Gilbertson TA et al. | Fatty acid responses in taste cells from obesity-prone and -resistant rats. | 2005 | Physiol. Behav. | pmid:16249010 |
Kabagambe EK et al. | The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica. | 2005 | J. Nutr. | pmid:16251629 |
Gülçin I | Antioxidant and antiradical activities of L-carnitine. | 2006 | Life Sci. | pmid:16253281 |
Feng DD et al. | Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids. | 2006 | Endocrinology | pmid:16254037 |
Ganga R et al. | Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:16257554 |
Ziylan ZY et al. | Effect of dietary n-3 fatty acid deficiency on blood-to-brain transfer of sucrose, alpha-aminoisobutyric acid and phenylalanine in the rat. | 1992 | Neurosci. Lett. | pmid:1625821 |
Staprans I et al. | The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. | 2005 | Mol Nutr Food Res | pmid:16270280 |
Godfrey DM et al. | Clinical linoleic acid deficiency in Dahl salt-sensitive (SS/Jr) rats. | 2005 | Comp. Med. | pmid:16270905 |
Napal L et al. | An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. | 2005 | J. Mol. Biol. | pmid:16271724 |
Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
Larbi A et al. | Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans. | 2005 | Am. J. Clin. Nutr. | pmid:16280424 |
Friesen R and Innis SM | Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16282365 |
Lake SL et al. | Body condition score at parturition and postpartum supplemental fat effects on cow and calf performance. | 2005 | J. Anim. Sci. | pmid:16282631 |
Song Q et al. | Enzymatic synthesis of L-ascorbyl linoleate in organic media. | 2006 | Bioprocess Biosyst Eng | pmid:16284781 |
Collier A et al. | Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria. | 1992 | Diabetes | pmid:1628764 |
Zuo X et al. | Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. | 2006 | Oncogene | pmid:16288226 |
Boken SL et al. | Effect of grazing and fat supplementation on production and reproduction of Holstein cows. | 2005 | J. Dairy Sci. | pmid:16291617 |
Rosa A et al. | Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA. | 2005 | Free Radic. Res. | pmid:16298741 |
Szuchman A et al. | Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages. | 2006 | Free Radic. Res. | pmid:16298758 |
Jaudszus A et al. | Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. | 2005 | Biochim. Biophys. Acta | pmid:16303327 |
Aragona P et al. | Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16303936 |
Onoue S and Tsuda Y | Analytical studies on the prediction of photosensitive/phototoxic potential of pharmaceutical substances. | 2006 | Pharm. Res. | pmid:16308671 |
Kreich M and Claus P | Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:16315163 |
Goyens PL and Mensink RP | The dietary alpha-linolenic acid to linoleic acid ratio does not affect the serum lipoprotein profile in humans. | 2005 | J. Nutr. | pmid:16317123 |
Auerbach BJ et al. | A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. | 1992 | Anal. Biochem. | pmid:1632527 |
Leik CE and Walsh SW | Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress. | 2005 | J. Soc. Gynecol. Investig. | pmid:16325749 |
Duthie GG et al. | Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. | 1992 | Arch. Biochem. Biophys. | pmid:1632646 |
Tavendale R et al. | Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. | 1992 | Atherosclerosis | pmid:1632870 |
Kharchenko OV et al. | [Inhibiting properties of stable nitroxyl radicals in reactions of linoleic acid and linoleyl alcohol oxidation catalyzed by 5-lipoxygenase]. | 2005 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:16335269 |
Zhao CX et al. | [Chemical components in essential oils from tender branches and leaves of Rhododendron]. | 2005 | Yao Xue Xue Bao | pmid:16342692 |
Sato M et al. | Linoleic acid-rich fats reduce atherosclerosis development beyond its oxidative and inflammatory stress-increasing effect in apolipoprotein E-deficient mice in comparison with saturated fatty acid-rich fats. | 2005 | Br. J. Nutr. | pmid:16351765 |
Thurmond DC et al. | Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. | 1993 | Obes. Res. | pmid:16353349 |
Lee JS et al. | Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. | 2006 | J. Appl. Physiol. | pmid:16357064 |
Yaguchi T et al. | Linoleic acid derivative DCP-LA improves learning impairment in SAMP8. | 2006 | Neuroreport | pmid:16361960 |
Sasaki T et al. | Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells. | 2006 | Virchows Arch. | pmid:16362414 |
Joubert E et al. | Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis). | 2005 | J. Agric. Food Chem. | pmid:16366725 |
Vinceti M et al. | A population-based case-control study of diet and melanoma risk in northern Italy. | 2005 | Public Health Nutr | pmid:16372927 |
Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
Hirabara SM et al. | Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. | 2006 | Biochim. Biophys. Acta | pmid:16375848 |
Akahoshi A et al. | Combined effects of dietary protein type and fat level on the body fat-reducing activity of conjugated linoleic acid (CLA) in rats. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16377901 |
Liavonchanka A and Feussner I | Lipoxygenases: occurrence, functions and catalysis. | 2006 | J. Plant Physiol. | pmid:16386332 |
Zapolska-Downar D et al. | Trans fatty acids induce apoptosis in human endothelial cells. | 2005 | J. Physiol. Pharmacol. | pmid:16391418 |
Taylor AJ et al. | Inhibition of glycogen synthesis by increased lipid availability is associated with subcellular redistribution of glycogen synthase. | 2006 | J. Endocrinol. | pmid:16394171 |
Oda E et al. | Relationships between serum unsaturated fatty acids and coronary risk factors: negative relations between nervonic acid and obesity-related risk factors. | 2005 | Int Heart J | pmid:16394593 |
Koshiishi I et al. | Radical scavenger can scavenge lipid allyl radicals complexed with lipoxygenase at lower oxygen content. | 2006 | Biochem. J. | pmid:16396633 |
Heikelä M et al. | Atomistic simulation studies of cholesteryl oleates: model for the core of lipoprotein particles. | 2006 | Biophys. J. | pmid:16399839 |
Feofilova EP et al. | [Biochemical mechanisms of temperature adaptation in the (+) and (-) strains of Blakeslea trispora]. | 2005 Nov-Dec | Mikrobiologiia | pmid:16400984 |
Boles DJ and Rizzo WB | Dietary fatty acids temporarily alter liver very long-chain fatty acid composition in mice. | 1992 | J. Nutr. | pmid:1640260 |
Pavero C et al. | Administration modalities and intestinal lymph absorption of arachidonic acid in rats. | 1992 | J. Nutr. | pmid:1640261 |
Lokesh B et al. | Effect of different dietary triglycerides on liver fatty acids and prostaglandin synthesis by mouse peritoneal cells. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1640628 |
Clouva-Molyvdas P et al. | Short-term dietary lipid manipulation does not affect survival in two models of murine sepsis. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1640632 |
Amaral JS et al. | Influence of Cultivar and Environmental Conditions on the Triacylglycerol Profile of Hazelnut (Corylus avellana L.). | 2006 | J. Agric. Food Chem. | pmid:16417303 |
Lee JH et al. | Incorporation of alpha-tocopherol and linoleic acid in fresh lambs by feeding chemically treated dietary supplements containing dl-alpha-tocopheryl acetate and sunflower oil. | 2006 | J. Agric. Food Chem. | pmid:16417322 |
Atkinson RL et al. | Site and extent of digestion, duodenal flow, and intestinal disappearance of total and esterified fatty acids in sheep fed a high-concentrate diet supplemented with high-linoleate safflower oil. | 2006 | J. Anim. Sci. | pmid:16424267 |
Tsuzuki T et al. | Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. | 2006 | J. Nutr. Biochem. | pmid:16426831 |
Reininger EA and Bauer R | Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix. | 2006 | Phytomedicine | pmid:16428023 |
Calder PC | Abnormal fatty acid profiles occur in atopic dermatitis but what do they mean? | 2006 | Clin. Exp. Allergy | pmid:16433850 |
Laitinen K et al. | Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. | 2006 | Clin. Exp. Allergy | pmid:16433853 |
Zulet MA et al. | Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health. | 2005 | J. Physiol. Biochem. | pmid:16440602 |
Gigli I et al. | Effects of oxygen tension and supplements to the culture medium on activation and development of bovine follicles in vitro. | 2006 | Theriogenology | pmid:16442155 |
Garbe LA et al. | Dual positional and stereospecificity of lipoxygenase isoenzymes from germinating barley (green malt): biotransformation of free and esterified linoleic acid. | 2006 | J. Agric. Food Chem. | pmid:16448207 |
Vahvaselkä M et al. | Microbially safe utilization of non-inactivated oats (Avena sativa L.) for production of conjugated linoleic acid. | 2006 | J. Agric. Food Chem. | pmid:16448209 |
McCormack DN et al. | Detection of free fatty acids following a conditioned taste aversion in rats. | 2006 | Physiol. Behav. | pmid:16448678 |
Kitaguchi H et al. | Electron-transfer oxidation properties of unsaturated fatty acids and mechanistic insight into lipoxygenases. | 2006 | J Phys Chem A | pmid:16451000 |
Templer J et al. | Influence of C18 long chain fatty acids on hydrogen metabolism. | 2006 Jan-Feb | Biotechnol. Prog. | pmid:16454511 |
Perez MA et al. | Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. | 2006 | J. Nutr. Biochem. | pmid:16457997 |
Laugier C et al. | Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1645959 |
Wadman MW et al. | Conversion of linoleic acid into novel oxylipins by the mushroom Agaricus bisporus. | 2005 | Lipids | pmid:16459929 |
Rogerson ML et al. | Kinetic studies of the interaction of fatty acids with phosphatidylcholine vesicles (liposomes). | 2006 | Colloids Surf B Biointerfaces | pmid:16466910 |
Zhang Q et al. | [Heteroexpression of Rhizopus arrhizus delta6-fatty acid desaturase gene in Pichia pastoris]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16468339 |
Voigt A et al. | Polyunsaturated but not conjugated linoleic acid supplementation of leukemic U937 cells can act as an amplification factor for photofrin-mediated photodynamic therapy. | 2006 May-Jun | Photochem. Photobiol. | pmid:16468943 |
Papetti A et al. | Isolation of an in vitro and ex vivo antiradical melanoidin from roasted barley. | 2006 | J. Agric. Food Chem. | pmid:16478238 |