Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zheng XB et al. | [Analysis of lipid compounds of high-yielded rhizoma pinelliae growing in the west of Hubei province by gas chromatography-mass spectrometry]. | 2007 | Zhong Yao Cai | pmid:17918435 |
Sarikurkcu C et al. | Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (lamiaceae) by three different chemical assays. | 2008 | Bioresour. Technol. | pmid:17920880 |
Cosgrove MC et al. | Dietary nutrient intakes and skin-aging appearance among middle-aged American women. | 2007 | Am. J. Clin. Nutr. | pmid:17921406 |
Rahman MM et al. | Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. | 2008 | J. Cell. Physiol. | pmid:17929247 |
Ku CS and Mun SP | Antioxidant activities of ethanol extracts from seeds in fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste. | 2008 | Bioresour. Technol. | pmid:17931856 |
Chechetkin IR et al. | Regio- and stereospecificity of recombinant soybean lipoxygenase-2. | 2007 Jul-Aug | Dokl. Biochem. Biophys. | pmid:17933341 |
Balesteros MR et al. | Determination of olive oil acidity by CE. | 2007 | Electrophoresis | pmid:17941122 |
Tannin-Spitz T et al. | Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17942079 |
Gilani GS and Nasim A | Impact of foods nutritionally enhanced through biotechnology in alleviating malnutrition in developing countries. | 2007 Sep-Oct | J AOAC Int | pmid:17955991 |
Grechkin AN et al. | Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoenoic acid in sunflower roots. | 2007 | Chembiochem | pmid:17957816 |
Shin SC et al. | Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. | 2007 | Pharm Dev Technol | pmid:17963142 |
AbouZid S and Orihara Y | Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. | 2007 | Planta Med. | pmid:17973205 |
Tang KH et al. | [Oil content of Pyracantha seeds and its relations to soil nutrients in northwestern Hunan Province]. | 2007 | Ying Yong Sheng Tai Xue Bao | pmid:17974264 |
Lin D et al. | Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. | 2007 | J. Org. Chem. | pmid:17979284 |
Ito T et al. | The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. | 2007 | Plant Cell | pmid:17981996 |
Kummerow FA et al. | Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991616 |
Roman-Nunez M et al. | Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739. | 2007 | J. Food Sci. | pmid:17995782 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Kanwar RK et al. | Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. | 2008 | Clin. Exp. Allergy | pmid:18005183 |
Farkas O et al. | Quantitative structure-antioxidant activity relationships of flavonoid compounds. | 2004 | Molecules | pmid:18007505 |
Boeckaert C et al. | Effect and working mechanism of DHA on rumen biohydrogenation of linoleic acid and implications for milk fat optimisation. | 2007 | Commun. Agric. Appl. Biol. Sci. | pmid:18018853 |
Ntawubizi M et al. | Relationships between indices for desaturase and elongase activity involved in the intramuscular long chain polyunsaturated fatty acid metabolism in pigs. | 2007 | Commun. Agric. Appl. Biol. Sci. | pmid:18018855 |
Liu B et al. | Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. | 1991 | Cell Regul. | pmid:1801923 |
pmid:1802216 | ||||
Walkowiak J et al. | Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:18030219 |
Lang I et al. | A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. | 2008 | Biochem. J. | pmid:18031288 |
Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
Netsu S et al. | Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis. | 2008 | Fertil. Steril. | pmid:18054352 |
Diniz YS et al. | Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets. | 2008 | Eur. J. Pharmacol. | pmid:18054909 |
Deng MD et al. | Linoleic acid isomerase from Propionibacterium acnes: purification, characterization, molecular cloning, and heterologous expression. | 2007 | Appl. Biochem. Biotechnol. | pmid:18057448 |
Ben-Shabat S et al. | Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. | 2007 | Drug Dev Ind Pharm | pmid:18058312 |
Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
Markaverich BM et al. | Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. | 2007 | Environ. Health Perspect. | pmid:18087590 |
Golfetto I et al. | Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? | 2007 | Nutr Health | pmid:18087864 |
Ogata K et al. | Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. | 2008 | J. Pharm. Pharmacol. | pmid:18088500 |
Kim T et al. | Pharmacokinetics of formulated tenoxicam transdermal delivery systems. | 2008 | J. Pharm. Pharmacol. | pmid:18088513 |
MAYOUX et al. | [Not Available]. | 1949 | Lyon Med | pmid:18136286 |
van der Schouw YT et al. | Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1815240 |
Mayer M | Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1815242 |
Byczkowski JZ et al. | Proline hydroxylation by soybean lipoxygenase. | 1991 | Biochem. Int. | pmid:1815499 |
Wang L et al. | Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. | 2008 | Chem. Biol. Interact. | pmid:18155686 |
Yazdanparast R and Ardestani A | In vitro antioxidant and free radical scavenging activity of Cyperus rotundus. | 2007 | J Med Food | pmid:18158839 |
Crean C et al. | Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals. | 2008 | Chem. Res. Toxicol. | pmid:18159932 |
Gaillard D et al. | The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. | 2008 | FASEB J. | pmid:18162488 |
Aronis A et al. | Lipotoxic effects of triacylglycerols in J774.2 macrophages. | 2008 | Nutrition | pmid:18165129 |
Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
Semplicini A et al. | Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. | 1991 | J Hypertens Suppl | pmid:1818979 |
James DR et al. | Increased susceptibility to peroxide-induced haemolysis with normal vitamin E concentrations in cystic fibrosis. | 1991 | Clin. Chim. Acta | pmid:1819470 |
Yu IS et al. | Conversion of linoleic acid into 10-Hydroxy-12(Z)-octadecenoic acid by whole cells of Stenotrophomonas nitritireducens. | 2008 Jan-Feb | Biotechnol. Prog. | pmid:18197675 |
Chavarro JE et al. | A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18199715 |
Tattersall AL and Wilkins RJ | Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. | 2008 | Pflugers Arch. | pmid:18204856 |
Onoue S et al. | In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study. | 2008 | Eur J Pharm Sci | pmid:18207709 |
KARTHA AR et al. | The determination of linoleic acid in glycerides. | 1949 | Curr. Sci. | pmid:18224838 |
Dreisbach AW et al. | Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. | 2008 | Hypertension | pmid:18227407 |
Wang T et al. | [Study on the chemical constituents of Heterosmilax japonica]. | 2007 | Zhong Yao Cai | pmid:18236752 |
Güllçin I and Daştan A | Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities. | 2007 | J Enzyme Inhib Med Chem | pmid:18237020 |
Pinnick KE et al. | Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. | 2008 | Obesity (Silver Spring) | pmid:18239594 |
Garelnabi M et al. | Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. | 2008 | Atherosclerosis | pmid:18243209 |
Hwang YC et al. | Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. | 2008 | Antiviral Res. | pmid:18243348 |
Spacek T et al. | Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18248766 |
Feng DD et al. | Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells. | 2008 | J. Endocrinol. | pmid:18252961 |
Eling TE and Glasgow WC | Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825423 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Ashby RD et al. | Property control of sophorolipids: influence of fatty acid substrate and blending. | 2008 | Biotechnol. Lett. | pmid:18264681 |
Ringseis R et al. | Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. | 2008 | Eur J Nutr | pmid:18264811 |
Fang KM et al. | Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. | 2008 | Cardiovasc. Res. | pmid:18267958 |
Rashid S et al. | Topical omega-3 and omega-6 fatty acids for treatment of dry eye. | 2008 | Arch. Ophthalmol. | pmid:18268213 |
Hofmann E and Pollmann S | Molecular mechanism of enzymatic allene oxide cyclization in plants. | 2008 | Plant Physiol. Biochem. | pmid:18272375 |
Ferrini G et al. | Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. | 2008 | Poult. Sci. | pmid:18281580 |
Moate PJ et al. | Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. | 2008 | J. Dairy Sci. | pmid:18292274 |
Zachut M et al. | Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. | 2008 | Reproduction | pmid:18296508 |
Ito-Inaba Y et al. | Characterization of the plant uncoupling protein, SrUCPA, expressed in spadix mitochondria of the thermogenic skunk cabbage. | 2008 | J. Exp. Bot. | pmid:18308738 |
Carrasco MP et al. | Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. | 2008 | FEBS J. | pmid:18312412 |
Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
Artmann A et al. | Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. | 2008 | Biochim. Biophys. Acta | pmid:18316044 |
Ramasamy S et al. | Linoleic acid-induced endothelial cell injury: role of membrane-bound enzyme activities and lipid oxidation. | 1991 | J. Biochem. Toxicol. | pmid:1831858 |
Sasaki N et al. | Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha. | 2008 | Eur J Nutr | pmid:18320257 |
El-Yassimi A et al. | Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. | 2008 | J. Biol. Chem. | pmid:18321850 |
Jiang X et al. | [Studies on chemical constituents of Valeriana officinalis]. | 2007 | Zhong Yao Cai | pmid:18323205 |
Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
O'Connell ED et al. | Diet and risk factors for age-related maculopathy. | 2008 | Am. J. Clin. Nutr. | pmid:18326611 |
Rózanowski B et al. | Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18326697 |
KoÅŸar M et al. | In vitro antioxidant properties and phenolic composition of Salvia virgata Jacq. from Turkey. | 2008 | J. Agric. Food Chem. | pmid:18327906 |
Koussoroplis AM et al. | From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. | 2008 | Lipids | pmid:18335265 |
Gülçin I | In vitro prooxidant effect of caffeine. | 2008 | J Enzyme Inhib Med Chem | pmid:18341268 |
Minami Y et al. | Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. | 2008 | Free Radic. Res. | pmid:18344113 |
Kwon JI et al. | Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. | 2008 | J Med Food | pmid:18361731 |
Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
Yara A et al. | Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18373976 |
Satou T et al. | The toxin produced by pleurotus ostreatus reduces the head size of nematodes. | 2008 | Biol. Pharm. Bull. | pmid:18379043 |
Gallardo E et al. | Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. | 2008 | J. Agric. Food Chem. | pmid:18386901 |
Morawicki RO and Beelman RB | Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. | 2008 | J. Food Sci. | pmid:18387089 |
Jäger AK et al. | Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. | 2008 | Phytother Res | pmid:18389471 |
Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
Zhang JS et al. | [Study on inhibitory effects of c9, t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway]. | 2007 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18399127 |
Swida A et al. | Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. | 2008 | Biochem. J. | pmid:18402555 |
Ates B et al. | Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC). | 2008 | Free Radic. Res. | pmid:18404536 |
Davison GW et al. | In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | 2008 | Free Radic. Res. | pmid:18404537 |
Brook MA et al. | Using a drug to structure its release matrix and release profile. | 2008 | Int J Pharm | pmid:18407444 |