Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Deficiency Diseases D003677 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Acidosis D000138 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Glucose Intolerance D018149 13 associated lipids
Mitochondrial Myopathies D017240 13 associated lipids
Critical Illness D016638 13 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Alopecia D000505 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Tremor D014202 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Zheng XB et al. [Analysis of lipid compounds of high-yielded rhizoma pinelliae growing in the west of Hubei province by gas chromatography-mass spectrometry]. 2007 Zhong Yao Cai pmid:17918435
Sarikurkcu C et al. Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (lamiaceae) by three different chemical assays. 2008 Bioresour. Technol. pmid:17920880
Cosgrove MC et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. 2007 Am. J. Clin. Nutr. pmid:17921406
Rahman MM et al. Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. 2008 J. Cell. Physiol. pmid:17929247
Ku CS and Mun SP Antioxidant activities of ethanol extracts from seeds in fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste. 2008 Bioresour. Technol. pmid:17931856
Chechetkin IR et al. Regio- and stereospecificity of recombinant soybean lipoxygenase-2. 2007 Jul-Aug Dokl. Biochem. Biophys. pmid:17933341
Balesteros MR et al. Determination of olive oil acidity by CE. 2007 Electrophoresis pmid:17941122
Tannin-Spitz T et al. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. 2007 Biochem. Biophys. Res. Commun. pmid:17942079
Gilani GS and Nasim A Impact of foods nutritionally enhanced through biotechnology in alleviating malnutrition in developing countries. 2007 Sep-Oct J AOAC Int pmid:17955991
Grechkin AN et al. Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoenoic acid in sunflower roots. 2007 Chembiochem pmid:17957816
Shin SC et al. Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. 2007 Pharm Dev Technol pmid:17963142
AbouZid S and Orihara Y Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. 2007 Planta Med. pmid:17973205
Tang KH et al. [Oil content of Pyracantha seeds and its relations to soil nutrients in northwestern Hunan Province]. 2007 Ying Yong Sheng Tai Xue Bao pmid:17974264
Lin D et al. Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. 2007 J. Org. Chem. pmid:17979284
Ito T et al. The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. 2007 Plant Cell pmid:17981996
Kummerow FA et al. Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. 2007 Prostaglandins Other Lipid Mediat. pmid:17991616
Roman-Nunez M et al. Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739. 2007 J. Food Sci. pmid:17995782
Kim CH et al. Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. 2008 Anaerobe pmid:17996466
Kanwar RK et al. Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. 2008 Clin. Exp. Allergy pmid:18005183
Farkas O et al. Quantitative structure-antioxidant activity relationships of flavonoid compounds. 2004 Molecules pmid:18007505
Boeckaert C et al. Effect and working mechanism of DHA on rumen biohydrogenation of linoleic acid and implications for milk fat optimisation. 2007 Commun. Agric. Appl. Biol. Sci. pmid:18018853
Ntawubizi M et al. Relationships between indices for desaturase and elongase activity involved in the intramuscular long chain polyunsaturated fatty acid metabolism in pigs. 2007 Commun. Agric. Appl. Biol. Sci. pmid:18018855
Liu B et al. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. 1991 Cell Regul. pmid:1801923
pmid:1802216
Walkowiak J et al. Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:18030219
Lang I et al. A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. 2008 Biochem. J. pmid:18031288
Al-Turkmani MR et al. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036797
Netsu S et al. Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis. 2008 Fertil. Steril. pmid:18054352
Diniz YS et al. Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets. 2008 Eur. J. Pharmacol. pmid:18054909
Deng MD et al. Linoleic acid isomerase from Propionibacterium acnes: purification, characterization, molecular cloning, and heterologous expression. 2007 Appl. Biochem. Biotechnol. pmid:18057448
Ben-Shabat S et al. Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. 2007 Drug Dev Ind Pharm pmid:18058312
Vögler O et al. Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. 2008 Int J Obes (Lond) pmid:18059405
Ruths M et al. Friction of fatty acids in nanometer-sized contacts of different adhesive strength. 2008 Langmuir pmid:18085802
Markaverich BM et al. Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. 2007 Environ. Health Perspect. pmid:18087590
Golfetto I et al. Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? 2007 Nutr Health pmid:18087864
Ogata K et al. Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. 2008 J. Pharm. Pharmacol. pmid:18088500
Kim T et al. Pharmacokinetics of formulated tenoxicam transdermal delivery systems. 2008 J. Pharm. Pharmacol. pmid:18088513
MAYOUX et al. [Not Available]. 1949 Lyon Med pmid:18136286
van der Schouw YT et al. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815240
Mayer M Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815242
Byczkowski JZ et al. Proline hydroxylation by soybean lipoxygenase. 1991 Biochem. Int. pmid:1815499
Wang L et al. Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. 2008 Chem. Biol. Interact. pmid:18155686
Yazdanparast R and Ardestani A In vitro antioxidant and free radical scavenging activity of Cyperus rotundus. 2007 J Med Food pmid:18158839
Crean C et al. Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals. 2008 Chem. Res. Toxicol. pmid:18159932
Gaillard D et al. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. 2008 FASEB J. pmid:18162488
Aronis A et al. Lipotoxic effects of triacylglycerols in J774.2 macrophages. 2008 Nutrition pmid:18165129
Pandey NR et al. Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. 2008 Biochemistry pmid:18189424
Semplicini A et al. Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. 1991 J Hypertens Suppl pmid:1818979
James DR et al. Increased susceptibility to peroxide-induced haemolysis with normal vitamin E concentrations in cystic fibrosis. 1991 Clin. Chim. Acta pmid:1819470
Yu IS et al. Conversion of linoleic acid into 10-Hydroxy-12(Z)-octadecenoic acid by whole cells of Stenotrophomonas nitritireducens. 2008 Jan-Feb Biotechnol. Prog. pmid:18197675
Chavarro JE et al. A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. 2008 Cancer Epidemiol. Biomarkers Prev. pmid:18199715
Tattersall AL and Wilkins RJ Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. 2008 Pflugers Arch. pmid:18204856
Onoue S et al. In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study. 2008 Eur J Pharm Sci pmid:18207709
KARTHA AR et al. The determination of linoleic acid in glycerides. 1949 Curr. Sci. pmid:18224838
Dreisbach AW et al. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. 2008 Hypertension pmid:18227407
Wang T et al. [Study on the chemical constituents of Heterosmilax japonica]. 2007 Zhong Yao Cai pmid:18236752
Güllçin I and Daştan A Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities. 2007 J Enzyme Inhib Med Chem pmid:18237020
Pinnick KE et al. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. 2008 Obesity (Silver Spring) pmid:18239594
Garelnabi M et al. Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. 2008 Atherosclerosis pmid:18243209
Hwang YC et al. Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. 2008 Antiviral Res. pmid:18243348
Spacek T et al. Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. 2008 Int. J. Biochem. Cell Biol. pmid:18248766
Feng DD et al. Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells. 2008 J. Endocrinol. pmid:18252961
Eling TE and Glasgow WC Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825423
Yen CH et al. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. 2008 Ann. Allergy Asthma Immunol. pmid:18254485
Ashby RD et al. Property control of sophorolipids: influence of fatty acid substrate and blending. 2008 Biotechnol. Lett. pmid:18264681
Ringseis R et al. Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. 2008 Eur J Nutr pmid:18264811
Fang KM et al. Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. 2008 Cardiovasc. Res. pmid:18267958
Rashid S et al. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. 2008 Arch. Ophthalmol. pmid:18268213
Hofmann E and Pollmann S Molecular mechanism of enzymatic allene oxide cyclization in plants. 2008 Plant Physiol. Biochem. pmid:18272375
Ferrini G et al. Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. 2008 Poult. Sci. pmid:18281580
Moate PJ et al. Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. 2008 J. Dairy Sci. pmid:18292274
Zachut M et al. Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. 2008 Reproduction pmid:18296508
Ito-Inaba Y et al. Characterization of the plant uncoupling protein, SrUCPA, expressed in spadix mitochondria of the thermogenic skunk cabbage. 2008 J. Exp. Bot. pmid:18308738
Carrasco MP et al. Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. 2008 FEBS J. pmid:18312412
Maeda H et al. Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. 2008 Plant Cell pmid:18314499
Artmann A et al. Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. 2008 Biochim. Biophys. Acta pmid:18316044
Ramasamy S et al. Linoleic acid-induced endothelial cell injury: role of membrane-bound enzyme activities and lipid oxidation. 1991 J. Biochem. Toxicol. pmid:1831858
Sasaki N et al. Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha. 2008 Eur J Nutr pmid:18320257
El-Yassimi A et al. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. 2008 J. Biol. Chem. pmid:18321850
Jiang X et al. [Studies on chemical constituents of Valeriana officinalis]. 2007 Zhong Yao Cai pmid:18323205
Sakai T et al. Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. 1991 Ann. Neurol. pmid:1832532
O'Connell ED et al. Diet and risk factors for age-related maculopathy. 2008 Am. J. Clin. Nutr. pmid:18326611
Rózanowski B et al. Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation. 2008 Invest. Ophthalmol. Vis. Sci. pmid:18326697
KoÅŸar M et al. In vitro antioxidant properties and phenolic composition of Salvia virgata Jacq. from Turkey. 2008 J. Agric. Food Chem. pmid:18327906
Koussoroplis AM et al. From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. 2008 Lipids pmid:18335265
Gülçin I In vitro prooxidant effect of caffeine. 2008 J Enzyme Inhib Med Chem pmid:18341268
Minami Y et al. Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. 2008 Free Radic. Res. pmid:18344113
Kwon JI et al. Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. 2008 J Med Food pmid:18361731
Warensjö E et al. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. 2008 Nutr Metab Cardiovasc Dis pmid:18367385
Yara A et al. Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. 2008 Biochem. Biophys. Res. Commun. pmid:18373976
Satou T et al. The toxin produced by pleurotus ostreatus reduces the head size of nematodes. 2008 Biol. Pharm. Bull. pmid:18379043
Gallardo E et al. Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. 2008 J. Agric. Food Chem. pmid:18386901
Morawicki RO and Beelman RB Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. 2008 J. Food Sci. pmid:18387089
Jäger AK et al. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. 2008 Phytother Res pmid:18389471
Chou YC et al. Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. 2008 Phytother Res pmid:18398904
Zhang JS et al. [Study on inhibitory effects of c9, t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway]. 2007 Zhonghua Yu Fang Yi Xue Za Zhi pmid:18399127
Swida A et al. Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. 2008 Biochem. J. pmid:18402555
Ates B et al. Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC). 2008 Free Radic. Res. pmid:18404536
Davison GW et al. In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. 2008 Free Radic. Res. pmid:18404537
Brook MA et al. Using a drug to structure its release matrix and release profile. 2008 Int J Pharm pmid:18407444