Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Akeo K et al. | Effects of superoxide dismutase and catalase on growth of retinal pigment epithelial cells in vitro following addition of linoleic acid or linoleic acid hydroperoxide. | 1996 | Ophthalmic Res. | pmid:8726672 |
Ritskes-Hoitinga J et al. | Effects of two dietary fat levels and four dietary linoleic acid levels on mammary tumor development in Balb/c-MMTV mice under ad libitum feeding conditions. | 1996 | Nutr Cancer | pmid:8710685 |
Surette ME et al. | Relationship between arachidonate--phospholipid remodeling and apoptosis. | 1996 | Biochemistry | pmid:8703924 |
Haraguchi H et al. | Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi. | 1996 | Experientia | pmid:8698092 |
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Jones GD et al. | Role of lipid hydroperoxides in the activation of 15-lipoxygenase. | 1996 | Biochemistry | pmid:8679548 |
van Greevenbroek MM et al. | Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. | 1996 | Atherosclerosis | pmid:8678919 |
Ghafoorunissa | Nutrition & health implications of palm oil in Indian diets. | 1995 | Indian J. Med. Res. | pmid:8675244 |
Chen ZY et al. | Accumulation of polyunsaturates is decreased by weight-cycling: whole-body analysis in young, growing rats. | 1996 | Br. J. Nutr. | pmid:8672410 |
Akeo K et al. | Comparative effects of linoleic acid and linoleic acid hydroperoxide on growth and morphology of bovine retinal pigment epithelial cells in vitro. | 1996 | Curr. Eye Res. | pmid:8670748 |
Murai A et al. | Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail. | 1996 | Am. J. Vet. Res. | pmid:8669766 |
Watanabe N and Yamada S | Activation of 20S proteasomes from spinach leaves by fatty acids. | 1996 | Plant Cell Physiol. | pmid:8665092 |
Loftin CD and Eling TE | Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. | 1996 | Arch. Biochem. Biophys. | pmid:8660674 |
Süttmann U et al. | Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support. | 1996 | J Am Diet Assoc | pmid:8655902 |
Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
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Osada K et al. | Dietary protein modifies oxidized cholesterol-induced alterations of linoleic acid and cholesterol metabolism in rats. | 1996 | J. Nutr. | pmid:8648438 |
Cleland LG et al. | Dietary (n-9) eicosatrienoic acid from a cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid. | 1996 | J. Nutr. | pmid:8648425 |
Ramasamy S et al. | Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. | 1996 | Atherosclerosis | pmid:8645361 |
Fischer SM et al. | Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis. | 1996 | J. Nutr. | pmid:8642440 |
Ip C et al. | The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. | 1996 | Carcinogenesis | pmid:8640911 |
Hudson JA et al. | Factors affecting the formation of 10-hydroxystearic acid from oleic acid by a ruminal strain of Enterococcus faecalis. | 1996 | Appl. Microbiol. Biotechnol. | pmid:8639306 |
Márquez-Ruiz G and Dobarganes MC | Assessments on the digestibility of oxidized compounds from [1-14C] linoleic acid using a combination of chromatographic techniques. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8634750 |
Reddy SR and Kotchen TA | Attenuation of experimental hypertension by dietary linoleic acid is model dependent. | 1996 | J Am Coll Nutr | pmid:8632122 |
Hussey HJ et al. | Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC). | 1996 | Br. J. Cancer | pmid:8630277 |
Iwase H et al. | Monoepoxide production from linoleic acid by cytochrome c in the presence of cardiolipin. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630079 |
De Luca C et al. | Lipoperoxidase activity of Pityrosporum: characterisation of by-products and possible rôle in pityriasis versicolor. | 1996 | Exp. Dermatol. | pmid:8624612 |
Sidransky H and Verney E | Toxic effect of valproic acid on tryptophan binding to rat hepatic nuclei. | 1996 | Toxicology | pmid:8619251 |
DeMar JC et al. | Biosynthesis of the unsaturated 14-carbon fatty acids found on the N termini of photoreceptor-specific proteins. | 1996 | J. Biol. Chem. | pmid:8617777 |
van Egmond AW et al. | Effect of linoleic acid intake on growth of infants with cystic fibrosis. | 1996 | Am. J. Clin. Nutr. | pmid:8615359 |
Louheranta AM et al. | Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. | 1996 | Am. J. Clin. Nutr. | pmid:8615351 |
Ip C et al. | Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. | 1995 | Nutr Cancer | pmid:8610043 |
Liu XH et al. | Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line. | 1996 | Clin. Exp. Metastasis | pmid:8605728 |
Yiin SJ and Lin TH | Lead-catalyzed peroxidation of essential unsaturated fatty acid. | 1995 | Biol Trace Elem Res | pmid:8605084 |
Iwase H et al. | Superoxide anion reduces the ability of myeloperoxidase to damage lipids. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8605038 |
Liew C et al. | Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. | 1995 | Carcinogenesis | pmid:8603482 |
Ogretmen B et al. | Effects of sodium saccharin and linoleic acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line. | 1996 | Cancer Lett. | pmid:8603385 |
Routi T et al. | Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. | 1996 | Am. J. Clin. Nutr. | pmid:8602597 |
Hennig B et al. | Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. | 1996 | Am. J. Clin. Nutr. | pmid:8602587 |
Babenko NA and Kavok NS | [The effect of thyroid hormones, phorbol esters, and sphingosine on incorporation of linoleic acid in liver lipids of white rats]. | 1995 | Biokhimiia | pmid:8600996 |
Aveldaño MI and Donnari D | Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy. | 1996 | Clin. Chem. | pmid:8598113 |
Guil JL et al. | Identification of fatty acids in edible wild plants by gas chromatography. | 1996 | J Chromatogr A | pmid:8589832 |
Rothacker DQ and Ellis PK | Linoleic acid supplementation in slimming products is unnecessary and may pose a potential added health risk to the user population. | 1995 | Int. J. Obes. Relat. Metab. Disord. | pmid:8589772 |
Périchon R and Bourre JM | Peroxisomal beta-oxidation activity and catalase activity during development and aging in mouse liver. | 1995 | Biochimie | pmid:8589059 |
Chawla A et al. | Effect of N-3 polyunsaturated fatty acid supplemented diet on neutrophil-mediated ileal permeability and neutrophil function in the rat. | 1995 | J Am Coll Nutr | pmid:8586775 |
Fuhrmann H and Sallmann HP | Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:8585700 |
Bondarenko LB et al. | [Effect of 1,25-dihydroxyvitamin D3 on 15-lipoxygenase activity]. | 1995 May-Jun | Vopr. Med. Khim. | pmid:8585174 |
Boscá F et al. | Evaluation of ketoprofen (R,S and R/S) phototoxicity by a battery of in vitro assays. | 1995 | J. Photochem. Photobiol. B, Biol. | pmid:8583281 |