Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kawooya JK and Law JH | Role of lipophorin in lipid transport to the insect egg. | 1988 | J. Biol. Chem. | pmid:3379043 |
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Hiramatsu N et al. | Effects of dose levels of autoxidized linoleic acid on the drug-metabolizing system in rat liver. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:3392612 |
Sugiyama S et al. | The role of leukotoxin (9,10-epoxy-12-octadecenoate) in the genesis of coagulation abnormalities. | 1988 | Life Sci. | pmid:3398695 |
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Griffiths G et al. | Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). | 1988 | Biochem. J. | pmid:3421914 |
Crandall DL et al. | Effect of varying concentrations of linoleic acid on alpha-adrenoceptor responses in spontaneously hypertensive rats. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2845438 |
Norman A et al. | Postirradiation protection of chromosomes by linoleate. | 1988 | Int. J. Radiat. Biol. | pmid:2902149 |
Hoffmann P et al. | Investigations on the mechanism of a diminished inotropic isoprenaline effect in isolated rat hearts after high linoleic acid diet. | 1988 | Biomed. Biochim. Acta | pmid:2854732 |
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Das UN | Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144272 |
Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |
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Hiramatsu N et al. | Effects of dietary pantethine levels on drug-metabolizing system in the liver of rats orally administered varying amounts of autoxidized linoleate. | 1989 | J. Nutr. Sci. Vitaminol. | pmid:2585150 |
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Gardner HW | Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. | 1989 | Biochim. Biophys. Acta | pmid:2492826 |
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Braughler JM and Pregenzer JF | The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. | 1989 | Free Radic. Biol. Med. | pmid:2806938 |
Toda S et al. | Peroxidation of linoleic acid induced by interaction with haemoglobin and hydrogen peroxide. | 1989 | Free Radic. Res. Commun. | pmid:2806947 |
Reddy SR et al. | Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. | 1989 | Am. J. Physiol. | pmid:2764141 |
Robertson DA et al. | Linoleic acid supplementation, membrane lipids and leucocyte sodium transport in normotensive humans. | 1989 | J Hum Hypertens | pmid:2760909 |
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Stein O et al. | Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. | 1989 | Biochim. Biophys. Acta | pmid:2730885 |
Reinaud O et al. | Oxidative metabolism of linoleic acid by human leukocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2735926 |
Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
Rose DP and Connolly JM | Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803300 |
Mahfouz MM et al. | Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. | 1989 | Biochim. Biophys. Acta | pmid:2804072 |
Chapkin RS et al. | Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. | 1989 | Cancer Res. | pmid:2503244 |
Diehl AK et al. | Dietary intake and the prevalence of gallbladder disease in Mexican Americans. | 1989 | Gastroenterology | pmid:2583417 |