Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Hyperlipoproteinemia Type II D006938 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Helicobacter Infections D016481 21 associated lipids
Cachexia D002100 21 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Brain Edema D001929 20 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Refsum Disease D012035 19 associated lipids
Carcinoma D002277 18 associated lipids
Olfaction Disorders D000857 17 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Booker ML et al. Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog. 1989 Gastroenterology pmid:2507386
Garcia Zevallos M and Farkas T Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. 1989 Arch. Biochem. Biophys. pmid:2786374
Fuse K et al. Effects of pectin on fatty acid and glucose absorption and on thickness of unstirred water layer in rat and human intestine. 1989 Dig. Dis. Sci. pmid:2545425
Bates D Lipids and multiple sclerosis. 1989 Biochem. Soc. Trans. pmid:2546837
Huang YS et al. Fatty acid changes in liver choline and ethanolamine glycerophospholipids in aspirin-treated rats fed linoleate, gamma-linolenate and fish oil. 1989 Clin Physiol Biochem pmid:2547543
Nanji AA and French SW Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury. 1989 Life Sci. pmid:2915600
Glatz JF et al. Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. 1989 Am. J. Clin. Nutr. pmid:2916448
Loesberg C et al. Membrane fluidity of guinea pig lymphocytes and the dysfunction of the respiratory airway and lymphocyte beta-adrenergic systems of the guinea pig. 1989 Life Sci. pmid:2554081
Bernbäck S et al. Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. 1989 Biochim. Biophys. Acta pmid:2917153
Hubbard NE and Erickson KL Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases. 1989 Cancer Lett. pmid:2920371
Sawazaki S et al. Comparison of the increment in plasma eicosapentaenoate concentrations by fish oil intake between young and middle-aged volunteers. 1989 J. Nutr. Sci. Vitaminol. pmid:2555467
Tchervenkov JI et al. The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. 1989 Transplantation pmid:2643225
Balakrishnan A et al. Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas. 1989 Cancer Res. pmid:2643465
Pitkänen OM et al. Determination of ethane and pentane in free oxygen radical-induced lipid peroxidation. 1989 Lipids pmid:2569148
Mcgregor L et al. Effects of dietary linoleic acid and gamma linolenic acid on platelets of patients with multiple sclerosis. 1989 Acta Neurol. Scand. pmid:2782038
Madison KC et al. Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. 1989 J. Invest. Dermatol. pmid:2473131
Kurganov BI et al. Kinetics of soybean lipoxygenase reaction in hydrated reversed micelles. 1989 Biochimie pmid:2474334
Zawadzki W [Effect of short-time intra-ruminal infusions of linoleic and cis-oleic acids on methane level in the blood of sheep]. 1989 Pol Arch Weter pmid:2486864
Grossi IM et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. 1989 Cancer Res. pmid:2492204
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Anderson GJ and Connor WE On the demonstration of omega-3 essential-fatty-acid deficiency in humans. 1989 Am. J. Clin. Nutr. pmid:2494878
Byczkowski JZ and Kulkarni AP Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. 1989 Biochem. Biophys. Res. Commun. pmid:2494999
Hicks M et al. Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation. 1989 Arch. Biochem. Biophys. pmid:2492180
Hansen O Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. 1989 Biochim. Biophys. Acta pmid:2554979
D'Aquino M et al. Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. 1989 Biochem. Biophys. Res. Commun. pmid:2568114
Stammers JP et al. High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets. 1989 Br. J. Nutr. pmid:2493804
Hrelia S et al. Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. 1989 Biochem. Biophys. Res. Commun. pmid:2570573
Levay-Young BK and Nandi S Spermidine is necessary for, but not the only mediator of, linoleic acid-stimulated alpha-casein accumulation in mouse mammary epithelial cells. 1989 Endocrinology pmid:2759031
Berlin E et al. Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women. 1989 Metab. Clin. Exp. pmid:2761416
Reddy SR et al. Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. 1989 Am. J. Physiol. pmid:2764141
Robertson DA et al. Linoleic acid supplementation, membrane lipids and leucocyte sodium transport in normotensive humans. 1989 J Hum Hypertens pmid:2760909
el Ashry A et al. The effect of dietary linoleic acid on blood pressure and erythrocyte sodium transport. 1989 J Hum Hypertens pmid:2724276
Stein O et al. Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. 1989 Biochim. Biophys. Acta pmid:2730885
Reinaud O et al. Oxidative metabolism of linoleic acid by human leukocytes. 1989 Biochem. Biophys. Res. Commun. pmid:2735926
Cunnane SC et al. Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. 1989 Am. J. Clin. Nutr. pmid:2801584
Rose DP and Connolly JM Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. 1989 Biochem. Biophys. Res. Commun. pmid:2803300
Mahfouz MM et al. Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. 1989 Biochim. Biophys. Acta pmid:2804072
Furr HC et al. The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. 1989 J. Nutr. pmid:2703916
Klein A et al. The effect of fatty acids on the vulnerability of lymphocytes to cortisol. 1989 Metab. Clin. Exp. pmid:2537454
Christon R et al. Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. 1989 Biochim. Biophys. Acta pmid:2538158
Chen Q et al. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. 1989 Biochim. Biophys. Acta pmid:2503032
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Hamazaki T et al. Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. 1989 Prostaglandins pmid:2503856
Mohsenin V and Gee JL Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. 1989 J. Appl. Physiol. pmid:2787317
Schneider YJ Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium. 1989 J. Immunol. Methods pmid:2644356
Watkins BA Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. 1989 Br. J. Nutr. pmid:2923859
Bourre JM et al. Composition of nerve biomembranes and nutritional fatty acids. 1989 Jul-Aug Nutrition pmid:2577681
Kamano K et al. Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice. 1989 Nov-Dec Anticancer Res. pmid:2627137
Buko VU et al. [Changes in the fatty acid composition of erythrocyte membranes in patients with chronic alcoholism under the effect of a diet enriched with linoleic acid]. 1989 Nov-Dec Vopr Pitan pmid:2629246
Brodersen R et al. Multiple fatty acid binding to albumin in human blood plasma. 1990 Eur. J. Biochem. pmid:2338079
Haas TA et al. Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. 1990 Biochim. Biophys. Acta pmid:2155665
Barros H et al. Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. 1990 Eur. J. Clin. Invest. pmid:2124981
Ha YL et al. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. 1990 Cancer Res. pmid:2297758
Kawahara J et al. Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. 1990 Hypertension pmid:2298478
Borgeson CE et al. Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. 1990 Biochim. Biophys. Acta pmid:2248971
Appel MJ et al. Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow. 1990 Cancer Lett. pmid:2257542
Pal S and Davis PJ N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. 1990 Biochem. Biophys. Res. Commun. pmid:2260969
Butovich IA et al. [Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process]. 1990 Bioorg. Khim. pmid:2344387
Singer P et al. Extreme decrease of linoleic acid in renal medulla from rats after a diet supplemented with cod liver oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353033
Katan MB and van Dusseldoys M [Premenstrual syndromes]. 1990 Ned Tijdschr Geneeskd pmid:2355986
Shimizu T et al. Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. 1990 J. Pediatr. Gastroenterol. Nutr. pmid:2324889
Parinandi NL et al. Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. 1990 Biochim. Biophys. Acta pmid:2123402
Hennig B et al. Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. 1990 J. Nutr. pmid:2329387
Roe CR et al. 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. 1990 J. Clin. Invest. pmid:2332510
Miyashita K et al. Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. 1990 Biochim. Biophys. Acta pmid:2386795
Medini L et al. Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. 1990 Biochem. Pharmacol. pmid:2105092
Kinsella JE and Lokesh B Dietary lipids, eicosanoids, and the immune system. 1990 Crit. Care Med. pmid:2105185
Kawada H et al. Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2363935
Lernhardt W Fatty acid requirement of B lymphocytes activated in vitro. 1990 Biochem. Biophys. Res. Commun. pmid:2302243
Galaris D et al. Ferrylmyoglobin-catalyzed linoleic acid peroxidation. 1990 Arch. Biochem. Biophys. pmid:2383021
Miller CC and Ziboh VA Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). 1990 J. Invest. Dermatol. pmid:2106562
Conquer J and Mahadevappa VG Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. 1990 Biochem. Biophys. Res. Commun. pmid:2106881
Opara EC et al. Enhancement of endocrine pancreatic secretions by essential fatty acids. 1990 J. Surg. Res. pmid:2187112
Dupont J and Dowd MK Icosanoid synthesis as a functional measurement of essential fatty acid requirement. 1990 J Am Coll Nutr pmid:2193052
Oliver MF Linoleic acid, antioxidants and coronary heart disease. 1990 Biochem. Soc. Trans. pmid:2088801
Bian RL et al. [Antianaphylactic components of Asarum forbsii Maxin]. 1990 Yao Xue Xue Bao pmid:2099089
Thomas CR and Lowy C The use of two in-situ simultaneously-perfused placentas to investigate the effect of carrier proteins on linoleic and palmitic acid transfer in the guinea pig. 1990 J. Dev. Physiol. pmid:2100741
Singer P et al. A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. 1990 Atherosclerosis pmid:2146966
Kitagawa S et al. Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. 1990 Biochim. Biophys. Acta pmid:2166588
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
van Doormaal JJ Linoleic acid metabolism in diabetes mellitus. 1990 Neth J Med pmid:2074912
Ando H et al. Protein kinase C and linoleic acid-induced inhibition of melanogenesis. 1990 Pigment Cell Res. pmid:2077533
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Bedotti R et al. Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. 1990 Biochim. Biophys. Acta pmid:2163687
Akamatsu H et al. Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. 1990 J. Invest. Dermatol. pmid:2143521
Piché LA and Mahadevappa VG Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. 1990 J. Nutr. pmid:2111377
Weaver BJ et al. Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. 1990 Am. J. Clin. Nutr. pmid:2181858
Renner HW Anticlastogenic dietary factors assessed in mammalian assays. 1990 Basic Life Sci. pmid:2183774
Farnworth ER and Kramer JK Fat supplementation to the gestation diet of older sows and its effect on maternal and fetal fat metabolism. 1990 Reprod. Nutr. Dev. pmid:1981311
Marra CA and de Alaniz MJ Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. 1990 Biochem. Int. pmid:1981670
Byczkowski JZ and Kulkarni AP Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. 1990 Bull Environ Contam Toxicol pmid:2176112
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Stocker R et al. Antioxidant activities of bile pigments: biliverdin and bilirubin. 1990 Meth. Enzymol. pmid:2233302
Glasgow WC and Eling TE Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. 1990 Mol. Pharmacol. pmid:2233691
Hernández-Caselles T et al. Stability of liposomes on long term storage. 1990 J. Pharm. Pharmacol. pmid:1979618
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Vaughan PF and Ball SG The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. 1990 Biochem. Pharmacol. pmid:1968340
Field CJ et al. Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. 1990 J. Biol. Chem. pmid:2113530
Hori T et al. Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2114113
Hjelte L et al. Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. 1990 Am. J. Physiol. pmid:2115302