Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Durgam VR and Fernandes G | The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. | 1997 | Cancer Lett. | pmid:9215854 |
Usha S et al. | Mitogenic stimulation of primary cultures of lung epithelial cells by linoleic acid. | 1996 | Biochem. Cell Biol. | pmid:9213439 |
Stein CA | Controversies in the cellular pharmacology of oligodeoxynucleotides. | 1997 | Antisense Nucleic Acid Drug Dev. | pmid:9212912 |
Nicolosi RJ et al. | Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. | 1997 | Artery | pmid:9209699 |
Yehuda S et al. | Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. | 1997 | Eur. J. Pharmacol. | pmid:9203563 |
Miura K et al. | The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors. | 1997 | Methods Find Exp Clin Pharmacol | pmid:9203161 |
Schut HA et al. | DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. | 1997 | Mutat. Res. | pmid:9202755 |
Sauer LA et al. | Dietary linoleic acid intake controls the arterial blood plasma concentration and the rates of growth and linoleic acid uptake and metabolism in hepatoma 7288CTC in Buffalo rats. | 1997 | J. Nutr. | pmid:9202100 |
Petrek JA et al. | Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis. | 1997 | J. Clin. Oncol. | pmid:9193329 |
Sharpe M et al. | Ligation, inhibition, and activation of cytochrome c oxidase by fatty acids. | 1997 | Biochem. Cell Biol. | pmid:9192076 |
Sanderson P et al. | Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. | 1997 | Biochem. Soc. Trans. | pmid:9191396 |
Peres CM et al. | Transference of fatty acids from macrophages to lymphocytes in culture. | 1997 | Biochem. Soc. Trans. | pmid:9191389 |
Berry H et al. | Excess substrate inhibition of soybean lipoxygenase-1 is mainly oxygen-dependent. | 1997 | FEBS Lett. | pmid:9188786 |
Ek BA et al. | Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. | 1997 | Biochim. Biophys. Acta | pmid:9187305 |
Memoli S et al. | Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. | 1997 | Biochim. Biophys. Acta | pmid:9187303 |
Banfi C et al. | Linoleic acid enhances the secretion of plasminogen activator inhibitor type 1 by HepG2 cells. | 1997 | J. Lipid Res. | pmid:9186904 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Hornstra G and Kester AD | Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model. | 1997 | Atherosclerosis | pmid:9180241 |
Harvei S et al. | Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. | 1997 | Int. J. Cancer | pmid:9178806 |
Nakayama T et al. | Lipid peroxidation in linoleic acid micelles caused by H2O2 in the presence of myoglobin. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9178558 |
Matsusue K et al. | A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. | 1997 | Toxicol. Lett. | pmid:9175845 |
Monette M and Lafleur M | Influence of lipid chain unsaturation on melittin-induced micellization. | 1996 | Biophys. J. | pmid:9172743 |
Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
Rogers AE | Diet and breast cancer: studies in laboratory animals. | 1997 | J. Nutr. | pmid:9164267 |
Salomaa VV et al. | Association of the fatty acid composition of serum phospholipids with hemostatic factors. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157941 |
Luthria DL et al. | Metabolites produced during the peroxisomal beta-oxidation of linoleate and arachidonate move to microsomes for conversion back to linoleate. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9144553 |
Cunnane SC and Anderson MJ | Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidation. | 1997 | J. Lipid Res. | pmid:9144095 |
Vargas F and Fuentes A | Evidence of formation and participation of singlet oxygen in the in vitro phototoxicity of the combined diuretic triamterene and hydrochlorothiazide. | 1997 | Pharmazie | pmid:9140146 |
Ohata T et al. | Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids. | 1997 | Jpn. J. Cancer Res. | pmid:9140106 |
Rao PU | Nutrient composition and biological evaluation of mesta (Hibiscus sabdariffa) seeds. | 1996 | Plant Foods Hum Nutr | pmid:9139301 |
Chew BP et al. | Effects of conjugated dienoic derivatives of linoleic acid and beta-carotene in modulating lymphocyte and macrophage function. | 1997 Mar-Apr | Anticancer Res. | pmid:9137456 |
Wong MW et al. | Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. | 1997 Mar-Apr | Anticancer Res. | pmid:9137439 |
Visonneau S et al. | Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. | 1997 Mar-Apr | Anticancer Res. | pmid:9137436 |
Bourre JM et al. | Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids. | 1997 | Neurosci. Lett. | pmid:9132678 |
Schneider C et al. | A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9125182 |
Ip C and Scimeca JA | Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. | 1997 | Nutr Cancer | pmid:9121939 |
Goldreich D et al. | The effect of retinol and retinoic acids on lipoxygenase activity. | 1997 | Int J Vitam Nutr Res | pmid:9119612 |
Fukushima M et al. | Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats. | 1997 | Lipids | pmid:9113627 |
Ip C et al. | Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis. | 1997 | Carcinogenesis | pmid:9111211 |
Nieuwenhuizen WF et al. | Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. | 1997 | Biochemistry | pmid:9109655 |
Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
Ikeda I et al. | Effect of dietary linoleic, alpha-linolenic and arachidonic acids on lipid metabolism, tissue fatty acid composition and eicosanoid production in rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:9089480 |
Yamaki T et al. | Acute and reversible fatty metamorphosis of cultured rat hepatocytes. | 1997 Feb-Mar | Pathol. Int. | pmid:9088028 |
Iwase H et al. | Formation of leukotoxin (9,10-epoxy-12-octadecenoic acid) during the autoxidation of phospholipids promoted by hemoproteins. | 1997 | Biochim. Biophys. Acta | pmid:9084498 |
Schneider C et al. | Analysis of lipoxygenase-derived fatty acid hydroperoxides by electrospray ionization tandem mass spectrometry. | 1997 | Lipids | pmid:9076671 |
Barclay LR et al. | Photo-initiated peroxidation of lipids in micelles by azaaromatics. | 1997 | Lipids | pmid:9076660 |
Belury MA and Kempa-Steczko A | Conjugated linoleic acid modulates hepatic lipid composition in mice. | 1997 | Lipids | pmid:9075211 |
Iwase H et al. | Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070266 |