Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Dermatitis D003872 30 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Migraine Disorders D008881 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Padayachee T et al. The Detection of Metabolite-Mediated Gene Module Co-Expression Using Multivariate Linear Models. 2016 PLoS ONE pmid:26918614
Harris WS et al. Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study. 2016 PLoS ONE pmid:26881936
Emery JA et al. Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. 2013 PLoS ONE pmid:23460861
Gouveia-Figueira S et al. Serum levels of oxylipins in achilles tendinopathy: an exploratory study. 2015 PLoS ONE pmid:25875933
Chen S et al. Profiling of volatile compounds and associated gene expression and enzyme activity during fruit development in two cucumber cultivars. 2015 PLoS ONE pmid:25799542
Manosalva C et al. Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. 2015 PLoS ONE pmid:25790461
Xing J et al. Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods. 2015 PLoS ONE pmid:25789875
Saccenti E et al. Strategies for individual phenotyping of linoleic and arachidonic acid metabolism using an oral glucose tolerance test. 2015 PLoS ONE pmid:25786212
Ciepiela P et al. Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting. 2015 PLoS ONE pmid:25763593
van Schalkwijk DB et al. Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation. 2014 PLoS ONE pmid:25049048
Fukuda S et al. Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. 2009 PLoS ONE pmid:19287504
Mesti T et al. Metabolic impact of anti-angiogenic agents on U87 glioma cells. 2014 PLoS ONE pmid:24922514
Woyda-Ploszczyca AM and Jarmuszkiewicz W Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. 2014 PLoS ONE pmid:24904988
Troche JR et al. Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers. 2016 PLoS ONE pmid:26967509
Prasad A and Pospíšil P Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. 2011 PLoS ONE pmid:21799835
Zhao Y et al. Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. 2013 PLoS ONE pmid:23565210
Yuan X et al. Identification of an endogenous ligand bound to a native orphan nuclear receptor. 2009 PLoS ONE pmid:19440305
de Goede J et al. N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. 2013 PLoS ONE pmid:23741290
Noel JT et al. Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. 2010 PLoS ONE pmid:20824208
Abdoul-Azize S et al. Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus. 2013 PLoS ONE pmid:23936306
Vinaixa M et al. Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. 2011 PLoS ONE pmid:22194988
Kenny JG et al. Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. 2013 PLoS ONE pmid:23861785
Benbrook CM et al. Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. 2013 PLoS ONE pmid:24349282
Zhao Z et al. The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. 2016 PLoS ONE pmid:27880795
Zhang YH et al. The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life. 2016 PLoS ONE pmid:27780226
Rodrigues HG et al. Oral Administration of Linoleic Acid Induces New Vessel Formation and Improves Skin Wound Healing in Diabetic Rats. 2016 PLoS ONE pmid:27764229
Paulsen SJ et al. Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. 2014 PLoS ONE pmid:24520357
Castro LF et al. Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 2012 PLoS ONE pmid:22384110
Alloatti A et al. Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. 2010 PLoS ONE pmid:21151902
Abdullah BM et al. Polyesters Based on Linoleic Acid for Biolubricant Basestocks: Low-Temperature, Tribological and Rheological Properties. 2016 PLoS ONE pmid:27008312
Ishida K and Jolly ER Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion. 2016 PLoS Negl Trop Dis pmid:27611863
Liu JH et al. Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. 1998 Planta Med. pmid:9741298
Haraguchi H et al. Antioxidative action of diterpenoids from Podocarpus nagi. 1997 Planta Med. pmid:9225601
Su BN et al. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. 2002 Planta Med. pmid:12494342
Sewram V et al. Supercritical fluid extraction and analysis of compounds from Clivia miniata for uterotonic activity. 2001 Planta Med. pmid:11488461
Malhotra S et al. Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. 2009 Planta Med. pmid:19031367
Hou WC et al. Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro. 2002 Planta Med. pmid:12494332
AbouZid S and Orihara Y Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. 2007 Planta Med. pmid:17973205
Hong CY et al. Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. 1993 Planta Med. pmid:8372148
Fernández-Moya V et al. Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. 2003 Planta pmid:12624771
de Virville JD et al. Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. 2008 Planta pmid:18663470
Smith MA et al. Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana. 2003 Planta pmid:14520576
Singh S et al. Transgenic expression of a delta 12-epoxygenase gene in Arabidopsis seeds inhibits accumulation of linoleic acid. 2001 Planta pmid:11346964
Quintana N et al. Phytotoxic compounds from roots of Centaurea diffusa Lam. 2009 Plant Signal Behav pmid:19568334
Kang J et al. Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa. 2011 Plant Physiol. Biochem. pmid:21215650
Hofmann E and Pollmann S Molecular mechanism of enzymatic allene oxide cyclization in plants. 2008 Plant Physiol. Biochem. pmid:18272375
Zhang D et al. Identification and expression of a new delta-12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. 2009 Plant Physiol. Biochem. pmid:19217793
Chua AC et al. Characterization of oil bodies in jelly fig achenes. 2008 May-Jun Plant Physiol. Biochem. pmid:18434174
Yu C et al. Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. 2009 Nov-Dec Plant Physiol. Biochem. pmid:19648018
Venegas-Calerón M et al. Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. 2009 Plant Physiol. Biochem. pmid:19342250