Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Carlotti ME et al. | Inhibition of lipoperoxidation of linoleic acid by five antioxidants of different lipophilicity. | 1994 | Pharmazie | pmid:8140131 |
Canudas N et al. | Photobiological properties of nabumetone (4-[6-methoxy-2-naphthalenyl]-2-butanone), a novel non-steroidal anti-inflammatory and analgesic agent. | 2000 | Pharmazie | pmid:10798241 |
Castell JV et al. | Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. | 1994 | Photochem. Photobiol. | pmid:8127938 |
Miolo G et al. | Photochemistry and phototoxicity of fluocinolone 16,17-acetonide. | 2005 Mar-Apr | Photochem. Photobiol. | pmid:15535735 |
Samadi A et al. | Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: product studies using linoleic acid and 1,4-cyclohexadienes as model substrates. | 2001 | Photochem. Photobiol. | pmid:11332030 |
Vargas F et al. | Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. | 1993 | Photochem. Photobiol. | pmid:8248320 |
Voigt A et al. | Polyunsaturated but not conjugated linoleic acid supplementation of leukemic U937 cells can act as an amplification factor for photofrin-mediated photodynamic therapy. | 2006 May-Jun | Photochem. Photobiol. | pmid:16468943 |
Markovic DZ and Patterson LK | Benzophenone-sensitized lipid peroxidation in linoleate micelles. | 1993 | Photochem. Photobiol. | pmid:8234464 |
Mujtaba SF et al. | Production of ROS by photosensitized anthracene under sunlight and UV-R at ambient environmental intensities. | 2011 Sep-Oct | Photochem. Photobiol. | pmid:21668866 |
Anthony FA et al. | Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. | 1997 Feb-Apr | Photodermatol Photoimmunol Photomed | pmid:9361122 |
Jones R et al. | The analysis of the red cell unsaturated fatty acid test for multiple sclerosis using laser cytopherometry. | 1983 | Phys Med Biol | pmid:6647546 |
KmonÃcková E et al. | Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions. | 1998 | Physiol Res | pmid:9706993 |
Ondrias K et al. | Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes. | 1998 | Physiol Res | pmid:9706995 |
Mourek J and Dohnalová A | Relationship between birth weight of newborns and unsaturated fatty acid(n-3) proportions in their blood serum. | 1996 | Physiol Res | pmid:9496767 |
Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
Smith JC et al. | Orosensory factors in the ingestion of corn oil/sucrose mixtures by the rat. | 2000 Apr 1-15 | Physiol. Behav. | pmid:10854925 |
Cox JE et al. | Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions. | 2004 | Physiol. Behav. | pmid:15059681 |
Ebba S et al. | The examination of fatty acid taste with edible strips. | 2012 | Physiol. Behav. | pmid:22521910 |
Stratford JM et al. | Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats. | 2006 | Physiol. Behav. | pmid:16963089 |
McCormack DN et al. | Detection of free fatty acids following a conditioned taste aversion in rats. | 2006 | Physiol. Behav. | pmid:16448678 |
Gilbertson TA et al. | Fatty acid responses in taste cells from obesity-prone and -resistant rats. | 2005 | Physiol. Behav. | pmid:16249010 |
Yoneda T et al. | The palatability of corn oil and linoleic acid to mice as measured by short-term two-bottle choice and licking tests. | 2007 | Physiol. Behav. | pmid:17459430 |
Greenberg D et al. | Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. | 1999 | Physiol. Behav. | pmid:10386906 |
Guillén N et al. | Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. | 2009 | Physiol. Genomics | pmid:19258494 |
LaRosa PC et al. | Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. | 2007 | Physiol. Genomics | pmid:17878318 |
Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
Kelly R | Drug treatment in multiple sclerosis. | 1982 | Physiotherapy | pmid:7111474 |
Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
Ogorodnikova AV et al. | Detection of divinyl ether synthase in Lily-of-the-Valley (Convallaria majalis) roots. | 2008 | Phytochemistry | pmid:18952245 |
Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
DoÄŸru-Koca A et al. | Chemotaxonomic perspectives of the Paracaryum (Cynoglosseae, Boraginaceae) taxa based on fruit fatty acid composition. | 2016 | Phytochemistry | pmid:27600716 |
Bergman M et al. | Scavenging of reactive oxygen species by a novel glucurinated flavonoid antioxidant isolated and purified from spinach. | 2003 | Phytochemistry | pmid:12620328 |
Ohnishi M et al. | Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. | 1998 | Phytochemistry | pmid:9611825 |
Hatano T et al. | Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects. | 2002 | Phytochemistry | pmid:11909632 |
Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
Bryant D et al. | Cloning and characterization of a theta class glutathione transferase from the potato pathogen Phytophthora infestans. | 2006 | Phytochemistry | pmid:16797619 |
Jablonická V et al. | Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. | 2016 | Phytochemistry | pmid:27473012 |
Reininger EA and Bauer R | Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix. | 2006 | Phytomedicine | pmid:16428023 |
Liu J et al. | Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). | 2004 | Phytomedicine | pmid:14974442 |
Lata M et al. | Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. | 2009 | Phytomedicine | pmid:17574826 |
Chen MH and Nelson EB | Microbial-induced carbon competition in the spermosphere leads to pathogen and disease suppression in a municipal biosolids compost. | 2012 | Phytopathology | pmid:22352306 |
Gülçin I et al. | Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. | 2007 | Phytother Res | pmid:17221941 |
Shinohara R et al. | Evaluation of antilipid peroxidative action of propolis ethanol extract. | 2002 | Phytother Res | pmid:12112290 |
Pérez G RM et al. | Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. | 2004 | Phytother Res | pmid:15174007 |
Jäger AK et al. | Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. | 2008 | Phytother Res | pmid:18389471 |
Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
Cui Y et al. | Potential biomedical properties of Pinus massoniana bark extract. | 2005 | Phytother Res | pmid:15798999 |
Higashi-Okai K et al. | Potent suppressive activity of fresh and dried peels from Satsuma mandarin Citrus unshiu (Marcorv.) on hydroperoxide generation from oxidized linoleic acid. | 2002 | Phytother Res | pmid:12458489 |
Marongiu B et al. | Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora. | 2004 | Phytother Res | pmid:15551397 |
Christensen KB et al. | Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. | 2010 | Phytother Res | pmid:20222152 |
Ulusu NN et al. | Abietic acid inhibits lipoxygenase activity. | 2002 | Phytother Res | pmid:11807975 |
Akeo K and Hiramitsu T | Changes in lipid peroxide level in retinal pigment epithelial cells in vitro upon addition of linoleic acids or linoleic acid hydroperoxides under varying concentrations of oxygen. | 1998 | Pigment Cell Res. | pmid:9877104 |
Ando H et al. | Protein kinase C and linoleic acid-induced inhibition of melanogenesis. | 1990 | Pigment Cell Res. | pmid:2077533 |
Akeo K et al. | Effects of fluorescent light on growth of bovine retinal pigment epithelial cells in vitro incubated with linoleic acid or linoleic acid hydroperoxide. | 1999 | Pigment Cell Res. | pmid:10385917 |
Hover CG and Kulkarni AP | Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid. | 2000 | Placenta | pmid:10985967 |
Huang FC and Schwab W | Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. | 2012 | Plant Biotechnol. J. | pmid:22967031 |
Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Ito T et al. | The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. | 2007 | Plant Cell | pmid:17981996 |
Runyon JB et al. | Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato. | 2010 | Plant Cell Environ. | pmid:19930126 |
Laus MN et al. | Plant inner membrane anion channel (PIMAC) function in plant mitochondria. | 2008 | Plant Cell Physiol. | pmid:18511459 |
Watanabe N and Yamada S | Activation of 20S proteasomes from spinach leaves by fatty acids. | 1996 | Plant Cell Physiol. | pmid:8665092 |
Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
Mohan VR and Janardhanan K | Chemical and nutritional evaluation of two germplasms of the tribal pulse, Bauhinia racemosa Lamk. | 1994 | Plant Foods Hum Nutr | pmid:7716120 |
Girgih AT et al. | Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. | 2013 | Plant Foods Hum Nutr | pmid:23417711 |
Essien EU et al. | Lipid composition of lesser known tropical seeds. | 1995 | Plant Foods Hum Nutr | pmid:8837872 |
Beevi SS et al. | Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. | 2010 | Plant Foods Hum Nutr | pmid:20072818 |
Freiberger CE et al. | Nutrient content of the edible leaves of seven wild plants from Niger. | 1998 | Plant Foods Hum Nutr | pmid:10890758 |
Rao PU | Nutrient composition and biological evaluation of mesta (Hibiscus sabdariffa) seeds. | 1996 | Plant Foods Hum Nutr | pmid:9139301 |
Valdez-Morales M et al. | Phenolic Compounds, Antioxidant Activity and Lipid Profile of Huitlacoche Mushroom (Ustilago maydis) Produced in Several Maize Genotypes at Different Stages of Development. | 2016 | Plant Foods Hum Nutr | pmid:27605221 |
Rahamatalla AB et al. | Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. | 2001 | Plant Foods Hum Nutr | pmid:11678443 |
Rao MS et al. | Yield, protein, and oil quality of soybean genotypes selected for tofu production. | 1998 | Plant Foods Hum Nutr | pmid:9950085 |
Forster C et al. | Molecular analysis of a null mutant for pea (Pisum sativum L.) seed lipoxygenase-2. | 1999 | Plant Mol. Biol. | pmid:10380807 |
Reddy AS et al. | Isolation of a delta 6-desaturase gene from the cyanobacterium Synechocystis sp. strain PCC 6803 by gain-of-function expression in Anabaena sp. strain PCC 7120. | 1993 | Plant Mol. Biol. | pmid:8389613 |
Fraser TC et al. | Expression of the Isochrysis C18-delta9 polyunsaturated fatty acid specific elongase component alters Arabidopsis glycerolipid profiles. | 2004 | Plant Physiol. | pmid:15173563 |
Woodfield HK et al. | Spatial and Temporal Mapping of Key Lipid Species in Brassica napus Seeds. | 2017 | Plant Physiol. | pmid:28188274 |
Cahoon EB et al. | Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. | 2002 | Plant Physiol. | pmid:11842164 |
DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
Kang J et al. | Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa. | 2011 | Plant Physiol. Biochem. | pmid:21215650 |
Hofmann E and Pollmann S | Molecular mechanism of enzymatic allene oxide cyclization in plants. | 2008 | Plant Physiol. Biochem. | pmid:18272375 |
Zhang D et al. | Identification and expression of a new delta-12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. | 2009 | Plant Physiol. Biochem. | pmid:19217793 |
Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
Lorenzi V et al. | Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). | 2006 Jul-Sep | Plant Physiol. Biochem. | pmid:17011785 |
Yu C et al. | Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19648018 |
Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
Quintana N et al. | Phytotoxic compounds from roots of Centaurea diffusa Lam. | 2009 | Plant Signal Behav | pmid:19568334 |
Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
de Virville JD et al. | Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. | 2008 | Planta | pmid:18663470 |
Smith MA et al. | Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana. | 2003 | Planta | pmid:14520576 |
Singh S et al. | Transgenic expression of a delta 12-epoxygenase gene in Arabidopsis seeds inhibits accumulation of linoleic acid. | 2001 | Planta | pmid:11346964 |
Liu JH et al. | Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. | 1998 | Planta Med. | pmid:9741298 |
Haraguchi H et al. | Antioxidative action of diterpenoids from Podocarpus nagi. | 1997 | Planta Med. | pmid:9225601 |
Su BN et al. | Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. | 2002 | Planta Med. | pmid:12494342 |
Sewram V et al. | Supercritical fluid extraction and analysis of compounds from Clivia miniata for uterotonic activity. | 2001 | Planta Med. | pmid:11488461 |
Malhotra S et al. | Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. | 2009 | Planta Med. | pmid:19031367 |
Hou WC et al. | Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro. | 2002 | Planta Med. | pmid:12494332 |
AbouZid S and Orihara Y | Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. | 2007 | Planta Med. | pmid:17973205 |
Hong CY et al. | Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. | 1993 | Planta Med. | pmid:8372148 |
Ishida K and Jolly ER | Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion. | 2016 | PLoS Negl Trop Dis | pmid:27611863 |