Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Embolism, Fat D004620 4 associated lipids
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Fatty Liver D005234 48 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Lance A et al. 13C-linoleic acid oxidation and transfer into milk in lactating women with contrasting body mass index. 2000 Adv. Exp. Med. Biol. pmid:11065106
Kelavkar U et al. 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. 2002 Adv. Exp. Med. Biol. pmid:12664577
Buchanan MR Linoleic acid metabolites in health and disease. 1999 Adv. Exp. Med. Biol. pmid:10667369
Greene JF and Hammock BD Toxicity of linoleic acid metabolites. 1999 Adv. Exp. Med. Biol. pmid:10667370
Jira W and Spiteller G Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. 1999 Adv. Exp. Med. Biol. pmid:10667371
Camacho M et al. IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. 1997 Adv. Exp. Med. Biol. pmid:9547616
Louw L et al. Impairment in the fatty acid composition of keloids. 1997 Adv. Exp. Med. Biol. pmid:9547645
Louw L et al. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. 1997 Adv. Exp. Med. Biol. pmid:9547646
Louw L et al. The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. 1997 Adv. Exp. Med. Biol. pmid:9547647
Brister SJ and Buchanan MR Effects of linoleic acid and/or marine fish oil supplements on vessel wall thromboresistance in patients undergoing cardiac surgery. 1997 Adv. Exp. Med. Biol. pmid:9561151
Giménez-Arnau A et al. Effects of linoleic acid supplements on atopic dermatitis. 1997 Adv. Exp. Med. Biol. pmid:9561153
Horrobin DF and Ziboh VA The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. 1997 Adv. Exp. Med. Biol. pmid:9561154
Agostoni C et al. Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation. 2001 Adv. Exp. Med. Biol. pmid:11787678
Eling TE et al. Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. 1997 Adv. Exp. Med. Biol. pmid:9321970
Asakawa T et al. Ca2+-activated, fatty acid-dependent guanylate cyclase in synaptic plasma membranes and its requirement for Ca2+ and Mg-GTP in the activation. 1984 Adv. Exp. Med. Biol. pmid:6149673
Louw L et al. Keloids: peripheral and central differences in cell morphology and fatty acid compositions of lipids. 1997 Adv. Exp. Med. Biol. pmid:9322000
Kinsella JE Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. 1991 Adv. Food Nutr. Res. pmid:1681826
Hoffmann P and Förster W Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system). 1981 Adv. Lipid Res. pmid:6798829
Ringertz B et al. High dietary linoleic acid content modulates neutrophil function in rats. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960199
Eling TE et al. Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7537437
Buchanan MR et al. Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526487
Eling TE and Glasgow WC Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825423
Gyllenhammar H et al. Dietary essential fatty acid deficiency in rats is accompanied by impairments in neutrophil function and leukotriene B4 generation. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823572
Loesberg C et al. Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. 1988 Agents Actions pmid:2833083
Iversen L et al. Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. 1991 Agents Actions pmid:1659156
Loesberg C et al. Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. 1987 Agents Actions pmid:2895570
Kramer HJ et al. The role of renal prostaglandins in the regulation of renal sodium excretion. 1987 Agents Actions Suppl. pmid:3481214
Henricks PA et al. Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. 1990 Agents Actions Suppl. pmid:2080762
Pamplona R et al. Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. 1999 Aging (Milano) pmid:10337442
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Pirozhkov SV et al. Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. 1992 Jul-Aug Alcohol pmid:1637499
Horrobin DF Essential fatty acids, prostaglandins, and alcoholism: an overview. 1987 Alcohol. Clin. Exp. Res. pmid:3032012
Buko VU Beef fat prevents alcoholic liver disease in the rat. 1990 Alcohol. Clin. Exp. Res. pmid:2221295
Tsukamoto S et al. Effects of bezafibrate on ethanol oxidation in rats. 1996 Alcohol. Clin. Exp. Res. pmid:8986210
Cunnane SC Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. 1987 Alcohol. Clin. Exp. Res. pmid:3032013
Szebeni J et al. Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. 1986 Alcohol. Clin. Exp. Res. pmid:3101533
Uden S et al. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. 1992 Aliment. Pharmacol. Ther. pmid:1600043
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Kelly GS Conjugated linoleic acid: a review. 2001 Altern Med Rev pmid:11578253
Poole E and McQueen CE Conjugated linoleic acid. 2006 Am J Health Syst Pharm pmid:17057041
Block RC et al. Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? 2008 Am. Heart J. pmid:19033007
Tilvis RS et al. Serum lipids and fatty acids in ischemic strokes. 1987 Am. Heart J. pmid:3812213
McDaniel HG et al. Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. 1981 Am. Heart J. pmid:6787909
Magsino CH et al. Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. 2000 Am. J. Cardiol. pmid:10946040
Siguel EN and Ratnayake WM Trans-fatty acid patterns in patients with demonstrated coronary artery disease. 1995 Am. J. Cardiol. pmid:7856548
Sentex E et al. Is the cytoprotective effect of trimetazidine associated with lipid metabolism? 1998 Am. J. Cardiol. pmid:9737482
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Wu MJ et al. Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). 2004 Am. J. Chin. Med. pmid:15633804
Cho EJ et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. 2003 Am. J. Chin. Med. pmid:14992543
CAMPBELL AM et al. SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. 1965 Am. J. Clin. Nutr. pmid:14332349
Hennig B et al. Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. 1996 Am. J. Clin. Nutr. pmid:8602587
Routi T et al. Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. 1996 Am. J. Clin. Nutr. pmid:8602597
Louheranta AM et al. Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. 1996 Am. J. Clin. Nutr. pmid:8615351
Anderson RL Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. 1982 Am. J. Clin. Nutr. pmid:7081132
Martinelli N et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. 2008 Am. J. Clin. Nutr. pmid:18842780
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
SCOTT RF et al. FATTY ACIDS OF SERUM AND ADIPOSE TISSUE IN SIX GROUPS EATING NATURAL DIETS CONTAINING 7 TO 40 PER CENT FAT. 1964 Am. J. Clin. Nutr. pmid:14157830
DeLany JP et al. Differential oxidation of individual dietary fatty acids in humans. 2000 Am. J. Clin. Nutr. pmid:11010930
Mantzioris E et al. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. 1995 Am. J. Clin. Nutr. pmid:7840069
Siguel E Does linoleic acid contribute to coronary artery disease? 1995 Am. J. Clin. Nutr. pmid:7840081
Granot E et al. Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. 2000 Am. J. Clin. Nutr. pmid:11063450
Villalpando S et al. [13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes. 2001 Am. J. Clin. Nutr. pmid:11729835
Hayes KC The linoleic acid content of test diets must be carefully monitored in cholesterol studies. 1997 Am. J. Clin. Nutr. pmid:9094899
Jeppesen PB et al. Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. 1999 Am. J. Clin. Nutr. pmid:10393142
Jannace PW et al. Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. 1992 Am. J. Clin. Nutr. pmid:1323926
Decsi T et al. Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. 1995 Am. J. Clin. Nutr. pmid:7491893
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Hrboticky N et al. Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. 1991 Am. J. Clin. Nutr. pmid:1989416
Del Prado M et al. Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. 2001 Am. J. Clin. Nutr. pmid:11470727
CENTURY B et al. INTERRELATIONSHIPS OF DIETARY LIPIDS UPON FATTY ACID COMPOSITION OF BRAIN MITOCHONDRIA, ERYTHROCYTES AND HEART TISSUE IN CHICKS. 1963 Am. J. Clin. Nutr. pmid:14101397
Carnielli VP et al. Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. 1996 Am. J. Clin. Nutr. pmid:8694014
Erickson KL Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? 1998 Am. J. Clin. Nutr. pmid:9665090
Zock PL and Katan MB Linoleic acid intake and cancer risk: a review and meta-analysis. 1998 Am. J. Clin. Nutr. pmid:9665108
Rioux FM and Innis SM Arachidonic acid concentrations in plasma and liver phospholipid and cholesterol esters of piglets raised on formulas with different linoleic and linolenic acid contents. 1992 Am. J. Clin. Nutr. pmid:1609747
Rudel LL et al. Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. 1995 Am. J. Clin. Nutr. pmid:7625361
Meerarani P et al. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. 2000 Am. J. Clin. Nutr. pmid:10617950
Baylin A et al. Adipose tissue biomarkers of fatty acid intake. 2002 Am. J. Clin. Nutr. pmid:12324287
Voorrips LE et al. Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. 2002 Am. J. Clin. Nutr. pmid:12324303
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Kalivianakis M et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. 1999 Am. J. Clin. Nutr. pmid:9925134
Jiang J et al. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. 1999 Am. J. Clin. Nutr. pmid:10393134
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Cosgrove MC et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. 2007 Am. J. Clin. Nutr. pmid:17921406
Iacono JM and Dougherty RM Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. 1991 Am. J. Clin. Nutr. pmid:1900384
Murphy J et al. Fat malabsorption in cystic fibrosis patients. 1999 Am. J. Clin. Nutr. pmid:10539762
Freese R et al. High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. 2002 Am. J. Clin. Nutr. pmid:12399265
Feunekes GI et al. Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. 1993 Am. J. Clin. Nutr. pmid:8379504
Cunnane SC Diodoquin and linoleic acid absorption in zinc deficiency. 1981 Am. J. Clin. Nutr. pmid:6792900
Chevrot M et al. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. 2014 Am. J. Clin. Nutr. pmid:24522446
Friesen RW and Innis SM Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. 2010 Am. J. Clin. Nutr. pmid:19923368
McMurchie EJ et al. Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. 1984 Am. J. Clin. Nutr. pmid:6720626
Cunnane SC et al. Beta-oxidation of linoleate in obese men undergoing weight loss. 2001 Am. J. Clin. Nutr. pmid:11273844
Elias SL and Innis SM Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. 2001 Am. J. Clin. Nutr. pmid:11273857
Freeman VL et al. Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? 2001 Am. J. Clin. Nutr. pmid:11273858
Merchant AT et al. Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. 2005 Am. J. Clin. Nutr. pmid:16155282
Seidelin KN et al. Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. 1993 Am. J. Clin. Nutr. pmid:8416668
Horrobin DF Fatty acid metabolism in health and disease: the role of delta-6-desaturase. 1993 Am. J. Clin. Nutr. pmid:8386433
Mahendran Y et al. Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. 2014 Am. J. Clin. Nutr. pmid:24153340
Yary T et al. Serum n-6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. 2016 Am. J. Clin. Nutr. pmid:27009754
Arca M et al. Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. 1987 Am. J. Clin. Nutr. pmid:3604961