Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Diabetic Ketoacidosis D016883 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Carcinoma D002277 18 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Refsum Disease D012035 19 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Tuberculosis D014376 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Brain Edema D001929 20 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cachexia D002100 21 associated lipids
Helicobacter Infections D016481 21 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Birth Weight D001724 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Hong CY et al. Effect of pravastatin on fatty acid profile of low density lipoprotein in patients with hypercholesterolemia. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8446653
Claassen N et al. The effect of different n-6/n-3 essential fatty acid ratios on calcium balance and bone in rats. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7675819
Stachowska E et al. Exchange of unsaturated fatty acids between adipose tissue and atherosclerotic plaque studied with artificial neural networks. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643180
Singer P et al. Extreme decrease of linoleic acid in renal medulla from rats after a diet supplemented with cod liver oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353033
Simopoulos AP Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991765
Galli C Commentary on the workshop statement. Essentiality of and recommended dietary intake of Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991767
Crawford MA Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991768
Whelan J The health implications of changing linoleic acid intakes. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990554
Fritsche KL Too much linoleic acid promotes inflammation-doesn't it? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990555
Wander RC et al. Influence of long-chain polyunsaturated fatty acids on oxidation of low density lipoprotein. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774178
Louw L et al. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part I, total fatty acid profiles. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849650
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Wenger FA et al. Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913224
Ramchurren N and Karmali R Effects of gamma-linolenic and dihomo-gamma-linolenic acids on 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors in rats. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480079
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Kim RS and Zaborniak CL The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946549
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Tribole E What happened to do no harm? The issue of dietary omega-6 fatty acids. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147337
Ramsden CE et al. Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147338
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
Rosing U and Olund A Endometrial content of prostaglandin precursors during the menstrual cycle. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2780764
Strandvik B et al. Prostanoid biosynthesis in patients with cystic fibrosis. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014220
Strandvik B Fatty acid metabolism in cystic fibrosis. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20673710
Gelderblom WC et al. Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574646
Arun Kumar C and Das UN Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574650
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Villa PM et al. Free fatty acid profiles in preeclampsia. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19497719
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Bandyopadhyay GK et al. Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8424125
Goodfriend TL et al. An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324236
Okui T et al. Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21723718
Shapiro H et al. Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27067460
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Cunnane SC et al. Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate. 1999 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:10471127
Salem N et al. In vivo conversion of linoleic acid to arachidonic acid in human adults. 1999 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:10471130
Sakuma S et al. The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161586
van der Schouw YT et al. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815240
Mayer M Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815242
Punchard NA et al. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765976
Mohan IK and Das UN Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765977
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Tisdale MJ Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8380931
Brestel EP and Koes MT Heparin inhibits the "quasi-lipoxygenase" activity of hemoglobin toward linoleic acid by oxidant scavenging. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2500671
Crandall DL et al. Effect of varying concentrations of linoleic acid on alpha-adrenoceptor responses in spontaneously hypertensive rats. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:2845438
Louw L and Dannhauser A Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090250
Louw L Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090251