Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Bylund J et al. | Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435160 |
Kaur K et al. | (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. | 1997 | Chem. Res. Toxicol. | pmid:9437530 |
Berry H et al. | Oxygen concentration determines regiospecificity in soybean lipoxygenase-1 reaction via a branched kinetic scheme. | 1998 | J. Biol. Chem. | pmid:9446584 |
Hamberg M | Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. | 1998 | Arch. Biochem. Biophys. | pmid:9448728 |
Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
Maheswari SU et al. | Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. | 1997 | Mol. Cell. Biochem. | pmid:9450644 |
van Roermund CW et al. | Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions. | 1998 | EMBO J. | pmid:9450993 |
Dadras SS et al. | Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. | 1998 | Int. J. Oncol. | pmid:9454884 |
Devor DC and Frizzell RA | Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. | 1998 | Am. J. Physiol. | pmid:9458723 |
Herbel BK et al. | Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9459383 |
Pomposiello SI et al. | Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery. | 1998 | Hypertension | pmid:9461230 |
Bouwstra JA et al. | Role of ceramide 1 in the molecular organization of the stratum corneum lipids. | 1998 | J. Lipid Res. | pmid:9469597 |
Agostoni C et al. | Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children. | 1998 | J Am Coll Nutr | pmid:9477386 |
Iwase H et al. | Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9480835 |
Chisholm A et al. | A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. | 1998 | Eur J Clin Nutr | pmid:9481526 |
Pareja A et al. | Unsaturated fatty acids alter the insulin secretion response of the islets of Langerhans in vitro. | 1997 | Diabetes Res. Clin. Pract. | pmid:9483379 |
Bogdanov KY et al. | Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. | 1998 | Am. J. Physiol. | pmid:9486261 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Bremmer DR et al. | Effects of chain length and unsaturation of fatty acid mixtures infused into the abomasum of lactating dairy cows. | 1998 | J. Dairy Sci. | pmid:9493093 |
Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
Mourek J and Dohnalová A | Relationship between birth weight of newborns and unsaturated fatty acid(n-3) proportions in their blood serum. | 1996 | Physiol Res | pmid:9496767 |
Saha SK et al. | Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. | 1997 | Jpn. J. Physiol. | pmid:9504135 |
Dänicke S et al. | Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. | 1997 | Br. Poult. Sci. | pmid:9511000 |
Freyaldenhoven MA et al. | Retinoic acid-dependent stimulation of 2,2'-azobis(2-amidinopropane)-initiated autoxidation of linoleic acid in sodium dodecyl sulfate micelles: a novel prooxidant effect of retinoic acid. | 1998 | Chem. Res. Toxicol. | pmid:9511901 |
Jiang WG et al. | The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. | 1998 | Br. J. Cancer | pmid:9514051 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Böhmer S et al. | Oxidation of phenanthrene by a fungal laccase in the presence of 1-hydroxybenzotriazole and unsaturated lipids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514895 |
Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
van der Veen C et al. | Factors affecting events during oxidation of low density lipoprotein: correlation of multiple parameters of oxidation. | 1997 | Free Radic. Res. | pmid:9518063 |
Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |
Liang JF and Akaike T | Protective effect of linoleic acid on IFN gamma-induced cellular injury in primary culture hepatocytes. | 1998 | J. Biochem. | pmid:9538194 |
Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
Voskuyl RA et al. | Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. | 1998 | Eur. J. Pharmacol. | pmid:9543232 |
Matthys LA and Widmaier EP | Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis. | 1998 | Horm. Metab. Res. | pmid:9543689 |
Liu SX et al. | Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. | 1998 | Atherosclerosis | pmid:9544730 |
Camacho M et al. | IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547616 |
Louw L et al. | Impairment in the fatty acid composition of keloids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547645 |
Louw L et al. | Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. | 1997 | Adv. Exp. Med. Biol. | pmid:9547646 |
Louw L et al. | The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. | 1997 | Adv. Exp. Med. Biol. | pmid:9547647 |
Li-Stiles B et al. | Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes. | 1998 | J. Lipid Res. | pmid:9548589 |
Kataoka K et al. | Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. | 1998 | Pancreas | pmid:9548669 |
Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
Romanini D et al. | Absorption and fluorescence spectra of polyene antibiotics in the presence of human serum albumin. | 1998 | Biochem. Mol. Biol. Int. | pmid:9556221 |
Rosenfield RL et al. | Mechanisms of androgen induction of sebocyte differentiation. | 1998 | Dermatology (Basel) | pmid:9557223 |
Akamatsu H and Horio T | The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. | 1998 | Dermatology (Basel) | pmid:9557235 |
Kowaltowski AJ et al. | Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. | 1998 | FEBS Lett. | pmid:9559650 |
Sugiyama K et al. | Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats. | 1998 | Lipids | pmid:9560797 |
You YQ et al. | Effect of continuous enteral medium-chain fatty acid infusion on lipid metabolism in rats. | 1998 | Lipids | pmid:9560800 |
Hörnsten L et al. | Bisallylic hydroxylation of linoleic and arachidonic acids by adult and fetal human liver microsomes and a comparison with human recombinant cytochromes P450. | 1997 | Adv. Exp. Med. Biol. | pmid:9561118 |
Riambau V et al. | Effect of linoleic acid supplements on vessel wall hyperplasia in rabbits. | 1997 | Adv. Exp. Med. Biol. | pmid:9561150 |