Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Biliary Atresia D001656 4 associated lipids
Leptospirosis D007922 2 associated lipids
Cachexia D002100 21 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Ascites D001201 25 associated lipids
Tremor D014202 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Disease D004194 2 associated lipids
Parkinson Disease D010300 53 associated lipids
Keloid D007627 12 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Alghazeer R et al. Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). 2008 Toxicol. Lett. pmid:18625293
Mitchell LA et al. Linoleic acid, cis-epoxyoctadecenoic acids, and dihydroxyoctadecadienoic acids are toxic to Sf-21 cells in the absence of albumin. 2002 Toxicol. Lett. pmid:11814707
Moran JH et al. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. 2000 Toxicol. Appl. Pharmacol. pmid:11042099
Ha J et al. Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. 2002 Toxicol. Appl. Pharmacol. pmid:12127265
Moran JH et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. 1997 Toxicol. Appl. Pharmacol. pmid:9299596
Moran JH et al. Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. 2001 Toxicol. Appl. Pharmacol. pmid:11714247
Yu WK and Wells PG Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. 1995 Toxicol. Appl. Pharmacol. pmid:7878664
Wey HE et al. Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation. 1993 Toxicol. Appl. Pharmacol. pmid:8511784
Moran JH et al. Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. 2001 Toxicol. Appl. Pharmacol. pmid:11298501
Slim R et al. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. 2001 Toxicol. Appl. Pharmacol. pmid:11243918
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
Blum JL et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. 2011 Toxicol In Vitro pmid:21443943
Okabe H et al. Effects of anti-convulsants on fatty acid metabolism in human serum. 1986 Tohoku J. Exp. Med. pmid:3705068
Sakayori N et al. Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice. 2016 Tohoku J. Exp. Med. pmid:27558477
OJI K CLINICAL EVALUATION OF LINOLEIC ACID IN THE TREATMENT OF CHRONIC LIVER DISEASES. 1964 Tijdschr Gastroenterol pmid:14272174
Coene MC et al. Inhibition of rabbit platelet activation by lipoxygenase products of arachidonic and linoleic acid. 1986 Thromb. Res. pmid:3087009
Vericel E et al. Effects of linoleic acid and gamma-linolenic acid intake on platelet functions in elderly people. 1986 Thromb. Res. pmid:3715813
Pirich C et al. Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. 1999 Thromb. Res. pmid:10588465
Setty BN et al. 1-Deamino-8 D-arginine vasopressin decreases the production of 13-hydroxyoctadecadienoic acid by endothelial cells. 1992 Thromb. Res. pmid:1448788
Salo MK et al. Platelet aggregation in Finnish men and its relation to fatty acids in platelets, plasma and adipose tissue. 1985 Thromb. Haemost. pmid:4089791