Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Coronary Restenosis D023903 10 associated lipids
Myocardial Stunning D017682 10 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Wounds, Penetrating D014950 10 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Hubbard VS and McKenna MC Absorption of safflower oil and structured lipid preparations in patients with cystic fibrosis. 1987 Lipids pmid:3613873
Marshall LA and Johnston PV Modulation of tissue prostaglandin synthesizing capacity by increased ratios of dietary alpha-linolenic acid to linoleic acid. 1982 Lipids pmid:6298554
Mann NJ et al. The effect of linoleic, arachidonic and eicosapentaenoic acid supplementation on prostacyclin production in rats. 1994 Lipids pmid:8170284
Wien M et al. Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. 2010 Lipids pmid:20496049
Hansen HS Essential fatty acid-supplemented diet decreases renal excretion of immunoreactive arginine-vasopressin in essential fatty acid-deficient rats. 1982 Lipids pmid:7078362
Eisen EJ et al. Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity. 1982 Lipids pmid:7087689
Gruffat D et al. In vitro comparison of hepatic metabolism of 9cis-11 trans and 10trans-12cis isomers of CLA in the rat. 2003 Lipids pmid:12733748
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Cunnane SC et al. Magnetic resonance imaging-based balance analysis of linoleate utilization during weight loss in obese humans. 1999 Lipids pmid:10419101
Matsui K and Kajiwara T Cucumber cotyledon lipoxygenase oxygenizes trilinolein at the lipid/water interface. 1995 Lipids pmid:7475989
Belza K et al. Carbon recycling from linoleate during severe dietary linoleate deficiency. 1999 Lipids pmid:10419120
Cunnane SC et al. Synthesis of linoleate and alpha-linolenate by chain elongation in the rat. 1995 Lipids pmid:7475996
Babin F et al. Suspicion of latent delta5-desaturase and peroxisomal beta-oxidation deficiency in elderly women over 75 years of age. 1999 Lipids pmid:10419136
Spartano NL et al. Linoleic acid suppresses cholesterol efflux and ATP-binding cassette transporters in murine bone marrow-derived macrophages. 2014 Lipids pmid:24595513
Gardner HW and Deighton N Effect of 4-hydroxy-2(E)-nonenal on soybean lipoxygenase-1. 2001 Lipids pmid:11485167
Scislowski V et al. Dietary linoleic acid-induced hypercholesterolemia and accumulation of very light HDL in steers. 2004 Lipids pmid:15134139
Fukushima M et al. Comparative hypocholesterolemic effects of six vegetable oils in cholesterol-fed rat. 1996 Lipids pmid:8743054
Mathias MM and Dupont J Quantitative relationships between dietary linoleate and prostaglandin (eicosanoid) biosynthesis. 1985 Lipids pmid:4068908
Schneider C et al. Analysis of lipoxygenase-derived fatty acid hydroperoxides by electrospray ionization tandem mass spectrometry. 1997 Lipids pmid:9076671
Venkatraman JT et al. Influence of genotype on diet-induced changes in membrane phosphatidylcholine and phosphatidylethanolamine composition of splenocytes, liver nuclear envelope and liver mitochondria. 1991 Lipids pmid:2046486
Handelman GJ et al. Biopsy method for human adipose with vitamin E and lipid measurements. 1988 Lipids pmid:3172989
Elabbadi N et al. Regulation of phosphatidic acid phosphohydrolase 1 by fatty acids. 2002 Lipids pmid:11876265
Vázquez CM et al. Changes in fatty acid desaturation in hepatic and intestinal tissues induced by intestinal resection. 1993 Lipids pmid:8316056
Schilstra MJ et al. Effect of nonionic detergents on lipoxygenase catalysis. 1994 Lipids pmid:8177015
Jie MS et al. Synthesis and nuclear magnetic resonance properties of all geometrical isomers of conjugated linoleic acids. 1997 Lipids pmid:9358429
de Tomás ME et al. Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats. 1991 Lipids pmid:1687158
Rondanelli M et al. Effects of two-months balanced diet in metabolically healthy obesity: lipid correlations with gender and BMI-related differences. 2015 Lipids Health Dis pmid:26511930
Min JS et al. Monitoring the formation of cholesterol oxidation products in model systems using response surface methodology. 2015 Lipids Health Dis pmid:26201850
Song Y et al. Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. 2013 Lipids Health Dis pmid:23879935
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Tang KS Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. 2014 Lipids Health Dis pmid:25522984
Maruyama H et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. 2014 Lipids Health Dis pmid:24885871
Dai J et al. Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. 2013 Lipids Health Dis pmid:23663688
Nasrollahzadeh J et al. The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. 2008 Lipids Health Dis pmid:19014610
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
Shen J et al. Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. 2012 Lipids Health Dis pmid:22781401
Bjørkkjaer T et al. Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease. 2006 Lipids Health Dis pmid:16549021
Muralikumar S et al. Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. 2017 Lipids Health Dis pmid:28109294
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Karupaiah T et al. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design. 2016 Lipids Health Dis pmid:27535127
Lu X et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. 2010 Lipids Health Dis pmid:20868498
Yoshiki Y et al. Chemiluminescence and reactive oxygen scavenging activities of the hydrogen peroxide/gallic acid/lactoperoxidase system. 2000 May-Jun Luminescence pmid:10862147
Stantcheva IG et al. Metabolic fate of fatty acids in type II cells isolated from adult rat lung. 1982 Lung pmid:7121064
MAYOUX et al. [Not Available]. 1949 Lyon Med pmid:18136286
Delmas-Beauvieux MC et al. Liposomes as fatty acids carriers in isolated rat liver: effect on energy metabolism and on isolated mitochondria activity. 2000 MAGMA pmid:10697225
Marinho GS et al. Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. 2015 Mar Drugs pmid:26184241
Yang Z and Huffman SL Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. 2013 Matern Child Nutr pmid:23167585
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Briend A et al. Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. 2011 Matern Child Nutr pmid:21366873
Parra-Cabrera S et al. Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. 2011 Matern Child Nutr pmid:21410881
Jokela H et al. Fatty acid and cholesterol composition of the uterine artery intima in relation to menopausal status, age, and serum cholesterol. 2004 Maturitas pmid:14757270
Jung S et al. Effect of dietary mixture of gallic acid and linoleic acid on antioxidative potential and quality of breast meat from broilers. 2010 Meat Sci. pmid:20609528
Jacob RH et al. Phenotypic characterisation of colour stability of lamb meat. 2014 Meat Sci. pmid:23415827
Moloney AP et al. Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. 2013 Meat Sci. pmid:23806853
Van Ba H et al. Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. 2013 Meat Sci. pmid:23632107
Zamora-Rojas E et al. Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. 2013 Meat Sci. pmid:23793086
Dal Bosco A et al. Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. 2014 Meat Sci. pmid:24036258
Jin G et al. Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. 2011 Meat Sci. pmid:21093161
Toomik P et al. The effect of tenderizing acids on linoleic acid oxidation during marination of pork. 2012 Meat Sci. pmid:22762994
Tume RK et al. Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. 2010 Meat Sci. pmid:20374755
Berthelot V et al. Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. 2010 Meat Sci. pmid:20374762
Della Casa G et al. Performance and fat quality of heavy pigs fed maize differing in linoleic acid content. 2010 Meat Sci. pmid:20374768
Aldai N et al. Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. 2010 Meat Sci. pmid:20374865
Song S et al. Identification of pork flavour precursors from enzyme-treated lard using Maillard model system assessed by GC-MS and partial least squares regression. 2017 Meat Sci. pmid:27792915
Hoffman LC et al. Lipid and protein stability and sensory evaluation of ostrich (Struthio camelus) droëwors with the addition of rooibos tea extract (Aspalathus linearis) as a natural antioxidant. 2014 Meat Sci. pmid:24334052
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Sohal RS et al. Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. 1984 Mech. Ageing Dev. pmid:6330462
Spiteller G Peroxidation of linoleic acid and its relation to aging and age dependent diseases. 2001 Mech. Ageing Dev. pmid:11322990
Haro AM et al. [Linoleic conjugated acid: current interest in human nutrition]. 2006 Med Clin (Barc) pmid:17043006
Campoy C et al. [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. 2010 Med Clin (Barc) pmid:20434734
KRITCHEVSKY D and TEPPER SA INFLUENCE OF FATTY ACIDS ON SERUM AND LIVER CHOLESTEROL IN RATS. 1964 Med Exp Int J Exp Med pmid:14165723
Pariza MW and Ha YL Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. 1990 Med Oncol Tumor Pharmacother pmid:2232933
Poompachee K and Chudapongse N Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. 2012 Med Princ Pract pmid:22024634
SOSNOVSKII AT [TREATMENT OF EXPERIMENTAL RADIATION INJURY TO THE SKIN WITH CYGEROL AND LINOL]. 1964 Med Radiol (Mosk) pmid:14234245
ROTH OA [Improved wound healing through linoleic and linolenic acid]. 1951 Med Welt pmid:14882090
Nanji AA and Narod S Multiple sclerosis, latitude and dietary fat: is pork the missing link? 1986 Med. Hypotheses pmid:3638477
Van Aswegen CH and Du Plessis DJ Can linoleic acid and gamma-linolenic acid be important in cancer treatment? 1994 Med. Hypotheses pmid:7739415
McCarty MF Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. 2001 Med. Hypotheses pmid:11425277
McCarty MF The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes. 2001 Med. Hypotheses pmid:11425290
Simpson LO The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis. 1988 Med. Hypotheses pmid:3367811
McCarty MF Toward a wholly nutritional therapy for type 2 diabetes. 2000 Med. Hypotheses pmid:10783493
Reid G Metabolic disorders of cattle. 1993 Med. Hypotheses pmid:8394500
Sammon AM and Iputo JE Maize meal predisposes to endemic squamous cancer of the oesophagus in Africa: breakdown of esterified linoleic acid to the free form in stored meal leads to increased intragastric PGE2 production and a low-acid reflux. 2006 Med. Hypotheses pmid:16824700
Heleniak EP and Lamola SW A new prostaglandin disturbance syndrome in schizophrenia: delta-6-pyroluria. 1986 Med. Hypotheses pmid:3520252
Nestel PJ The role of fats in the lifecycle stages. Adulthood--prevention: cardiovascular disease. 2002 Med. J. Aust. pmid:12064973
Cvetković Z et al. Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin's lymphoma patients. 2013 Med. Oncol. pmid:24085546
Ristić V and Ristić G [Role and importance of dietary polyunsaturated fatty acids in the prevention and therapy of atherosclerosis]. 2003 Jan-Feb Med. Pregl. pmid:12793187
Chaitidis P et al. Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines. 2005 Med. Sci. Monit. pmid:16049371
ISSELBACHER KJ et al. CONGENITAL BETA-LIPOPROTEIN DEFICIENCY: AN HEREDITARY DISORDER INVOLVING A DEFECT IN THE ABSORPTION AND TRANSPORT OF LIPIDS. 1964 Medicine (Baltimore) pmid:14168744
Zhao J et al. Dietary fat intake and endometrial cancer risk: A dose response meta-analysis. 2016 Medicine (Baltimore) pmid:27399120
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
NESTEL PJ METABOLISM OF LINOLEATE AND PALMITATE IN PATIENTS WITH HYPERTRIGLYCERIDEMIA AND HEART DISEASE. 1965 Metab. Clin. Exp. pmid:14252339
Jung CH et al. The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. 2013 Metab. Clin. Exp. pmid:23639572
ORMSBY JW et al. THE INCORPORATION OF LINOLEIC-1-C14 ACID IN HUMAN PLASMA AND ADIPOSE TISSUE. 1963 Metab. Clin. Exp. pmid:14062764
Berlin E et al. Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women. 1989 Metab. Clin. Exp. pmid:2761416
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Perona JS et al. Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. 2011 Metab. Clin. Exp. pmid:20934731