Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Coronary Restenosis D023903 10 associated lipids
Myocardial Stunning D017682 10 associated lipids
Wounds, Penetrating D014950 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
NESTEL PJ METABOLISM OF LINOLEATE AND PALMITATE IN PATIENTS WITH HYPERTRIGLYCERIDEMIA AND HEART DISEASE. 1965 Metab. Clin. Exp. pmid:14252339
Siguel EN and Lerman RH Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. 1994 Metab. Clin. Exp. pmid:8052156
Meerarani P et al. Cholesterol attenuates linoleic acid-induced endothelial cell activation. 2003 Metab. Clin. Exp. pmid:12701065
Wang L et al. The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. 2008 Metab. Clin. Exp. pmid:18803934
Jung CH et al. The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. 2013 Metab. Clin. Exp. pmid:23639572
Even P et al. Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. 2010 Metab. Clin. Exp. pmid:19775712
Jones PJ et al. The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. 2008 Metab. Clin. Exp. pmid:18702944
Pelikánová T et al. Serum phospholipid fatty acid composition and insulin action in type 2 diabetic patients. 2001 Metab. Clin. Exp. pmid:11735096
Yang J et al. Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. 1994 Metab. Clin. Exp. pmid:7914345
Fernández-Real JM et al. Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. 2001 Metab. Clin. Exp. pmid:11735097
Hennig B et al. Fatty acid-mediated activation of vascular endothelial cells. 2000 Metab. Clin. Exp. pmid:10954018
Felton CV et al. Erythrocyte-derived measures of membrane lipid composition in healthy men: associations with arachidonic acid at low to moderate but not high insulin sensitivity. 2004 Metab. Clin. Exp. pmid:15131759
CARLSTEN A et al. MYOCARDIAL ARTERIOVENOUS DIFFERENCES OF INDIVIDUAL FREE FATTY ACIDS IN HEALTHY HUMAN INDIVIDUALS. 1963 Metab. Clin. Exp. pmid:14100278
Pitchumoni S et al. Reoxygenation injury affects isolated islet response to fatty acid stimulation. 1998 Metab. Clin. Exp. pmid:9667226
ORMSBY JW et al. THE INCORPORATION OF LINOLEIC-1-C14 ACID IN HUMAN PLASMA AND ADIPOSE TISSUE. 1963 Metab. Clin. Exp. pmid:14062764
Dichtl W et al. Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-kappaB activation. 2002 Metab. Clin. Exp. pmid:11887169
Berlin E et al. Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women. 1989 Metab. Clin. Exp. pmid:2761416
Siguel EN and Lerman RH Prevalence of essential fatty acid deficiency in patients with chronic gastrointestinal disorders. 1996 Metab. Clin. Exp. pmid:8544768
Ollero M et al. Evidence of increased flux to n-6 docosapentaenoic acid in phospholipids of pancreas from cftr-/- knockout mice. 2006 Metab. Clin. Exp. pmid:16919538
Klein A et al. The effect of fatty acids on the vulnerability of lymphocytes to cortisol. 1989 Metab. Clin. Exp. pmid:2537454
Hamel FG Preliminary report: inhibition of cellular proteasome activity by free fatty acids. 2009 Metab. Clin. Exp. pmid:19423142
Perona JS et al. Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. 2011 Metab. Clin. Exp. pmid:20934731
Romon M et al. Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. 1995 Metab. Clin. Exp. pmid:7666786
Kwok CF et al. Linoleic acid and oleic acid increase the endothelin-1 binding and action in cultured rat aortic smooth muscle cells. 2000 Metab. Clin. Exp. pmid:11092498
Banti CN et al. Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. 2012 Metallomics pmid:22552402
Murphy DJ and Stumpf PK Polyunsaturation systems from higher plants. 1981 Meth. Enzymol. pmid:7311864
Christen MO et al. Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. 1995 Meth. Enzymol. pmid:7476369
Stocker R et al. Antioxidant activities of bile pigments: biliverdin and bilirubin. 1990 Meth. Enzymol. pmid:2233302
Kovár J and Franĕk F Serum-free medium for hybridoma and parental myeloma cell cultivation. 1986 Meth. Enzymol. pmid:3523123
Livrea MA and Tesoriere L Lipoperoxyl radical-scavenging activity of vitamin A and analogs in homogeneous solution. 1994 Meth. Enzymol. pmid:7808312
Miura K et al. The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors. 1997 Methods Find Exp Clin Pharmacol pmid:9203161
Armstrong D et al. Preparation of microspheres and incorporation of lipid hydroperoxide for sustained release studies. 2002 Methods Mol. Biol. pmid:12152211
Devillard E et al. Differences between human subjects in the composition of the faecal bacterial community and faecal metabolism of linoleic acid. 2009 Microbiology (Reading, Engl.) pmid:19202099
Wilson RA et al. Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction. 2004 Microbiology (Reading, Engl.) pmid:15347747
Goodrich-Tanrikulu M et al. Changes in fatty acid composition of Neurospora crassa accompany sexual development and ascospore germination. 1998 Microbiology (Reading, Engl.) pmid:9695905
Murayama SY et al. Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. 2006 Microbiology (Reading, Engl.) pmid:16622072
Chatterjee MT et al. Alterations in cellular lipids may be responsible for the transient nature of the yeast heat shock response. 1997 Microbiology (Reading, Engl.) pmid:9308188
Rosberg-Cody E et al. Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid. 2007 Microbiology (Reading, Engl.) pmid:17660413
Rosberg-Cody E et al. Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. 2011 Microbiology (Reading, Engl.) pmid:21178166
Stewart CJ et al. Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease. 2016 Microbiome pmid:28034304
Mysiakina IS et al. [Lipid composition of fungus Mucor hiemalis mycelium grown in the presence of trehalose, triacylglycerols, and itraconazole]. 2012 Nov-Dec Mikrobiologiia pmid:23610922
Mysiakina IS et al. [Effect of biological factors on morphogenesis, growth, and lipid composition of fungus Mucor hiemalis mycelium]. 2012 Nov-Dec Mikrobiologiia pmid:23610923
Feofilova EP et al. [Biochemical mechanisms of temperature adaptation in the (+) and (-) strains of Blakeslea trispora]. 2005 Nov-Dec Mikrobiologiia pmid:16400984
GORBACH G and MALISSA H [Not Available]. 1947 Mikrochemie pmid:18921865
CORTELLA E [Vitamin F in therapy of psoriasis]. 1952 Minerva Dermatol pmid:12982586
Salzano P et al. [Prevention of gestational hypertension with calcium, linoleic acid, mono and polyunsaturated fatty acid supplements]. 2001 Minerva Ginecol pmid:11431639
Fritsche KL Linoleic acid, vegetable oils & inflammation. 2014 Jan-Feb Mo Med pmid:24645297
Shen SR et al. Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines. 2007 Mol Nutr Food Res pmid:17262883
Lagarde M et al. Lipidomics of essential fatty acids and oxygenated metabolites. 2013 Mol Nutr Food Res pmid:23818385
Fang IM et al. Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. 2009 Mol Nutr Food Res pmid:19437483
Reynolds CM et al. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. 2012 Mol Nutr Food Res pmid:22700321
Staprans I et al. The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. 2005 Mol Nutr Food Res pmid:16270280
Bradley RM et al. Influence of tissue, diet, and enzymatic remodeling on cardiolipin fatty acyl profile. 2016 Mol Nutr Food Res pmid:27061349
Lindenmeier M et al. A novel method to measure both the reductive and the radical scavenging activity in a linoleic acid model system. 2007 Mol Nutr Food Res pmid:17680718
Ruparel S et al. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 2012 Mol Pain pmid:23006841
Green D et al. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. 2016 Mol Pain pmid:27411353
Ramsden CE et al. Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? 2016 Mol Pain pmid:27030719
Abdel Baset H et al. Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni. 1995 Mol. Biochem. Parasitol. pmid:8577345
Rainey PM et al. Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture. 1991 Mol. Biochem. Parasitol. pmid:1775152
Alloatti A and Uttaro AD Highly specific methyl-end fatty-acid desaturases of trypanosomatids. 2011 Mol. Biochem. Parasitol. pmid:20974196
Buckley MT et al. Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes. 2017 Mol. Biol. Evol. pmid:28333262
Luo X et al. Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. 2013 Mol. Biol. Rep. pmid:24062071
Moonen HJ et al. Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. 2004 Mol. Carcinog. pmid:15224350
Thuillier P et al. Activators of peroxisome proliferator-activated receptor-alpha partially inhibit mouse skin tumor promotion. 2000 Mol. Carcinog. pmid:11108658
Eren R and Duksin D Inhibition of the formation of lipid-linked intermediates in normal and transformed cells by a purified tunicamycin homologue. 1985 Mol. Cell. Biochem. pmid:2991743
Berdeaux O et al. In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes. 1998 Mol. Cell. Biochem. pmid:9746207
Huang YS et al. N-3 and n-6 fatty acid metabolism in undifferentiated and differentiated human intestine cell line (Caco-2). 1995 Mol. Cell. Biochem. pmid:8569757
Narce M et al. Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats. 1994 Mol. Cell. Biochem. pmid:7877612
Ves-Losada A and Brenner RR Long-chain fatty Acyl-CoA synthetase enzymatic activity in rat liver cell nuclei. 1996 Mol. Cell. Biochem. pmid:8813703
Chang W et al. Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells. 2001 Mol. Cell. Biochem. pmid:11506175
Kitts DD et al. Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. 1999 Mol. Cell. Biochem. pmid:10705999
Bordoni A et al. Metabolism of linoleic and alpha-linolenic acids in cultured cardiomyocytes: effect of different N-6 and N-3 fatty acid supplementation. 1996 Apr 12-26 Mol. Cell. Biochem. pmid:8739249
Tappia PS et al. Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. 1995 Mol. Cell. Biochem. pmid:7596352
Raju M et al. Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the beta-carotene uptake and its cleavage into retinol in rats. 2006 Mol. Cell. Biochem. pmid:16845492
Szachowicz-Petelska B et al. Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue. 2007 Mol. Cell. Biochem. pmid:16858511
Huang YS et al. Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. 2011 Mol. Cell. Biochem. pmid:21688154
Grasso EJ and Calderón RO Urinary bladder membrane permeability differentially induced by membrane lipid composition. 2009 Mol. Cell. Biochem. pmid:19412731
Maheswari SU et al. Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. 1997 Mol. Cell. Biochem. pmid:9450644
Liu WM et al. Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes. 2011 Mol. Cell. Biochem. pmid:21274596
Kelder B et al. Expression of fungal desaturase genes in cultured mammalian cells. 2001 Mol. Cell. Biochem. pmid:11354256
Kim S et al. C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. 1999 Mol. Cell. Biol. pmid:10409760
Grammatopoulos D et al. The human myometrial CRH receptor: G proteins and second messengers. 1994 Mol. Cell. Endocrinol. pmid:8206332
Plaisance V et al. Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. 2009 Mol. Cell. Endocrinol. pmid:19133313
Warnotte C et al. Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. 1999 Mol. Cell. Endocrinol. pmid:10459862
Kim SY et al. S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. 2013 Mol. Cells pmid:24046187
Lee C et al. Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18. 2003 Mol. Cells pmid:12661762
Lee MJ et al. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. 2011 Mol. Cells pmid:21331775
Sakai H and Kajiwara S Cloning and functional characterization of a Delta12 fatty acid desaturase gene from the basidiomycete Lentinula edodes. 2005 Mol. Genet. Genomics pmid:15838640
Ripoll-Rozada J et al. Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. 2016 Mol. Microbiol. pmid:26915347
King LM et al. Cloning of CYP2J2 gene and identification of functional polymorphisms. 2002 Mol. Pharmacol. pmid:11901223
Glasgow WC and Eling TE Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. 1990 Mol. Pharmacol. pmid:2233691
Farkas O et al. Quantitative structure-antioxidant activity relationships of flavonoid compounds. 2004 Molecules pmid:18007505
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Sandoval-Montemayor NE et al. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. 2012 Molecules pmid:22992784
Ndhlala AR et al. Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. 2013 Molecules pmid:23377133
Olszewska MA et al. Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. 2010 Molecules pmid:21127463
Manzoor M et al. Variation in minerals, phenolics and antioxidant activity of peel and pulp of different varieties of peach (Prunus persica L.) fruit from Pakistan. 2012 Molecules pmid:22728349
Ambrozova JV et al. Influence of extractive solvents on lipid and fatty acids content of edible freshwater algal and seaweed products, the green Microalga Chlorella kessleri and the Cyanobacterium Spirulina platensis. 2014 Molecules pmid:24566307
Bazongo P et al. Characteristics, composition and oxidative stability of Lannea microcarpa seed and seed oil. 2014 Molecules pmid:24566330
Gull J et al. Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. 2012 Molecules pmid:22418924