| MeSH term | MeSH ID | Detail |
|---|---|---|
| Retinal Degeneration | D012162 | 9 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
| Myocardial Stunning | D017682 | 10 associated lipids |
| Wounds, Penetrating | D014950 | 10 associated lipids |
| Dry Eye Syndromes | D015352 | 10 associated lipids |
| Dermatitis, Seborrheic | D012628 | 10 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Foreign-Body Reaction | D005549 | 10 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wieland E et al. | Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8327462 |
| Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
| Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
| Baker PR et al. | Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273286 |
| Whittle EJ et al. | Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18796606 |
| Jiang Q et al. | gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15596715 |
| Asaoka Y et al. | Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8099446 |
| Kliewer SA et al. | Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8041794 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
| Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
| Hill EG et al. | Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6951178 |
| Lange LG | Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6955782 |
| Keler T et al. | Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1594582 |
| REISER R | Conjugated linoleic acid in rat tissue lipids after ingestion as free acid and as triglyceride. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:14781143 |
| STEIN O and STEIN Y | FATTY ACID METABOLISM BY IN VIVO LABELED ADIPOSE TISSUE IN ESSENTIAL FATTY ACID DEFICIENT RATS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14264515 |
| SWELL L et al. | ESTERIFICATION OF CHOLESTEROL BY CANINE ADRENAL CELL FRACTIONS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14297887 |
| Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
| KRITCHEVSKY D and TEPPER SA | AUTOXIDATION OF METHYL LINOLEATE: EFFECT OF SEX HORMONES AND OF NICOTINIC ACID AND RELATED COMPOUNDS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14155843 |
| WALKER BL and KUMMEROW FA | ERYTHROCYTE FATTY ACID COMPOSITION AND APPARENT PERMEABILITY TO NON-ELECTROLYTES. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14166569 |
| TUREEN LL et al. | EFFECT OF HIGH LINOLEIC ACID AND ANTIOXIDANT DEFICIENT DIET ON BLOOD SERUM PROTEINS IN CHICKS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14121629 |
| DESAI ID et al. | PEROXIDATION AND LYSOSOMES IN NUTRITIONAL MUSCULAR DYSTROPHY OF CHICKS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14121639 |
| HOPKINS DT et al. | A RESPIRATORY DISEASE SYNDROME IN CHICKENS FED ESSENTIAL FATTY ACID DEFICIENT DIETS. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:14076921 |
| SWELL L et al. | Influence of a family diet pattern high in linoleic acid on serum cholesterol level: one year study. | 1962 | Proc. Soc. Exp. Biol. Med. | pmid:13979681 |
| HOLMAN RT | Metabolism of isomers of linoleic and linolenic acids. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816402 |
| GORDON S and MEAD JF | CONVERSION OF LINOLEIC-1-C14 ACID TO ARACHIDONIC ACID IN THE GERBIL. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14194646 |
| Izumi Y et al. | Effects of dietary linoleic acid on blood pressure and renal function in subtotally nephrectomized rats. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3532127 |
| Johnston DV and Marshall LA | Dietary fat, prostaglandins and the immune response. | 1984 | Prog Food Nutr Sci | pmid:6091179 |
| Champe SP et al. | Sexual sporulation. | 1994 | Prog Ind Microbiol | pmid:7765136 |
| Jones R et al. | Monitoring changes in the blood of patients with multiple sclerosis. | 1983 | Prog. Brain Res. | pmid:6665128 |
| Rey HG et al. | Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. | 1988 | Prog. Clin. Biol. Res. | pmid:2906133 |
| Vergroesen AJ | Effects of dietary lipid composition on serum lipoproteins. | 1985 | Prog. Clin. Biol. Res. | pmid:3903769 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
| Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
| Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
| Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
| Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
| Cunnane SC | Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. | 1981 | Prog. Lipid Res. | pmid:7342114 |
| Lynn WS et al. | Linoleic acid: a specific cytotaxin for macrophages. | 1981 | Prog. Lipid Res. | pmid:7342119 |
| Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
| Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
| Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
| Holman RT | Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids. | 1986 | Prog. Lipid Res. | pmid:3423089 |
| Burr GO | The essential fatty acids fifty years ago. | 1981 | Prog. Lipid Res. | pmid:7043474 |
| Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
| Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
| Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
| Murphy MG | Increasing membrane polyunsaturated fatty-acid content augments cyclic AMP formation and prostaglandin production in NIE-115 neuroblastoma. | 1984 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:6099586 |
| Sakuma S et al. | Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. | 1993 | Prostaglandins | pmid:8210445 |
| Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |
| Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
| Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
| Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
| Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
| Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
| Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
| Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
| Bronstein JC and Bull AW | The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. | 1993 | Prostaglandins | pmid:8278616 |
| Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
| Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
| Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |
| Singer P et al. | Defective desaturation and elongation of n-6 and n-3 fatty acids in hypertensive patients. | 1984 | Prostaglandins Leukot Med | pmid:6387718 |
| Kher V et al. | Protective effect of polyunsaturated fatty acid supplementation in apoferritin induced murine glomerulonephritis. | 1986 | Prostaglandins Leukot Med | pmid:3014561 |
| Huang YS et al. | Effect of dietary depletion and repletion of linoleic acid on renal fatty acid composition and urinary prostaglandin excretion. | 1984 | Prostaglandins Leukot Med | pmid:6593743 |
| Strong AM et al. | Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar. | 1984 | Prostaglandins Leukot Med | pmid:6588390 |
| Ito Y et al. | A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass. | 1987 | Prostaglandins Leukot Med | pmid:3477824 |
| Hoffmann P et al. | Augmented acute hypotensive effect of dihydralazine and clonidine after linoleic acid rich diet in normotensive conscious rats. | 1982 | Prostaglandins Leukot Med | pmid:6955801 |
| Sullivan LM and Mathias MM | Eicosanoid production in rat blood as affected by fasting and dietary fat. | 1982 | Prostaglandins Leukot Med | pmid:6956928 |
| Abeywardena MY et al. | Effects of variable linoleate intake on aortic PGI2-like activity and fatty acid composition: difference between rat and marmoset (Callithrix jacchus). | 1986 | Prostaglandins Leukot Med | pmid:3103139 |
| Hoffmann P et al. | Circadian rhythm of eicosanoid formation as affected by dietary linoleate. | 1986 | Prostaglandins Leukot Med | pmid:3547416 |
| Noguchi M et al. | Effects of indomethacin with or without linoleic acid on human breast cancer cells in vitro. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644559 |
| Simopoulos AP | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991765 |
| Galli C | Commentary on the workshop statement. Essentiality of and recommended dietary intake of Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991767 |
| Matsuo N et al. | Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951990 |
| McKenzie KE et al. | Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7535935 |
| Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
| Kim RS and Zaborniak CL | The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946549 |
| Vancassel S et al. | Plasma fatty acid levels in autistic children. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487301 |
| Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
| Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
| Ramsden CE et al. | Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147338 |
| Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
| Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20673710 |
| Gelderblom WC et al. | Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574646 |
| Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
| Tonogai Y and Tai HH | Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2111553 |
| Villa PM et al. | Free fatty acid profiles in preeclampsia. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19497719 |
| Bandyopadhyay GK et al. | Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424125 |
| Risé P et al. | Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23910046 |
| Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
| Smith DE and Salerno JW | Selective growth inhibition of a human malignant melanoma cell line by sesame oil in vitro. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1502251 |
| Mayer M | Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1815242 |
| Krumhardt B and Dupont J | The relationship between thromboxane and cytosolic calcium modifiers in rat platelets. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1652770 |
| Porras-Reyes BH et al. | Essential fatty acids are not required for wound healing. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1603819 |
| Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
| Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
| Louw L | Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090251 |
| Kritchevsky D | Trans fatty acids and cardiovascular risk. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430386 |
| Renaud SC | Dietary management of cardiovascular diseases. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430390 |