Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Cunnane SC | The Canadian Society for Nutritional Sciences 1995 Young Scientist Award Lecture. Recent studies on the synthesis, beta-oxidation, and deficiency of linoleate and alpha-linolenate: are essential fatty acids more aptly named indispensable or conditionally dispensable fatty acids? | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909772 |
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van den Boom MA et al. | The influence of a fish oil-enriched diet on the phospholipid fatty acid turnover in the rabbit red cell membrane in vivo. | 1996 | Lipids | pmid:8900458 |
Lomascolo A et al. | Study of the delta 12-desaturase system of Lipomyces starkeyi. | 1996 | Lipids | pmid:8900454 |
Avery SV et al. | Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition. | 1996 | Appl. Environ. Microbiol. | pmid:8899983 |
Ito MK and Simpson KL | The biosynthesis of omega 3 fatty acids from 18:2 omega 6 in Artemia spp. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8896333 |
Aksnes J et al. | Long term lipid-based parenteral nutrition causes pulmonary hypertension in pigs. | 1996 | Eur J Surg | pmid:8891624 |
Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
Langley-Evans SC et al. | Influence of dietary fats upon systolic blood pressure in the rat. | 1996 | Int J Food Sci Nutr | pmid:8889627 |
Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
Eder K and Kirchgessner M | Zinc deficiency and the desaturation of linoleic acid in rats force-fed fat-free diets. | 1996 | Biol Trace Elem Res | pmid:8886317 |
Van Nevel CJ and Demeyer DI | Influence of pH on lipolysis and biohydrogenation of soybean oil by rumen contents in vitro. | 1996 | Reprod. Nutr. Dev. | pmid:8881592 |
Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
Lammoglia MA et al. | Effects of dietary fat and season on steroid hormonal profiles before parturition and on hormonal, cholesterol, triglycerides, follicular patterns, and postpartum reproduction in Brahman cows. | 1996 | J. Anim. Sci. | pmid:8880430 |
Godessart N et al. | Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta. | 1996 | J. Invest. Dermatol. | pmid:8875957 |
Belury MA et al. | Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. | 1996 | Nutr Cancer | pmid:8875552 |
Schingoethe DJ et al. | Lactational responses of dairy cows fed unsaturated fat from extruded soybeans or sunflower seeds. | 1996 | J. Dairy Sci. | pmid:8872718 |
Schurz HH et al. | Products of aniline and triglycerides in oil samples associated with the toxic oil syndrome. | 1996 | Chem. Res. Toxicol. | pmid:8870988 |
Hudson JA et al. | Hydration of oleic acid by a Selenomonas strain from the ovine rumen. | 1996 | Lett. Appl. Microbiol. | pmid:8862016 |
Okaniwa Y et al. | A high linoleate and a high alpha-linolenate diet induced changes in learning behavior of rats. Effects of a shift in diets and reversal of training stimuli. | 1996 | Biol. Pharm. Bull. | pmid:8860953 |
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Canudas N et al. | Photodegradation of bezafibrate in aqueous media. Studies of its in vitro phototoxicity. | 1996 | Arzneimittelforschung | pmid:8842340 |
Glickman MH and Klinman JP | Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. | 1996 | Biochemistry | pmid:8841132 |
Essien EU et al. | Lipid composition of lesser known tropical seeds. | 1995 | Plant Foods Hum Nutr | pmid:8837872 |
Boyd NF et al. | Long-term effects of participation in a randomized trial of a low-fat, high-carbohydrate diet. | 1996 | Cancer Epidemiol. Biomarkers Prev. | pmid:8833622 |
Engberg RM et al. | Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. | 1996 | Poult. Sci. | pmid:8829233 |
Hatch GM and McClarty G | Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. | 1996 | J. Biol. Chem. | pmid:8824210 |
Toborek M et al. | Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. | 1996 | J. Lipid Res. | pmid:8820108 |
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Banni S et al. | A novel approach to study linoleic acid autoxidation: importance of simultaneous detection of the substrate and its derivative oxidation products. | 1996 | Free Radic. Res. | pmid:8814443 |
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Yamada Y et al. | Production of hydroxy fatty acid (10-hydroxy-12(Z)-octadecenoic acid) by Lactobacillus plantarum from linoleic acid and its cardiac effects to guinea pig papillary muscles. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806645 |
Porkkala-Sarataho E et al. | Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. | 1996 | Atherosclerosis | pmid:8800496 |
Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
Ain Baziz H et al. | Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. | 1996 | Poult. Sci. | pmid:8786940 |
Murphy MG | Effects of exogenous linoleic acid on fatty acid composition, receptor-mediated cAMP formation, and transport functions in rat astrocytes in primary culture. | 1995 | Neurochem. Res. | pmid:8786824 |
Fellner V et al. | Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. | 1995 | J. Dairy Sci. | pmid:8786265 |
Connolly JM et al. | Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. | 1996 | Nutr Cancer | pmid:8771566 |
Aoshima H | Potentiation and inhibition of ionotropic neurotransmitter receptors expressed in Xenopus oocyte by linoleic acid and its hydroperoxide. | 1996 | J. Neurochem. | pmid:8769897 |
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Rosenquist A and Hølmer G | Nutritional value of micro-encapsulated fish oils in rats. | 1996 | Z Ernahrungswiss | pmid:8766891 |
Wiesner R et al. | Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species. | 1996 | FEBS Lett. | pmid:8766705 |
Hrboticky N et al. | Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. | 1996 | Biochim. Biophys. Acta | pmid:8765140 |
Moghaddam M et al. | Novel metabolic pathways for linoleic and arachidonic acid metabolism. | 1996 | Biochim. Biophys. Acta | pmid:8765137 |
Dunham WR et al. | Oleic acid and linoleic acid are the major determinants of changes in keratinocyte plasma membrane viscosity. | 1996 | J. Invest. Dermatol. | pmid:8751966 |
Earashi M et al. | In vitro effects of eicosanoid synthesis inhibitors in the presence of linoleic acid on MDA-MB-231 human breast cancer cells. | 1996 | Breast Cancer Res. Treat. | pmid:8750525 |
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Cunnane SC and Yang J | Zinc deficiency impairs whole-body accumulation of polyunsaturates and increases the utilization of [1-14C]linoleate for de novo lipid synthesis in pregnant rats. | 1995 | Can. J. Physiol. Pharmacol. | pmid:8748973 |
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Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
Jenkins TC et al. | Butylsoyamide increases unsaturation of fatty acids in plasma and milk of lactating dairy cows. | 1996 | J. Dairy Sci. | pmid:8744223 |
Fukushima M et al. | Comparative hypocholesterolemic effects of six vegetable oils in cholesterol-fed rat. | 1996 | Lipids | pmid:8743054 |
Bordoni A et al. | Metabolism of linoleic and alpha-linolenic acids in cultured cardiomyocytes: effect of different N-6 and N-3 fatty acid supplementation. | 1996 Apr 12-26 | Mol. Cell. Biochem. | pmid:8739249 |
Campbell FM and Dutta-Roy AK | Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. | 1996 | Biochem. Soc. Trans. | pmid:8736907 |
Chaloner C et al. | Effect of oral supplementation with micronutrient antioxidants on trans fatty acid content of lipoproteins in healthy humans. | 1996 | Biochem. Soc. Trans. | pmid:8736849 |
Griffin ME et al. | Non-insulin-dependent diabetes mellitus: dietary monounsaturated fatty acids and low-density lipoprotein composition and function. | 1996 | QJM | pmid:8731565 |
Ziboh VA | The significance of polyunsaturated fatty acids in cutaneous biology. | 1996 | Lipids | pmid:8729128 |
Pawlosky RJ et al. | Essential fatty acid uptake and metabolism in the developing rodent brain. | 1996 | Lipids | pmid:8729103 |
Kuroe K et al. | Pericholangitis in a rabbit colitis model induced by injection of muramyl dipeptide emulsified with a long-chain fatty acid. | 1996 | J. Gastroenterol. | pmid:8726825 |