Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wieland E et al. | Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8327462 |
| Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
| Baker PR et al. | Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273286 |
| Whittle EJ et al. | Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18796606 |
| Asaoka Y et al. | Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8099446 |
| Saeki K et al. | Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15067141 |
| Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
| Wright JR et al. | Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3045812 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
| Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
| Hill EG et al. | Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6951178 |
| Lange LG | Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6955782 |
| Keler T et al. | Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1594582 |
| REISER R | Conjugated linoleic acid in rat tissue lipids after ingestion as free acid and as triglyceride. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:14781143 |
| STEIN O and STEIN Y | FATTY ACID METABOLISM BY IN VIVO LABELED ADIPOSE TISSUE IN ESSENTIAL FATTY ACID DEFICIENT RATS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14264515 |
| SWELL L et al. | ESTERIFICATION OF CHOLESTEROL BY CANINE ADRENAL CELL FRACTIONS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14297887 |
| Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
| KRITCHEVSKY D and TEPPER SA | AUTOXIDATION OF METHYL LINOLEATE: EFFECT OF SEX HORMONES AND OF NICOTINIC ACID AND RELATED COMPOUNDS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14155843 |
| WALKER BL and KUMMEROW FA | ERYTHROCYTE FATTY ACID COMPOSITION AND APPARENT PERMEABILITY TO NON-ELECTROLYTES. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14166569 |
| TUREEN LL et al. | EFFECT OF HIGH LINOLEIC ACID AND ANTIOXIDANT DEFICIENT DIET ON BLOOD SERUM PROTEINS IN CHICKS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14121629 |
| DESAI ID et al. | PEROXIDATION AND LYSOSOMES IN NUTRITIONAL MUSCULAR DYSTROPHY OF CHICKS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14121639 |
| HOPKINS DT et al. | A RESPIRATORY DISEASE SYNDROME IN CHICKENS FED ESSENTIAL FATTY ACID DEFICIENT DIETS. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:14076921 |
| SWELL L et al. | Influence of a family diet pattern high in linoleic acid on serum cholesterol level: one year study. | 1962 | Proc. Soc. Exp. Biol. Med. | pmid:13979681 |
| HOLMAN RT | Metabolism of isomers of linoleic and linolenic acids. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816402 |
| GORDON S and MEAD JF | CONVERSION OF LINOLEIC-1-C14 ACID TO ARACHIDONIC ACID IN THE GERBIL. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14194646 |
| Izumi Y et al. | Effects of dietary linoleic acid on blood pressure and renal function in subtotally nephrectomized rats. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3532127 |
| Johnston DV and Marshall LA | Dietary fat, prostaglandins and the immune response. | 1984 | Prog Food Nutr Sci | pmid:6091179 |
| Champe SP et al. | Sexual sporulation. | 1994 | Prog Ind Microbiol | pmid:7765136 |
| Jones R et al. | Monitoring changes in the blood of patients with multiple sclerosis. | 1983 | Prog. Brain Res. | pmid:6665128 |
| Rey HG et al. | Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. | 1988 | Prog. Clin. Biol. Res. | pmid:2906133 |
| Vergroesen AJ | Effects of dietary lipid composition on serum lipoproteins. | 1985 | Prog. Clin. Biol. Res. | pmid:3903769 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
| Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
| Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
| Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
| Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
| Cunnane SC | Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. | 1981 | Prog. Lipid Res. | pmid:7342114 |
| Lynn WS et al. | Linoleic acid: a specific cytotaxin for macrophages. | 1981 | Prog. Lipid Res. | pmid:7342119 |
| Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
| Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
| Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
| Holman RT | Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids. | 1986 | Prog. Lipid Res. | pmid:3423089 |
| Burr GO | The essential fatty acids fifty years ago. | 1981 | Prog. Lipid Res. | pmid:7043474 |
| Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
| Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
| Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
| Murphy MG | Increasing membrane polyunsaturated fatty-acid content augments cyclic AMP formation and prostaglandin production in NIE-115 neuroblastoma. | 1984 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:6099586 |
| Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |