Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hiramatsu N et al. | Effect of autoxidized linoleic acid on the contents of cytochrome P-450 and cytochrome b5, and drug-metabolizing enzyme activities in rat liver. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3612314 |
Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
Hubbard VS and McKenna MC | Absorption of safflower oil and structured lipid preparations in patients with cystic fibrosis. | 1987 | Lipids | pmid:3613873 |
Tilvis RS et al. | Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. | 1987 | Atherosclerosis | pmid:3619988 |
Klein A et al. | The effect of linoleic acid on the sensitivity of human lymphocytes to cortisol and their capacity to catabolize the steroid. | 1987 | Biochem. Cell Biol. | pmid:3620157 |
Tarnawski A et al. | Protection of the gastric mucosa by linoleic acid--a nutrient essential fatty acid. | 1987 | Clin Invest Med | pmid:3621708 |
Christophe A et al. | Efficacy of linoleic acid administered rectally as monoglyceride. | 1987 | Lipids | pmid:3600208 |
Melton JL et al. | Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. | 1987 | Biochim. Biophys. Acta | pmid:3651483 |
Salonen R et al. | Effect of omega-3 fatty acid supplementation on platelet aggregability and platelet produced thromboxane. | 1987 | Thromb. Haemost. | pmid:3660329 |
Dupont J | Essential fatty acids and prostaglandins. | 1987 | Prev Med | pmid:3628199 |
Steinberg WM et al. | Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency. | 1987 | Pancreas | pmid:3628223 |
Kissil GW et al. | Capacity of the European eel (Anguilla anguilla) to elongate and desaturate dietary linoleic acid. | 1987 | J. Nutr. | pmid:3114442 |
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Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
Maher ER et al. | Increased free-radical activity during haemodialysis? | 1987 | Nephrol. Dial. Transplant. | pmid:3114676 |
Effect of parenteral linoleate on fatty acid composition of infant brain and liver. | 1987 | Nutr. Rev. | pmid:3114686 | |
McLennan PL et al. | Dietary lipid modulation of myocardial beta-adrenergic mechanisms, Ca2+-dependent automaticity, and arrhythmogenesis in the marmoset. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2444777 |
Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
Ludwig P et al. | A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes. | 1987 | Eur. J. Biochem. | pmid:3117544 |
Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
Ha YL et al. | Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. | 1987 | Carcinogenesis | pmid:3119246 |
Stocker R et al. | Bilirubin is an antioxidant of possible physiological importance. | 1987 | Science | pmid:3029864 |
Griffin JF et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material. | 1987 | Clin. Chim. Acta | pmid:3568417 |
Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
Tay SK et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells. | 1987 | Clin. Chim. Acta | pmid:3568418 |
Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
Popp-Snijders C et al. | Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes. | 1987 | Diabetes Res. | pmid:3038454 |
Quik M | Evidence for an involvement of membrane lipids in the control of neuronal nicotinic receptor function using bungarotoxin II-S1. | 1987 | J. Neurochem. | pmid:3106571 |
Bandyopadhyay GK et al. | Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor. | 1987 | J. Biol. Chem. | pmid:3102474 |
Das UN et al. | Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro. | 1987 | Free Radic. Biol. Med. | pmid:3040539 |
Nilsson A et al. | Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. | 1987 | Am. J. Physiol. | pmid:3109253 |
Vrignaud P and Robert J | Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. | 1987 | Biochim. Biophys. Acta | pmid:2886153 |
Sani BP et al. | Interference of retinoic acid binding to its binding protein by omega-6 fatty acids. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820396 |
Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
Emken EA et al. | Metabolism of cis-12-octadecenoic acid and trans-9,trans-12-octadecadienoic acid and their influence on lipogenic enzyme activities in mouse liver. | 1987 | Biochim. Biophys. Acta | pmid:3580379 |
Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
Mackie BS et al. | Melanoma and dietary lipids. | 1987 | Nutr Cancer | pmid:3110746 |
Cunnane SC | Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032013 |
Haines KA et al. | The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. | 1987 | Biochem. J. | pmid:3032161 |
Hagve TA and Christophersen BO | Sex-related differences in desaturation and chain elongation of essential fatty acids studied in isolated rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3607076 |
Persegol L and Paris R | Influence of dietary lipids and linoleic acid amounts on fatty acid content and composition of pig serum lipoproteins. | 1987 | J. Physiol. (Paris) | pmid:3430364 |
Spann W et al. | [Effects of equal amounts of linoleic acid in orally administered, polyunsaturated phospholipids or in safflower oil on blood lipoproteins]. | 1987 | Klin. Wochenschr. | pmid:3431029 |
Frank H et al. | Monohydroperoxides of linoleic acid in endoplasmic lipids of rats exposed to tetrachloromethane. | 1987 | Lipids | pmid:3431344 |
Kovár J | Hybridoma cultivation in defined serum-free media: growth-supporting substances. IV. Lipids and serum albumin. | 1987 | Folia Biol. (Praha) | pmid:3436465 |
McIntosh GH et al. | The influence of linoleate and vitamin E from sunflower seed oil on platelet function and prostaglandin production in the common marmoset monkey. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3437342 |
Watkins BA and Kratzer FH | Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. | 1987 | Poult. Sci. | pmid:3452223 |
Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
McKinney M | Blockade of receptor-mediated cyclic GMP formation by hydroxyeicosatetraenoic acid. | 1987 | J. Neurochem. | pmid:3037024 |
Ito Y et al. | A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass. | 1987 | Prostaglandins Leukot Med | pmid:3477824 |
Kramer HJ et al. | The role of renal prostaglandins in the regulation of renal sodium excretion. | 1987 | Agents Actions Suppl. | pmid:3481214 |
Berge RK et al. | Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:2880562 |
Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
Coté GG and Brody S | Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. | 1987 | Biochim. Biophys. Acta | pmid:2889471 |
Thoresen L and Bjerve KS | [From clinical nursing: long-term tube feeding can cause deficiency diseases]. | 1987 | Sykepleien | pmid:2891206 |
Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
Setty BN et al. | 13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3113422 |
Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
Perez RV et al. | The effect of donor specific transfusions and dietary fatty acids on rat cardiac allograft survival. | 1987 | J. Surg. Res. | pmid:3553741 |
Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |
Arca M et al. | Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. | 1987 | Am. J. Clin. Nutr. | pmid:3604961 |
Palta M and Cook T | Some considerations in the analysis of rates of change in longitudinal studies. | 1987 Jul-Aug | Stat Med | pmid:3659670 |
Iwai K et al. | Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver. | 1987 May-Jun | Anticancer Res. | pmid:2820293 |
Dormandy TL and Wickens DG | The experimental and clinical pathology of diene conjugation. | 1987 Nov-Dec | Chem. Phys. Lipids | pmid:3319233 |
Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
Atrokhov VV and Markov KhM | [Influence of rations with various linoleic acid contents on the fatty acid composition of phospholipids in blood platelets of rats]. | 1987 Sep-Oct | Vopr Pitan | pmid:2894094 |
Kataoka K et al. | [A rat model of chronic pancreatic insufficiency induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3184515 |
Pepin D et al. | Essential fatty acid pattern of glycerolipids in rat hepatocytes in primary culture and in coculture with rat liver epithelial cells. | 1988 | Lipids | pmid:3185111 |
Takahashi R and Horrobin DF | Linoleic acid-induced fatty acid changes in platelet and aorta of the rat: effect of age and cholesterol. | 1988 | Lipids | pmid:3185125 |
Kurinami S et al. | Effects of polyunsaturated fatty acids and/or lecithin on the plasma concentrations of very low density lipoprotein-tryglyceride (VLDL) and ketone bodies in humans. | 1988 | Kurume Med J | pmid:3193745 |
Babin F et al. | Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. | 1988 | Ann. Nutr. Metab. | pmid:3195990 |
Høy CE and Hølmer G | Dietary linoleic acid and the fatty acid profiles in rats fed partially hydrogenated marine oils. | 1988 | Lipids | pmid:3200121 |
Kulkarni AP and Cook DC | Hydroperoxidase activity of lipoxygenase: a potential pathway for xenobiotic metabolism in the presence of linoleic acid. | 1988 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3141996 |
Rey HG et al. | Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. | 1988 | Prog. Clin. Biol. Res. | pmid:2906133 |
Perisho K et al. | Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. | 1988 | J. Invest. Dermatol. | pmid:2964492 |
Collier A et al. | Reduced free radical activity detected by decreased diene conjugates in insulin-dependent diabetic patients. | 1988 | Diabet. Med. | pmid:2975566 |
Stephens RJ et al. | Lipid peroxidation and retinal phototoxic degeneration. | 1988 | Basic Life Sci. | pmid:2977946 |
Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
Innis SM and Yuen DE | Microsomal desaturation-elongation of linoleic acid following parenteral feeding with lipid emulsions in the rat. | 1988 | Lipids | pmid:3139951 |
Albro PW et al. | Comparison of the effects of carbon tetrachloride and of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the disposition of linoleic acid in rat liver in vitro. | 1988 | Chem. Biol. Interact. | pmid:3135123 |
Craven PA and DeRubertis FR | Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. | 1988 | Gastroenterology | pmid:3135225 |
Lindström P and Palmblad J | Dietary linoleic acid and rat neutrophil adhesion and chemotaxis. | 1988 | J Clin Lab Immunol | pmid:3373519 |
Schauder P et al. | [The effect of free fatty acids on the leucine oxidation of human lymphocytes]. | 1988 | Beitr Infusionther Klin Ernahr | pmid:3377747 |
Kawooya JK and Law JH | Role of lipophorin in lipid transport to the insect egg. | 1988 | J. Biol. Chem. | pmid:3379043 |
Bester R and Lochner A | Sarcolemmal phospholipid fatty acid composition and permeability. | 1988 | Biochim. Biophys. Acta | pmid:3382645 |
Hiramatsu N et al. | Effects of dose levels of autoxidized linoleic acid on the drug-metabolizing system in rat liver. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:3392612 |
Sugiyama S et al. | The role of leukotoxin (9,10-epoxy-12-octadecenoate) in the genesis of coagulation abnormalities. | 1988 | Life Sci. | pmid:3398695 |
Jager FC | Vitamin E. | 1988 | Vet. Rec. | pmid:3407122 |
Asciutti-Moura LS et al. | Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. | 1988 | Am. J. Clin. Nutr. | pmid:3421207 |
Griffiths G et al. | Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). | 1988 | Biochem. J. | pmid:3421914 |
Spector R | Fatty acid transport through the blood-brain barrier. | 1988 | J. Neurochem. | pmid:3335863 |
Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |
Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
Fukuzawa K et al. | Site-specific induction of lipid peroxidation by iron in charged micelles. | 1988 | Arch. Biochem. Biophys. | pmid:2829725 |
Hashimoto A et al. | [Effect of dietary alpha-linolenate/linoleate balance on the formation of leukotrienes in rat polymorphonuclear leukocytes]. | 1988 | Arerugi | pmid:2901255 |