Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
Tamatani T et al. | Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase. | 1999 | Int. J. Oncol. | pmid:10493957 |
Masella R et al. | Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. | 1999 | Redox Rep. | pmid:10496414 |
Xu M and Dashwood RH | Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. | 1999 | Cancer Lett. | pmid:10503900 |
Arutselvan N et al. | Antioxidative activity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. | 1999 | Arzneimittelforschung | pmid:10514898 |
Minich DM et al. | Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. | 1999 | Biochim. Biophys. Acta | pmid:10526224 |
Dauchy RT et al. | Dim light during darkness stimulates tumor progression by enhancing tumor fatty acid uptake and metabolism. | 1999 | Cancer Lett. | pmid:10529012 |
Eulitz K et al. | Preparation, separation, and confirmation of the eight geometrical cis/trans conjugated linoleic acid isomers 8,10- through 11,13-18:2. | 1999 | Lipids | pmid:10529099 |
Filley SJ et al. | Prostaglandin f(2alpha) concentrations, fatty acid profiles, and fertility in lipid-infused postpartum beef heifers. | 1999 | Biol. Reprod. | pmid:10529280 |
Howard FA and Henderson C | Hydrogenation of polyunsaturated fatty acids by human colonic bacteria. | 1999 | Lett. Appl. Microbiol. | pmid:10530040 |
Dhiman TR et al. | Conjugated linoleic acid content of milk from cows fed different diets. | 1999 | J. Dairy Sci. | pmid:10531600 |
Rose DP and Connolly JM | Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. | 1999 | Int. J. Oncol. | pmid:10536186 |
Murphy J et al. | Fat malabsorption in cystic fibrosis patients. | 1999 | Am. J. Clin. Nutr. | pmid:10539762 |
Kulkarni AP and Sajan M | Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. | 1999 | Arch. Biochem. Biophys. | pmid:10545208 |
Domingo N et al. | Effects of dexamethasone and linoleic acid on hepatic secretion of biliary lipids and anionic polypeptide factor: In vivo and in vitro studies. | 1999 Nov-Dec | Digestion | pmid:10545720 |
Sánchez-Vioque R et al. | Interaction of chickpea (Cicer arietinum L.) legumin with oxidized linoleic acid. | 1999 | J. Agric. Food Chem. | pmid:10552371 |
Angerosa F et al. | Virgin olive oil volatile compounds from lipoxygenase pathway and characterization of some italian cultivars. | 1999 | J. Agric. Food Chem. | pmid:10552376 |
Budi Santosa FX and Padua GW | Tensile properties and water absorption of zein sheets plasticized with oleic and linoleic acids. | 1999 | J. Agric. Food Chem. | pmid:10552498 |
Henderson DE et al. | Quantitative HPLC determination of the antioxidant activity of capsaicin on the formation of lipid hydroperoxides of linoleic acid: a comparative study against BHT and melatonin. | 1999 | J. Agric. Food Chem. | pmid:10552527 |
Kuo JM et al. | Rapid photometric assay evaluating antioxidative activity in edible plant material. | 1999 | J. Agric. Food Chem. | pmid:10552632 |
Grobas S et al. | Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. | 1999 | Poult. Sci. | pmid:10560827 |
Du M et al. | Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. | 1999 | Poult. Sci. | pmid:10560841 |
López-Nicolás JM et al. | Rapid reversed-phase high-performance liquid chromatographic determination of the regiospecificity of lipoxygenase products on linoleic acid. | 1999 | J Chromatogr A | pmid:10563421 |
Jung MY and Ha YL | Conjugated linoleic acid isomers in partially hydrogenated soybean oil obtained during nonselective and selective hydrogenation processes. | 1999 | J. Agric. Food Chem. | pmid:10563957 |
Masuda T et al. | Evaluation of the antioxidant activity of environmental plants: activity of the leaf extracts from seashore plants. | 1999 | J. Agric. Food Chem. | pmid:10564049 |
Ip C et al. | Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. | 1999 | J. Nutr. | pmid:10573540 |
Kamlage B et al. | Intestinal microorganisms do not supply associated gnotobiotic rats with conjugated linoleic acid. | 1999 | J. Nutr. | pmid:10573552 |
Gelderblom WC et al. | Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574646 |
Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
Haas MJ et al. | Lipase-catalyzed fractionation of conjugated linoleic acid isomers. | 1999 | Lipids | pmid:10574663 |
Sakono M et al. | Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver. | 1999 | Lipids | pmid:10574665 |
Hsu AF et al. | Immobilized lipoxygenase in a packed-bed column bioreactor: continuous oxygenation of linoleic acid. | 1999 | Biotechnol. Appl. Biochem. | pmid:10574694 |
Fukuda N et al. | Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10575634 |
Yin JJ et al. | Effects of conjugated linoleic acid on oxygen diffusion-concentration product and depletion in membranes by using electron spin resonance spin-label oximetry. | 1999 | Lipids | pmid:10580328 |
Dionisi F et al. | Stability of cyclopropane and conjugated linoleic acids during fatty acid quantification in lactic acid bacteria. | 1999 | Lipids | pmid:10580338 |
Velēna A et al. | Derivatives of 1,4-dihydropyridines as modulators of ascorbate-induced lipid peroxidation and high-amplitude swelling of mitochondria, caused by ascorbate, sodium linoleate and sodium pyrophosphate. | 1999 | Cell Biochem. Funct. | pmid:10587611 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Sprinz H et al. | Mechanism of thiyl radical-catalyzed isomerization of unsaturated fatty acid residues in homogeneous solution and in liposomes. | 2000 | Biochim. Biophys. Acta | pmid:10601698 |
Klein J et al. | Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. | 1999 | Ther Drug Monit | pmid:10604826 |
Matsusue K et al. | A highly toxic coplanar polychlorinated biphenyl compound suppresses Delta5 and Delta6 desaturase activities which play key roles in arachidonic acid synthesis in rat liver. | 1999 | Chem. Res. Toxicol. | pmid:10604864 |
Hamberg M | An epoxy alcohol synthase pathway in higher plants: biosynthesis of antifungal trihydroxy oxylipins in leaves of potato. | 1999 | Lipids | pmid:10606035 |
Peres CM et al. | Thioglycolate-elicited rat macrophages exhibit alterations in incorporation and oxidation of fatty acids. | 1999 | Lipids | pmid:10606042 |
Speake BK et al. | Lipid composition of eggs of an oviparous lizard (Bassiana duperreyi). | 1999 | Lipids | pmid:10606044 |
Jie MS and Cheung SW | Fullerene lipids: synthesis of C60 fullerene derivatives bearing a long-chain saturated or unsaturated triester system. | 1999 | Lipids | pmid:10606046 |
Ghebremeskel K et al. | Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. | 1999 | Br. J. Nutr. | pmid:10615212 |
Meerarani P et al. | Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. | 2000 | Am. J. Clin. Nutr. | pmid:10617950 |
Sanders TA | Polyunsaturated fatty acids in the food chain in Europe. | 2000 | Am. J. Clin. Nutr. | pmid:10617968 |
Uauy R and Hoffman DR | Essential fat requirements of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617979 |
Gibson RA and Makrides M | n-3 polyunsaturated fatty acid requirements of term infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617980 |
Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
Ziboh VA et al. | Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. | 2000 | Am. J. Clin. Nutr. | pmid:10617998 |
Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
Connolly JM et al. | Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. | 1999 | Nutr Cancer | pmid:10624705 |
Chung FL et al. | Role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans. | 1999 | IARC Sci. Publ. | pmid:10626207 |
Nair J | Lipid peroxidation-induced etheno-DNA adducts in humans. | 1999 | IARC Sci. Publ. | pmid:10626208 |
Pariza MW et al. | Conjugated linoleic acid and the control of cancer and obesity. | 1999 | Toxicol. Sci. | pmid:10630598 |
Hayat L et al. | Fatty acid composition of human milk in Kuwaiti mothers. | 1999 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10631803 |
Salo P et al. | Low-saturated fat, low-cholesterol diet in 3-year-old children: effect on intake and composition of trans fatty acids and other fatty acids in serum phospholipid fraction-The STRIP study. Special Turku coronary Risk factor Intervention Project for children. | 2000 | J. Pediatr. | pmid:10636973 |
Oriani G et al. | Effects of intramuscular injection of alpha-tocopheryl acetate on fatty acid profile in lamb liver. | 1999 | Int J Vitam Nutr Res | pmid:10642895 |
de Deckere EA et al. | Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. | 1999 | Br. J. Nutr. | pmid:10655980 |
Berghaus TM et al. | Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation. | 2000 | Biol. Neonate | pmid:10657686 |
Romero P et al. | Short communication: concentration of conjugated linoleic acid from milk fat with a continuous supercritical fluid processing system. | 2000 | J. Dairy Sci. | pmid:10659958 |
Rukkwamsuk T et al. | Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum. | 2000 | J. Dairy Sci. | pmid:10659963 |
Heeley EL et al. | Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666114 |
Brash AR et al. | Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. | 1999 | Adv. Exp. Med. Biol. | pmid:10667314 |
Buchanan MR | Linoleic acid metabolites in health and disease. | 1999 | Adv. Exp. Med. Biol. | pmid:10667369 |
Greene JF and Hammock BD | Toxicity of linoleic acid metabolites. | 1999 | Adv. Exp. Med. Biol. | pmid:10667370 |
Jira W and Spiteller G | Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. | 1999 | Adv. Exp. Med. Biol. | pmid:10667371 |
Grobas S et al. | Influence of dietary energy, supplemental fat and linoleic acid concentration on performance of laying hens at two ages. | 1999 | Br. Poult. Sci. | pmid:10670682 |
Halle I | [The effect of palm oil and safflower oil in the feed of parent fattening hens on fertility, hatchability and growth of progeny]. | 1999 | Arch Tierernahr | pmid:10674173 |
Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
Jarmuszkiewicz W et al. | First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis. | 2000 | FEBS Lett. | pmid:10675527 |
Rüttinger HH and Radschuweit A | Determination of peroxides by capillary zone electrophoresis with amperometric detection. | 2000 | J Chromatogr A | pmid:10677087 |
Sébédio JL et al. | Recent advances in conjugated linoleic acid research. | 1999 | Curr Opin Clin Nutr Metab Care | pmid:10678680 |
Saito A et al. | Effects of capsaicin on biliary free fatty acids in rats. | 2000 | Int J Vitam Nutr Res | pmid:10683757 |
López-Nicolás JM et al. | Effect of calcium on the oxidation of linoleic acid by potato (Solanum tuberosum var. Desiree) tuber 5-lipoxygenase. | 2000 | J. Agric. Food Chem. | pmid:10691630 |
Sekiwa Y et al. | Isolation of novel glucosides related to gingerdiol from ginger and their antioxidative activities. | 2000 | J. Agric. Food Chem. | pmid:10691642 |
Kim D and Pleumsamran A | Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel. | 2000 | J. Gen. Physiol. | pmid:10694258 |
Fox SR et al. | The biosynthesis of oxylipins of linoleic and arachidonic acids by the sewage fungus Leptomitus lacteus, including the identification of 8R-Hydroxy-9Z,12Z-octadecadienoic acid. | 2000 | Lipids | pmid:10695920 |
Martin JC et al. | Effects of conjugated linoleic acid isomers on lipid-metabolizing enzymes in male rats. | 2000 | Lipids | pmid:10695929 |
Delmas-Beauvieux MC et al. | Liposomes as fatty acids carriers in isolated rat liver: effect on energy metabolism and on isolated mitochondria activity. | 2000 | MAGMA | pmid:10697225 |
Shimada A et al. | Phytotoxicity of indole-3-acetic acid produced by the fungus, Pythium aphanidermatum. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10705467 |
Kitts DD et al. | Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. | 1999 | Mol. Cell. Biochem. | pmid:10705999 |
Takahashi N | Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide). | 2000 | Biol. Pharm. Bull. | pmid:10706389 |
Cox JE et al. | Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10712279 |
Chavali SR and Forse RA | Decreased production of interleukin-6 and prostaglandin E2 associated with inhibition of delta-5 desaturation of omega6 fatty acids in mice fed safflower oil diets supplemented with sesamol. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10718106 |
Baron CP et al. | Peroxidation of linoleate at physiological pH: hemichrome formation by substrate binding protects against metmyoglobin activation by hydrogen peroxide. | 2000 | Free Radic. Biol. Med. | pmid:10719236 |
Adeyeye EI et al. | Fatty acid composition of six varieties of dehulled African yam bean (Sphenostylis stenocarpa) flour. | 1999 | Int J Food Sci Nutr | pmid:10719567 |
Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
Adam O | Linoleic acid - the fall of an angel? | 1999 | Ann. Nutr. Metab. | pmid:10725772 |
Draper AJ and Hammock BD | Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. | 2000 | Arch. Biochem. Biophys. | pmid:10729206 |
Kemp B et al. | Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. | 1998 | Theriogenology | pmid:10732036 |
Hochi S et al. | Effect of linoleic acid-albumin in the culture medium on freezing sensitivity of in vitro-produced bovine morulae. | 1999 | Theriogenology | pmid:10734383 |
Clemmesen JO et al. | Plasma phospholipid fatty acid pattern in severe liver disease. | 2000 | J. Hepatol. | pmid:10735619 |
Hudson JA et al. | Identification and enumeration of oleic acid and linoleic acid hydrating bacteria in the rumen of sheep and cows. | 2000 | J. Appl. Microbiol. | pmid:10735997 |
Larqué E et al. | Dietary trans fatty acids affect the essential fatty-acid concentration of rat milk. | 2000 | J. Nutr. | pmid:10736340 |
Whalen MM et al. | Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells. | 1999 | Cell. Physiol. Biochem. | pmid:10749996 |
Garcia HS et al. | Interesterification (acidolysis) of butterfat with conjugated linoleic acid in a batch reactor. | 2000 | J. Dairy Sci. | pmid:10750090 |
Rubbo H et al. | Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbate. | 2000 | J. Biol. Chem. | pmid:10753874 |