Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
Zeng YX et al. | Comparative analysis of volatile components from Clematis species growing in China. | 2007 | Anal. Chim. Acta | pmid:17606017 |
P Wrobel T et al. | Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. | 2011 | Analyst | pmid:22007352 |
Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
Kreich M and Claus P | Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:16315163 |
O'Quinn PR et al. | Conjugated linoleic acid. | 2000 | Anim Health Res Rev | pmid:11706843 |
McNamara S et al. | Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. | 2003 | Anim. Reprod. Sci. | pmid:12853178 |
Kawahara S et al. | Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. | 2009 | Anim. Sci. J. | pmid:20163609 |
Shibata H et al. | Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. | 2011 | Anim. Sci. J. | pmid:21794014 |
Guo J et al. | Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. | 2013 | Animal | pmid:23031491 |
Men XM et al. | Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. | 2013 | Animal | pmid:23764195 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Zened A et al. | In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. | 2012 | Animal | pmid:22436225 |
Stachowska E et al. | Is conjugated linoleic acid (CLA) a protective factor in atherosclerosis? Study with the use of neural networks. | 2005 | Ann Acad Med Stetin | pmid:16519093 |
GHOSH A and GHOSH JJ | EFFECT OF NYSTATIN AND AMPHOTERICIN B ON THE GROWTH OF CANDIDA ALBICANS. | 1963 | Ann Biochem Exp Med | pmid:14060842 |
GHOSH A and GHOSH JJ | RELEASE OF INTRACELLULAR CONSTITUENTS OF CANDIDA ALBICANS IN PRESENCE OF POLYENE ANTIBIOTICS. | 1963 | Ann Biochem Exp Med | pmid:14154207 |
GHOSH A and GHOSH JJ | ABSORPTION OF AMPHOTERICIN B BY CANDIDA ALBICANS. | 1963 | Ann Biochem Exp Med | pmid:14154206 |
SOIVA K and CASTREN O | Analysis of the lipids from ovarian tumours. | 1963 | Ann Med Exp Biol Fenn | pmid:13989890 |
MARTINET M | [Embryonic hemorrhages caused by deficiency in linoleic acid]. | 1952 | Ann Med Interne (Paris) | pmid:14952971 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Ranganath LR et al. | Increased mean platelet volume after oestrogen replacement therapy. | 1996 | Ann. Clin. Biochem. | pmid:8937589 |
Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
Fairfield K | ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. | 2013 | Ann. Intern. Med. | pmid:23689785 |
Davis PA et al. | A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. | 1993 | Ann. Intern. Med. | pmid:8363165 |
Kankaanpää P et al. | Dietary fatty acids and allergy. | 1999 | Ann. Med. | pmid:10480759 |
Chopra M et al. | Free radical scavenging of lutein in vitro. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8129303 |
Thompson RL et al. | Cigarette smoking, polyunsaturated fats, and coronary heart disease. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8512244 |
Sugano M and Koba K | Dietary protein and lipid metabolism: a multifunctional effect. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8489133 |
Merendino N et al. | Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. | 2003 | Ann. N. Y. Acad. Sci. | pmid:15033753 |
Schlame M et al. | Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. | 2002 | Ann. Neurol. | pmid:12112112 |
Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
Charnock JS et al. | Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. | 1985 | Ann. Nutr. Metab. | pmid:3922279 |
Babin F et al. | Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. | 1988 | Ann. Nutr. Metab. | pmid:3195990 |
Carreau JP et al. | Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. | 1982 | Ann. Nutr. Metab. | pmid:6814348 |
Romijn D et al. | A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. | 1998 | Ann. Nutr. Metab. | pmid:9745111 |
Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
Mogenson GJ and Box BM | Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. | 1982 | Ann. Nutr. Metab. | pmid:7137945 |
Adam O et al. | Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. | 1982 | Ann. Nutr. Metab. | pmid:7137955 |
Fuhrmann H and Sallmann HP | Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:8585700 |
Saito M and Yamaguchi M | Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. | 1994 | Ann. Nutr. Metab. | pmid:7832581 |
SaÃn J et al. | Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. | 2013 | Ann. Nutr. Metab. | pmid:23594856 |
Boissonneault GA et al. | Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:7872651 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
Kort WJ et al. | Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. | 1986 | Ann. Nutr. Metab. | pmid:3963748 |
Roshanai F and Sanders TA | Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4037727 |
Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
Charnock JS et al. | Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4051450 |
Adam O | Linoleic acid - the fall of an angel? | 1999 | Ann. Nutr. Metab. | pmid:10725772 |
Charnock JS et al. | Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. | 1985 | Ann. Nutr. Metab. | pmid:4051452 |
Soltysova T and Bellisle F | Nutrition in ten-year-old children of the Liberec area (Czech Republic). | 1994 | Ann. Nutr. Metab. | pmid:7979168 |
Pascaud M and Strouve-Vallet C | Desaturation of 14C linoleic acid by the rat fetus. | 1985 | Ann. Nutr. Metab. | pmid:2983600 |
Roth HP and Kirchgessner M | [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. | 1992 | Ann. Nutr. Metab. | pmid:1354951 |
Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
Jensen MM et al. | Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. | 1994 | Ann. Nutr. Metab. | pmid:8067685 |
Heine RJ et al. | The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. | 1984 | Ann. Nutr. Metab. | pmid:6476785 |
de Deckere EA et al. | Hepatic de novo fatty acid synthesis in the rat. | 1993 | Ann. Nutr. Metab. | pmid:8215236 |
Katan MB et al. | Biological markers of dietary intake, with emphasis on fatty acids. | 1991 | Ann. Nutr. Metab. | pmid:1776820 |
Xiang M et al. | Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. | 2006 | Ann. Nutr. Metab. | pmid:16988497 |
Decsi T and Koletzko B | Do trans fatty acids impair linoleic acid metabolism in children? | 1995 | Ann. Nutr. Metab. | pmid:7872654 |
De Vriese SR et al. | Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. | 2001 | Ann. Nutr. Metab. | pmid:11786650 |
Black JM and Kinsella JE | Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. | 1993 | Ann. Nutr. Metab. | pmid:8373135 |
Adam O et al. | Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. | 2003 | Ann. Nutr. Metab. | pmid:12624485 |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
Jakobsen K et al. | Heat production and quantitative oxidation of nutrients by physical activity in pigs. | 1994 | Ann. Nutr. Metab. | pmid:8185282 |
Ferry DR et al. | A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. | 2000 | Ann. Oncol. | pmid:11061613 |
Polesel J et al. | Linoleic acid, vitamin D and other nutrient intakes in the risk of non-Hodgkin lymphoma: an Italian case-control study. | 2006 | Ann. Oncol. | pmid:16556850 |
Alexander JW et al. | The importance of lipid type in the diet after burn injury. | 1986 | Ann. Surg. | pmid:3015058 |
Franco-Pons N et al. | Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. | 2013 | Ann. Surg. | pmid:22964727 |
Singer S et al. | Correlation of lipid content and composition with liposarcoma histology and grade. | 1997 Oct-Nov | Ann. Surg. Oncol. | pmid:9367021 |
Belury MA | Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. | 2002 | Annu. Rev. Nutr. | pmid:12055356 |
Bauman DE and Griinari JM | Nutritional regulation of milk fat synthesis. | 2003 | Annu. Rev. Nutr. | pmid:12626693 |
Lipkin M et al. | Dietary factors in human colorectal cancer. | 1999 | Annu. Rev. Nutr. | pmid:10448536 |
Tsubura A et al. | Anticancer effects of garlic and garlic-derived compounds for breast cancer control. | 2011 | Anticancer Agents Med Chem | pmid:21269259 |
Schønberg S and Krokan HE | The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. | 1995 Jul-Aug | Anticancer Res. | pmid:7654003 |
Nohl H et al. | Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone. | 2005 Jul-Aug | Anticancer Res. | pmid:16080529 |
desBordes C and Lea MA | Effects of C18 fatty acid isomers on DNA synthesis in hepatoma and breast cancer cells. | 1995 Sep-Oct | Anticancer Res. | pmid:8572595 |
Kamano K et al. | Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice. | 1989 Nov-Dec | Anticancer Res. | pmid:2627137 |
Cohen LA et al. | The influence of different varieties of olive oil on N-methylnitrosourea(NMU)-induced mammary tumorigenesis. | 2000 Jul-Aug | Anticancer Res. | pmid:10953289 |
Davidson BC et al. | Individual fatty acids influence cultured human liver cells differently when compared to plant oils. | 2003 Jan-Feb | Anticancer Res. | pmid:12680255 |
Gadducci A et al. | Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management. | 2001 Jul-Aug | Anticancer Res. | pmid:11712791 |
Cunningham DC et al. | Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. | 1997 Jan-Feb | Anticancer Res. | pmid:9066651 |
Visonneau S et al. | Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. | 1997 Mar-Apr | Anticancer Res. | pmid:9137436 |
Wong MW et al. | Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. | 1997 Mar-Apr | Anticancer Res. | pmid:9137439 |
Chew BP et al. | Effects of conjugated dienoic derivatives of linoleic acid and beta-carotene in modulating lymphocyte and macrophage function. | 1997 Mar-Apr | Anticancer Res. | pmid:9137456 |
Cesano A et al. | Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. | 1998 May-Jun | Anticancer Res. | pmid:9673351 |
Senzaki H et al. | Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. | 1998 May-Jun | Anticancer Res. | pmid:9673380 |
Iwai K et al. | Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver. | 1987 May-Jun | Anticancer Res. | pmid:2820293 |
Shultz TD et al. | Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. | 1992 Nov-Dec | Anticancer Res. | pmid:1295460 |
Cantrill RC et al. | Variations in temperature and oxygen content do not alter levels of thiobarbiturate reactive material in human breast tumour cells (ZR-75-1) incubated with gamma-linolenic acid. | 1993 Sep-Oct | Anticancer Res. | pmid:8239521 |
O'Shea M et al. | Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. | 1999 May-Jun | Anticancer Res. | pmid:10470140 |
De Antueno RJ et al. | Metabolism of radiolabelled 18:2n-6 and 18:3n-6 by NIH-3T3 cells and the DT subclone. | 1993 Jul-Aug | Anticancer Res. | pmid:8394680 |
Davidson BC et al. | The influence of fatty acids on normal and transformed human liver cells in culture. | 1998 Sep-Oct | Anticancer Res. | pmid:9858936 |
Cai YJ et al. | The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities. | 2004 Mar-Apr | Anticancer Res. | pmid:15161055 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Stein CA | Controversies in the cellular pharmacology of oligodeoxynucleotides. | 1997 | Antisense Nucleic Acid Drug Dev. | pmid:9212912 |
Hwang YC et al. | Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. | 2008 | Antiviral Res. | pmid:18243348 |
Hou CT et al. | Evaluation of microbial strains for linoleic acid hydroxylation and reclassification of strain ALA2. | 2005 | Antonie Van Leeuwenhoek | pmid:16096693 |