| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemia, Familial Combined | D006950 | 9 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Parnas M et al. | Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. | 2009 | J. Neurosci. | pmid:19244513 |
| Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
| Hennessy AA et al. | Optimization of a reconstituted skim milk based medium for enhanced CLA production by bifidobacteria. | 2009 | J. Appl. Microbiol. | pmid:19187142 |
| Zhao Z et al. | Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. | 2009 | Biomacromolecules | pmid:19175304 |
| Eriksson S et al. | Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. | 2009 | Br. J. Nutr. | pmid:19175947 |
| Garscha U and Oliw EH | Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity. | 2009 | J. Biol. Chem. | pmid:19289462 |
| Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
| Wecksler AT et al. | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. | 2009 | Bioorg. Med. Chem. | pmid:19716306 |
| Takasuka N et al. | Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil. | 2009 | Cancer Lett. | pmid:19028010 |
| Malhotra S et al. | Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. | 2009 | Planta Med. | pmid:19031367 |
| Gemeinhardt A et al. | The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. | 2009 | Biol. Chem. | pmid:19090716 |
| Blask DE | Melatonin, sleep disturbance and cancer risk. | 2009 | Sleep Med Rev | pmid:19095474 |
| Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
| Robinson NJ et al. | A potential role for free fatty acids in the pathogenesis of preeclampsia. | 2009 | J. Hypertens. | pmid:19462499 |
| Lausada N et al. | Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells. | 2009 | Transplant. Proc. | pmid:19545746 |
| Tesoriere L et al. | Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes. | 2009 | Free Radic. Res. | pmid:19548153 |
| Alves BN et al. | Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). | 2009 | Cell Biochem. Funct. | pmid:19548271 |
| Miranda J et al. | Hepatomegaly induced by trans-10,cis-12 conjugated linoleic acid in adult hamsters fed an atherogenic diet is not associated with steatosis. | 2009 | J Am Coll Nutr | pmid:19571159 |
| Deshpande GC et al. | Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial. | 2009 | J. Pediatr. Gastroenterol. Nutr. | pmid:19644398 |
| Kim JI et al. | Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants (tert-butylhydroxyanisol, tert-di-butylhydroxytoluene, and tert-butylhydroquinone) as compared with alpha-tocopherol. | 2009 | J. Food Sci. | pmid:19646028 |
| Whelan J | The health implications of changing linoleic acid intakes. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990554 |
| Fritsche KL | Too much linoleic acid promotes inflammation-doesn't it? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990555 |
| Harris WS | Linoleic acid and coronary heart disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951772 |
| Adam O et al. | Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973995 |
| Libkind D et al. | Fatty acid composition of cold-adapted carotenogenic basidiomycetous yeasts. | 2008 Oct-Dec | Rev. Argent. Microbiol. | pmid:19213239 |
| Webb AN et al. | Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. | 2008 Nov-Dec | Nutrition | pmid:18619813 |
| Magalhães MS et al. | Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats. | 2008 May-Jun | Acta Cir Bras | pmid:18552998 |
| Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
| Skaterna TD and Kharchenko OV | [Effect of phosphatidic acid on the reaction of linoleic acid oxidation by 5-lipooxygenase from potatoes]. | 2008 May-Jun | Ukr Biokhim Zh (1999) | pmid:18959024 |
| Mendis S et al. | Fatty acid profile of Canadian dairy products with special attention to the trans-octadecenoic acid and conjugated linoleic acid isomers. | 2008 Jul-Aug | J AOAC Int | pmid:18727541 |
| Yu IS et al. | Conversion of linoleic acid into 10-Hydroxy-12(Z)-octadecenoic acid by whole cells of Stenotrophomonas nitritireducens. | 2008 Jan-Feb | Biotechnol. Prog. | pmid:18197675 |
| Nushida H et al. | Adipocere formation via hydrogenation of linoleic acid in a victim kept under dry concealment. | 2008 | Forensic Sci. Int. | pmid:17644293 |
| Garelnabi M et al. | Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. | 2008 | Atherosclerosis | pmid:18243209 |
| Hwang YC et al. | Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. | 2008 | Antiviral Res. | pmid:18243348 |
| Berquin IM et al. | Multi-targeted therapy of cancer by omega-3 fatty acids. | 2008 | Cancer Lett. | pmid:18479809 |
| Spacek T et al. | Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18248766 |
| Al-Turkmani MR et al. | A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA. | 2008 | J. Lipid Res. | pmid:18480495 |
| Feng DD et al. | Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells. | 2008 | J. Endocrinol. | pmid:18252961 |
| Canudas N et al. | Photosensitizing properties of Actarit, an antirheumatic drug. | 2008 | Arzneimittelforschung | pmid:18540480 |
| Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
| Sikorski AM et al. | Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain. | 2008 | Brain Res. | pmid:18456247 |
| Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
| Maicas VT and Rochina IJ | [Linoleic acid emulsion on the peri-lesion skin of venal ulcers. Action and cicatrizant effect. Corpus study]. | 2008 | Rev Enferm | pmid:18564784 |
| Jang A et al. | Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. | 2008 | Chem. Biol. Interact. | pmid:18571153 |
| Koszelak-Rosenblum M et al. | His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase. | 2008 | J. Biol. Chem. | pmid:18596034 |
| Frenette M and Scaiano JC | Evidence for hydroxyl radical generation during lipid (linoleate) peroxidation. | 2008 | J. Am. Chem. Soc. | pmid:18597469 |
| Pinnick KE et al. | Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. | 2008 | Obesity (Silver Spring) | pmid:18239594 |
| Eder E et al. | Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | 2008 | Mutat. Res. | pmid:18602860 |
| Li Y et al. | Molecular recognition of nitrated fatty acids by PPAR gamma. | 2008 | Nat. Struct. Mol. Biol. | pmid:18604218 |
| Kuiper HC et al. | Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. | 2008 | J. Biol. Chem. | pmid:18442969 |
| Ohmori H et al. | Linoleic-acid-induced growth suppression induces quiescent cancer cell nests in nude mice. | 2008 | Pathobiology | pmid:18580068 |
| Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
| Meguid NA et al. | Role of polyunsaturated fatty acids in the management of Egyptian children with autism. | 2008 | Clin. Biochem. | pmid:18582451 |
| Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
| Morishita M et al. | Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion. | 2008 | J Control Release | pmid:18804128 |
| O'Connell ED et al. | Diet and risk factors for age-related maculopathy. | 2008 | Am. J. Clin. Nutr. | pmid:18326611 |
| Rózanowski B et al. | Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18326697 |
| KoÅŸar M et al. | In vitro antioxidant properties and phenolic composition of Salvia virgata Jacq. from Turkey. | 2008 | J. Agric. Food Chem. | pmid:18327906 |
| Koussoroplis AM et al. | From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. | 2008 | Lipids | pmid:18335265 |
| Ito-Inaba Y et al. | Characterization of the plant uncoupling protein, SrUCPA, expressed in spadix mitochondria of the thermogenic skunk cabbage. | 2008 | J. Exp. Bot. | pmid:18308738 |
| Granvogl M et al. | Development of a stable isotope dilution assay for the quantitation of glycidamide and its application to foods and model systems. | 2008 | J. Agric. Food Chem. | pmid:18624425 |
| Carrasco MP et al. | Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. | 2008 | FEBS J. | pmid:18312412 |
| Alghazeer R et al. | Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). | 2008 | Toxicol. Lett. | pmid:18625293 |
| Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
| Lukovac S et al. | Essential fatty acid deficiency in mice impairs lactose digestion. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18653724 |
| Fagali N and Catalá A | Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH techniques. | 2008 | Biophys. Chem. | pmid:18656302 |
| Gülçin I | In vitro prooxidant effect of caffeine. | 2008 | J Enzyme Inhib Med Chem | pmid:18341268 |
| Minami Y et al. | Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. | 2008 | Free Radic. Res. | pmid:18344113 |
| Zachut M et al. | Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. | 2008 | Reproduction | pmid:18296508 |
| Horowitz Brown S et al. | Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. | 2008 | Appl. Environ. Microbiol. | pmid:18658287 |
| Ashby RD et al. | Property control of sophorolipids: influence of fatty acid substrate and blending. | 2008 | Biotechnol. Lett. | pmid:18264681 |
| Zhu H et al. | 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. | 2008 | Int. J. Cancer | pmid:18785202 |
| Ringseis R et al. | Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. | 2008 | Eur J Nutr | pmid:18264811 |
| Fang KM et al. | Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. | 2008 | Cardiovasc. Res. | pmid:18267958 |
| Kishino T et al. | Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. | 2008 | Clin. Chim. Acta | pmid:18771663 |
| Jones PJ et al. | The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. | 2008 | Metab. Clin. Exp. | pmid:18702944 |
| Dai F et al. | Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. | 2008 | Biochimie | pmid:18554517 |
| McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
| Or-Rashid MM et al. | Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoa. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18797866 |
| Chicco AJ et al. | Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. | 2008 | Hypertension | pmid:18663155 |
| Davison GW et al. | In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | 2008 | Free Radic. Res. | pmid:18404537 |
| Brook MA et al. | Using a drug to structure its release matrix and release profile. | 2008 | Int J Pharm | pmid:18407444 |
| Simopoulos AP | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | 2008 | Exp. Biol. Med. (Maywood) | pmid:18408140 |
| Satou T et al. | The toxin produced by pleurotus ostreatus reduces the head size of nematodes. | 2008 | Biol. Pharm. Bull. | pmid:18379043 |
| Gallardo E et al. | Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. | 2008 | J. Agric. Food Chem. | pmid:18386901 |
| Morawicki RO and Beelman RB | Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. | 2008 | J. Food Sci. | pmid:18387089 |
| Kwon JI et al. | Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. | 2008 | J Med Food | pmid:18361731 |
| Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
| Chung SH et al. | Synthesis of conjugated linoleic acid by human-derived Bifidobacterium breve LMC 017: utilization as a functional starter culture for milk fermentation. | 2008 | J. Agric. Food Chem. | pmid:18410112 |
| Block RC et al. | Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? | 2008 | Am. Heart J. | pmid:19033007 |
| Kuriki K et al. | Relationships between intestinal polyp formation and fatty acid levels in plasma, erythrocytes, and intestinal polyps in Min mice. | 2008 | Cancer Sci. | pmid:19038002 |
| Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
| Maqbool A et al. | Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis. | 2008 | J. Pediatr. Gastroenterol. Nutr. | pmid:18955866 |
| Zuo Y et al. | ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. | 2008 | J. Biol. Chem. | pmid:18957418 |
| Safaa HM et al. | Effects of the levels of methionine, linoleic Acid, and added fat in the diet on productive performance and egg quality of brown laying hens in the late phase of production. | 2008 | Poult. Sci. | pmid:18648054 |
| Wang J et al. | Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. | 2008 | Nutr Cancer | pmid:18584483 |
| Zanoni S et al. | Growth kinetics on oligo- and polysaccharides and promising features of three antioxidative potential probiotic strains. | 2008 | J. Appl. Microbiol. | pmid:18778294 |
| Tao M et al. | Relationship of polyunsaturated fatty acid intake to peripheral neuropathy among adults with diabetes in the National Health and Nutrition Examination Survey (NHANES) 1999 2004. | 2008 | Diabetes Care | pmid:17914029 |
| Mateu-de Antonio J et al. | Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition. | 2008 | Br. J. Nutr. | pmid:17916276 |
| Moon CD et al. | Reclassification of Clostridium proteoclasticum as Butyrivibrio proteoclasticus comb. nov., a butyrate-producing ruminal bacterium. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768601 |