Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Cantrill RC et al. | Variations in temperature and oxygen content do not alter levels of thiobarbiturate reactive material in human breast tumour cells (ZR-75-1) incubated with gamma-linolenic acid. | 1993 Sep-Oct | Anticancer Res. | pmid:8239521 |
Biagi PL et al. | Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. | 1993 | Acta Paediatr. | pmid:8241678 |
Tanner JT et al. | Analysis of milk-based infant formula. Phase IV. Iodide, linoleic acid, and vitamins D and K: U.S. Food and Drug Administration-Infant Formula Council: collaborative study. | 1993 Sep-Oct | J AOAC Int | pmid:8241809 |
Darmani H et al. | Interferon-gamma-stimulated uptake and turnover of linoleate and arachidonate in macrophages: a possible pathway for hypersensitivity to endotoxin. | 1993 | Cell. Immunol. | pmid:8242772 |
Vargas F et al. | Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. | 1993 | Photochem. Photobiol. | pmid:8248320 |
Jones AL et al. | Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. | 1993 | Biochem. J. | pmid:8250841 |
Viola G et al. | Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. | 1993 | J. Lipid Res. | pmid:8263409 |
Whelan J et al. | Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters. | 1993 | J. Nutr. | pmid:8263613 |
Blee E et al. | Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267615 |
Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
Ettinger WH et al. | Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. | 1994 | Arterioscler. Thromb. | pmid:8274481 |
Oulhaj H et al. | Synthesis and distribution of rat Sertoli cell proteoglycans are modulated by linoleate and vitamin E. | 1993 | Biochem. Mol. Biol. Int. | pmid:8275018 |
Lamb RG et al. | An in vitro model of ethanol-dependent liver cell injury. | 1994 | Hepatology | pmid:8276354 |
Bronstein JC and Bull AW | The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. | 1993 | Prostaglandins | pmid:8278616 |
Murray MJ et al. | Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. | 1993 | Am. J. Physiol. | pmid:8279548 |
Hrboticky N et al. | Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. | 1994 | J. Clin. Invest. | pmid:8282787 |
Saito M and Yamaguchi M | Response of liver microsomal mixed-function oxidases to dietary linoleic acid levels in rats. | 1993 | J. Nutr. Sci. Vitaminol. | pmid:8283320 |
Judd JT and Clevidence BA | Trans fatty acids in human nutrition. | 1993 | Acta Cardiol | pmid:8284978 |
Grech ED et al. | Differential free-radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction. | 1993 | Coron. Artery Dis. | pmid:8287210 |
Sunzeri FJ and Buehring GC | Lipids alter the level and distribution of mouse mammary tumor virus gp52 in vitro. | 1993 | Cancer Lett. | pmid:8287372 |
Sanjurjo P et al. | Cross-sectional study of percentual changes in total plasmatic fatty acids during pregnancy. | 1993 | Horm. Metab. Res. | pmid:8288163 |
Li Y et al. | Chemical and alpha-chymotrypsin-mediated proteolytic degradation of insulin in bile salt-unsaturated fatty acid mixed micellar systems. | 1993 | Pharm. Res. | pmid:8290478 |
Ramasamy S et al. | Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. | 1993 | Atherosclerosis | pmid:8292102 |
Marcelo CL and Dunham WR | Fatty acid metabolism studies of human epidermal cell cultures. | 1993 | J. Lipid Res. | pmid:8301228 |
Yamaguchi Y et al. | Enhancement of aortic cholesterol deposition by dietary linoleic acid in cholesterol-fed mice: an animal model for primary screening of antiatherosclerotic agents. | 1993 | J Pharmacol Toxicol Methods | pmid:8305719 |
Takatori T | [Relationship between postmortem change and biological reaction]. | 1993 | Nihon Hoigaku Zasshi | pmid:8309098 |
Larner JM et al. | The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. | 1993 | J. Biol. Chem. | pmid:8314757 |
Hernell O et al. | Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids? | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8315552 |
Koba K et al. | Effects of dietary proteins on linoleic acid desaturation and membrane fluidity in rat liver microsomes. | 1993 | Lipids | pmid:8316055 |
Vázquez CM et al. | Changes in fatty acid desaturation in hepatic and intestinal tissues induced by intestinal resection. | 1993 | Lipids | pmid:8316056 |
Louw L and van der Westhuizen JP | Correlation between histopathology and linoleic acid levels in five meningioma types. | 1993 | Pathol. Res. Pract. | pmid:8321745 |
Kaneko T et al. | Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. | 1993 | Arch. Biochem. Biophys. | pmid:8323284 |
Wieland E et al. | Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8327462 |
Hansen HS | Linoleic acid as a precursor for acylation of transducin, a retinol G protein? | 1993 | Trends Biochem. Sci. | pmid:8328015 |
Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
Hara I et al. | Role of calcium ion in Schistosoma mansoni cercarial tail loss induced by unsaturated fatty acids. | 1993 | J. Parasitol. | pmid:8331471 |
Jacobsen BK et al. | Re: "Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men". | 1993 | Am. J. Epidemiol. | pmid:8333420 |
Dutta-Roy AK et al. | Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. | 1993 | Biochim. Biophys. Acta | pmid:8334153 |
Kühn H et al. | Overexpression, purification and characterization of human recombinant 15-lipoxygenase. | 1993 | Biochim. Biophys. Acta | pmid:8334154 |
Bioque G et al. | Metabolism of N-phenyllinoleamide by rat liver. | 1993 | J. Chromatogr. | pmid:8335697 |
Guha SN et al. | Free radical reductive degradation of vic-dibromoalkanes and reaction of bromine atoms with polyunsaturated fatty acids: possible involvement of Br(.) in the 1,2-dibromoethane-induced lipid peroxidation. | 1993 | Arch. Biochem. Biophys. | pmid:8342946 |
Roy R and Bélanger A | ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone. | 1993 | Endocrinology | pmid:8344206 |
Mao-Qiang M et al. | Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis. | 1993 | J. Invest. Dermatol. | pmid:8345219 |
Roy SK et al. | Lipoxygenase activity in rat embryos and its potential for xenobiotic oxidation. | 1993 | Biol. Neonate | pmid:8353158 |
Buchanan MR and Brister SJ | Altering vessel wall fatty acid metabolism: a new strategy for antithrombotic treatment. | 1993 | Semin. Thromb. Hemost. | pmid:8356461 |
Zheng RL et al. | Inhibition of the autoxidation of linoleic acid by phenylpropanoid glycosides from Pedicularis in micelles. | 1993 | Chem. Phys. Lipids | pmid:8358852 |
Chang WC et al. | Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells. | 1993 | J. Biol. Chem. | pmid:8360167 |
Davis PA et al. | A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. | 1993 | Ann. Intern. Med. | pmid:8363165 |
Rabinowitch HD et al. | Escherichia coli produces linoleic acid during late stationary phase. | 1993 | J. Bacteriol. | pmid:8366020 |