Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Infant, Newborn, Diseases D007232 9 associated lipids
Infertility D007246 3 associated lipids
Infertility, Male D007248 11 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Keloid D007627 12 associated lipids
Darier Disease D007644 2 associated lipids
Kidney Diseases D007674 29 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Whelan J The health implications of changing linoleic acid intakes. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990554
Fritsche KL Too much linoleic acid promotes inflammation-doesn't it? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990555
Wenger FA et al. Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913224
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Tribole E What happened to do no harm? The issue of dietary omega-6 fatty acids. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147337
Alava MA et al. Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10359023
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
van der Schouw YT et al. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815240
Punchard NA et al. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765976
Singer P et al. Defective desaturation and elongation of n-6 and n-3 fatty acids in hypertensive patients. 1984 Prostaglandins Leukot Med pmid:6387718
Kher V et al. Protective effect of polyunsaturated fatty acid supplementation in apoferritin induced murine glomerulonephritis. 1986 Prostaglandins Leukot Med pmid:3014561
Huang YS et al. Effect of dietary depletion and repletion of linoleic acid on renal fatty acid composition and urinary prostaglandin excretion. 1984 Prostaglandins Leukot Med pmid:6593743
Strong AM et al. Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar. 1984 Prostaglandins Leukot Med pmid:6588390
Ito Y et al. A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass. 1987 Prostaglandins Leukot Med pmid:3477824
Hoffmann P et al. Augmented acute hypotensive effect of dihydralazine and clonidine after linoleic acid rich diet in normotensive conscious rats. 1982 Prostaglandins Leukot Med pmid:6955801
Sullivan LM and Mathias MM Eicosanoid production in rat blood as affected by fasting and dietary fat. 1982 Prostaglandins Leukot Med pmid:6956928
Abeywardena MY et al. Effects of variable linoleate intake on aortic PGI2-like activity and fatty acid composition: difference between rat and marmoset (Callithrix jacchus). 1986 Prostaglandins Leukot Med pmid:3103139
Hoffmann P et al. Circadian rhythm of eicosanoid formation as affected by dietary linoleate. 1986 Prostaglandins Leukot Med pmid:3547416
Sakuma S et al. Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. 1993 Prostaglandins pmid:8210445
Lewis MG et al. Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. 1981 Prostaglandins pmid:6799988
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Needleman SW et al. Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. 1982 Prostaglandins pmid:6819602
Hashimoto A et al. Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. 1988 Prostaglandins pmid:2459732
Beneytout JL et al. Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. 1986 Prostaglandins pmid:3086939
Engels F et al. Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. 1996 Prostaglandins pmid:8880897
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Bronstein JC and Bull AW The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. 1993 Prostaglandins pmid:8278616
Andersen BR et al. The effects of arachidonic and other fatty acids on canine neutrophil metabolism. 1981 Prostaglandins pmid:6795686
Hamazaki T et al. Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. 1989 Prostaglandins pmid:2503856
Singer P et al. Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. 1984 Prostaglandins pmid:6328578
Murphy MG Increasing membrane polyunsaturated fatty-acid content augments cyclic AMP formation and prostaglandin production in NIE-115 neuroblastoma. 1984 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:6099586
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Cunnane SC Problems with essential fatty acids: time for a new paradigm? 2003 Prog. Lipid Res. pmid:14559071
Cunnane SC Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. 1982 Prog. Lipid Res. pmid:7051042
Dwyer LA and Blomquist GJ Biosynthesis of linoleic acid in the American cockroach. 1981 Prog. Lipid Res. pmid:7342085
Launay M et al. Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. 1981 Prog. Lipid Res. pmid:7342098
Houtsmuller AJ et al. Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. 1981 Prog. Lipid Res. pmid:7342100
Cunnane SC Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. 1981 Prog. Lipid Res. pmid:7342114
Lynn WS et al. Linoleic acid: a specific cytotaxin for macrophages. 1981 Prog. Lipid Res. pmid:7342119
Kitada S et al. Characterization of a lipid mobilizing factor from tumors. 1981 Prog. Lipid Res. pmid:7342133
Houtsmuller UM and van der Beek A Effects of topical application of fatty acids. 1981 Prog. Lipid Res. pmid:6804961
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Holman RT Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids. 1986 Prog. Lipid Res. pmid:3423089
Burr GO The essential fatty acids fifty years ago. 1981 Prog. Lipid Res. pmid:7043474
Spector AA et al. Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. 1981 Prog. Lipid Res. pmid:7043481
Agradi E et al. Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. 1981 Prog. Lipid Res. pmid:7043483
Mercuri O and De Tomás ME Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. 1981 Prog. Lipid Res. pmid:6804968
Rey HG et al. Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. 1988 Prog. Clin. Biol. Res. pmid:2906133
Vergroesen AJ Effects of dietary lipid composition on serum lipoproteins. 1985 Prog. Clin. Biol. Res. pmid:3903769
Jones R et al. Monitoring changes in the blood of patients with multiple sclerosis. 1983 Prog. Brain Res. pmid:6665128
Champe SP et al. Sexual sporulation. 1994 Prog Ind Microbiol pmid:7765136
Johnston DV and Marshall LA Dietary fat, prostaglandins and the immune response. 1984 Prog Food Nutr Sci pmid:6091179
REISER R Conjugated linoleic acid in rat tissue lipids after ingestion as free acid and as triglyceride. 1950 Proc. Soc. Exp. Biol. Med. pmid:14781143
STEIN O and STEIN Y FATTY ACID METABOLISM BY IN VIVO LABELED ADIPOSE TISSUE IN ESSENTIAL FATTY ACID DEFICIENT RATS. 1965 Proc. Soc. Exp. Biol. Med. pmid:14264515
SWELL L et al. ESTERIFICATION OF CHOLESTEROL BY CANINE ADRENAL CELL FRACTIONS. 1965 Proc. Soc. Exp. Biol. Med. pmid:14297887
Watkins BA et al. Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. 1996 Proc. Soc. Exp. Biol. Med. pmid:8650253
KRITCHEVSKY D and TEPPER SA AUTOXIDATION OF METHYL LINOLEATE: EFFECT OF SEX HORMONES AND OF NICOTINIC ACID AND RELATED COMPOUNDS. 1964 Proc. Soc. Exp. Biol. Med. pmid:14155843
WALKER BL and KUMMEROW FA ERYTHROCYTE FATTY ACID COMPOSITION AND APPARENT PERMEABILITY TO NON-ELECTROLYTES. 1964 Proc. Soc. Exp. Biol. Med. pmid:14166569
TUREEN LL et al. EFFECT OF HIGH LINOLEIC ACID AND ANTIOXIDANT DEFICIENT DIET ON BLOOD SERUM PROTEINS IN CHICKS. 1964 Proc. Soc. Exp. Biol. Med. pmid:14121629
DESAI ID et al. PEROXIDATION AND LYSOSOMES IN NUTRITIONAL MUSCULAR DYSTROPHY OF CHICKS. 1964 Proc. Soc. Exp. Biol. Med. pmid:14121639
HOPKINS DT et al. A RESPIRATORY DISEASE SYNDROME IN CHICKENS FED ESSENTIAL FATTY ACID DEFICIENT DIETS. 1963 Proc. Soc. Exp. Biol. Med. pmid:14076921
SWELL L et al. Influence of a family diet pattern high in linoleic acid on serum cholesterol level: one year study. 1962 Proc. Soc. Exp. Biol. Med. pmid:13979681
HOLMAN RT Metabolism of isomers of linoleic and linolenic acids. 1951 Proc. Soc. Exp. Biol. Med. pmid:14816402
GORDON S and MEAD JF CONVERSION OF LINOLEIC-1-C14 ACID TO ARACHIDONIC ACID IN THE GERBIL. 1964 Proc. Soc. Exp. Biol. Med. pmid:14194646
Izumi Y et al. Effects of dietary linoleic acid on blood pressure and renal function in subtotally nephrectomized rats. 1986 Proc. Soc. Exp. Biol. Med. pmid:3532127
Wieland E et al. Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8327462
Levay-Young BK et al. Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3317407
Yehuda S and Carasso RL Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7901853
Baker PR et al. Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15273286
Whittle EJ et al. Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18796606
Jiang Q et al. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15596715
Asaoka Y et al. Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8099446
Saeki K et al. Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15067141
Kliewer SA et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8041794
Chu S et al. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624373
Wright JR et al. Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3045812
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Stocker R et al. Antioxidant activity of albumin-bound bilirubin. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3475708
Hill EG et al. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6951178
Lange LG Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6955782
Keler T et al. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1594582
Blaul B and Ruther J How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. 2011 Proc. Biol. Sci. pmid:21429922
Utermohlen V and Tucker MA Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. 1986 Proc Nutr Soc pmid:3797410
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Permiakova MD and Trufanov VA [Effect of soybean lipoxygenae on baking properties of wheat flour]. 2011 May-Jun Prikl. Biokhim. Mikrobiol. pmid:21790037
Dupont J Essential fatty acids and prostaglandins. 1987 Prev Med pmid:3628199
Cohen LA Fat and endocrine-responsive cancer in animals. 1987 Prev Med pmid:3476922
WAREMBOURG H et al. [COMPARATIVE STUDY OF THE LIPID COMPOSITION OF THE PLASMA IN THE HEALTHY SUBJECT AND IN SIMPLE AND COMPLICATED DIABETES]. 1964 Presse Med pmid:14214759
Wadekar SD et al. Microbial synthesis of rhamnolipids by Pseudomonas aeruginosa (ATCC 10145) on waste frying oil as low cost carbon source. 2012 Prep. Biochem. Biotechnol. pmid:22509850
TORRES LM and VOROBIOFF S [TREATMENT OF CIRRHOSIS]. 1963 Prensa Med Argent pmid:14091581
DUDAN A [Essential polyunsaturated fatty acids; clinical study and therapeutic indications]. 1956 Praxis pmid:13335660
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Carrillo-Domínguez S et al. Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). 2005 Poult. Sci. pmid:15685957
Wang YW et al. Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. 2004 Poult. Sci. pmid:15615018
Grobas S et al. Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. 1999 Poult. Sci. pmid:10560827
Du M et al. Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. 1999 Poult. Sci. pmid:10560841
Chamruspollert M and Sell JL Transfer of dietary conjugated linoleic acid to egg yolks of chickens. 1999 Poult. Sci. pmid:10472840
Kim JH et al. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. 2007 Poult. Sci. pmid:17495090