Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Wang L et al. [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. 2010 Sheng Li Xue Bao pmid:21170499
Bartók T et al. Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₁ fumonisin isomers from a solid culture of Fusarium verticillioides. 2010 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:21108092
Zaman MM et al. Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20656894
Frangioudakis G et al. Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. 2010 Endocrinology pmid:20660065
Beezhold BL et al. Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. 2010 Nutr J pmid:20515497
Brito GA et al. Lymphocytes transfer [(14)C]-labeled fatty acids to skeletal muscle in culture; modulation by exercise. 2010 Cell Biochem. Funct. pmid:20517891
Li TL et al. [Study on the chemical constituents of Humulus scandens]. 2010 Zhong Yao Cai pmid:20518305
Czernichow S et al. n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. 2010 Br. J. Nutr. pmid:20522273
Sorrentino F et al. Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. 2010 Appl. Microbiol. Biotechnol. pmid:20571794
Tu WC et al. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20573490
Li GY et al. [Studies on chemistry component and the biological activity of petroleum ether extraction from pre-and post-processed of Cornus officinalis]. 2010 Zhong Yao Cai pmid:20575409
Wei M et al. [Kinetics of bioconversion of linoleic acid to conjugated linoleic acid by permeabilized Lactobacillus acidophilus cells]. 2010 Sheng Wu Gong Cheng Xue Bao pmid:20575439
Castellanos P et al. Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. 2010 Reprod. Toxicol. pmid:20096347
Coyral-Castel S et al. Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells. 2010 Domest. Anim. Endocrinol. pmid:20097509
Nakamura T et al. Excessive fat restriction might promote the recurrence of colorectal tumors. 2010 Nutr Cancer pmid:20099189
Beevi SS et al. Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. 2010 Plant Foods Hum Nutr pmid:20072818
Privé F et al. Temperature and duration of heating of sunflower oil affect ruminal biohydrogenation of linoleic acid in vitro. 2010 J. Dairy Sci. pmid:20105542
Rodríguez AM et al. Time-course effects of increased fatty acid supply on the expression of genes involved in lipid/glucose metabolism in muscle cells. 2010 Cell. Physiol. Biochem. pmid:20110694
Ivanova L et al. Phomenins and fatty acids from Alternaria infectoria. 2010 Toxicon pmid:20060014
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Dimri M et al. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. 2010 Carcinogenesis pmid:19969553
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Renaville B et al. Plasma and follicular fluid fatty acid profiles in dairy cows. 2010 Reprod. Domest. Anim. pmid:19055554
Kubala L et al. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. 2010 Free Radic. Biol. Med. pmid:20156554
Li YF et al. Properties of synthetic homoisoflavonoids to reduce oxidants and to protect linoleic acid and dna against oxidation. 2010 J. Agric. Food Chem. pmid:20199083
Jernerén F et al. Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. 2010 Arch. Biochem. Biophys. pmid:20043865
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Gholivand MB et al. Chemical composition and antioxidant activities of the essential oil and methanol extracts of Psammogeton canescens. 2010 Food Chem. Toxicol. pmid:19748545
Kim BS et al. Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. 2010 N Biotechnol pmid:19748603
Joshi SC et al. Antioxidant and antibacterial activities of the leaf essential oils of Himalayan Lauraceae species. 2010 Food Chem. Toxicol. pmid:19766161
Fekete K and Decsi T Long-chain polyunsaturated fatty acids in inborn errors of metabolism. 2010 Nutrients pmid:22254065
Alvaro A et al. Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids. 2010 J. Nutr. Biochem. pmid:19443194
Walloschke B et al. Enrichment of RAW264.7 macrophages with essential 18-carbon fatty acids affects both respiratory burst and production of immune modulating cytokines. 2010 J. Nutr. Biochem. pmid:19447017
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Noel JT et al. Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. 2010 PLoS ONE pmid:20824208
Macouzet M et al. Genetic and structural comparison of linoleate isomerases from selected food-grade bacteria. 2010 J. Appl. Microbiol. pmid:20825518
Collin F et al. Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals. 2010 Biochimie pmid:20685376
Calder PC The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? 2010 Br. J. Nutr. pmid:21118616
Ramsden CE et al. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. 2010 Br. J. Nutr. pmid:21118617
Duckett SK and Gillis MH Effects of oil source and fish oil addition on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. 2010 J. Anim. Sci. pmid:20348369
Aluf Y et al. Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydroxydopamine as assessed by a novel multifunctional marker molecule. 2010 Free Radic. Res. pmid:20370558
Tume RK et al. Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. 2010 Meat Sci. pmid:20374755
Berthelot V et al. Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. 2010 Meat Sci. pmid:20374762
Della Casa G et al. Performance and fat quality of heavy pigs fed maize differing in linoleic acid content. 2010 Meat Sci. pmid:20374768
Aldai N et al. Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. 2010 Meat Sci. pmid:20374865
Christensen KB et al. Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. 2010 Phytother Res pmid:20222152
Chen T et al. Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. 2010 J Diet Suppl pmid:22435611
Xiao C et al. Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA. 2010 Eur J Med Chem pmid:20332056
Bitis L et al. Flavonoids and antioxidant activity of Rosa agrestis leaves. 2010 Nat. Prod. Res. pmid:20397108
Georgiadi A et al. Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. 2010 Circ. Res. pmid:20378851
Matsuoka T et al. Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. 2010 Br. J. Cancer pmid:20842125
Lau BY et al. Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. 2010 Appl Physiol Nutr Metab pmid:20962915
Giroix MH et al. Fatty acid pattern of pancreatic islet lipids in Goto-Kakizaki rats. 2010 Endocrine pmid:20963567
Corriher VA et al. Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets. 2010 J. Dairy Sci. pmid:20965347
Liu S and Han B Differential expression pattern of an acidic 9/13-lipoxygenase in flower opening and senescence and in leaf response to phloem feeders in the tea plant. 2010 BMC Plant Biol. pmid:20969806
Brodhun F et al. PpoC from Aspergillus nidulans is a fusion protein with only one active haem. 2010 Biochem. J. pmid:19878096
Khiaosa-Ard R et al. Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. 2010 J. Dairy Res. pmid:20482940
Sahoo PK and Behera P Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. 2010 Eur J Med Chem pmid:20434240
Campoy C et al. [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. 2010 Med Clin (Barc) pmid:20434734
Goicoechea E and Guillen MD Analysis of hydroperoxides, aldehydes and epoxides by 1H nuclear magnetic resonance in sunflower oil oxidized at 70 and 100 degrees C. 2010 J. Agric. Food Chem. pmid:20438132
Zurabashvili DZ et al. [The effect of toxic components in tobacco smoke on the fatty acid profile of dental pulp]. 2010 Georgian Med News pmid:20413813
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Zovko Koncić M et al. Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. 2010 Aug-Sep Food Chem. Toxicol. pmid:20488218
Hajlaoui H et al. Chemical composition and biological activities of Tunisian Cuminum cyminum L. essential oil: a high effectiveness against Vibrio spp. strains. 2010 Aug-Sep Food Chem. Toxicol. pmid:20488223
NaÄ­dina VP et al. [Changes in lipid composition of human plasma and erythrocyte membranes due to sodium hydroxybutyrate and normobaric hyperoxia during bed rest]. 2010 Jan-Feb Aviakosm Ekolog Med pmid:20804001
McCusker MM and Grant-Kels JM Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. 2010 Jul-Aug Clin. Dermatol. pmid:20620762
Shirakawa J et al. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. 2011 J. Biol. Chem. pmid:21613229
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Monfregola L et al. Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. 2011 Biomacromolecules pmid:21553919
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Wang L et al. Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. 2011 J. Endocrinol. pmid:21565851
Nigam S et al. On mechanism of quorum sensing in Candida albicans by 3(R)-hydroxy-tetradecaenoic acid. 2011 Curr. Microbiol. pmid:20509029
Retamal MA et al. Biphasic effect of linoleic acid on connexin 46 hemichannels. 2011 Pflugers Arch. pmid:21360038
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Popescu FD et al. Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21328065
Lee MJ et al. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. 2011 Mol. Cells pmid:21331775
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Khadake R et al. Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. 2011 J. Sci. Food Agric. pmid:21769878
Banta JP et al. Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. 2011 J. Anim. Sci. pmid:21788431
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Arciniega JC et al. Effects of free fatty acids on meibomian lipid films. 2011 Exp. Eye Res. pmid:21718696
Lam WM et al. In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. 2011 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:21053263
Yang Y et al. Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. 2011 Free Radic. Res. pmid:21128731
Aewsiri T et al. Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. 2011 Int. J. Biol. Macromol. pmid:21334373
You Q et al. Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. 2011 Bioprocess Biosyst Eng pmid:21340675
Rybicka M et al. Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. 2011 J. Agric. Food Chem. pmid:21391598
Rakib MA et al. Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. 2011 J. Agric. Food Chem. pmid:21391601
Tuei VC et al. Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. 2011 Life Sci. pmid:21396379
Mihaljević B et al. Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. 2011 Org. Biomol. Chem. pmid:21442126
Blum JL et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. 2011 Toxicol In Vitro pmid:21443943
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Alloatti A and Uttaro AD Highly specific methyl-end fatty-acid desaturases of trypanosomatids. 2011 Mol. Biochem. Parasitol. pmid:20974196
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Siddique BM et al. Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. 2011 J. Food Sci. pmid:22417332
Chen HH and Chiu TH Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. 2011 J. Food Sci. pmid:22417350
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381