Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Malaria, Cerebral D016779 1 associated lipids
Onchocerciasis D009855 1 associated lipids
Liposarcoma D008080 1 associated lipids
Gastroschisis D020139 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Refeeding Syndrome D055677 1 associated lipids
Pellagra D010383 1 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Refractive Errors D012030 1 associated lipids
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Lactose Intolerance D007787 2 associated lipids
Disease D004194 2 associated lipids
Hypokinesia D018476 2 associated lipids
Darier Disease D007644 2 associated lipids
Aneurysm D000783 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Lymphopenia D008231 2 associated lipids
Leptospirosis D007922 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Dermatitis, Toxicodendron D011040 3 associated lipids
Infertility D007246 3 associated lipids
Wasting Syndrome D019282 3 associated lipids
Haemophilus Infections D006192 3 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Varicocele D014646 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Melanosis D008548 4 associated lipids
Embolism, Fat D004620 4 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Biliary Atresia D001656 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Varicose Ulcer D014647 4 associated lipids
Choroidal Neovascularization D020256 5 associated lipids
Sigmoid Neoplasms D012811 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Meningeal Neoplasms D008577 5 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Anemia, Iron-Deficiency D018798 6 associated lipids
Mucositis D052016 7 associated lipids
Nausea D009325 7 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Aarsland A and Wolfe RR Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. 1998 J. Lipid Res. pmid:9643360
Murthy S et al. 13-hydroxy octadecadienoic acid (13-HODE) inhibits triacylglycerol-rich lipoprotein secretion by CaCo-2 cells. 1998 J. Lipid Res. pmid:9643357
Iwase H et al. Formation of keto and hydroxy compounds of linoleic acid in submitochondrial particles of bovine heart. 1998 Free Radic. Biol. Med. pmid:9641268
Hughes RK et al. Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. 1998 Biochem. J. pmid:9639559
Mizushina Y et al. An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta. 1998 Biol. Pharm. Bull. pmid:9635497
Battu S et al. Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. 1998 Biochim. Biophys. Acta pmid:9630716
Emken EA et al. Effect of dietary arachidonic acid on metabolism of deuterated linoleic acid by adult male subjects. 1998 Lipids pmid:9625594
Liu KL and Belury MA Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes. 1998 Cancer Lett. pmid:9619853
Ohnishi M et al. Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. 1998 Phytochemistry pmid:9611825
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kleinfeld AM et al. Transport of long-chain native fatty acids across human erythrocyte ghost membranes. 1998 Biochemistry pmid:9609694
Kouba M and Mourot J Effect of a high linoleic acid diet on delta 9-desaturase activity, lipogenesis and lipid composition of pig subcutaneous adipose tissue. 1998 Jan-Feb Reprod. Nutr. Dev. pmid:9606747
Tsai WS et al. Inhibitory effects of n-3 polyunsaturated fatty acids on sigmoid colon cancer transformants. 1998 J. Gastroenterol. pmid:9605950
Geetha T et al. Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. 1998 Pharmacol. Res. pmid:9602466
Schaloske R et al. Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. 1998 Biochem. J. pmid:9601085
Dokko RC et al. Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. 1998 Int. J. Biochem. Cell Biol. pmid:9597754
Egashira Y et al. Dietary linoleic acid alters alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of niacin synthesis from tryptophan, in the process of protein expression in rat liver. 1998 J. Nutr. Sci. Vitaminol. pmid:9591240
Kwan KY et al. Inhibitory effect of linoleic acid on chain elongation and desaturation of 18:2 c,t isomers in lactating and neonatal rats. 1998 Lipids pmid:9590629
Kambayashi Y et al. Preferential hydrolysis of oxidized phosphatidylcholine in cholesterol-containing phosphatidylcholine liposome by phospholipase A2. 1998 Biochem. Biophys. Res. Commun. pmid:9588178
Peterson DB Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. 1998 Nutrition pmid:9583379
Hamberg M et al. Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction. 1998 J. Biol. Chem. pmid:9582346
Lee M et al. Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. 1998 Science pmid:9572738
Hill EM et al. Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9569236
Kelly ML et al. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. 1998 J. Nutr. pmid:9566998
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Yehuda S et al. Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. 1998 Neurochem. Res. pmid:9566600
Horrobin DF and Ziboh VA The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. 1997 Adv. Exp. Med. Biol. pmid:9561154
Giménez-Arnau A et al. Effects of linoleic acid supplements on atopic dermatitis. 1997 Adv. Exp. Med. Biol. pmid:9561153
Brister SJ and Buchanan MR Effects of linoleic acid and/or marine fish oil supplements on vessel wall thromboresistance in patients undergoing cardiac surgery. 1997 Adv. Exp. Med. Biol. pmid:9561151
Riambau V et al. Effect of linoleic acid supplements on vessel wall hyperplasia in rabbits. 1997 Adv. Exp. Med. Biol. pmid:9561150
Hörnsten L et al. Bisallylic hydroxylation of linoleic and arachidonic acids by adult and fetal human liver microsomes and a comparison with human recombinant cytochromes P450. 1997 Adv. Exp. Med. Biol. pmid:9561118
You YQ et al. Effect of continuous enteral medium-chain fatty acid infusion on lipid metabolism in rats. 1998 Lipids pmid:9560800
Sugiyama K et al. Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats. 1998 Lipids pmid:9560797
Kowaltowski AJ et al. Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. 1998 FEBS Lett. pmid:9559650
Akamatsu H and Horio T The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. 1998 Dermatology (Basel) pmid:9557235
Rosenfield RL et al. Mechanisms of androgen induction of sebocyte differentiation. 1998 Dermatology (Basel) pmid:9557223
Romanini D et al. Absorption and fluorescence spectra of polyene antibiotics in the presence of human serum albumin. 1998 Biochem. Mol. Biol. Int. pmid:9556221
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Kataoka K et al. Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. 1998 Pancreas pmid:9548669
Li-Stiles B et al. Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes. 1998 J. Lipid Res. pmid:9548589
Louw L et al. The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. 1997 Adv. Exp. Med. Biol. pmid:9547647
Louw L et al. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. 1997 Adv. Exp. Med. Biol. pmid:9547646
Louw L et al. Impairment in the fatty acid composition of keloids. 1997 Adv. Exp. Med. Biol. pmid:9547645
Camacho M et al. IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. 1997 Adv. Exp. Med. Biol. pmid:9547616
Liu SX et al. Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. 1998 Atherosclerosis pmid:9544730
Matthys LA and Widmaier EP Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis. 1998 Horm. Metab. Res. pmid:9543689
Voskuyl RA et al. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. 1998 Eur. J. Pharmacol. pmid:9543232
Herrera JA et al. Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. 1998 Obstet Gynecol pmid:9540946
Liang JF and Akaike T Protective effect of linoleic acid on IFN gamma-induced cellular injury in primary culture hepatocytes. 1998 J. Biochem. pmid:9538194
Oh-hashi K et al. Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. 1997 J Lipid Mediat Cell Signal pmid:9524928
van der Veen C et al. Factors affecting events during oxidation of low density lipoprotein: correlation of multiple parameters of oxidation. 1997 Free Radic. Res. pmid:9518063
Jiang WG et al. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. 1998 Biochem. Biophys. Res. Commun. pmid:9514943
Böhmer S et al. Oxidation of phenanthrene by a fungal laccase in the presence of 1-hydroxybenzotriazole and unsaturated lipids. 1998 Biochem. Biophys. Res. Commun. pmid:9514895
Larsen LN et al. Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. 1998 Biochem. Pharmacol. pmid:9514074
Jiang WG et al. The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. 1998 Br. J. Cancer pmid:9514051
Freyaldenhoven MA et al. Retinoic acid-dependent stimulation of 2,2'-azobis(2-amidinopropane)-initiated autoxidation of linoleic acid in sodium dodecyl sulfate micelles: a novel prooxidant effect of retinoic acid. 1998 Chem. Res. Toxicol. pmid:9511901
Dänicke S et al. Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. 1997 Br. Poult. Sci. pmid:9511000
Saha SK et al. Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. 1997 Jpn. J. Physiol. pmid:9504135
Mourek J and Dohnalová A Relationship between birth weight of newborns and unsaturated fatty acid(n-3) proportions in their blood serum. 1996 Physiol Res pmid:9496767
Yehuda S et al. Fatty acids and brain peptides. 1998 Peptides pmid:9493877
Bremmer DR et al. Effects of chain length and unsaturation of fatty acid mixtures infused into the abomasum of lactating dairy cows. 1998 J. Dairy Sci. pmid:9493093
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Bogdanov KY et al. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. 1998 Am. J. Physiol. pmid:9486261
Pareja A et al. Unsaturated fatty acids alter the insulin secretion response of the islets of Langerhans in vitro. 1997 Diabetes Res. Clin. Pract. pmid:9483379
Chisholm A et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. 1998 Eur J Clin Nutr pmid:9481526
Iwase H et al. Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH. 1998 Biochem. Biophys. Res. Commun. pmid:9480835
Agostoni C et al. Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children. 1998 J Am Coll Nutr pmid:9477386
Bouwstra JA et al. Role of ceramide 1 in the molecular organization of the stratum corneum lipids. 1998 J. Lipid Res. pmid:9469597
Pomposiello SI et al. Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery. 1998 Hypertension pmid:9461230
Herbel BK et al. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. 1998 Am. J. Clin. Nutr. pmid:9459383
Devor DC and Frizzell RA Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. 1998 Am. J. Physiol. pmid:9458723
Dadras SS et al. Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. 1998 Int. J. Oncol. pmid:9454884
van Roermund CW et al. Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions. 1998 EMBO J. pmid:9450993
Maheswari SU et al. Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. 1997 Mol. Cell. Biochem. pmid:9450644
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Hamberg M Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. 1998 Arch. Biochem. Biophys. pmid:9448728
Berry H et al. Oxygen concentration determines regiospecificity in soybean lipoxygenase-1 reaction via a branched kinetic scheme. 1998 J. Biol. Chem. pmid:9446584
Kaur K et al. (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. 1997 Chem. Res. Toxicol. pmid:9437530
Bylund J et al. Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. 1998 J. Pharmacol. Exp. Ther. pmid:9435160
Zhou L et al. Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. 1997 Biochim. Biophys. Acta pmid:9434134
Renaud SC Dietary management of cardiovascular diseases. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430390
Kritchevsky D Trans fatty acids and cardiovascular risk. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430386
van Niel MH and Beynen AC The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. 1997 Vet Q pmid:9413110
Gniwotta C et al. Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409317
Ali I and Steele JE Evidence that free fatty acids in trophocytes of Periplaneta americana fat body may be regulated by the activity of phospholipase A2 and cyclooxygenase. 1997 Insect Biochem. Mol. Biol. pmid:9404012
Christie WW et al. Isomers in commercial samples of conjugated linoleic acid. 1997 Lipids pmid:9397410
Sjövall O et al. Elution factors of synthetic oxotriacylglycerols as an aid in identification of peroxidized natural triacylglycerols by reverse-phase high-performance liquid chromatography with electrospray mass spectrometry. 1997 Lipids pmid:9397407
Schmid PC et al. Generation and remodeling of highly polyunsaturated molecular species of rat hepatocyte phospholipids. 1997 Lipids pmid:9397404
Hoptroff MJ et al. Influence of altered plasma membrane fatty acid composition on cesium transport characteristics and toxicity in Saccharomyces cerevisiae. 1997 Can. J. Microbiol. pmid:9396148
Willett WC Specific fatty acids and risks of breast and prostate cancer: dietary intake. 1997 Am. J. Clin. Nutr. pmid:9394715
Ip C Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. 1997 Am. J. Clin. Nutr. pmid:9394710
Rose DP Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. 1997 Am. J. Clin. Nutr. pmid:9394709
Dullaart RP et al. Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. 1997 Diabetes pmid:9392500
Howlett NG and Avery SV Relationship between cadmium sensitivity and degree of plasma membrane fatty acid unsaturation in Saccharomyces cerevisiae. 1997 Appl. Microbiol. Biotechnol. pmid:9390462
Priyadarsini KI Free radical reactions of curcumin in membrane models. 1997 Free Radic. Biol. Med. pmid:9378362
Guidot DM et al. Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. 1997 Am. J. Physiol. pmid:9374722
Liu F et al. Permeability properties of monolayers of the human trophoblast cell line BeWo. 1997 Am. J. Physiol. pmid:9374645
Toborek M et al. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. 1997 J. Lipid Res. pmid:9374137
Thompson H et al. Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. 1997 Cancer Res. pmid:9371504