Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Vidal-Mas J et al. | Cloning and expression of a lipoxygenase from Pseudomonas aeruginosa 42A2. | 2005 | Antonie Van Leeuwenhoek | pmid:15803390 |
Maia MR et al. | Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen. | 2007 | Antonie Van Leeuwenhoek | pmid:17072533 |
Palmblad J and Gyllenhammar H | Effect of dietary lipids on immunity and inflammation. Review article. | 1988 | APMIS | pmid:2841953 |
Lau BY et al. | Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. | 2010 | Appl Physiol Nutr Metab | pmid:20962915 |
Deng MD et al. | Linoleic acid isomerase from Propionibacterium acnes: purification, characterization, molecular cloning, and heterologous expression. | 2007 | Appl. Biochem. Biotechnol. | pmid:18057448 |
Mantzouridou F et al. | Optimization of beta-carotene production from synthetic medium by Blakeslea trispora: a mathematical modeling. | 2002 | Appl. Biochem. Biotechnol. | pmid:12049204 |
Nurachman Z et al. | Oil from the tropical marine benthic-diatom Navicula sp. | 2012 | Appl. Biochem. Biotechnol. | pmid:22926527 |
Osuji GO et al. | Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. | 2012 | Appl. Biochem. Biotechnol. | pmid:22918723 |
Dubey V et al. | Appraisal of conjugated linoleic acid production by probiotic potential of Pediococcus spp. GS4. | 2012 | Appl. Biochem. Biotechnol. | pmid:22971829 |
Ogawa J et al. | Conjugated linoleic acid accumulation via 10-hydroxy-12-octadecaenoic acid during microaerobic transformation of linoleic acid by Lactobacillus acidophilus. | 2001 | Appl. Environ. Microbiol. | pmid:11229917 |
Avery SV et al. | Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition. | 1996 | Appl. Environ. Microbiol. | pmid:8899983 |
Howlett NG and Avery SV | Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. | 1997 | Appl. Environ. Microbiol. | pmid:9251184 |
Barrett E et al. | Rapid screening method for analyzing the conjugated linoleic acid production capabilities of bacterial cultures. | 2007 | Appl. Environ. Microbiol. | pmid:17277221 |
Windstam S and Nelson EB | Temporal release of fatty acids and sugars in the spermosphere: impacts on Enterobacter cloacae-induced biological control. | 2008 | Appl. Environ. Microbiol. | pmid:18515478 |
Saito HE et al. | Incorporation of exogenous fatty acids protects Enterococcus faecalis from membrane-damaging agents. | 2014 | Appl. Environ. Microbiol. | pmid:25128342 |
Horowitz Brown S et al. | Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. | 2008 | Appl. Environ. Microbiol. | pmid:18658287 |
Minto RE et al. | Atypical biosynthetic properties of a Delta 12/nu+3 desaturase from the model basidiomycete Phanerochaete chrysosporium. | 2009 | Appl. Environ. Microbiol. | pmid:19088315 |
Avery SV et al. | Stimulation of strontium accumulation in linoleate-enriched Saccharomyces cerevisiae is a result of reduced Sr2+ efflux. | 1999 | Appl. Environ. Microbiol. | pmid:10049882 |
Huang FC et al. | Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. | 2014 | Appl. Environ. Microbiol. | pmid:24242247 |
Eyssen H and Verhulst A | Biotransformation of linoleic acid and bile acids by Eubacterium lentum. | 1984 | Appl. Environ. Microbiol. | pmid:6582800 |
Calvo AM et al. | Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. | 1999 | Appl. Environ. Microbiol. | pmid:10427064 |
Seward RA et al. | Effects of potassium sorbate and other antibotulinal agents on germination and outgrowth of Clostridium botulinum type E spores in microcultures. | 1982 | Appl. Environ. Microbiol. | pmid:6758699 |
Kim YJ et al. | Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. | 2000 | Appl. Environ. Microbiol. | pmid:11097894 |
van Dijk K and Nelson EB | Fatty acid competition as a mechanism by which Enterobacter cloacae suppresses Pythium ultimum sporangium germination and damping-off. | 2000 | Appl. Environ. Microbiol. | pmid:11097912 |
Howlett NG and Avery SV | Relationship between cadmium sensitivity and degree of plasma membrane fatty acid unsaturation in Saccharomyces cerevisiae. | 1997 | Appl. Microbiol. Biotechnol. | pmid:9390462 |
Sorrentino F et al. | Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20571794 |
Hudson JA et al. | Factors affecting the formation of 10-hydroxystearic acid from oleic acid by a ruminal strain of Enterococcus faecalis. | 1996 | Appl. Microbiol. Biotechnol. | pmid:8639306 |
Fabritius D et al. | Biotransformation of linoleic acid with the Candida tropicalis M25 mutant. | 1997 | Appl. Microbiol. Biotechnol. | pmid:9274051 |
Or-Rashid MM et al. | Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoa. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18797866 |
Rainio A et al. | Cell-adhered conjugated linoleic acid regulates isomerization of linoleic acid by resting cells of Propionibacterium freudenreichii. | 2002 | Appl. Microbiol. Biotechnol. | pmid:12466891 |
Buchhaupt M et al. | Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21789493 |
Kojima K et al. | A simple method for isolation and construction of markerless cyanobacterial mutants defective in acyl-acyl carrier protein synthetase. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27704180 |
Kot AM et al. | Rhodotorula glutinis-potential source of lipids, carotenoids, and enzymes for use in industries. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27209039 |
Macouzet M et al. | Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20461509 |
Strauss JS et al. | The effect of 13-cis-retinoic acid on sebaceous glands. | 1987 | Arch Dermatol | pmid:2960273 |
Orchard S et al. | Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis. | 1986 | Arch Dermatol | pmid:2942115 |
Wertz PW et al. | Essential fatty acids and epidermal integrity. | 1987 | Arch Dermatol | pmid:3310912 |
Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
Cherif A | [Linoleic acid synthesis in oleaginous seeds]. | 1981 Sep-Dec | Arch Inst Pasteur Tunis | pmid:7316620 |
Knorr A et al. | Cardiostimulating effect of sodium linoleate and its influence on effects of cardiac glycosides. | 1981 | Arch Int Pharmacodyn Ther | pmid:6279044 |
Hoffmann P et al. | Alterations in renal and aortic prostaglandin E and F formation correlate with blood pressure dietary linoleate deficiency. | 1982 | Arch Int Pharmacodyn Ther | pmid:7181575 |
Giron MD et al. | Long-term effects of dietary monounsaturated and polyunsaturated fatty acids on plasma lipids in dogs. | 1992 Sep-Oct | Arch Int Physiol Biochim Biophys | pmid:1282382 |
Azavache V et al. | [Is brown adipose tissue a store of long chain polyunsaturated fatty acids during postnatal developing brain?]. | 2007 | Arch Latinoam Nutr | pmid:17824193 |
Araujo de Vizcarrondo C et al. | Fatty acid composition of beef, pork, and poultry fresh cuts, and some of their processed products. | 1998 | Arch Latinoam Nutr | pmid:10347702 |
LORIETTE C et al. | [NUTRITIONAL VALUE OF FATTY SUBSTANCES CONTAINING ISOMERIZED FATTY ACIDS]. | 1963 | Arch Sci Physiol (Paris) | pmid:14106990 |
Muakkassa FF et al. | Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. | 1991 | Arch Surg | pmid:1992995 |
Wagner K et al. | Research note: effect of duodenal--infused unsaturated fatty acids on dairy milk composition. | 1998 | Arch Tierernahr | pmid:9850802 |
Takeuchi T | Essential fatty acid requirements in carp. | 1996 | Arch Tierernahr | pmid:8766970 |
Radunz-Neto J et al. | Estimation of essential fatty acid requirements of common carp larvae using semi-purified artificial diets. | 1996 | Arch Tierernahr | pmid:8766972 |
Halle I | [The effect of palm oil and safflower oil in the feed of parent fattening hens on fertility, hatchability and growth of progeny]. | 1999 | Arch Tierernahr | pmid:10674173 |
Richter G and Lemser A | [The use of native triticale in poultry. 3. Use in laying hens]. | 1993 | Arch Tierernahr | pmid:8517768 |
Liu Y et al. | Effects of fish oil on lymphocyte proliferation, cytokine production and intracellular signalling in weanling pigs. | 2003 | Arch Tierernahr | pmid:12903861 |
Jakobsen K et al. | The biological activity of natural source tocopherols in chickens fed fresh or oxidized fat rich in linoleic acid. | 1993 | Arch Tierernahr | pmid:8215903 |
Soita HW et al. | Effects of flaxseed supplementation on milk production, milk fatty acid composition and nutrient utilization by lactating dairy cows. | 2003 | Arch Tierernahr | pmid:12866781 |
DeLange RJ and Glazer AN | Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. | 1990 | Arch. Biochem. Biophys. | pmid:2297222 |
Rustin P et al. | Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. | 1983 | Arch. Biochem. Biophys. | pmid:6414377 |
Volpe JJ and Obert KA | Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. | 1981 | Arch. Biochem. Biophys. | pmid:6118099 |
Fuller MA et al. | Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. | 2001 | Arch. Biochem. Biophys. | pmid:11361131 |
Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
Hamberg M and Hamberg G | Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). | 1990 | Arch. Biochem. Biophys. | pmid:2275553 |
Shichiri G et al. | Polyunsaturated fatty acid metabolism and acetylated low density lipoprotein uptake in J774A.1 cells. | 1993 | Arch. Biochem. Biophys. | pmid:8099780 |
Glasgow WC and Eling TE | Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8203891 |
Sutherland MW and Gebicki JM | A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles. | 1982 | Arch. Biochem. Biophys. | pmid:6282219 |
CENTURY B and HORWITT MK | ROLE OF ARACHIDONIC ACID IN NUTRITIONAL ENCEPHALOMALACIA: INTERRELATIONSHIP OF ESSENTIAL AND NONESSENTIAL POLYUNSATURATED FATTY ACIDS. | 1964 | Arch. Biochem. Biophys. | pmid:14161009 |
BRESSLER R and FRIEDBERG SJ | SUBSTRATE SPECIFICITY OF THE FATTY ACID OXIDASE IN THE HEART. | 1964 | Arch. Biochem. Biophys. | pmid:14161011 |
Hamazaki S et al. | Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. | 1989 | Arch. Biochem. Biophys. | pmid:2500058 |
Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
PORTMAN OW and SUGANO M | THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. | 1963 | Arch. Biochem. Biophys. | pmid:14072510 |
MATSUSHITA S et al. | CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS. | 1963 | Arch. Biochem. Biophys. | pmid:14072524 |
KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
Gerwick WH et al. | Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. | 1991 | Arch. Biochem. Biophys. | pmid:1929410 |
Draper AJ and Hammock BD | Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. | 2000 | Arch. Biochem. Biophys. | pmid:10729206 |
Loftin CD and Eling TE | Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. | 1996 | Arch. Biochem. Biophys. | pmid:8660674 |
Fukuzawa K et al. | Peroxide-dependent and -independent lipid peroxidations catalyzed by chelated iron. | 1991 | Arch. Biochem. Biophys. | pmid:1656881 |
VAHOUNY GV et al. | MICELLAR-SOLUBILIZED SUBSTRATES AND CHOLESTEROL ESTERASE ACTIVITY IN VITRO. | 1964 | Arch. Biochem. Biophys. | pmid:14211570 |
Hamberg M et al. | Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. | 1994 | Arch. Biochem. Biophys. | pmid:8117115 |
VIOQUE E and HOLMAN RT | Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase. | 1962 | Arch. Biochem. Biophys. | pmid:13997422 |
Moon HS et al. | Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis. | 2006 | Arch. Biochem. Biophys. | pmid:17084379 |
PORTMAN OW and SUGANO M | FACTORS INFLUENCING THE LEVEL AND FATTY ACID SPECIFICITY OF THE CHOLESTEROL ESTERIFICATION ACTIVITY IN HUMAN PLASMA. | 1964 | Arch. Biochem. Biophys. | pmid:14236639 |
JACKSON HD et al. | FORMATION OF KETONE BODIES FROM LONG-CHAIN FATTY ACIDS IN RUMEN EPITHELIUM AND LIVER FROM KETOTIC SHEEP. | 1964 | Arch. Biochem. Biophys. | pmid:14240563 |
Ashida H et al. | Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:3688880 |
Bafor M et al. | Biosynthesis of vernoleate (cis-12-epoxyoctadeca-cis-9-enoate) in microsomal preparations from developing endosperm of Euphorbia lagascae. | 1993 | Arch. Biochem. Biophys. | pmid:8489257 |
Hörnsten L et al. | Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8806734 |
Oliw EH et al. | Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids. | 1993 | Arch. Biochem. Biophys. | pmid:8424677 |
PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
Sánchez J and Stumpf PK | The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. | 1984 | Arch. Biochem. Biophys. | pmid:6696430 |
Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
Kaneko T et al. | Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. | 1993 | Arch. Biochem. Biophys. | pmid:8323284 |
Kulkarni AP and Sajan M | Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. | 1999 | Arch. Biochem. Biophys. | pmid:10545208 |
Behrends W et al. | The glyoxysomal beta-oxidation system in cucumber seedlings: identification of enzymes required for the degradation of unsaturated fatty acids. | 1988 | Arch. Biochem. Biophys. | pmid:3369861 |
Duthie GG et al. | Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. | 1992 | Arch. Biochem. Biophys. | pmid:1632646 |
PRIVETT OS et al. | Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. | 1955 | Arch. Biochem. Biophys. | pmid:13239196 |
TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
KHAN NA | Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. | 1953 | Arch. Biochem. Biophys. | pmid:13058378 |
TAPPEL AL | The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. | 1953 | Arch. Biochem. Biophys. | pmid:13058395 |
Kawajiri H et al. | Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. | 2002 | Arch. Biochem. Biophys. | pmid:11811948 |
Nemecz G et al. | Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. | 1991 | Arch. Biochem. Biophys. | pmid:1897956 |
KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
Fukuzawa K et al. | Site-specific induction of lipid peroxidation by iron in charged micelles. | 1988 | Arch. Biochem. Biophys. | pmid:2829725 |