| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kelavkar U et al. | 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. | 2002 | Adv. Exp. Med. Biol. | pmid:12664577 |
| Egashira Y et al. | Dietary linoleic acid suppresses gene expression of rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum. | 2003 | Adv. Exp. Med. Biol. | pmid:15206789 |
| Sharma HM et al. | Effect of MAK-4 and MAK-5 on endothelial cell and soyabean lipoxygenase-induced LDL oxidation. | 1994 | Adv. Exp. Med. Biol. | pmid:7771286 |
| Gibson RA et al. | Long chain omega 3 polyunsaturates in formula-fed term infants. | 1992 | Adv. Exp. Med. Biol. | pmid:1353286 |
| Tanaka R et al. | Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities. | 2012 | Adv. Exp. Med. Biol. | pmid:22259110 |
| Camacho M et al. | IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547616 |
| Louw L et al. | Impairment in the fatty acid composition of keloids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547645 |
| Louw L et al. | Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. | 1997 | Adv. Exp. Med. Biol. | pmid:9547646 |
| Louw L et al. | The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. | 1997 | Adv. Exp. Med. Biol. | pmid:9547647 |
| Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
| Agostoni C et al. | Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation. | 2001 | Adv. Exp. Med. Biol. | pmid:11787678 |
| Demmelmair H et al. | Investigation of long-chain polyunsaturated fatty acid metabolism in lactating women by means of stable isotope techniques. | 2001 | Adv. Exp. Med. Biol. | pmid:11787680 |
| Fidler N et al. | Fat content and fatty acid composition of fresh, pasteurized, or sterilized human milk. | 2001 | Adv. Exp. Med. Biol. | pmid:11787720 |
| Blask DE et al. | New insights into melatonin regulation of cancer growth. | 1999 | Adv. Exp. Med. Biol. | pmid:10810531 |
| Eling TE et al. | Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. | 1997 | Adv. Exp. Med. Biol. | pmid:9321970 |
| Louw L et al. | Keloids: peripheral and central differences in cell morphology and fatty acid compositions of lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9322000 |
| Kinsella JE | Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. | 1991 | Adv. Food Nutr. Res. | pmid:1681826 |
| Hoffmann P and Förster W | Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system). | 1981 | Adv. Lipid Res. | pmid:6798829 |
| Ringertz B et al. | High dietary linoleic acid content modulates neutrophil function in rats. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960199 |
| Eling TE et al. | Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7537437 |
| Buchanan MR et al. | Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526487 |
| Eling TE and Glasgow WC | Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825423 |
| Gyllenhammar H et al. | Dietary essential fatty acid deficiency in rats is accompanied by impairments in neutrophil function and leukotriene B4 generation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823572 |
| Loesberg C et al. | Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. | 1988 | Agents Actions | pmid:2833083 |
| Iversen L et al. | Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. | 1991 | Agents Actions | pmid:1659156 |
| Loesberg C et al. | Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. | 1987 | Agents Actions | pmid:2895570 |
| Kramer HJ et al. | The role of renal prostaglandins in the regulation of renal sodium excretion. | 1987 | Agents Actions Suppl. | pmid:3481214 |
| Henricks PA et al. | Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. | 1990 | Agents Actions Suppl. | pmid:2080762 |
| Pamplona R et al. | Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. | 1999 | Aging (Milano) | pmid:10337442 |
| Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
| Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
| Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
| Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
| Tsukamoto S et al. | Effects of bezafibrate on ethanol oxidation in rats. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8986210 |
| Cunnane SC | Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032013 |
| Szebeni J et al. | Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. | 1986 | Alcohol. Clin. Exp. Res. | pmid:3101533 |
| Uden S et al. | Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. | 1992 | Aliment. Pharmacol. Ther. | pmid:1600043 |
| Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
| Kelly GS | Conjugated linoleic acid: a review. | 2001 | Altern Med Rev | pmid:11578253 |
| Poole E and McQueen CE | Conjugated linoleic acid. | 2006 | Am J Health Syst Pharm | pmid:17057041 |
| Block RC et al. | Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? | 2008 | Am. Heart J. | pmid:19033007 |
| Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
| McDaniel HG et al. | Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. | 1981 | Am. Heart J. | pmid:6787909 |
| Magsino CH et al. | Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. | 2000 | Am. J. Cardiol. | pmid:10946040 |
| Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
| Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
| Kim JB et al. | Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. | 2013 | Am. J. Cardiol. | pmid:24050409 |
| Wu MJ et al. | Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). | 2004 | Am. J. Chin. Med. | pmid:15633804 |
| Cho EJ et al. | The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. | 2003 | Am. J. Chin. Med. | pmid:14992543 |
| CHRISTAKIS GJ et al. | EFFECT OF A SERUM CHOLESTEROL-LOWERING DIET ON COMPOSITION OF DEPOT FAT IN MAN. | 1965 | Am. J. Clin. Nutr. | pmid:14253897 |
| ZUKEL MC | FAT-CONTROLLED DIETS. | 1965 | Am. J. Clin. Nutr. | pmid:14253901 |
| Brynes AE et al. | Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. | 2000 | Am. J. Clin. Nutr. | pmid:11063437 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. | 2000 | Am. J. Clin. Nutr. | pmid:10966889 |
| Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
| Kark JD et al. | Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12663274 |
| Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
| Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
| KRAUSE RF | LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A. | 1965 | Am. J. Clin. Nutr. | pmid:14301352 |
| Anderson RL | Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. | 1982 | Am. J. Clin. Nutr. | pmid:7081132 |
| Turpeinen AM et al. | Bioconversion of vaccenic acid to conjugated linoleic acid in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12197992 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| O'Connell ED et al. | Diet and risk factors for age-related maculopathy. | 2008 | Am. J. Clin. Nutr. | pmid:18326611 |
| Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
| Erickson KL | Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? | 1998 | Am. J. Clin. Nutr. | pmid:9665090 |
| Zock PL and Katan MB | Linoleic acid intake and cancer risk: a review and meta-analysis. | 1998 | Am. J. Clin. Nutr. | pmid:9665108 |
| MACDONALD I and BARRY PJ | CHANGES IN THE FATTY ACID PATTERN OF THE ADIPOSE TISSUE OF OBESE SUBJECTS WHILE ON A REDUCING REGIMEN. | 1964 | Am. J. Clin. Nutr. | pmid:14212750 |
| Rudel LL et al. | Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. | 1995 | Am. J. Clin. Nutr. | pmid:7625361 |
| PINTER KG et al. | FAT ABSORPTION STUDIES IN VARIOUS FORMS OF STEATORRHEA. | 1964 | Am. J. Clin. Nutr. | pmid:14220479 |
| Cleland LG et al. | Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. | 1992 | Am. J. Clin. Nutr. | pmid:1310374 |
| Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
| Herbel BK et al. | Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9459383 |
| Green P et al. | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. | 1990 | Am. J. Clin. Nutr. | pmid:2239789 |
| Kinsella JE et al. | Metabolism of trans fatty acids with emphasis on the effects of trans, trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. | 1981 | Am. J. Clin. Nutr. | pmid:6794350 |
| Adam O and Wolfram G | Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. | 1984 | Am. J. Clin. Nutr. | pmid:6486083 |
| Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
| SINGLETON WS | CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. | 1965 | Am. J. Clin. Nutr. | pmid:14262113 |
| Hodgson JM et al. | Can linoleic acid contribute to coronary artery disease? | 1993 | Am. J. Clin. Nutr. | pmid:8192728 |
| Truswell AS | Can linoleic acid contribute to coronary artery disease? | 1994 | Am. J. Clin. Nutr. | pmid:8198070 |
| Innis SM and Hansen JW | Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. | 1996 | Am. J. Clin. Nutr. | pmid:8694015 |
| Jones PJ et al. | Whole body oxidation of dietary fatty acids: implications for energy utilization. | 1985 | Am. J. Clin. Nutr. | pmid:3933323 |
| Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. | 2005 | Am. J. Clin. Nutr. | pmid:16155261 |
| Warensjö E et al. | Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. | 2006 | Am. J. Clin. Nutr. | pmid:16895896 |
| Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
| Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
| Asciutti-Moura LS et al. | Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. | 1988 | Am. J. Clin. Nutr. | pmid:3421207 |
| Terpstra AH | Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. | 2004 | Am. J. Clin. Nutr. | pmid:14985207 |
| Cunnane SC | Diodoquin and linoleic acid absorption in zinc deficiency. | 1981 | Am. J. Clin. Nutr. | pmid:6792900 |
| Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |
| Goyens PL et al. | Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. | 2006 | Am. J. Clin. Nutr. | pmid:16825680 |
| Abbey M et al. | Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8438773 |
| Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
| Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
| Oosthuizen W et al. | Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study. | 2006 | Am. J. Clin. Nutr. | pmid:16685065 |
| Seidelin KN et al. | Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. | 1993 | Am. J. Clin. Nutr. | pmid:8416668 |
| Larbi A et al. | Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans. | 2005 | Am. J. Clin. Nutr. | pmid:16280424 |
| OLSON FE et al. | The use of diets containing large amounts of linoleic acid. | 1958 Nov-Dec | Am. J. Clin. Nutr. | pmid:13594895 |
| Nestel PJ et al. | Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations. | 1998 | Am. J. Clin. Nutr. | pmid:9846846 |