2,3-hexanedione

2,3-hexanedione is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 105 references associated with 2,3-hexanedione in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 2,3-hexanedione

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2,3-hexanedione

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Total 4

NCBI Entrez Crosslinks

All references with 2,3-hexanedione

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Authors Title Published Journal PubMed Link
Hintzpeter J et al. Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1. 2015 Chem. Biol. Interact. pmid:25541467
Hartmanová T et al. S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity. 2013 Chem. Biol. Interact. pmid:23295225
Calam E et al. Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases. 2013 Chem. Biol. Interact. pmid:23295224
Anderson SE et al. Evaluation of the hypersensitivity potential of alternative butter flavorings. 2013 Food Chem. Toxicol. pmid:24007741
Day G et al. Identification and measurement of diacetyl substitutes in dry bakery mix production. 2011 J Occup Environ Hyg pmid:21253982
Kisiela M et al. Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans. 2011 Chem. Biol. Interact. pmid:21300042
Tshala-Katumbay D et al. Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. 2009 Toxicol. Sci. pmid:19033394
Endo S et al. Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. 2009 Chem. Biol. Interact. pmid:18845131
Coleman MD et al. A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y. 2008 Basic Clin. Pharmacol. Toxicol. pmid:17973901
Endo S et al. Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase. 2007 Biol. Pharm. Bull. pmid:17827741
Zilz TR et al. Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH. 2007 Toxicology pmid:17229511
Lacey ES et al. Male-produced aggregation pheromone of the cerambycid beetle Neoclytus acuminatus acuminatus. 2004 J. Chem. Ecol. pmid:15537155
O'connor T et al. Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. 1999 Biochem. J. pmid:10510318
Stipani I et al. Inhibition of the reconstituted mitochondrial oxoglutarate carrier by arginine-specific reagents. 1996 Arch. Biochem. Biophys. pmid:8660682
Zimmermann FK and Mohr A Formaldehyde, glyoxal, urethane, methyl carbamate, 2,3-butanedione, 2,3-hexanedione, ethyl acrylate, dibromoacetonitrile and 2-hydroxypropionitrile induce chromosome loss in Saccharomyces cerevisiae. 1992 Mutat. Res. pmid:1383732
Iwasaki K and Tsuruta H Molecular mechanism of hexane neuropathy: significant differences in pharmacokinetics between 2.3-, 2.4-, and 2.5-hexanedione. 1984 Ind Health pmid:6501003
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