| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Ascorbic Acid Deficiency | D001206 | 9 associated lipids |
| Back Pain | D001416 | 5 associated lipids |
| Bacteriuria | D001437 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma 256, Walker | D002279 | 22 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Carpal Tunnel Syndrome | D002349 | 3 associated lipids |
gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bégin ME et al. | Selective killing of human cancer cells by polyunsaturated fatty acids. | 1985 | Prostaglandins Leukot Med | pmid:2864701 |
| Segarnick DJ et al. | Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver. | 1985 | Prostaglandins Leukot Med | pmid:2986177 |
| Botha JH et al. | The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis. | 1985 | Prostaglandins Leukot Med | pmid:2994114 |
| Varma PK and Persaud TV | Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. | 1982 | Prostaglandins Leukot Med | pmid:6287501 |
| Vaddadi KS | Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1321448 |
| Joubert AM et al. | Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582657 |
| Efstathopoulos N et al. | N-6 polyunsaturated fatty acids confer hemodynamic stability in an experimental model of multiple trauma. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850717 |
| Vang K and Ziboh VA | 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850718 |
| Murray MJ and Zhang T | The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089803 |
| Howie A et al. | The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1502249 |
| Jiang WG et al. | Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780877 |
| Navarette R et al. | Dietary intake of concentrated gamma-linolenic acid (GLA)-enriched oil suppresses cutaneous level of dihomo-gamma-linolenic acid (DGLA): possible in vivo inhibition of microsomal elongation of GLA to DGLA. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1323857 |
| Jiang WG et al. | Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150377 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Das UN and Rao KP | Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16488586 |
| Cleland LG et al. | The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2169063 |
| van der Merwe CF et al. | The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2169638 |
| Miles EA et al. | Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16820286 |
| Horrobin DF et al. | The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871175 |
| Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
| Arisaka M et al. | Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871184 |
| Hrelia S et al. | Kinetic analysis of delta-6-desaturation in liver microsomes: influence of gamma-linoleic acid dietary supplementation to young and old rats. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808628 |
| Guivernau M et al. | Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846101 |
| Engler MM and Engler MB | Dietary borage oil alters plasma, hepatic and vascular tissue fatty acid composition in spontaneously hypertensive rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758202 |
| Gardiner NS and Duncan JR | Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic acid. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1650000 |
| Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
| de Kock M et al. | Differential cytotoxic effects of gamma-linolenic acid on MG-63 and HeLa cells. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972263 |
| Stevens EJ et al. | Prostacyclin release in experimental diabetes: effects of evening primrose oil. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248277 |
| du Toit PJ et al. | The effect of gamma-linolenic acid and eicosapentaenoic acid on urokinase activity. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972265 |
| Morphake P et al. | Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146206 |
| Das UN | Occlusion of infusion vessels on gamma-linolenic acid infusion. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643176 |
| Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
| Botha JH et al. | The role of prostaglandins in the inhibition of cultured carcinoma cell growth produced by gamma-linolenic acid. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2541450 |
| Giamarellos-Bourboulis EJ et al. | In vitro activity of polyunsaturated fatty acids on Pseudomonas aeruginosa: relationship to lipid peroxidation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654401 |
| Kahler CP and Du Plooy WJ | Effect of gammalinolenic acid, dihomogammalinolenic acid, ascorbyl-6-gammalinolenic acid, and ascorbyl-6-dihomo gammalinolenic acid on histamine- and methacholine-induced contraction of the isolated guinea pig tracheal chain. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654407 |
| Moodley J and Norman RJ | Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2608693 |
| Karmali RA et al. | Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8388566 |
| Ebden P et al. | A study of evening primrose seed oil in atopic asthma. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717651 |
| Huang YS et al. | The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2717652 |
| Ramesh G and Das UN | Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844986 |
| Kuruvilla R et al. | Evening primrose oil treatment corrects reduced conduction velocity but not depletion of arachidonic acid in nerve from streptozotocin-induced diabetic rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844993 |
| Sangeetha P et al. | Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2160083 |
| Bunce OR and Abou-El-Ela SH | Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2177199 |
| Kaku S et al. | Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728173 |
| Nwankwo JO and Robbins ME | Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418018 |
| Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
| Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
| Puri BK | The safety of evening primrose oil in epilepsy. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17764919 |
| Duttaroy AK et al. | Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538089 |
| Rosenstein ED et al. | Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591005 |