Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Montserrat-de la Paz S et al. | Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages. | 2014 | J Ethnopharmacol | pmid:24239848 |
Park SO et al. | Gamma-linolenic acid egg production enriched with hemp seed oil and evening primrose oil in diet of laying hens. | 2014 | J Environ Biol | pmid:25004746 |
Julu PO | Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats. | 1988 Oct-Dec | J Diabet Complications | pmid:2853165 |
Patel GK and Logan RA | Golden nail pigmentation. | 2002 | J Dermatolog Treat | pmid:12006139 |
Itoh S et al. | Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. | 2010 | J Clin Biochem Nutr | pmid:20664735 |
Sýkora J et al. | High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. | 2007 | J Chromatogr A | pmid:17157864 |
LÃsa M et al. | Comparison of various types of stationary phases in non-aqueous reversed-phase high-performance liquid chromatography-mass spectrometry of glycerolipids in blackcurrant oil and its enzymatic hydrolysis mixture. | 2009 | J Chromatogr A | pmid:19837411 |
Arnold LE et al. | Does zinc moderate essential fatty acid and amphetamine treatment of attention-deficit/hyperactivity disorder? | 2000 | J Child Adolesc Psychopharmacol | pmid:10933121 |
Giamarellos-Bourboulis EJ et al. | Do Escherichia coli susceptibilities to various antibiotics decrease in the presence of polyunsaturated fatty acids? A preliminary report. | 1994 | J Chemother | pmid:8071677 |
Singh NK et al. | Essential fatty acids and cancer with particular reference to Hodgkin's disease. | 1987 | J Assoc Physicians India | pmid:3693269 |
Das UN et al. | Beneficial effect of essential fatty acids in cirrhosis of the liver. | 1987 | J Assoc Physicians India | pmid:3693270 |
OtleÅŸ S and Pire R | Fatty acid composition of Chlorella and Spirulina microalgae species. | 2001 Nov-Dec | J AOAC Int | pmid:11767135 |
Horner NK and Lampe JW | Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. | 2000 | J Am Diet Assoc | pmid:11103660 |
McCollum JR | FDA alert on evening primrose oil. | 1989 | J Am Diet Assoc | pmid:2542387 |
Halat KM and Dennehy CE | Botanicals and dietary supplements in diabetic peripheral neuropathy. | 2003 Jan-Feb | J Am Board Fam Pract | pmid:12583650 |
Prencipe M et al. | Naudicelle and platelet reactivity in TIA patients. | 1982 | Ital J Neurol Sci | pmid:7166485 |
Aragona P et al. | Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjögren's syndrome patients. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16303936 |
Hopewell JW et al. | Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. | 1994 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7961020 |
Rahbeeni F et al. | The effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissue. | 2000 | Int. J. Radiat. Biol. | pmid:10902742 |
Jiang WG et al. | gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. | 1998 | Int. J. Oncol. | pmid:9683802 |
Menendez JA et al. | Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. | 2004 | Int. J. Oncol. | pmid:15138577 |
Menendez JA et al. | Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. | 2004 | Int. J. Cancer | pmid:15027132 |
Kenny FS et al. | Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. | 2000 | Int. J. Cancer | pmid:10699943 |
Pham H et al. | Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. | 2004 | Int. J. Cancer | pmid:15197770 |
Kenny FS et al. | Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts. | 2001 | Int. J. Cancer | pmid:11291069 |
Dib A and Carreau JP | Effects of gamma-linolenic acid supplementation on lipogenesis regulation in pregnant zinc-deficient rat and fetus. | 1986 | Int. J. Biochem. | pmid:3026865 |
Kast RE | Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. | 2001 | Int. Immunopharmacol. | pmid:11710548 |
Harrison RA et al. | Who and how many people are taking herbal supplements? A survey of 21,923 adults. | 2004 | Int J Vitam Nutr Res | pmid:15296076 |
MartÃnez-Augustin O et al. | Bioactive anti-obesity food components. | 2012 | Int J Vitam Nutr Res | pmid:23258394 |
Heard CM et al. | Preferential pi-pi complexation between tamoxifen and borage oil/gamma linolenic acid: transcutaneous delivery and NMR spectral modulation. | 2005 | Int J Pharm | pmid:16115741 |
Karia C et al. | Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. | 2004 | Int J Pharm | pmid:15129999 |
Redden PR et al. | Acyloxymethyl acidic drug derivatives: in vitro hydrolytic reactivity. | 1999 | Int J Pharm | pmid:10370185 |
Wilson JH et al. | The effect of very low energy diets on the fatty acid composition of serum lipids. | 1989 | Int J Obes | pmid:2613428 |
Haslett C et al. | A double-blind evaluation of evening primrose oil as an antiobesity agent. | 1983 | Int J Obes | pmid:6360923 |
Ranieri M et al. | The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. | 2009 Jul-Sep | Int J Immunopathol Pharmacol | pmid:19887043 |
Ribeiro P et al. | Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. | 2012 | Int J Food Sci Nutr | pmid:21707451 |
Viikari J and Lehtonen A | Effect of primrose oil on serum lipids and blood pressure in hyperlipidemic subjects. | 1986 | Int J Clin Pharmacol Ther Toxicol | pmid:3028968 |
Martens-Lobenhoffer J and Meyer FP | Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). | 1998 | Int J Clin Pharmacol Ther | pmid:9707349 |
Chang CS et al. | Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. | 2010 | Inflammation | pmid:19842026 |
Senapati S et al. | Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. | 2008 Sep-Oct | Indian J Dermatol Venereol Leprol | pmid:19052401 |
Purasiri P et al. | Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. | 1997 | Immunology | pmid:9415022 |
St Louis C et al. | Antihypertensive effect of gamma-linolenic acid in spontaneously hypertensive rats. | 1992 | Hypertension | pmid:1310479 |
Chaintreuil J et al. | Effects of dietary gamma-linolenate supplementation on serum lipids and platelet function in insulin-dependent diabetic patients. | 1984 | Hum Nutr Clin Nutr | pmid:6323358 |
Ramrath S et al. | Stimulation of cardiac glucose transport by thioctic acid and insulin. | 1999 | Horm. Metab. Res. | pmid:10668913 |
Vogelzang JL | Fat facts and fallacies. | 2003 | Home Healthc Nurse | pmid:14614382 |
Cohen SM et al. | Therapeutic use of selected herbs. | 2000 | Holist Nurs Pract | pmid:12119629 |
Melnik B and Plewig G | [A new concept of the etiopathogenesis and prevention of atopic dermatitis]. | 1989 | Hautarzt | pmid:2558092 |
Melnik B and Plewig G | [External treatment of atopic eczema with gamma-linolenic acid?]. | 1993 | Hautarzt | pmid:8407331 |
Jenkins AP et al. | Effects of bolus doses of fat on small intestinal structure and on release of gastrin, cholecystokinin, peptide tyrosine-tyrosine, and enteroglucagon. | 1992 | Gut | pmid:1541417 |
Jenkins AP and Thompson RP | Effect of dietary fat on the distribution of mucosal mass and cell proliferation along the small intestine. | 1992 | Gut | pmid:1541418 |