Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Murray MJ and Zhang T | The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089803 |
Horrobin DF et al. | The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871175 |
Arisaka M et al. | Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1871184 |
Hrelia S et al. | Kinetic analysis of delta-6-desaturation in liver microsomes: influence of gamma-linoleic acid dietary supplementation to young and old rats. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808628 |
Guivernau M et al. | Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846101 |
Laivuori H et al. | Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8248275 |
Das UN | Occlusion of infusion vessels on gamma-linolenic acid infusion. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643176 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Botha JH et al. | The role of prostaglandins in the inhibition of cultured carcinoma cell growth produced by gamma-linolenic acid. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2541450 |
Karmali RA et al. | Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8388566 |
Ramesh G and Das UN | Effect of evening primrose and fish oils on two stage skin carcinogenesis in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844986 |
Kuruvilla R et al. | Evening primrose oil treatment corrects reduced conduction velocity but not depletion of arachidonic acid in nerve from streptozotocin-induced diabetic rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844993 |
Sangeetha P et al. | Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2160083 |
Bunce OR and Abou-El-Ela SH | Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2177199 |
Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
Puri BK | The safety of evening primrose oil in epilepsy. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17764919 |
Duttaroy AK et al. | Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538089 |
Bégin ME et al. | Selective killing of human cancer cells by polyunsaturated fatty acids. | 1985 | Prostaglandins Leukot Med | pmid:2864701 |
Segarnick DJ et al. | Gamma-linolenic acid inhibits the development of the ethanol-induced fatty liver. | 1985 | Prostaglandins Leukot Med | pmid:2986177 |
Botha JH et al. | The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis. | 1985 | Prostaglandins Leukot Med | pmid:2994114 |
Fujiwara F et al. | Fatty acid modification of cultured neuroblastoma cells by gamma linolenic acid relevant to its antitumor effect. | 1987 | Prostaglandins Leukot Med | pmid:2829239 |
Varma PK and Persaud TV | Protection against ethanol-induced embryonic damage by administering gamma-linolenic and linoleic acids. | 1982 | Prostaglandins Leukot Med | pmid:6287501 |
Nassar BA et al. | The influence of dietary marine oil (Polepa) and evening primrose oil (Efamol) on prostaglandin production by the rat mesenteric vasculature. | 1987 | Prostaglandins Leukot Med | pmid:3033691 |
Hoffman P and Förster W | Effects of sunflowerseed oil, linseed oil, evening primrose oil and hydrogenated palm kernel oil on hypertension development in spontaneously hypertensive rats. | 1983 | Prostaglandins Leukot Med | pmid:6348801 |
Papanikolaou N | Alteration of mercuric chloride-induced autoimmune glomerulonephritis in brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor. | 1987 | Prostaglandins Leukot Med | pmid:3475724 |
Robinson KM and Botha JH | Effects of gamma-linolenic acid, dihomo-gamma-linolenic acid and ethanol on cultured human mammary carcinoma cells. | 1985 | Prostaglandins Leukot Med | pmid:2999828 |
Singer P et al. | Serum triglycerides and HDL cholesterol from SHR after evening primrose oil and other polyunsaturated fats. | 1986 | Prostaglandins Leukot Med | pmid:3523538 |
Fujiwara F et al. | Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells. | 1986 | Prostaglandins Leukot Med | pmid:3020590 |
Das UN et al. | Prostaglandins and their precursors can modify genetic damage-induced by gamma-radiation and benzo(a)pyrene. | 1985 | Prostaglandins | pmid:2994175 |
Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
Chaud M et al. | Gamma-linolenic acid improves the constancy of contractions in uteri from sprayed rats and is metabolized to prostaglandin E1 but not to bisenoic prostanoids. | 1988 | Prostaglandins | pmid:2836889 |
Costall B et al. | Dihomo-gamma-linolenic acid, prostaglandins and dyskinesias. | 1986 | Prog. Lipid Res. | pmid:2827191 |
Karmali RA et al. | Prostaglandins and essential fatty acids in regulation of autoimmunity and development of antibodies to DNA in NZB x NZW F1 mice. | 1981 | Prog. Lipid Res. | pmid:7342118 |
Kunkel SL et al. | Suppression of chronic inflammation by evening primrose oil. | 1981 | Prog. Lipid Res. | pmid:7342138 |
Gunstone FD | Gamma linolenic acid--occurrence and physical and chemical properties. | 1992 | Prog. Lipid Res. | pmid:1334265 |
Horrobin DF | Nutritional and medical importance of gamma-linolenic acid. | 1992 | Prog. Lipid Res. | pmid:1334266 |
Papanikolaou N et al. | Partial protection against acute renal failure by Efamol. | 1989 | Prog. Clin. Biol. Res. | pmid:2798451 |
Papanikolaou N et al. | Effect of thromboxane A2-synthetase inhibitor OKY-046 and evening primrose oil (Efamol) on mercuric chloride induced autoimmune glomerulonephritis in Brown-Norway rats. | 1987 | Prog. Clin. Biol. Res. | pmid:3671393 |
Huang YS et al. | Stress modulates cholesterol-induced changes in plasma and liver fatty acid composition in rats fed n-6 fatty acid-rich oils. | 1990 | Proc. Soc. Exp. Biol. Med. | pmid:2399256 |
Engler MM et al. | Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. | 1998 | Proc. Soc. Exp. Biol. Med. | pmid:9648942 |
Nassar BA et al. | The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets. | 1992 | Proc. Soc. Exp. Biol. Med. | pmid:1539039 |
Huang YS et al. | Effect of dietary alpha- and gamma-linolenic acid on tissue fatty acids in guinea pigs. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:2857052 |
Huang YS and Horrobin DF | Sex differences in n-3 and n-6 fatty acid metabolism in EFA-depleted rats. | 1987 | Proc. Soc. Exp. Biol. Med. | pmid:3037555 |
Mills DE and Ward R | Attenuation of psychosocial stress-induced hypertension by gamma-linolenic acid (GLA) administration in rats. | 1984 | Proc. Soc. Exp. Biol. Med. | pmid:6324224 |
Parker-Barnes JM et al. | Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10899997 |
Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
Calder PC | Rationale and use of n-3 fatty acids in artificial nutrition. | 2010 | Proc Nutr Soc | pmid:20441676 |
Funtikova NS et al. | [Synthesis of biologically active lipids by fungus Mucor lusitanicus 306D grown on media with various composition]. | 2002 Nov-Dec | Prikl. Biokhim. Mikrobiol. | pmid:12449793 |
Funtikova NS and Mysiakina IS | [Effects of conditions for obtaining sporangiospores of the inoculum on the morphology and productivity of the fungus Mucor circinelloides var. lusitanicus 12 M, a producer of gamma-linolenic acid]. | 2008 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:18924414 |
Watkins BA | Levels of dihomo-gamma-linolenate are depressed in heart phosphatidylcholine and phosphatidylethanolamine in the biotin-deficient chick. | 1989 | Poult. Sci. | pmid:2547210 |