gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Gastritis D005756 27 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Kidney Calculi D007669 7 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hyperplasia D006965 34 associated lipids
Arteriosclerosis D001161 86 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Psoriasis D011565 47 associated lipids
Alcoholism D000437 27 associated lipids
Bacteriuria D001437 7 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Dermatitis D003872 30 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Hyperlipidemias D006949 73 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Premenstrual Syndrome D011293 7 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Raynaud Disease D011928 7 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Dysmenorrhea D004412 9 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Synovitis D013585 15 associated lipids
Arthritis, Psoriatic D015535 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Insulin Resistance D007333 99 associated lipids
Fatigue D005221 10 associated lipids
Nausea D009325 7 associated lipids
Critical Illness D016638 13 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Acute Lung Injury D055371 33 associated lipids
Intermittent Claudication D007383 6 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Tietze's Syndrome D013991 1 associated lipids
Pityriasis D010915 3 associated lipids
Xerostomia D014987 6 associated lipids
Fallopian Tube Neoplasms D005185 1 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Scurvy D012614 2 associated lipids
Hand Dermatoses D006229 5 associated lipids
Mucocele D009078 1 associated lipids
Salivary Gland Diseases D012466 1 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Back Pain D001416 5 associated lipids
Urolithiasis D052878 1 associated lipids
Mastocytoma D034801 3 associated lipids
Ecchymosis D004438 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Liu FX et al. [Study on the encapsulation technique of high purity gamma-linolenic acid, part 1--Single factor, and two-factor tests for encapsulation process]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810447
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Shi LM et al. [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260318
Wang H et al. [Separation of gamma linolenic acid from evening primrose oil with urea inclusion--orthogonal experiment of optimizing technological parameters and observation of urea inclusion compound I]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20707192
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Bond R and Lloyd DH A double-blind comparison of olive oil and a combination of evening primrose oil and fish oil in the management of canine atopy. 1992 Vet. Rec. pmid:1481346
Bond R and Lloyd DH Combined treatment with concentrated essential fatty acids and prednisolone in the management of canine atopy. 1994 Vet. Rec. pmid:8135003
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Noli C et al. Conjugated linoleic acid and black currant seed oil in the treatment of canine atopic dermatitis: a preliminary report. 2007 Vet. J. pmid:16495095
Bloom P Atopic dermatitis: the quest for the silver bullet. 2008 Vet. J. pmid:18554562
Gueck T et al. Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. 2004 Vet. Dermatol. pmid:15500483
Saevik BK et al. A randomized, controlled study to evaluate the steroid sparing effect of essential fatty acid supplementation in the treatment of canine atopic dermatitis. 2004 Vet. Dermatol. pmid:15214949
Solomon LZ et al. Is gamma-linolenic acid an effective intravesical agent for superficial bladder cancer? In vitro cytotoxicity and in vivo tolerance studies. 1998 Urol. Res. pmid:9537690
Simán CM et al. Failure of short-term gamma-linolenic acid treatment to reduce urinary calcium loss of diabetic rats. 2000 Urol. Res. pmid:10850637
Tulloch I et al. Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. 1994 Urol. Res. pmid:7871634
du Toit PJ et al. Pyelonephritis: renal urokinase activity in rats on essential fatty acid diets. 1994 Urol. Res. pmid:7992455
Burgess NA et al. Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. 1995 Urol. Res. pmid:8533210
Crook TJ et al. The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. 2002 Urol. Res. pmid:11942327
Schumacher MC et al. A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens. 2013 Urol. Oncol. pmid:21414816
Omran OM Histopathological study of evening primrose oil effects on experimental diabetic neuropathy. 2012 Ultrastruct Pathol pmid:22574767
Lindskov R and Petersen CS [Oral gamma-linoleic acid (Epogam) in the treatment of atopic dermatitis]. 1995 Ugeskr. Laeg. pmid:7483071
Nykiforuk CL et al. High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds. 2012 Transgenic Res. pmid:21853296
Kong X et al. Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. 2009 Toxicol In Vitro pmid:19268700
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
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De La Cruz JP et al. Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. 1997 Thromb. Res. pmid:9253809
Nakahara T et al. Inhibitory effects of mold oil including gamma-linolenate on platelet thrombus formation in mesenteric microvessels of the rat. 1990 Thromb. Res. pmid:2156348
Pirich C et al. Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. 1999 Thromb. Res. pmid:10588465
Takahashi R et al. Effect of different ratios of dietary N-6 and N-3 fatty acids on fatty acid composition, prostaglandin formation and platelet aggregation in the rat. 1987 Thromb. Res. pmid:3660347
Akahane N et al. Antithrombotic activity of a symmetrical triglyceride with eicosapentaenoic acid and gamma-linolenic acid in guinea pig mesenteric microvasculature. 1995 Thromb. Res. pmid:7660360
Villalobos MA et al. Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits. 1998 Thromb. Haemost. pmid:9798993
Belch JJ et al. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. 1985 Thromb. Haemost. pmid:4082084
Paccalin J et al. [Changes in the higher derivatives of linoleic acid in cirrhotics treated with gamma-linolenic acid]. 1983 May-Jun Therapie pmid:6310813
Saied GM et al. Low intensity laser therapy is comparable to bromocriptine-evening primrose oil for the treatment of cyclical mastalgia in Egyptian females. 2007 Tanzan Health Res Bull pmid:18087899
Qureshi S and Sultan N Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. 2005 Surgeon pmid:15789786
Mohajeri S and Newman SA Review of evidence for dietary influences on atopic dermatitis. 2014 Jul-Aug Skin Therapy Lett. pmid:25188523
Yoon S et al. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. 2002 Jan-Feb Skin Pharmacol. Appl. Skin Physiol. pmid:11803254