gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Gastritis D005756 27 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Kidney Calculi D007669 7 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hyperplasia D006965 34 associated lipids
Arteriosclerosis D001161 86 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Psoriasis D011565 47 associated lipids
Alcoholism D000437 27 associated lipids
Bacteriuria D001437 7 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Dermatitis D003872 30 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Hyperlipidemias D006949 73 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Premenstrual Syndrome D011293 7 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Raynaud Disease D011928 7 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Dysmenorrhea D004412 9 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Synovitis D013585 15 associated lipids
Arthritis, Psoriatic D015535 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Insulin Resistance D007333 99 associated lipids
Fatigue D005221 10 associated lipids
Nausea D009325 7 associated lipids
Critical Illness D016638 13 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Acute Lung Injury D055371 33 associated lipids
Intermittent Claudication D007383 6 associated lipids
Fibrocystic Breast Disease D005348 1 associated lipids
Tietze's Syndrome D013991 1 associated lipids
Pityriasis D010915 3 associated lipids
Xerostomia D014987 6 associated lipids
Fallopian Tube Neoplasms D005185 1 associated lipids
Carcinoma, Mucoepidermoid D018277 3 associated lipids
Scurvy D012614 2 associated lipids
Hand Dermatoses D006229 5 associated lipids
Mucocele D009078 1 associated lipids
Salivary Gland Diseases D012466 1 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Back Pain D001416 5 associated lipids
Urolithiasis D052878 1 associated lipids
Mastocytoma D034801 3 associated lipids
Ecchymosis D004438 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

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Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Bordoni A et al. Manipulation of lipid composition of rat heart myocytes aged in culture and its effect on alpha1-adrenoceptor stimulation. 1997 Biochim. Biophys. Acta pmid:9366250
Larsen LN et al. Polyunsaturated thia- and oxa-fatty acids: incorporation into cell-lipids and their effects on arachidonic acid- and eicosanoid synthesis. 1997 Biochim. Biophys. Acta pmid:9366251
Ziboh VA et al. gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. 1997 Lipids pmid:9252965
De La Cruz JP et al. Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. 1997 Thromb. Res. pmid:9253809
Küpper C [Premenstrual syndrome: does gamma-linolenic acid help?]. 1997 Fortschr. Med. pmid:9173016
Vassilopoulos D et al. Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. 1997 Clin. Immunol. Immunopathol. pmid:9175912
Manninen P and Laakso P Capillary supercritical fluid chromatography--atmospheric pressure chemical ionization mass spectrometry of gamma- and alpha-linolenic acid containing triacylglycerols in berry oils. 1997 Lipids pmid:9270973
Magnusson G et al. Plasma and tissue levels of lipids, fatty acids and plasma carnitine in neonates receiving a new fat emulsion. 1997 Acta Paediatr. pmid:9202801
Garland HO et al. Dietary essential fatty acid supplementation, urinary calcium excretion and reproductive performance in the diabetic pregnant rat. 1997 J. Endocrinol. pmid:9203989
Murray MJ and Zhang T The incorporation of dietary n-3 polyunsaturated fatty acids into porcine platelet phospholipids and their effects on platelet thromboxane A2 release. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089803
Wagner W and Nootbaar-Wagner U Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. 1997 Cephalalgia pmid:9137851
Jiang WG et al. Gamma linolenic acid regulates gap junction communication in endothelial cells and their interaction with tumour cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150377
Biernat J and Grajeta H Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 1. Blood serum and liver lipids. 1997 Nahrung pmid:9113670
Grajeta H and Biernat J Effect of high-fat cholesterol enriched diets on hypolipemic action of Oenothera paradoxa oil in rats. Part 2. Blood serum and liver fatty acids. 1997 Nahrung pmid:9113671
Utsunomiya T Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1997 Br J Surg pmid:9117334
Mancuso P et al. Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. 1997 Crit. Care Med. pmid:9118672
Vartak S et al. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. 1997 Lipids pmid:9076665
Bard JM et al. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. 1997 Fundam Clin Pharmacol pmid:9107561
Fang C et al. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051726
McGahon B et al. The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. 1997 Neuroscience pmid:9300396
Quoc KP and Dubacq JP Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. 1997 Biochim. Biophys. Acta pmid:9219908
Purasiri P et al. Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. 1997 Immunology pmid:9415022
de Antueno R et al. In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. 1997 Br. J. Cancer pmid:9192987
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Mpanju O et al. Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. 1997 Antivir. Ther. (Lond.) pmid:11322262
Griffiths G et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. 1997 Prostate pmid:9108883
Pohl CH et al. The production of gamma-linolenic acid by selected members of the Dikaryomycota grown on different carbon sources. 1997 Antonie Van Leeuwenhoek pmid:9403104
Jiang WG et al. Regulation of desmosomal cell adhesion in human tumour cells by polyunsaturated fatty acids. 1997 Clin. Exp. Metastasis pmid:9344043
Campbell EM et al. Premenstrual symptoms in general practice patients. Prevalence and treatment. 1997 J Reprod Med pmid:9350019
al-Shabanah OA Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. 1997 Food Chem. Toxicol. pmid:9350221
Bíró K et al. Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. 1997 Brain Res. Bull. pmid:9323440
Steinbrunn BS et al. Mastalgia. Tailoring treatment to type of breast pain. 1997 Postgrad Med pmid:9385340
Tocher DR et al. Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. 1997 Lipids pmid:9438233
Fearon KC et al. An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. 1996 Mar-Apr Anticancer Res. pmid:8687143
Dines KC et al. Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8931113
Reddy AS and Thomas TL Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. 1996 Nat. Biotechnol. pmid:9630958
Sadi AM et al. Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. 1996 Exp. Anim. pmid:8689581
Cameron NE et al. Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. 1996 Diabetologia pmid:8635669
Chilton SA Cognitive behaviour therapy for the chronic fatigue syndrome. Evening primrose oil and magnesium have been shown to be effective. 1996 BMJ pmid:8616424
Cantrill RC et al. Exogenous gamma-linolenic acid alters hormone stimulated cyclic AMP levels in U937 cells. 1996 Cancer Lett. pmid:8620439
Wainwright PE et al. Effects of dietary gamma-linolenic acid and prenatal ethanol on mouse brain and behavior. 1996 Pharmacol. Biochem. Behav. pmid:8801587
Each of the following has been shown to be effective for cyclical breast pain. 1996 Can Fam Physician pmid:8704485
Schöpf E et al. [Gamma-linolenic acid in atopic patients?]. 1996 Med Monatsschr Pharm pmid:8684312
Jiang WG et al. Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1996 Br J Surg pmid:8689213
McCarty MF Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. 1996 Med. Hypotheses pmid:8692033
Ells GW et al. Vitamin E blocks the cytotoxic effect of gamma-linolenic acid when administered as late as the time of onset of cell death--insight into the mechanism of fatty acid induced cytotoxicity. 1996 Cancer Lett. pmid:8556710
Palombo JD et al. Rapid modulation of lung and liver macrophage phospholipid fatty acids in endotoxemic rats by continuous enteral feeding with n-3 and gamma-linolenic fatty acids. 1996 Am. J. Clin. Nutr. pmid:8561062
Redden PR et al. Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic acid. 1996 Chem. Phys. Lipids pmid:8907238
Julu PO et al. Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats. 1996 J Lipid Mediat Cell Signal pmid:8925193
Julu PO Latency of neuroactivity and optimum period of treatment with evening primrose oil in diabetic rats. 1996 J Lipid Mediat Cell Signal pmid:8925199