gamma-Linolenic acid
Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
Cross Reference
Introduction
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with gamma-Linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with gamma-Linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with gamma-Linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with gamma-Linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
| OlguÃn EJ et al. | The effect of low light flux and nitrogen deficiency on the chemical composition of Spirulina sp. (Arthrospira) grown on digested pig waste. | 2001 | Bioresour. Technol. | pmid:11211071 |
| Corbett JW et al. | Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212098 |
| Khamaisi M et al. | Metabolic effects of gamma-linolenic acid-alpha-lipoic acid conjugate in streptozotocin diabetic rats. | 1999 | Antioxid. Redox Signal. | pmid:11233149 |
| Shahidi F | Antioxidant factors in plant foods and selected oilseeds. | 2000 | Biofactors | pmid:11237180 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
| Menéndez JA et al. | Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. | 2001 | Eur. J. Cancer | pmid:11239764 |
| Borenshtein D et al. | Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. | 2001 Jan-Feb | Diabetes Metab. Res. Rev. | pmid:11241890 |
| Keysser G | [Are there effective dietary recommendations for patients with rheumatoid arthritis?]. | 2001 | Z Rheumatol | pmid:11263011 |
| Little C and Parsons T | Herbal therapy for treating rheumatoid arthritis. | 2001 | Cochrane Database Syst Rev | pmid:11279784 |
| Kenny FS et al. | Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts. | 2001 | Int. J. Cancer | pmid:11291069 |
| Kaku S et al. | Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302164 |
| Sims EC and Plowman PN | Stereotactic radiosurgery XII. Large AVM and the failure of the radiation response modifier gamma linolenic acid to improve the therapeutic ratio. | 2001 | Br J Neurosurg | pmid:11303657 |
| Fauconnot L and Buist PH | Gamma-linolenic acid biosynthesis: cryptoregiochemistry of delta6 desaturation. | 2001 | J. Org. Chem. | pmid:11312950 |
| Mpanju O et al. | Selective cytotoxicity of lithium gamma-linolenic acid in human T cells chronically and productively infected with HIV. | 1997 | Antivir. Ther. (Lond.) | pmid:11322262 |
| Colquhoun A and Schumacher RI | Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid. | 2001 | Mol. Cell. Biochem. | pmid:11330827 |
| Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
| Hounsom L et al. | Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. | 2001 | Diabetologia | pmid:11357471 |
| Barre DE | Potential of evening primrose, borage, black currant, and fungal oils in human health. | 2001 | Ann. Nutr. Metab. | pmid:11359029 |
| Fuller MA et al. | Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. | 2001 | Arch. Biochem. Biophys. | pmid:11361131 |
| Fan YY et al. | Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. | 2001 | J. Nutr. | pmid:11385052 |
| Nwankwo JO | Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells. | 2001 | Med. Hypotheses | pmid:11388772 |
| Nwankwo JO and Robbins ME | Peroxisome proliferator-activated receptor- gamma expression in human malignant and normal brain, breast and prostate-derived cells. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418018 |
| Furse RK et al. | Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. | 2001 | J. Immunol. | pmid:11418687 |
| Kankaanpää P et al. | Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy. | 2001 | Allergy | pmid:11421921 |
| Kamphuis MM et al. | Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid. | 2001 | Eur J Clin Nutr | pmid:11423927 |
| Mainou-Fowler T et al. | Gamma-linolenic acid induces apoptosis in B-chronic lymphocytic leukaemia cells in vitro. | 2001 | Leuk. Lymphoma | pmid:11426562 |
| Chakrabarti KB et al. | Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane). | 2001 | Eur. J. Cancer | pmid:11435077 |
| Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
| Yogo Y and Fujishima S | [Nutritional support for ARDS]. | 2001 | Nippon Rinsho | pmid:11439576 |
| Serrano I et al. | Ethanol-induced dimorphism and lipid composition changes in Mucor fragilis CCMI 142. | 2001 | Lett. Appl. Microbiol. | pmid:11442823 |
| Hou X et al. | 2,3-Dinor-5,6-dihydro-15-F(2t)-isoprostane: a bioactive prostanoid metabolite. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11448840 |
| Ford I et al. | The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. | 2001 | Metab. Clin. Exp. | pmid:11474472 |
| Cunnane SC et al. | NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478372 |
| Demmelmair H et al. | Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants. | 2001 | Lipids | pmid:11485158 |
| Guil-Guerrero JL et al. | Occurrence and characterization of oils rich in gamma-linolenic acid (III): the taxonomical value of the fatty acids in Echium (Boraginaceae). | 2001 | Phytochemistry | pmid:11524120 |
| Birch AE et al. | Antioxidant properties of evening primrose seed extracts. | 2001 | J. Agric. Food Chem. | pmid:11559161 |
| Ide T et al. | Dietary mold oil rich in gamma linolenic acid increases insulin-dependent glucose utilization in isolated rat adipocytes. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11567903 |
| Zavodnik LB et al. | [Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation]. | 2001 Jul-Aug | Eksp Klin Farmakol | pmid:11589114 |
| Reinikainen M et al. | The toxicities of a polyunsaturated fatty acid and a microcystin to Daphnia magna. | 2001 | Environ. Toxicol. | pmid:11594032 |
| Agatha G et al. | Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. | 2001 | Cancer Lett. | pmid:11597788 |
| Wollheim FA | [Meager support for herbal therapy of rheumatoid arthritis]. | 2001 | Lakartidningen | pmid:11699249 |
| Kast RE | Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. | 2001 | Int. Immunopharmacol. | pmid:11710548 |
| Kaku S et al. | Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728173 |
| Colquhoun A and Schumacher RI | gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. | 2001 | Biochim. Biophys. Acta | pmid:11731331 |
| Tsimaratos M et al. | Gamma-linolenic acid restores renal medullary thick ascending limb Na(+),K(+)-ATPase activity in diabetic rats. | 2001 | J. Nutr. | pmid:11739860 |
| Keegan A et al. | Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. | 2001 Sep-Oct | Diabetes Metab. Res. Rev. | pmid:11747143 |
| OtleÅŸ S and Pire R | Fatty acid composition of Chlorella and Spirulina microalgae species. | 2001 Nov-Dec | J AOAC Int | pmid:11767135 |
| Deng X et al. | Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779162 |
| Thies F et al. | Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. | 2001 | Lipids | pmid:11795850 |
| Yoon S et al. | The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. | 2002 Jan-Feb | Skin Pharmacol. Appl. Skin Physiol. | pmid:11803254 |
| Senanayake SP and Shahidi F | Structured lipids via lipase-catalyzed incorporation of eicosapentaenoic acid into borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils. | 2002 | J. Agric. Food Chem. | pmid:11804516 |
| Tso P et al. | Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. | 2002 | J. Nutr. | pmid:11823581 |
| Gema H et al. | Production of gamma-linolenic acid by Cunninghamella echinulata cultivated on glucose and orange peel. | 2002 | Appl. Microbiol. Biotechnol. | pmid:11935180 |
| Crook TJ et al. | The effects of meglumine gamma linolenic acid (MeGLA) on an organ culture model of superficial bladder cancer. | 2002 | Urol. Res. | pmid:11942327 |
| Furse RK et al. | Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. | 2002 | J. Clin. Immunol. | pmid:11998897 |
| Patel GK and Logan RA | Golden nail pigmentation. | 2002 | J Dermatolog Treat | pmid:12006139 |
| Leigh-Firbank EC et al. | Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. | 2002 | Br. J. Nutr. | pmid:12010583 |
| Braddock R et al. | gamma-Linoleic acid and ascorbic acid ameliorate the effects of experimental diabetes on electrolyte and bone homeostasis in pregnant rats. | 2002 | J. Endocrinol. | pmid:12010635 |
| Hong H et al. | High-level production of gamma-linolenic acid in Brassica juncea using a delta6 desaturase from Pythium irregulare. | 2002 | Plant Physiol. | pmid:12011365 |
| GarcÃa-Maroto F et al. | Cloning and molecular characterization of the delta6-desaturase from two echium plant species: production of GLA by heterologous expression in yeast and tobacco. | 2002 | Lipids | pmid:12030323 |
| Leaver HA et al. | Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12051954 |
| Menéndez JA et al. | Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. | 2002 | Breast Cancer Res. Treat. | pmid:12058962 |
| Cook D et al. | Modification of fatty acid composition in tomato (Lycopersicon esculentum) by expression of a borage delta6-desaturase. | 2002 | Mol. Biotechnol. | pmid:12059112 |
| Colquhoun A | Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. | 2002 | Biochim. Biophys. Acta | pmid:12069851 |
| Das UN | Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. | 2002 Jul-Aug | Nutrition | pmid:12093450 |
| Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
| Theander E et al. | Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome. | 2002 | Scand. J. Rheumatol. | pmid:12109650 |
| Cohen SM et al. | Therapeutic use of selected herbs. | 2000 | Holist Nurs Pract | pmid:12119629 |
| Harris NM et al. | Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study. | 2002 | Eur. Urol. | pmid:12121728 |
| Jack AM et al. | Effects of diabetes and evening primrose oil treatment on responses of aorta, corpus cavernosum and mesenteric vasculature in rats. | 2002 | Life Sci. | pmid:12175702 |
| Hornych A et al. | The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. | 2002 | Bratisl Lek Listy | pmid:12190041 |
| Khunyoshyeng S et al. | Differential expression of desaturases and changes in fatty acid composition during sporangiospore germination and development in Mucor rouxii. | 2002 | Fungal Genet. Biol. | pmid:12223185 |
| Hamburger M et al. | Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities. | 2002 | J. Agric. Food Chem. | pmid:12236675 |
| Dyer O | Doctor accused of giving false information to drug trial. | 2002 | BMJ | pmid:12269314 |
| Das UN | Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid. | 2002 | Nutrition | pmid:12297217 |
| Chung S et al. | Gamma-linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs. | 2002 | J. Nutr. | pmid:12368400 |
| Senanayake SP and Shahidi F | Positional distribution of FA in TAG of enzymatically modified borage and evening primrose oils. | 2002 | Lipids | pmid:12371752 |
| Turon F et al. | A direct method for regiospecific analysis of TAG using alpha-MAG. | 2002 | Lipids | pmid:12371754 |
| Gillis RC et al. | Eicosapentaenoic acid and gamma-linolenic acid induce apoptosis in HL-60 cells. | 2002 | J. Surg. Res. | pmid:12384078 |
| Pérez Y et al. | Measurement by nuclear magnetic resonance diffusion of the dimensions of the mobile lipid compartment in C6 cells. | 2002 | Cancer Res. | pmid:12384523 |
| Berry JA | Benign breast pain. New approaches manage this common condition more effectively. | 2001 | Adv Nurse Pract | pmid:12400335 |
| Ernst E | Ayurvedic medicines. | 2002 | Pharmacoepidemiol Drug Saf | pmid:12426929 |
| Uesaka Y | [Prevention and treatment of diabetic neuropathy]. | 2002 | Nippon Rinsho | pmid:12430238 |
| Blommers J et al. | Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. | 2002 | Am. J. Obstet. Gynecol. | pmid:12439536 |
| Leaver HA et al. | Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12445487 |
| Pham H et al. | Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells. | 2003 | Cancer Lett. | pmid:12445673 |
| Funtikova NS et al. | [Synthesis of biologically active lipids by fungus Mucor lusitanicus 306D grown on media with various composition]. | 2002 Nov-Dec | Prikl. Biokhim. Mikrobiol. | pmid:12449793 |
| SimoncÃkova P et al. | Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected]. | 2002 | Endocr Regul | pmid:12466014 |
| Samuels R et al. | Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome. | 2002 | J Med Food | pmid:12487756 |
| Harris NM et al. | Epirubicin and meglumine gamma-linolenic acid: a logical choice of combination therapy for patients with superficial bladder carcinoma. | 2003 | Cancer | pmid:12491507 |
| Shotton HR et al. | The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. | 2003 | Diabetes | pmid:12502507 |
| Duttaroy AK et al. | Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538089 |
| Gimeno RE et al. | Characterization of a heart-specific fatty acid transport protein. | 2003 | J. Biol. Chem. | pmid:12556534 |
| Pacht ER et al. | Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. | 2003 | Crit. Care Med. | pmid:12576957 |
| Xian M et al. | Production of gamma-linolenic acid by disrupted mycelia of Mortierella isabellina. | 2003 | Lett. Appl. Microbiol. | pmid:12581380 |
| Halat KM and Dennehy CE | Botanicals and dietary supplements in diabetic peripheral neuropathy. | 2003 Jan-Feb | J Am Board Fam Pract | pmid:12583650 |
| Pham H and Ziboh VA | 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:12589947 |
| Rosenstein ED et al. | Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591005 |