Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.
To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Barar J et al. | Barrier functionality and transport machineries of human ECV304 cells. | 2010 | Med. Sci. Monit. | pmid:20037486 |
Khongto B et al. | Fermentation process development of recombinant Hansenula polymorpha for gamma-linolenic acid production. | 2010 | J. Microbiol. Biotechnol. | pmid:21124062 |
Itoh S et al. | Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. | 2010 | J Clin Biochem Nutr | pmid:20664735 |
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Chang CS et al. | Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. | 2010 | Inflammation | pmid:19842026 |
Ribeiro G et al. | The novel ruthenium-gamma-linolenic complex [Ru(2)(aGLA)(4)Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitro. | 2010 | Cell Biochem. Funct. | pmid:19927275 |
Kishino S et al. | Microbial production of conjugated gamma-linolenic acid from gamma-linolenic acid by Lactobacillus plantarum AKU 1009a. | 2010 | J. Appl. Microbiol. | pmid:19919619 |
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Chuang LT et al. | Co-expression of heterologous desaturase genes in Yarrowia lipolytica. | 2010 | N Biotechnol | pmid:20188875 |
Ruenwai R et al. | Oxygen-induced expression of Delta(6)-, Delta(9)- and Delta(12)-desaturase genes modulates fatty acid composition in Mucor rouxii. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20187298 |
Fa-lin Z et al. | Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment. | 2010 | Phytother Res | pmid:20041414 |
Wang H et al. | [Separation of gamma linolenic acid from evening primrose oil with urea inclusion--orthogonal experiment of optimizing technological parameters and observation of urea inclusion compound I]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20707192 |
Habermann N et al. | Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. | 2009 Sep-Oct | Biofactors | pmid:19798733 |
Tsai NP et al. | Activation of testicular orphan receptor 4 by fatty acids. | 2009 Nov-Dec | Biochim. Biophys. Acta | pmid:19800043 |
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Ranieri M et al. | The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. | 2009 Jul-Sep | Int J Immunopathol Pharmacol | pmid:19887043 |
Ahmed SU et al. | Application of response surface method for studying the role of dissolved oxygen and agitation speed on gamma-linolenic acid production. | 2009 | Appl. Biochem. Biotechnol. | pmid:18480973 |
De Spirt S et al. | Intervention with flaxseed and borage oil supplements modulates skin condition in women. | 2009 | Br. J. Nutr. | pmid:18761778 |
Kong X et al. | Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. | 2009 | Toxicol In Vitro | pmid:19268700 |
Schnebelen C et al. | Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. | 2009 | Lipids | pmid:19242743 |
Miyake JA et al. | Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. | 2009 | Lipids Health Dis | pmid:19292920 |
Ge H et al. | Gamma-linolenic acid induces apoptosis and lipid peroxidation in human chronic myelogenous leukemia K562 cells. | 2009 | Cell Biol. Int. | pmid:19356705 |
Weaver KL et al. | Effect of dietary fatty acids on inflammatory gene expression in healthy humans. | 2009 | J. Biol. Chem. | pmid:19359242 |
Zaniewska A et al. | The activity of lysosomal exoglycosidases in serum of alcohol-dependent men supplemented with borage oil enriched with vitamin E. | 2009 | J Med Food | pmid:19735195 |
Lu H et al. | Identification and characterization of a novel delta6-fatty acid desaturase gene from Rhizopus nigricans. | 2009 | Mol. Biol. Rep. | pmid:19152021 |
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Jangbua P et al. | Gamma-linolenic acid production of Mucor rouxii by solid-state fermentation using agricultural by-products. | 2009 | Lett. Appl. Microbiol. | pmid:19453951 |
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Viau S et al. | Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. | 2009 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:19415319 |
Wan X et al. | Production of gamma-linolenic acid in Pichia pastoris by Expression of a delta-6 desaturase gene from Cunninghamella echinulata. | 2009 | J. Microbiol. Biotechnol. | pmid:19884765 |
LÃsa M et al. | Comparison of various types of stationary phases in non-aqueous reversed-phase high-performance liquid chromatography-mass spectrometry of glycerolipids in blackcurrant oil and its enzymatic hydrolysis mixture. | 2009 | J Chromatogr A | pmid:19837411 |
Cameron M et al. | Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 2: Rheumatoid arthritis. | 2009 | Phytother Res | pmid:19941324 |
Rodgers A et al. | Evening primrose oil supplementation increases citraturia and decreases other urinary risk factors for calcium oxalate urolithiasis. | 2009 | J. Urol. | pmid:19846138 |
Scheim DE | Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. | 2009 | Lipids Health Dis | pmid:20003514 |
Lindemann J et al. | Clinical study of the effects on asthma-related QOL and asthma management of a medical food in adult asthma patients. | 2009 | Curr Med Res Opin | pmid:19811112 |
Riaz A et al. | Assessment of anticoagulant effect of evening primrose oil. | 2009 | Pak J Pharm Sci | pmid:19783511 |
Labruzzo BA et al. | Which complementary therapies can help patients with PMS? | 2009 | J Fam Pract | pmid:19874736 |
Senapati S et al. | Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. | 2008 Sep-Oct | Indian J Dermatol Venereol Leprol | pmid:19052401 |
Pontes-Arruda A et al. | The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974237 |
Preiser JC | Nutrition therapy for acute respiratory distress syndrome. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974251 |
Dickerson RN | Modified EN support for patients with acute respiratory distress syndrome. | 2008 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:18974252 |
Funtikova NS and Mysiakina IS | [Effects of conditions for obtaining sporangiospores of the inoculum on the morphology and productivity of the fungus Mucor circinelloides var. lusitanicus 12 M, a producer of gamma-linolenic acid]. | 2008 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:18924414 |
Mysiakina IS and Funtikova NS | [Activity of NAD-dependent isocitrate dehydrogenase, isocitrate lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of nitrogen supply]. | 2008 Jul-Aug | Mikrobiologiia | pmid:18825970 |
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Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Clément M et al. | Purification and identification of bovine cheese whey fatty acids exhibiting in vitro antifungal activity. | 2008 | J. Dairy Sci. | pmid:18565910 |
Leskinen H et al. | Regioisomeric structure determination of alpha- and gamma-linolenoyldilinoleoylglycerol in blackcurrant seed oil by silver ion high-performance liquid chromatography and mass spectrometry. | 2008 | Anal. Chem. | pmid:18578547 |
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Fakas S et al. | Gamma-linolenic acid production by Cunninghamella echinulata growing on complex organic nitrogen sources. | 2008 | Bioresour. Technol. | pmid:18609766 |
Yu Q et al. | LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenase-catalysed peroxidation of gamma-linolenic acid. | 2008 | Free Radic. Res. | pmid:18484409 |
Thumfart J et al. | Magnesium stimulates renal phosphate reabsorption. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18701629 |
Bloom P | Atopic dermatitis: the quest for the silver bullet. | 2008 | Vet. J. | pmid:18554562 |
Adam O | [Ankylosing Spondylitis and convenient nutrition]. | 2008 | Wien Med Wochenschr | pmid:18560957 |
Wedig KE and Whitsett JA | Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. | 2008 | J. Pediatr. | pmid:18154917 |
Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
Shi LM et al. | [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260318 |
Nandakumar M and Tan MW | Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. | 2008 | PLoS Genet. | pmid:19023415 |
Won J et al. | Stability analysis of zinc oxide-nanoencapsulated conjugated linoleic acid and gamma-linolenic acid. | 2008 | J. Food Sci. | pmid:19019122 |
Geppert J et al. | Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. | 2008 | Br. J. Nutr. | pmid:17678567 |
Rühl R et al. | Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. | 2008 | Br. J. Nutr. | pmid:18005485 |
Chilton FH et al. | Mechanisms by which botanical lipids affect inflammatory disorders. | 2008 | Am. J. Clin. Nutr. | pmid:18258646 |
Surette ME et al. | The impact of a medical food containing gammalinolenic and eicosapentaenoic acids on asthma management and the quality of life of adult asthma patients. | 2008 | Curr Med Res Opin | pmid:18194593 |
Cui PH et al. | Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. | 2008 | Chem. Phys. Lipids | pmid:18339314 |
Wu CC et al. | Metabolism of omega-6 polyunsaturated fatty acids in women with dysmenorrhea. | 2008 | Asia Pac J Clin Nutr | pmid:18296341 |
Jeennor S et al. | Evaluation of inoculum performance for enhancing gamma-linolenic acid production from Mucor rouxii. | 2008 | Lett. Appl. Microbiol. | pmid:18298455 |
Puch F et al. | Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. | 2008 | Exp. Dermatol. | pmid:18318715 |
Vinggaard AM et al. | Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008 | Chem. Res. Toxicol. | pmid:18324785 |
Song C et al. | Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. | 2008 | J. Nutr. | pmid:18424607 |
Choi GG et al. | Enhanced biomass and gamma-linolenic acid production of mutant strain Arthrospira platensis. | 2008 | J. Microbiol. Biotechnol. | pmid:18388474 |
Prociuk MA et al. | Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. | 2008 | Can. J. Physiol. Pharmacol. | pmid:18418423 |
Kanehara S et al. | Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children. | 2007 Sep-Oct | Eur J Dermatol | pmid:17673396 |
Puri BK | Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). | 2007 | J. Clin. Pathol. | pmid:16935966 |
Dasgupta S and Bhattacharyya DK | Dietary effect of gamma-linolenic acid on the lipid profile of rat fed erucic acid rich oil. | 2007 | J Oleo Sci | pmid:17938547 |
Martin TA et al. | Enhanced tight junction function in human breast cancer cells by antioxidant, selenium and polyunsaturated lipid. | 2007 | J. Cell. Biochem. | pmid:17243118 |
Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
Christie A et al. | Effectiveness of nonpharmacological and nonsurgical interventions for patients with rheumatoid arthritis: an overview of systematic reviews. | 2007 | Phys Ther | pmid:17906290 |
Dobryniewski J et al. | [The gamma-linolenic acid (GLA)--the therapeutic value]. | 2007 | Prz. Lek. | pmid:17892041 |
Theilla M et al. | A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study. | 2007 | Clin Nutr | pmid:17933438 |
Garaiova I et al. | A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. | 2007 | Nutr J | pmid:17254329 |
Das UN | Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. | 2007 | Med. Sci. Monit. | pmid:17599036 |
Schirmer MA and Phinney SD | Gamma-linolenate reduces weight regain in formerly obese humans. | 2007 | J. Nutr. | pmid:17513402 |
Villamor E et al. | Long-chain n-6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. | 2007 | Am. J. Clin. Nutr. | pmid:17823433 |