gamma-Linolenic acid

Gamma-linolenic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Drug Interactions. Gamma-linolenic acid often locates in Articular system.

Cross Reference

Introduction

To understand associated biological information of gamma-Linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with gamma-Linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alcoholism D000437 27 associated lipids
Arteriosclerosis D001161 86 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Back Pain D001416 5 associated lipids
Bacteriuria D001437 7 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Carpal Tunnel Syndrome D002349 3 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with gamma-Linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with gamma-Linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with gamma-Linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with gamma-Linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with gamma-Linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 1121
Authors Title Published Journal PubMed Link
Liu J et al. Δ6-Desaturase from Mortierella alpina: cDNA cloning, expression, and phylogenetic analysis. 2011 Biotechnol. Lett. pmid:21691840
Wang P et al. Production of γ-linolenic acid using a novel heterologous expression system in the oleaginous yeast Lipomyces kononenkoae. 2011 Biotechnol. Lett. pmid:21681556
Torres CF et al. Lipase-catalyzed ethanolysis of borage oil: a kinetic study. 2004 May-Jun Biotechnol. Prog. pmid:15176879
Yan Y et al. Survey of the total fatty acid and triacylglycerol composition and content of 30 duckweed species and cloning of a Δ6-desaturase responsible for the production of γ-linolenic and stearidonic acids in Lemna gibba. 2013 BMC Plant Biol. pmid:24308551
Dyer O Doctor accused of giving false information to drug trial. 2002 BMJ pmid:12269314
Berth-Jones J and Graham-Brown RA Evening primrose oil. Does not show promise in atopic dermatitis. 1994 BMJ pmid:7819863
Chenoy R et al. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. 1994 BMJ pmid:8136666
Kmietowicz Z Evening primrose oil and borage oil do not help eczema symptoms, finds Cochrane review. 2013 BMJ pmid:23628953
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Kleijnen J Evening primrose oil. 1994 BMJ pmid:7950599
Claassen N et al. Supplemented gamma-linolenic acid and eicosapentaenoic acid influence bone status in young male rats: effects on free urinary collagen crosslinks, total urinary hydroxyproline, and bone calcium content. 1995 Bone pmid:7626328
O'Brien PM et al. The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? 1985 Br J Clin Pharmacol pmid:2985102
Hornych A et al. Effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandins in old subjects. 1999 Br J Clin Pharmacol pmid:10651470
Schoemaker JH Pharmacological treatment of diabetic peripheral neuropathy: challenges and possibilities. 1994 Mar-Apr Br J Clin Pract pmid:8024999
Van der Merwe CF et al. Oral gamma-linolenic acid in 21 patients with untreatable malignancy. An ongoing pilot open clinical trial. 1987 Br J Clin Pract pmid:2837264
Strong AM et al. The effect of oral linoleic acid and gamma-linolenic acid (Efamol [G]). 1985 Nov-Dec Br J Clin Pract pmid:4092010
McFayden IJ et al. Cyclical breast pain--some observations and the difficulties in treatment. 1992 Br J Clin Pract pmid:1286012
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Gateley CA and Mansel RE Management of cyclical breast pain. 1990 Br J Hosp Med pmid:2364227
Sims EC and Plowman PN Stereotactic radiosurgery XII. Large AVM and the failure of the radiation response modifier gamma linolenic acid to improve the therapeutic ratio. 2001 Br J Neurosurg pmid:11303657
McCaul JA and Lamey PJ Multiple oral mucoceles treated with gamma-linolenic acid: report of a case. 1994 Br J Oral Maxillofac Surg pmid:7849001
Ranchordas MK et al. A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. 2011 Br J Sports Med pmid:21743106
Pritchard GA et al. Lipids in breast carcinogenesis. 1989 Br J Surg pmid:2557113
Utsunomiya T Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1997 Br J Surg pmid:9117334
Gateley CA et al. Plasma fatty acid profiles in benign breast disorders. 1992 Br J Surg pmid:1596720
Ravichandran D et al. Effect of lithium gamma-linolenate on the growth of experimental human pancreatic carcinoma. 1998 Br J Surg pmid:9752859
Gateley CA et al. Mastalgia refractory to drug treatment. 1990 Br J Surg pmid:2224458
Jiang WG et al. Inhibition of neutrophil respiratory burst and cytokine priming by gamma-linolenic acid. 1996 Br J Surg pmid:8689213
Solomon LZ et al. Bladder cancer recurrence by implantation of exfoliated cells: is gamma-linolenic acid an effective tumoricidal agent? 1998 Br J Urol pmid:9698674
Simpson LO Pinch skin grafting or porcine dermis in venous ulcers. 1987 Br Med J (Clin Res Ed) pmid:3109651
McIllmurray MB and Turkie W Controlled trial of gamma linolenic acid in Duke's C colorectal cancer. 1987 Br Med J (Clin Res Ed) pmid:3036291
de Antueno R et al. In vivo and in vitro biotransformation of the lithium salt of gamma-linolenic acid by three human carcinomas. 1997 Br. J. Cancer pmid:9192987
Hopewell JW et al. The modulation of radiation-induced damage to pig skin by essential fatty acids. 1993 Br. J. Cancer pmid:8391301
Vartak S et al. Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. 1998 Br. J. Cancer pmid:9635836
Plumb JA et al. Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. 1993 Br. J. Cancer pmid:8385976
Jiang WG et al. The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. 1998 Br. J. Cancer pmid:9514051
Jiang WG et al. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. 1995 Br. J. Cancer pmid:7710939
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Kapoor R and Klimaszewski A Efficacy of borage oil in patients with atopic eczema. 2000 Br. J. Dermatol. pmid:10886164
Johnston GA et al. The use of dietary manipulation by parents of children with atopic dermatitis. 2004 Br. J. Dermatol. pmid:15214908
Tollesson A and Frithz A Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. 1993 Br. J. Dermatol. pmid:8396411
Morse PF et al. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. 1989 Br. J. Dermatol. pmid:2667620
van Gool CJ et al. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. 2004 Br. J. Dermatol. pmid:15099370
Henz BM et al. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. 1999 Br. J. Dermatol. pmid:10233322
Greaves MW and Corbett MF Treatment of atopic eczema with evening primrose oil. 1988 Br. J. Dermatol. pmid:3355786
Schalin-Karrila M et al. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. 1987 Br. J. Dermatol. pmid:3307886
Daneshmand R et al. Associations of estimated Δ-5-desaturase and Δ-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. 2017 Br. J. Nutr. pmid:28382895
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952